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Dietary supplement

Coltsfoot Ingredients & Drug Interactions

by TerraVita

Coltsfoot label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Coltsfoot against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Coltsfoot is a dietary supplement by TerraVita with 1 active ingredient. Its ingredients are commonly taken for cough, sore throat, bronchitis and congestion.Based on those ingredients, 374 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coltsfoot Glycerite Liquid Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Coltsfoot by TerraVita

Ask about any prescription or over-the-counter medication and we check it for interactions with Coltsfoot by TerraVita — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Coltsfoot by TerraVita

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Coltsfoot Glycerite Liquid Extract. Glycerin is listed as an inactive ingredient — it's the liquid carrier that helps deliver the coltsfoot extract.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Coltsfoot product and its label doesn't state a use — see Coltsfoot's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We have no effectiveness ratings on file for coltsfoot, so the evidence for how well it works isn't established in the data we hold.

The evidence, ingredient by ingredient Coltsfoot

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's the main concern: coltsfoot naturally contains pyrrolizidine alkaloids (PAs) that can damage your liver and lungs. The facts advise using only certified PA-free products, if at all.

Even with certified PA-free material, chronic use has been linked to veno-occlusive disease — a condition where liver blood vessels scar and narrow, causing pain, vomiting, diarrhea, bloating, and eventually liver enlargement. Lung damage with pulmonary high blood pressure is also a documented risk.

During pregnancy, coltsfoot is rated as likely unsafe due to potential liver toxicity and harm to the baby. While breastfeeding, it's also rated likely unsafe because toxic alkaloids can pass into breast milk.

Do not use this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Coltsfoot

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Coltsfoot.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check it with your pharmacist if you take blood thinners or antiplatelet drugs like warfarin, aspirin, or enoxaparin (Moderate severity); blood pressure medications (Moderate); or seizure and antibiotic drugs like carbamazepine, phenytoin, or rifampin that speed up liver processing (Moderate).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Coltsfoot carries serious safety and interaction risks. If you're taking blood thinners, blood pressure medications, or seizure or antibiotic drugs, talk to your pharmacist before considering this product.

The liver and lung toxicity risk is real — even certified PA-free versions warrant caution. Check with a pharmacist or doctor about whether this is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Coltsfoot, straight from the product label.

Brand TerraVita
Barcode (UPC) 064434285754
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 280238
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Coltsfoot by TerraVita, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
25 Drop(s)
Maximum serving Sizes:
40 Drop(s)
Servings per container
227
UPC/BARCODE
064434285754
IngredientAmount% DV
Coltsfoot Glycerite Liquid Extract0.13 mL--

Other ingredients: Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Formula

Glycerite liquid extract (1:5)

Formulation

Alcohol free No Flavor

Suggested/Recommended/Usage/Directions

Suggested Use: Take 25-40 drops of extract in a small amount of warm water 3-4 times daily. Shake well before using.

Precautions

Keep away from children.

Do not use if safety seal around cap is broken or missing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Coltsfoot by TerraVita label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Coltsfoot label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Coltsfoot by TerraVita

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size25 Drop(s) Dosage formLiquid Servings per container227 Amounts shown are per serving.

Coltsfoot Glycerite Liquid Extract

Interacts with
374 drugs
0.13 mL per serving

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the...

Coltsfoot Glycerite Liquid Extract monograph & interactions

Other (inactive) ingredients: Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Coltsfoot by TerraVita Drug Interactions

Want to check YOUR meds against Coltsfoot?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
374Drugs
374 Moderate

Ingredients driving the most interactions

Coltsfoot Glycerite Liquid Extract 374

Individual Drug Interactions

The ingredients in Coltsfoot interact with 374 drugs. Click any drug to see the details.

1 of the 1 ingredient in Coltsfoot interact with drugs. Each result below shows which ingredient is responsible. Coltsfoot Glycerite Liquid Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Coltsfoot with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Coltsfoot Glycerite Liquid Extract3 drug types · 374 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use might increase the risk of bleeding due to decreased platelet aggregation. Coltsfoot has been reported to inhibit platelet aggregation; avoid concomitant use. Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, excessive doses of coltsfoot may interfere with antihypertensive or cardiovascular therapy.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Inducers

Hepatotoxic pyrrolizidine alkaloids (PA) are substrates of cytochrome P450 3A4 (CYP3A4). Theoretically, drugs that induce CYP3A4 might increase the conversion of PAs to toxic metabolites. Some drugs that induce CYP3A4 include carbamazepine (Tegretol), phenobarbital, phenytoin (Dilantin), rifampin, rifabutin (Mycobutin), and others.

Likelihood Possible Evidence D
Coltsfoot Glycerite Liquid Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Coltsfoot, from the product label.

TerraVita

See all TerraVita products
Name
ZooScape LLC
Phone Number
844-449-0444
Web Address
www.ZooScape.com
Pharmacist Counseling Corner

Coltsfoot by TerraVita: Common Questions

Does Coltsfoot by TerraVita interact with any medications?
Yes. Based on its ingredients, Coltsfoot has a known interaction with 374 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Coltsfoot contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is coltsfoot safe during pregnancy?
No. The safety data rates coltsfoot as likely unsafe in pregnancy because of potential liver toxicity and risk of harm to your baby. You should not use this product if you are pregnant or trying to become pregnant.
Can I use coltsfoot if I'm breastfeeding?
No. Coltsfoot is rated likely unsafe while breastfeeding because toxic alkaloids can pass into breast milk and reach your baby. Avoid this product if you are nursing.
What's the biggest safety issue with coltsfoot?
Coltsfoot contains pyrrolizidine alkaloids that can damage your liver and lungs. Chronic exposure is linked to a serious liver condition called veno-occlusive disease, which causes pain, vomiting, bloating, and liver enlargement. Use only certified PA-free versions, if at all.
Will coltsfoot interfere with my blood pressure medication?
It may. Excessive doses of coltsfoot can theoretically interfere with how blood pressure medications work. Talk to your pharmacist before adding this to your regimen.
Can I take coltsfoot with aspirin or other blood thinners?
You should not. Coltsfoot slows blood clotting, so mixing it with aspirin, warfarin, enoxaparin, or other antiplatelet and anticoagulant drugs raises your bleeding risk. This is a Moderate severity interaction — check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Coltsfoot is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Coltsfoot label
Go deeper

The Full Monographs Behind Coltsfoot’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Coltsfoot

Interacts with 374 drugs

Coltsfoot is a traditional herb long used to soothe coughs and clear mucus, but solid human evidence for these uses is lacking. More importantly, the raw plant can contain liver-toxic pyrrol...

Read the full Coltsfoot monograph →
Sources

Sources & How We Checked

Coltsfoot's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Coltsfoot 8 references
  1. Roulet M, Laurini R, Rivier L, Calame A. Hepatic veno-occlusive disease in newborn infant of a woman drinking herbal tea. J Pediatr 1988;112:433-6. PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  4. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  5. Wilson BE, Hobbs WN. Case report: pseudoephedrine-associated thyroid storm: thyroid hormone-catecholamine interactions. Am J Med Sci 1993;306:317-9. PubMed
  6. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  7. Hwang SB, Chang MN, Garcia ML, et al. L-652,469--a dual receptor antagonist of platelet activating factor and dihydropyridines from Tussilago farfara L. Eur J Pharmacol 1987;141:269-81. PubMed
  8. Freshour JE, Odle B, Rikhye S, Stewart DW. Coltsfoot as a potential cause of deep vein thrombosis and pulmonary embolism in a patient also consuming kava and blue vervain. J Diet Suppl 2012;9:149-54. PubMed

See these in context on the Coltsfoot monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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