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Dietary supplement

Cu-Zyme Ingredients & Drug Interactions

by Biotics Research Corporation

Cu-Zyme label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cu-Zyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cu-Zyme is a dietary supplement by Biotics Research Corporation with 1 active ingredient. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 31 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Copper. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cu-Zyme by Biotics Research Corporation

Ask about any prescription or over-the-counter medication and we check it for interactions with Cu-Zyme by Biotics Research Corporation — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cu-Zyme by Biotics Research Corporation

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cu-Zyme contains a single active ingredient: copper. Copper is an essential mineral your body needs to form red blood cells, maintain nerve function, and support immune health.

The tablet also includes inactive ingredients (cellulose, vegetable culture, stearic acid, and magnesium stearate) that help hold it together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Copper's overall clinical evidence instead.

Strong

Strong clinical evidence supports Copper for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Copper deficiency — rated "Likely Effective" (Natural Medicines).

Copper supplementation is likely effective for treating copper deficiency. For other uses — Alzheimer's disease, acne, chemotherapy-related anemia, and brain tumors — the evidence we hold is either insufficient to rate or suggests it may not help (as with Alzheimer's disease).

If you're considering this supplement for a reason other than documented copper deficiency, talk with your doctor about whether the evidence supports it.

The evidence, ingredient by ingredient Copper

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper from food and standard supplements is generally well tolerated at normal doses, but excess copper is toxic. The safety data advises caution: copper is needed in pregnancy, but stay within recommended amounts and avoid high-dose supplements without medical guidance.

The same caution applies during lactation. Rarely, contact dermatitis from copper has been reported.

There's also evidence that people with diabetes tend to have higher copper levels in their blood, though it's unclear whether elevated copper itself worsens diabetes.

Side effects, ingredient by ingredient Copper

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 31 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take Cu-Zyme, check whether you're on penicillamine (Cuprimine, Depen) — copper can reduce its absorption and you'll need to separate the doses. If you take oral contraceptives, be aware that this combination may raise your copper levels; mention it to your pharmacist or doctor so they can monitor if needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Cu-Zyme is appropriate if you have a documented copper deficiency and aren't taking penicillamine or hormonal birth control. If you're on either of those medications, talk with your pharmacist before starting — penicillamine absorption is the bigger concern.

For other uses, check with your doctor about whether the evidence supports supplementation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cu-Zyme, straight from the product label.

Brand Biotics Research Corporation
Net contents 100 Tablet(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21616
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cu-Zyme by Biotics Research Corporation, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Copper2 mg100%

Other ingredients: Cellulose, vegetable culture, Stearic Acid, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Sealed with an imprinted safety seal for your protection.

Lot Number: Exp. Date:

General

Rev. 1/08

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

(C) Copyright 2008

Suggested/Recommended/Usage/Directions

RECOMMENDATION: One (1) tablet daily as a dietary supplement or as otherwise recommended by a healthcare professional.

Precautions

KEEP OUT OF REACH OF CHILDREN

Storage

Store in a cool, dry area.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cu-Zyme by Biotics Research Corporation label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cu-Zyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cu-Zyme by Biotics Research Corporation

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Copper

Interacts with
31 drugs
2 mg per serving Form: Copper Citrate, Copper Gluconate

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Copper monograph & interactions

Other (inactive) ingredients: Cellulose, Vegetable culture, Stearic Acid, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cu-Zyme by Biotics Research Corporation Drug Interactions

Want to check YOUR meds against Cu-Zyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
31Drugs
1 Moderate 30 Minor

Ingredients driving the most interactions

Copper 31

Individual Drug Interactions

The ingredients in Cu-Zyme interact with 31 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cu-Zyme interact with drugs. Each result below shows which ingredient is responsible. Copper

Each ingredient & the kinds of drugs it affects

For each ingredient in Cu-Zyme with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Copper2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Copper full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cu-Zyme, from the product label.

Biotics Research Corporation

See all Biotics Research Corporation products
Name
BIOTICS RESEARCH CORP.
City
Rosenberg
State
Texas
Phone Number
(281) 344-0909
Pharmacist Counseling Corner

Cu-Zyme by Biotics Research Corporation: Common Questions

Does Cu-Zyme by Biotics Research Corporation interact with any medications?
Yes. Based on its ingredients, Cu-Zyme has a known interaction with 31 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cu-Zyme contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will copper help my Alzheimer's disease?
The evidence we hold suggests copper may not be effective for Alzheimer's disease, so supplementation isn't likely to help. Talk with your doctor about treatments that do have solid evidence behind them.
Is it safe to take this copper supplement while pregnant?
The data shows copper is likely safe in pregnancy at recommended amounts, but you should avoid high-dose supplements without medical advice. Talk with your doctor or pharmacist about what dose is right for you.
Can copper cause side effects?
Copper is generally well tolerated at normal doses, though excess copper is toxic. Rarely, contact dermatitis (a skin rash) from copper exposure has been reported. If you notice skin changes after starting this supplement, let your pharmacist know.
What is copper used for in the body?
Copper is an essential mineral that helps your body form red blood cells, maintain nerve function, and support immune health. It's needed in small amounts, and deficiency is uncommon in people eating a balanced diet.
Is it safe to take copper while breastfeeding?
Copper is considered likely safe during lactation at recommended amounts. As always, stick to standard supplement doses and talk with your pharmacist if you have questions about what's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cu-Zyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cu-Zyme label
Go deeper

The Full Monographs Behind Cu-Zyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph →
Sources

Sources & How We Checked

Cu-Zyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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