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Dietary supplement

Cynarol Ingredients & Drug Interactions

by Dr. Dunner

Cynarol label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cynarol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cynarol is a dietary supplement by Dr. Dunner with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke leaf 5:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cynarol by Dr. Dunner

Ask about any prescription or over-the-counter medication and we check it for interactions with Cynarol by Dr. Dunner — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cynarol by Dr. Dunner

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cynarol contains one active ingredient: artichoke leaf extract in a 5:1 concentrate form, meaning five parts of artichoke leaf are reduced to one part extract. This ingredient is also the capsule's inactive component, so what you're getting is straightforward—just concentrated artichoke leaf.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive system support and cholesterol maintenance.
  • We looked for evidence on: Dyspepsia, Hyperlipidemia, Biliary disorders, indigestion, bloating, liver health.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders.

The evidence supports artichoke leaf extract for two uses. It's possibly effective for high cholesterol (hyperlipidemia) and digestive upset (dyspepsia)—small clinical trials show modest improvements in both.

For fatty liver disease (nonalcoholic fatty liver disease or NAFLD), the evidence isn't established yet in the data we hold.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated when used short-term, though quality and dosing vary between products. The most common side effects are mild: abdominal pain, diarrhea, gas, increased hunger, and nausea.

Rarely, people sensitive to artichoke inulin have had severe allergic reactions (anaphylaxis). If you're allergic to ragweed, chrysanthemums, marigolds, daisies, or other plants in the Asteraceae family, you're at higher risk for an allergic reaction to artichoke.

During pregnancy, there isn't enough safety data, so it's best avoided; the same goes for breastfeeding.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you're on blood pressure medications (antihypertensives), blood sugar medications (antidiabetes drugs), or any drug metabolized by the liver enzymes CYP2C19 or CYP2B6. Artichoke may lower blood pressure further, raise low-blood-sugar risk, or raise drug levels in your blood.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Cynarol is worth considering if you're looking to support cholesterol or digestion with a generally well-tolerated herbal extract. But if you take blood pressure or blood sugar medications, or drugs that depend on liver enzymes CYP2C19 or CYP2B6, talk to your pharmacist before starting—the extract can amplify or interfere with how those work.

Avoid it if you're pregnant or nursing, or if you have allergies to ragweed and related plants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cynarol, straight from the product label.

Brand Dr. Dunner
Barcode (UPC) 7611278900782
Net contents 40 Capsule(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33334
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cynarol by Dr. Dunner, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
20
UPC/BARCODE
7611278900782
IngredientAmount% DV
Calories2.8 {Calories}--
Calories from Fat0 {Calories}--
Artichoke leaf 5:1 extract940 mg--

Other ingredients: Artichoke (Cynara scolymus L.) leaf extract 5:1

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Made in Switzerland

Formula

Artichoke leaf dry extract

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules daily with some liquid. A course of capsules should be taken for at least 12 weeks.

Storage

Store in a daylight protected, dry and cool place.

Brand IP Statement(s)

The high concentration of artichoke in Cynarol(R) provides support for the digestive system and helps maintain cholesterol levels that are already within the normal range.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cynarol by Dr. Dunner label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cynarol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cynarol by Dr. Dunner

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container20 Amounts shown are per serving.

Artichoke leaf 5:1 extract

Interacts with
363 drugs
940 mg per serving

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke leaf 5:1 extract monograph & interactions

Other (inactive) ingredients: Artichoke (Cynara scolymus L.) leaf extract 5:1. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cynarol by Dr. Dunner Drug Interactions

Want to check YOUR meds against Cynarol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke leaf 5:1 extract 363

Individual Drug Interactions

The ingredients in Cynarol interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cynarol interact with drugs. Each result below shows which ingredient is responsible. Artichoke leaf 5:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Cynarol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke leaf 5:1 extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke leaf 5:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cynarol, from the product label.

Dr. Dunner

See all Dr. Dunner products
Name
Flora, Inc.
Street Address
805 E. Badger Rd.
City
Lynden
State
WA
ZipCode
98264
Phone Number
1.800.446.2110
Web Address
www.florahealth.com
Pharmacist Counseling Corner

Cynarol by Dr. Dunner: Common Questions

Does Cynarol by Dr. Dunner interact with any medications?
Yes. Based on its ingredients, Cynarol has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cynarol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Cynarol if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided. The same goes for breastfeeding. Talk to your doctor or pharmacist if you're considering it during either time.
What are the most common side effects?
Most people tolerate artichoke extract well. The most common side effects are mild: abdominal pain, diarrhea, gas, increased hunger, and nausea. Rarely, people sensitive to artichoke inulin have had severe allergic reactions.
Who shouldn't take this product?
Avoid it if you're allergic to ragweed, chrysanthemums, marigolds, daisies, or other plants in the Asteraceae family—you're at higher risk for an allergic reaction. Also skip it if you're pregnant or breastfeeding.
Does Cynarol actually work for high cholesterol and digestion?
The evidence says it's possibly effective for both. Small clinical trials show artichoke leaf extract can modestly lower cholesterol and ease digestive upset, but the improvements are modest, not dramatic.
Why does artichoke interact with so many medications?
Artichoke leaf extract lowers blood pressure and blood sugar slightly on its own, so it can amplify those effects if you're already on medications for either. It also inhibits two liver enzymes that break down many drugs, potentially raising their levels in your blood.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cynarol label
Go deeper

The Full Monographs Behind Cynarol’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Cynarol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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