Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

D-Aspartic Acid Ingredients & Drug Interactions

by 5% Core

D-Aspartic Acid label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Aspartic Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D-Aspartic Acid is a dietary supplement by 5% Core with 2 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3,3'-Diindolymethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D-Aspartic Acid by 5% Core

Ask about any prescription or over-the-counter medication and we check it for interactions with D-Aspartic Acid by 5% Core — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D-Aspartic Acid by 5% Core

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

5% Core contains 2 active ingredients: D-Aspartic Acid and 3,3'-diindolylmethane (also called diindolylmethane). The product also includes inactive ingredients — gelatin capsules, microcrystalline cellulose, silicon dioxide, and magnesium stearate — which are fillers and binders that help form and stabilize the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Diindolylmethane product and its label doesn't state a use — see Diindolylmethane's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The effectiveness data we hold shows insufficient reliable evidence to rate diindolylmethane for benign prostate enlargement, breast cancer, colorectal cancer, cervical cell changes, or breast pain. We don't hold effectiveness ratings for D-Aspartic Acid, so we can't speak to how well either ingredient works for the claims made about this product.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, though long-term safety hasn't been established. The most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious side effect (drug rash with eosinophilia and systemic symptoms, or DRESS) has been reported. One case of stroke occurred in a woman taking diindolylmethane, but she had multiple stroke risk factors, so it's unclear if the supplement played a role.

Because of possible effects on hormones, diindolylmethane is best avoided during pregnancy. There isn't enough safety data to use it while breastfeeding.

For D-Aspartic Acid, we don't hold pregnancy or breastfeeding safety information.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you take estrogens (birth control pills, hormone replacement therapy, or estrogen patches) — diindolylmethane might change how they work. Also ask your pharmacist if you take diuretic drugs (water pills), especially for blood pressure or heart conditions, or any medications your liver metabolizes through CYP1A2.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're not on hormonal birth control or hormone replacement therapy and don't take water pills or medications your liver breaks down quickly, this product may be worth discussing with your pharmacist. If you do take any of those, check your exact medications with the tool below first.

Long-term safety data is thin, so this is a shorter-term option worth talking through.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Aspartic Acid, straight from the product label.

Brand 5% Core
Barcode (UPC) 850029555216
Net contents 150 Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333956
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Aspartic Acid by 5% Core, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Capsule(s)
Maximum serving Sizes:
5 Capsule(s)
Servings per container
30
UPC/BARCODE
850029555216
IngredientAmount% DV
D-Aspartic Acid3120 mg--
3,3'-Diindolymethane200 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Take 5 capsules by mouth once daily with a meal.

Precautions

Warning Not intended for persons under the age of 18. Keep out of reach of children

Consult your health care professional prior to use if you have or suspect a medical condition, are taking prescription drugs or are pregnant or breast feeding.

California's Proposition 65 Warning Warning: Consuming this product can expose you to chemicals including lead, which is known to the state of California to cause birth defects or other reproductive harm. For more information go to: www.P65Warnings.ca.gov/food

This product was produced in a facility that may also process ingredients containing milk, egg, soy, shellfish, fish, tree nuts, wheat and peanuts.

Storage

Store in a cool, dry place away from sunlight & with lid securely tightened.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. Thia product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

GMP Good Manufacturing Practice

Third Party Tested Product Guarantee

Formula

D-Aspartic Acid 3,120mg with 200mg DIM per serving

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Aspartic Acid by 5% Core label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Aspartic Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Aspartic Acid by 5% Core

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size5 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

D-Aspartic Acid

3120 mg per serving

3,3'-Diindolymethane

Interacts with
269 drugs
200 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

3,3'-Diindolymethane monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Aspartic Acid by 5% Core Drug Interactions

Want to check YOUR meds against D-Aspartic Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

3,3'-Diindolymethane 269

Individual Drug Interactions

The ingredients in D-Aspartic Acid interact with 269 drugs. Click any drug to see the details.

1 of the 2 ingredients in D-Aspartic Acid interact with drugs. Each result below shows which ingredient is responsible. 3,3'-Diindolymethane

Each ingredient & the kinds of drugs it affects

For each ingredient in D-Aspartic Acid with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

3,3'-Diindolymethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
3,3'-Diindolymethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D-Aspartic Acid, from the product label.

5% Core

See all 5% Core products
Name
Rich Piana 5% Nutrition
City
Largo
State
FL
ZipCode
33777
Phone Number
727-202-9088
Web Address
5PercentNutrition.com
Pharmacist Counseling Corner

D-Aspartic Acid by 5% Core: Common Questions

Does D-Aspartic Acid by 5% Core interact with any medications?
Yes. Based on its ingredients, D-Aspartic Acid has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D-Aspartic Acid contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
You should check with your pharmacist first. Diindolylmethane might increase or decrease how your body handles estrogen in birth control, which could affect how well it protects you. This is important enough to verify with your exact medication before starting.
What are the most common side effects?
Diarrhea, gas, headache, nausea, rash, and vomiting. Most people tolerate it well in short-term use, but if any of these bother you or don't go away, let your pharmacist know.
Is this safe to take long-term?
The data we have is limited. Diindolylmethane is generally well tolerated in short-term studies, but we don't have good long-term safety information, so talk with your pharmacist about how long you plan to use it.
Can I take this while pregnant or breastfeeding?
We don't have enough safety data for diindolylmethane while breastfeeding, so it's best to avoid it then. For pregnancy, talk with your doctor or pharmacist for personalized advice.
Does this actually work?
We don't have reliable evidence to say whether diindolylmethane works for the conditions it's marketed for — benign prostate enlargement, breast cancer risk, or other uses. The evidence just isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Aspartic Acid label
Go deeper

The Full Monographs Behind D-Aspartic Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

D-Aspartic Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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