Interactions on record — worth a quick check against your medications. Based on 4 of 9 ingredients. Check your meds →
Dietary supplement

DuoZyme Ingredients & Drug Interactions

by Karuna

DuoZyme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DuoZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DuoZyme is a dietary supplement by Karuna with 9 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine Hydrochloride, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DuoZyme by Karuna

Ask about any prescription or over-the-counter medication and we check it for interactions with DuoZyme by Karuna — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DuoZyme by Karuna

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 6 of its 9 active ingredients.

DuoZyme contains 9 active ingredients—mostly digestive enzymes and cofactors designed to support your digestion. Papain (from papaya) and pepsin are proteases (protein-digesting enzymes); lipase breaks down fats; amylase breaks down carbohydrates.

Betaine hydrochloride and glutamic hydrochloride are meant to increase stomach acid. Pancreatin 6X is a blend of multiple enzymes, and ox bile extract supports fat digestion.

The capsule also contains inactive ingredients like silica, stearate, vegetable stearine, and maltodextrin.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Fast-acting full range digestive enzymes.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Food allergies, Inflammatory bowel disease (IBD), Wound healing, Indigestion — and 2 related terms.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Dyspepsia.

The evidence we hold for these ingredients is thin. Papain, lipase, betaine hydrochloride, pepsin, protease, and amylase all lack reliable evidence for the uses people typically try them for—dyspepsia (indigestion), inflammatory bowel disease, and other digestive complaints.

That doesn't mean they don't work; it means well-designed clinical trials either haven't been done or didn't show clear benefit. You'd be trying this largely on the theory that replacing digestive enzymes or acid helps your digestion, not on proven results.

The evidence, ingredient by ingredient Papain Lipase Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term use of these enzymes at standard doses is generally well tolerated, but some people do experience side effects. Papain and pepsin can trigger allergic reactions—itching, watery eyes, swelling, or rash—in sensitive individuals, and high oral doses of papain may cause severe stomach irritation or even esophageal damage.

Betaine hydrochloride can irritate your stomach and is not safe if you have ulcers or gastritis. If you're pregnant, the safety data advises against papain and betaine hydrochloride; for the other ingredients, there isn't enough data to know either way, so talk with your doctor.

While breastfeeding, safety information is limited across most ingredients—check with your healthcare provider before use.

Side effects, ingredient by ingredient Papain Lipase Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DuoZyme, double-check if you're on warfarin (Coumadin)—papain in this product may increase its blood-thinning effects. Also verify any H2-blockers (like famotidine), antacids, or PPIs (like omeprazole, lansoprazole) you take; betaine hydrochloride may weaken their acid-reducing action.

If you're on any of these, run them through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

DuoZyme is a digestive enzyme blend that may appeal to people who feel their digestion needs support, but the clinical evidence for its ingredients is sparse. If you take warfarin or acid-reducing medications, you must check with your pharmacist first.

Pregnancy and breastfeeding aren't ideal times to use this product without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DuoZyme, straight from the product label.

Brand Karuna
Barcode (UPC) 018647031035
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 327088
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DuoZyme by Karuna, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
018647031035
IngredientAmount% DV
Papain100 mg--
Lipase0 NP--
Betaine Hydrochloride300 mg--
Pepsin40 mg--
Ox Bile extract120 mg--
Pancreatin 6X300 mg--
Protease0 NP--
Amylase0 NP--
Glutamic Hydrochloride300 mg--

Other ingredients: Silica, Stearate, Vegetable Stearine, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Fast-acting, full range digestive enzymes

Brand IP Statement(s)

Karuna Responsible Nutrition

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use for adults: Two or more capsules, taken with meals, or as directed by your health care practitioner.

Precautions

Patients with active peptic ulcer should use HCI products with caution.

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Formulation

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Storage

Keep in a cool, dry place, tightly capped.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DuoZyme by Karuna label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DuoZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DuoZyme by Karuna

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
100 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Betaine Hydrochloride

Interacts with
36 drugs
300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Pepsin

No known
interactions
40 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Ox Bile extract

120 mg per serving

Pancreatin 6X

300 mg per serving

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Amylase

0 NP per serving

Glutamic Hydrochloride

300 mg per serving

Other (inactive) ingredients: Silica, Stearate, Vegetable Stearine, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

DuoZyme by Karuna Drug Interactions

Want to check YOUR meds against DuoZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36
Papain 2

Individual Drug Interactions

The ingredients in DuoZyme interact with 38 drugs. Click any drug to see the details.

2 of the 9 ingredients in DuoZyme interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in DuoZyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DuoZyme, from the product label.

Karuna

See all Karuna products
Name
Karuna Corporation
Street Address
42 Digital Drive #7
City
Novato
State
CA
ZipCode
94949
Phone Number
800-826-7225
Pharmacist Counseling Corner

DuoZyme by Karuna: Common Questions

Does DuoZyme by Karuna interact with any medications?
Yes. Based on its ingredients, DuoZyme has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DuoZyme contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
No, not without checking with your doctor first. Papain and betaine hydrochloride should be avoided in pregnancy due to safety concerns. For the other ingredients and while breastfeeding, there isn't enough safety data, so personalized medical advice is important.
Will DuoZyme help with my indigestion?
The evidence for these ingredients in indigestion (dyspepsia) isn't well established in our data. These enzymes are based on the theory that they support digestion, but clinical studies haven't proven they work for that purpose. Ask your pharmacist if trying it makes sense for your situation.
What's in here—just enzymes?
Mostly. You get nine active ingredients: papain, pepsin, protease, and amylase (digestive enzymes); lipase (fat digestion); betaine and glutamic hydrochloride (acid); pancreatin and ox bile extract (multienzyme and fat support). The capsule also has fillers like silica and maltodextrin.
Can I take this with my antacid or PPI?
Not safely, without talking to your pharmacist first. Betaine hydrochloride in DuoZyme boosts stomach acid, which could make your antacid or PPI (like omeprazole) less effective. You'll need personalized advice on timing or alternatives.
Are there any common side effects?
Most people tolerate it okay at normal doses, but some experience allergic reactions—rash, itching, watery eyes, swelling—especially if sensitive to papain or the other enzymes. High doses of papain may cause stomach upset or heartburn. Stop and call your doctor if you notice severe stomach pain.
What are the proteases—pepsin and protease—for?
They break down protein into smaller pieces so your body can absorb it more easily. The idea is to support your own digestive process, though the clinical evidence for their effectiveness isn't established in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DuoZyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DuoZyme label
Go deeper

The Full Monographs Behind DuoZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

DuoZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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