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Dietary supplement

Coltsfoot Leaf Powder Ingredients & Drug Interactions

by TerraVita Premium Collection

Coltsfoot Leaf Powder label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coltsfoot Leaf Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coltsfoot Leaf Powder is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for cough, sore throat, bronchitis and congestion.Based on those ingredients, 374 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coltsfoot, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coltsfoot Leaf Powder by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Coltsfoot Leaf Powder by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coltsfoot Leaf Powder by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: coltsfoot powder. Coltsfoot is an herb traditionally used for respiratory support, though the evidence for its effectiveness isn't established in our data.

The concern here is significant: coltsfoot naturally contains pyrrolizidine alkaloids (PA)—toxic compounds that can injure your liver and lungs. There are no inactive ingredients listed for this product.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coltsfoot product and its label doesn't state a use — see Coltsfoot's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for coltsfoot in our data, so we can't tell you whether it works for its intended purpose based on the evidence we track.

The evidence, ingredient by ingredient Coltsfoot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Coltsfoot carries serious safety concerns. The major risk is liver and lung damage from pyrrolizidine alkaloids—the toxic compounds naturally present in the plant.

Chronic exposure can lead to veno-occlusive disease, a condition where blood vessels in the liver narrow, causing vague early symptoms like stomach pain, vomiting, diarrhea, and fluid buildup, followed within weeks by persistent liver enlargement. The safety data advises against use during pregnancy due to potential liver toxicity and harm to the baby, and against breastfeeding because these toxic alkaloids may pass into breast milk.

If you do consider using a coltsfoot product, use only certified pyrrolizidine alkaloid-free versions.

Side effects, ingredient by ingredient Coltsfoot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coltsfoot.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with us about blood thinners and antiplatelet drugs (warfarin, heparin, aspirin, clopidogrel, and similar agents); blood pressure medications; and drugs that induce the CYP3A4 liver enzyme (carbamazepine, phenobarbital, phenytoin, rifampin, and similar agents). All carry Moderate-severity interaction risks.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Coltsfoot carries significant liver and lung toxicity risk from its natural alkaloid content, plus documented interactions with blood thinners, blood pressure medications, and certain anti-seizure and antibiotic drugs. It's not safe in pregnancy or while breastfeeding.

Talk to your pharmacist before using any coltsfoot product, especially if you take medications for blood clotting or blood pressure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coltsfoot Leaf Powder, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435117474
Net contents 4 Ounce(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 290425
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coltsfoot Leaf Powder by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.25 Teaspoon(s)
Maximum serving Sizes:
0.25 Teaspoon(s)
Servings per container
113
UPC/BARCODE
064435117474
IngredientAmount% DV
Coltsfoot, Powder1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2004 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Stir 1/4 of a teaspoon into a glass of water and consume 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coltsfoot Leaf Powder by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coltsfoot Leaf Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coltsfoot Leaf Powder by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.25 Teaspoon(s) Dosage formPowder Servings per container113 Amounts shown are per serving.

Coltsfoot, Powder

Interacts with
374 drugs
1000 mg per serving

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the...

Coltsfoot, Powder monograph & interactions
Interaction report

Coltsfoot Leaf Powder by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Coltsfoot Leaf Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
374Drugs
374 Moderate

Ingredients driving the most interactions

Coltsfoot, Powder 374

Individual Drug Interactions

The ingredients in Coltsfoot Leaf Powder interact with 374 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coltsfoot Leaf Powder interact with drugs. Each result below shows which ingredient is responsible. Coltsfoot, Powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Coltsfoot Leaf Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coltsfoot, Powder3 drug types · 374 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use might increase the risk of bleeding due to decreased platelet aggregation. Coltsfoot has been reported to inhibit platelet aggregation; avoid concomitant use. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Coltsfoot, Powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coltsfoot Leaf Powder, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Coltsfoot Leaf Powder by TerraVita Premium Collection: Common Questions

Does Coltsfoot Leaf Powder by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Coltsfoot Leaf Powder has a known interaction with 374 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coltsfoot Leaf Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pyrrolizidine alkaloid and why is it a problem in coltsfoot?
Pyrrolizidine alkaloids are toxic compounds naturally found in coltsfoot. They can damage your liver and lungs. With long-term exposure, they can cause a serious condition called veno-occlusive disease, where blood vessels in the liver narrow, leading to abdominal pain, vomiting, diarrhea, and eventually liver enlargement. That's why we recommend using only certified PA-free products, if at all.
Is this safe to use while I'm pregnant or breastfeeding?
No. The safety data advises against coltsfoot during pregnancy because of potential liver toxicity and harm to the baby. It's also not safe while breastfeeding because the toxic alkaloids can pass into breast milk and reach your baby. Talk to your doctor or pharmacist if you're considering it.
Can I take coltsfoot if I'm on a blood thinner like warfarin or aspirin?
No. Coltsfoot inhibits platelet aggregation—the clotting process—and using it with blood thinners or antiplatelet drugs increases your bleeding risk. Avoid concomitant use. Check with your pharmacist about your specific medication before taking this product.
What symptoms would tell me coltsfoot is harming my liver?
Early signs of liver damage from coltsfoot's alkaloids can be vague: stomach pain or cramping, vomiting, diarrhea, and abdominal swelling. Within weeks, you might notice your liver is enlarged. If you develop any of these symptoms after taking coltsfoot, stop and contact your doctor or pharmacist immediately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coltsfoot Leaf Powder label
Go deeper

The Full Monographs Behind Coltsfoot Leaf Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coltsfoot

Interacts with 374 drugs

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrol...

Read the full Coltsfoot monograph →
Sources

Sources & How We Checked

Coltsfoot Leaf Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coltsfoot 8 references
  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

See these in context on the Coltsfoot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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