Interactions on record — worth a quick check against your medications. Based on 4 of 7 ingredients. Check your meds →
Dietary supplement

Dyzime Ingredients & Drug Interactions

by DC

Dyzime label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dyzime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Dyzime is a dietary supplement by DC with 7 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine Hydrochloride, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dyzime by DC

Ask about any prescription or over-the-counter medication and we check it for interactions with Dyzime by DC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Dyzime by DC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 7 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.

Dyzime contains 7 active ingredients, most of them digestive enzymes. Betaine hydrochloride is a stomach-acid booster; papain is a protein-digesting enzyme from papaya; lipase breaks down fats; protease breaks down proteins; amylase breaks down starches; pepsin is another protease; and glutamic acid hydrochloride is an amino acid.

Together they're designed to support digestion. The tablet also contains inactive ingredients — calcium phosphate, vegetable cellulose, vegetable stearic acid, vegetable magnesium stearate, silica, and vanillin — which are fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Wound healing, indigestion, bloating, protein digestion.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for Dyzime's ingredients is limited. For betaine hydrochloride, we don't have reliable evidence that it works for indigestion, low thyroid function, diarrhea, rheumatoid arthritis, food allergies, or hay fever.

Papain similarly lacks solid evidence for cancer, tooth decay, radiation skin damage, muscle soreness, shingles, or parasitic infections. Lipase and the other enzymes show insufficient evidence in our data for the conditions they're marketed for.

That doesn't mean they don't work — it means the research to prove it isn't in the records we hold.

The evidence, ingredient by ingredient Betaine Hydrochloride Papain Proteolytic Enzymes (proteases) Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride can irritate the stomach and is not safe if you have ulcers, gastritis, or true acid reflux — it may trigger heartburn. Papain is generally tolerated as a food but can irritate the digestive tract and cause allergic reactions in sensitive people; high doses may be unsafe.

Lipase and the proteases (protease and pepsin) are generally well tolerated but may cause digestive upset or allergic reactions in some people. For pregnancy: betaine hydrochloride and papain are not recommended — there isn't enough safety data, and papain is rated possibly unsafe due to concentration concerns.

Lipase, protease, and pepsin have little safety data in pregnancy, so use only if your doctor advises it. For breastfeeding: avoid betaine hydrochloride and papain; lipase and protease are not recommended without medical advice.

We have no pregnancy or breastfeeding data on file for amylase and glutamic acid hydrochloride.

Side effects, ingredient by ingredient Betaine Hydrochloride Papain Proteolytic Enzymes (proteases) Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Dyzime, check with your doctor or pharmacist if you take warfarin (Coumadin) or any blood thinners — papain may increase their effects. Also flag any H2-blockers (like famotidine or ranitidine), antacids, or proton pump inhibitors (like omeprazole or pantoprazole) — betaine hydrochloride may weaken them.

We could not check amylase and glutamic acid hydrochloride for interactions, so bring your full medication list to the conversation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Dyzime is a digestive enzyme blend that may appeal to people looking for enzyme support, but the evidence for its effectiveness isn't established in our data. If you take warfarin or any acid-reducing medication, talk to your doctor or pharmacist before adding this product — the interactions could matter.

It's not safe in pregnancy or breastfeeding, and it's off-limits if you have ulcers or gastritis.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dyzime, straight from the product label.

Brand DC
Net contents 180 Tablet(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 266600
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dyzime by DC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
180
IngredientAmount% DV
Betaine Hydrochloride10 mg--
Papain50 mg--
Lipase0 NP--
Protease0 NP--
Amylase0 NP--
Pepsin75 mg--
Pancreatin200 mg--
Glutamic Acid Hydrochloride10 mg--

Other ingredients: Calcium Phosphate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Silica, Vanillin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a food enzyme dietary supplement, take 1 tablet with each meal and if necessary at bedtime. Don't hesitate to use two servings (2 tablets) with each meal and at bedtime if needed.

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing do not take this product.

Contains wheat & milk ingredients.

Formulation

FDA Registered Facility (Reg. #1023013) Mfg. under Good Manufacturing Practices (GMPs)

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.

Nutritionally supports digestive health

Seals/Symbols

Keep tightly closed. Store at room temperature: 59 degrees-86 degrees F (15 degrees to 30 degrees C).

Quali Pure

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Food Enzyme Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dyzime by DC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dyzime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dyzime by DC

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container180 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Betaine Hydrochloride

Interacts with
36 drugs
10 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine Hydrochloride monograph & interactions

Papain

Interacts with
2 drugs
50 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Pepsin

No known
interactions
75 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Pancreatin

200 mg per serving

Glutamic Acid Hydrochloride

10 mg per serving

Other (inactive) ingredients: Calcium Phosphate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Stearate, Silica, Vanillin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dyzime by DC Drug Interactions

Want to check YOUR meds against Dyzime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betaine Hydrochloride 36
Papain 2

Individual Drug Interactions

The ingredients in Dyzime interact with 38 drugs. Click any drug to see the details.

2 of the 7 ingredients in Dyzime interact with drugs. Each result below shows which ingredient is responsible. Betaine Hydrochloride Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Dyzime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine Hydrochloride full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dyzime, from the product label.

DC

See all DC products
Name
Dee Cee Laboratories, Inc.
Street Address
304 Dee Cee Ct.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Dyzime by DC: Common Questions

Does Dyzime by DC interact with any medications?
Yes. Based on its ingredients, Dyzime has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dyzime contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Dyzime if I'm pregnant?
No — both betaine hydrochloride and papain are not recommended in pregnancy due to safety concerns, and papain is rated possibly unsafe. Lipase, protease, and pepsin have little data, so use only if your doctor advises it. Talk to your doctor or pharmacist before taking this product if you're pregnant or planning to become pregnant.
Can I take Dyzime if I'm breastfeeding?
Betaine hydrochloride and papain should be avoided while breastfeeding — there isn't enough safety information. Lipase and protease are not recommended without medical advice. Check with your doctor or pharmacist for personalized guidance.
Can I take Dyzime if I have acid reflux or an ulcer?
No. Betaine hydrochloride increases stomach acid, which can irritate ulcers and gastritis and may worsen acid reflux symptoms — it could even trigger heartburn. If you have these conditions, talk to your doctor before considering any digestive supplement.
What does each enzyme in Dyzime do?
Lipase breaks down fats, protease and pepsin break down proteins, and amylase breaks down starches. Papain is also a protein-digesting enzyme. Betaine hydrochloride boosts stomach acid to help activate these enzymes. Together they're meant to support overall digestion.
Is Dyzyme actually effective for digestion?
We don't have reliable evidence in our data that these ingredients work for indigestion or other digestive complaints. That doesn't mean they don't help — it means the research to prove it hasn't been established in the records we hold. If you're considering it for a specific digestive issue, talk to your doctor or pharmacist first.
Can Dyzime cause allergic reactions?
Yes — papain, protease, and pepsin can all trigger allergic reactions in sensitive people, including itchy eyes, runny nose, sneezing, abdominal cramps, and diarrhea. If you have a history of enzyme allergies or occupational exposure to protease dust, mention that to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dyzime label
Go deeper

The Full Monographs Behind Dyzime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

Dyzime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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