Major interaction on record — check this product against your medications before combining. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

Combat Powder Chocolate Peanut Butter Ingredients & Drug Interactions

by MusclePharm

Combat Powder Chocolate Peanut Butter label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Combat Powder Chocolate Peanut Butter against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Combat Powder Chocolate Peanut Butter is a dietary supplement by MusclePharm with 9 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,052 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Combat Powder Chocolate Peanut Butter by MusclePharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Combat Powder Chocolate Peanut Butter by MusclePharm — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Combat Powder Chocolate Peanut Butter by MusclePharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 7 active ingredients.
  • “Multi-Level Amino Acid Growth Matrix” is a proprietary blend — the label gives one combined amount (35 g) without saying how much of each component you get.

Combat Powder has 6 active ingredients. Sodium, potassium, and calcium are electrolytes and minerals that support muscle function, bone health, and nerve signaling.

Iron supports oxygen transport in blood and energy production. The product also includes a multi-level amino acid growth matrix (its components are listed separately in the full ingredient panel) and a digestive enzyme blend to aid nutrient breakdown.

The powder also contains inactive ingredients like cocoa powder, inulin, natural and artificial flavors, sodium chloride, acesulfame potassium, sucralose, soy lecithin, and potassium citrate. These are fillers, thickeners, and sweeteners that give the product its taste and texture.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: muscle growth and protein nutrition.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Muscle recovery, Lean muscle mass, Protein synthesis.
  • The closest evidence on file: Iron is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Iron is rated "Insufficient Reliable Evidence To Rate" for Postoperative recovery.

Our data on this product's effectiveness for muscle building or recovery isn't established in the facts we hold. However, individual ingredients do have established uses: calcium is effective for weak bones (osteoporosis), low blood calcium (hypocalcemia), and indigestion (dyspepsia); iron is effective for iron-deficiency anemia and anemia from chronic disease; and iron is possibly effective for heart failure.

For the product's primary intended use as a muscle-building supplement, the evidence we hold isn't complete enough to rate.

The evidence, ingredient by ingredient Black Psyllium Sodium Potassium Calcium Iron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The minerals in this powder—sodium, potassium, calcium, and iron—are generally well tolerated at recommended dietary amounts. Common mild side effects from oral iron include belly pain, constipation, diarrhea, nausea, and vomiting.

Potassium can cause abdominal pain, nausea, diarrhea, and flatulence. Calcium commonly causes constipation, diarrhea, and stomach upset.

The safety notes caution that excess sodium is linked to high blood pressure and heart strain, and potassium and calcium supplements can be risky for people with kidney disease. In pregnancy, sodium safety data show conflicting evidence (rated both likely safe and possibly unsafe); potassium is likely safe; and calcium and iron are likely safe.

During breastfeeding, calcium is likely safe, and iron is generally considered acceptable—but check with your provider about all supplements while nursing.

Side effects, ingredient by ingredient Black Psyllium Sodium Potassium Calcium Iron

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Black Psyllium, Calcium, Potassium, Iron, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 2,053 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on an HIV integrase inhibitor (dolutegravir, elvitegravir), any blood pressure or heart medication (ACE inhibitors, ARBs, antihypertensives, diltiazem, sotalol), the antibiotic ceftriaxone, water pills (potassium-sparing diuretics), lithium, levothyroxine (thyroid medication), antibiotics (quinolones, tetracyclines), or bisphosphonates. Calcium, sodium, potassium, and iron in this product can all reduce how well these drugs work or raise the risk of serious side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Combat Powder is a multi-nutrient supplement aimed at muscle recovery. If you take any blood pressure medications, heart drugs, thyroid medication, antibiotics, or lithium, check your exact medications with the tool on this page before using it.

People with kidney disease should talk to their doctor first. For anyone else, run your prescriptions through the checker—the interactions here are real but manageable with timing and medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Combat Powder Chocolate Peanut Butter, straight from the product label.

Brand MusclePharm
Barcode (UPC) 736211050472
Net contents 2 lb; 907 g
Market status On market
Date entered into DSLD Jan 25, 2013
DSLD ID 18056
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Combat Powder Chocolate Peanut Butter by MusclePharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
34.9 Gram(s)
Maximum serving Sizes:
69.8 Gram(s)
Servings per container
26
UPC/BARCODE
736211050472
IngredientAmount% DV
Calories130 {Calories}--
Total Carbohydrates5 g2%
Sugar2 g--
Calories from Fat15 {Calories}--
Total Fat1.5 g4%
Dietary Fiber1 g4%
Protein25 g50%
Saturated Fat1 g8%
Sodium220 mg11%
Trans Fat0 g--
Potassium257 mg7%
Cholesterol75 mg30%
Calcium0 NP12%
Iron0 NP6%
Multi-Level Amino Acid Growth Matrix35 g--
Digestive Enzyme Blend0 NP--
Combat Powder(TM) Proprietary Time Release System0 NP--

Other ingredients: Cocoa powder, Inulin, Natural and Artificial flavors, Sodium Chloride, Acesulfame Potassium, Sucralose, Soy Lecithin, Potassium Citrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

NATURAL & ARTIFICIAL FLAVORS HYBRID SERIES

ADVANCED TIME RELEASED PROTEIN -FAST, MEDIUM, AND SLOW-RELEASING PROTEINS -ADDED DIGESTIVE BLEND FOR EASE OF ABSORPTION -5 POWERFUL PROTEINS PLUS ADDED BCAA'S -EXTRA GLUTAMINE -ADDED DIETARY FIBER

NOTICE: Powder density may be affected by settling which may cause variations in the scoop serving size and fill levels from bottle to bottle.

**Packed by weight, not by volume. Settling of product occurs after filling. Do not use if tamper evident security feature is broken or missing. Exposure to heat, light or air can affect flavor or aroma; therefore keep out of direct light or heat and store in a cool dark place. Keep sealed when not in use.

MADE IN A cGMP CERTIFIED FACILITY MADE IN USA

FDA Statement of Identity

DIETARY SUPPLEMENT

Brand IP Statement(s)

FEED MUSCLE UP TO 8 HOURS(TM)

MP MUSCLEPHARM(R) OFFICIAL NUTRITIONAL SUPPLEMENT PROVIDER OF THE UFC(R) ULTIMATE FIGHTING(R) CHAMPIONSHIP(R)

MP FUELING ATHLETES SAFELY(TM) A precision engineered matrix, COMBAT POWDER(R) is the ultimate timed-release protein super-food! Each of the distinct protein sources found within COMBAT POWDER(R) digest at varying rates - because this unique feature, amino acids not only food into the bloodstream within minutes after consumption, but will also continuously be "trickle fed" to your muscles for up to 8 hours afterward! WHAT'S IN COMBAT POWDER(R)?

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As a dietary supplement, mix 1 to 2 scoops of COMBAT POWDER(R) with 8-12 fl oz of cold water. Vary the amount of water to achieve your desired consistency and taste. Consume 2-3 times a day for optimal muscle growth. FOR MEN: As a dietary supplement, mix 2 scoops (providing 50 grams of protein) with 8-12 fl oz of cold water or any beverage you prefer. Consume 2-3 times a day for optimal muscle growth. To increase your protein intake per serving and achieve a delicious milkshake taste, use skim or low fat milk instead of water. FOR WOMEN: As a dietary supplement, mix 1 scoop (providing 25 grams of protein) with 8-12 fl oz of cold water or any beverage you prefer. Vary the amount of water to achieve your desired consistency and taste. Consume 2-3 times a day for optimal body shaping requirements. To increase your protein intake per serving and achieve a delicious milkshake taste, use skim or low fat milk instead of water.

Precautions

ALLERGEN WARNING: This product contains milk and soy. This product was produced in a facility that may also process ingredients containing milk, egg, soybeans, shellfish, fish, tree nuts, and peanuts.

WARNING: This product is intended as a dietary supplement only. Do not use as a sole source of nutrition.

KEEP OUT OF REACH OF CHILDREN.

Storage

STORAGE AND MAINTENANCE: Due to the amount of active ingredients in this product, shake weekly and before use to ensure proper ingredient mixture and effectiveness per dose.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

COMBAT'S POWERFUL PROTEIN SOURCES: -WHEY PROTEIN ISOLATE: Highest available yield of protein, gram for gram, of any whey protein source, WPI absorbs quickly into the muscle tissues, and has immune-boosting properties to protect the body system during periods of intense training. -PARTIALLY HYDROLYZED WHEY PROTEIN: Hydrolyzed whey is protein that's been broken down into fast-absorbing peptides. The fastest absorbing of all forms of whey, hydrolyzed whey hits the bloodstream first, providing a rapid infusion of muscle-building amino acids. -MICELLAR CASEIN: Very slow-digesting, micellar casein has the capability of slowly infusing amino acids over several hours, protecting muscle tissue from breakdown over time. There is no substitute for the anti-catabolic effects of micellar casein. -WHEY PROTEIN CONCENTRATE: Closer to the whole food sources than other whey proteins, concentrate contains real food subfractions such as the alpha-lactoglobulins and lactoferrins, with specific immune-boosting and muscle-building properties. -EGG ALBUMEN: Highly bio-available and well-tolerated by most individuals, egg albumin has a high BCAA content and arginine. Egg albumin is a powerful contributor to hormone production and the muscle-building process. -COMBAT'S POWERFUL DIGESTIVE ENZYME BLEND: Digestive enzymes break down food along the digestive tract so that nutrients can be absorbed into the bloodstream. COMBAT contains 60mg of a Digestive Enzyme Blend to aid in the digestion and absorption of they key muscle-building proteins contained herein. The body cannot absorb what it cannot break down. The added Digestive Enzyme Blend ensures maximum utilization of COMBAT's muscle-building protein component.

General

Dom v2.2 20120806

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See for yourself

Combat Powder Chocolate Peanut Butter by MusclePharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Combat Powder Chocolate Peanut Butter label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Combat Powder Chocolate Peanut Butter by MusclePharm

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size34.9 Gram(s) Dosage formPowder Servings per container26 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 g per serving

Dietary Fiber

Interacts with
2,025 drugs
1 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

25 g per serving

Sodium

Interacts with
205 drugs
220 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
257 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Calcium

Interacts with
168 drugs
0 NP per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Iron

Interacts with
80 drugs
0 NP per serving

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Multi-Level Amino Acid Growth Matrix

35 g per serving
  • › Digestive Enzyme Blend
  • › Combat Powder(TM) Proprietary Time Release System

Other (inactive) ingredients: Cocoa powder, Inulin, Natural and Artificial flavors, Sodium Chloride, Acesulfame Potassium, Sucralose, Soy Lecithin, Potassium Citrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Combat Powder Chocolate Peanut Butter by MusclePharm Drug Interactions

Want to check YOUR meds against Combat Powder Chocolate Peanut Butter?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,052Drugs
7 Major 331 Moderate 1,714 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Calcium 168
Iron 80
Potassium 62

Individual Drug Interactions

The ingredients in Combat Powder Chocolate Peanut Butter interact with 2,052 drugs. Click any drug to see the details.

5 of the 9 ingredients in Combat Powder Chocolate Peanut Butter interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Calcium Iron Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Combat Powder Chocolate Peanut Butter with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Combat Powder Chocolate Peanut Butter, from the product label.

MusclePharm

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Web Address
MUSCLEPHARM.COM
Pharmacist Counseling Corner

Combat Powder Chocolate Peanut Butter by MusclePharm: Common Questions

Does Combat Powder Chocolate Peanut Butter by MusclePharm interact with any medications?
Yes. Based on its ingredients, Combat Powder Chocolate Peanut Butter has a known interaction with 2,052 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Combat Powder Chocolate Peanut Butter contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data for sodium shows conflicting evidence in pregnancy—one entry says likely safe, another says possibly unsafe. Potassium is likely safe, and calcium and iron are also likely safe. But pregnancy needs are individual, so talk with your OB or midwife before adding any supplement.
Is this safe while breastfeeding?
Calcium is likely safe while breastfeeding, and iron is generally considered acceptable at appropriate doses. Potassium safety during lactation isn't detailed in our data. Check with your doctor or lactation consultant about the full product.
What does the amino acid matrix do?
The multi-level amino acid growth matrix is included to support muscle repair and recovery. Amino acids are the building blocks of protein and muscle tissue, which is why they're standard in muscle-building supplements.
Does this cause gas or stomach upset?
Yes, commonly. Iron, potassium, and the digestive enzymes can each cause bloating, gas, diarrhea, nausea, or constipation in some people. Taking it with food may help, and these effects often settle with use.
Can I take this with my blood pressure medication?
Sodium in this product can reduce how well blood pressure drugs work, and potassium can raise levels to dangerous heights if you're on an ACE inhibitor or ARB. Before you start, use the medication checker on this page with your exact medication names.
How much sodium and potassium is in one serving?
The product facts don't specify the exact amounts per serving. Contact the manufacturer (MusclePharm) or check the nutrition label on the package for serving sizes and mineral content.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Combat Powder Chocolate Peanut Butter label
Go deeper

The Full Monographs Behind Combat Powder Chocolate Peanut Butter’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph →
Sources

Sources & How We Checked

Combat Powder Chocolate Peanut Butter's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 202 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
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  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Sodium 38 references
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  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
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  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
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See these in context on the Sodium monograph →

Potassium 12 references
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  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
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See these in context on the Potassium monograph →

Calcium 62 references
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