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Dietary supplement

Elderberry 450 mg Ingredients & Drug Interactions

by Solaray

Elderberry 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Elderberry 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Elderberry 450 mg is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Elderberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Elderberry 450 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Elderberry 450 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Elderberry 450 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 450 mg of elderberry per capsule. Elderberry is a concentrated extract from the ripe fruit of the elder plant.

The product also includes inactive ingredients—vegetable cellulose for the capsule, organic rice bran extract blend, and silica—which are fillers and binders that help hold the capsule together.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Elderberry product and its label doesn't state a use — see Elderberry's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold on elderberry doesn't establish that it works for any of the conditions commonly marketed for it—hay fever, heart disease, chronic fatigue, COPD, thinking and memory, or respiratory infections all carry a rating of insufficient reliable evidence. That doesn't mean it doesn't help; it means the research so far hasn't been strong enough to confirm it one way or the other.

The evidence, ingredient by ingredient Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Elderberry extracts made from ripe, properly cooked fruit are generally well tolerated. The main caution: raw or unripe berries, seeds, leaves, and bark contain compounds that can cause nausea, vomiting, severe diarrhea, weakness, dizziness, and numbness—but cooking destroys these toxins, so this product shouldn't pose that risk.

There is one case report of autoimmune hepatitis in a patient with underlying autoimmune disease who took elderberry for years; symptoms resolved after stopping it and starting prednisone. Regarding pregnancy and breastfeeding, the safety data is not enough to know either way—talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Elderberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you're on immunosuppressants (such as those used after organ transplant or for autoimmune disease) or pazopanib (Votrient) for cancer. Both have documented moderate interactions with elderberry.

Your doctor or pharmacist can tell you whether it's safe to combine them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Elderberry is generally well tolerated as a cooked extract, but if you take immunosuppressants or pazopanib, this product isn't for you without checking first. Evidence for what it actually does remains unproven.

Talk to your doctor or pharmacist before starting it, especially if you're pregnant, breastfeeding, or have an autoimmune condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Elderberry 450 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280124453
Net contents 100 VegCap(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255692
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Elderberry 450 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 VegCap(s)
Maximum serving Sizes:
1 VegCap(s)
Servings per container
100
UPC/BARCODE
076280124453
IngredientAmount% DV
Elderberry350 mg--
Elderberry100 mg--

Other ingredients: Vegetable Cellulose Capsule, organic Rice Bran extract blend, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formula

Sambucus nigra 450 mg per capsule Whole berry & flower

Discussion: Elderberry (Sambucus nigra) is a small shrub native to Europe. The fruit is a sweet, juicy, dark purple berry which has commonly been used in teas, wines and jellies.

Elderberry contains naturally-occurring antioxidants including flavonoids and phenolic compounds.

Formulation

Lab verified

Elderberry has a history of use both topically and internally and is intended to provide nutritive support for general well-being during the cold season.

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep your licensed health care practitioner informed when using this product.

California residents only Warning: Reproductive harm - www.P65Warnings.ca.gov

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take one VegCap three times daily with a meal or glass of water.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Elderberry 450 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Elderberry 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Elderberry 450 mg by Solaray

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 VegCap(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Elderberry

Interacts with
121 drugs
350 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry monograph & interactions

Elderberry

Interacts with
121 drugs
100 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Elderberry monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule, Organic Rice Bran extract blend, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Elderberry 450 mg by Solaray Drug Interactions

Want to check YOUR meds against Elderberry 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Elderberry 121

Individual Drug Interactions

The ingredients in Elderberry 450 mg interact with 121 drugs. Click any drug to see the details.

1 of the 2 ingredients in Elderberry 450 mg interact with drugs. Each result below shows which ingredient is responsible. Elderberry

Each ingredient & the kinds of drugs it affects

For each ingredient in Elderberry 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Elderberry2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Elderberry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Elderberry 450 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Elderberry 450 mg by Solaray: Common Questions

Does Elderberry 450 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Elderberry 450 mg has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Elderberry 450 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
We don't have enough safety data to say yes or no either way. The facts advise caution and say it's best to avoid it during pregnancy and breastfeeding until there's more information. Talk with your doctor or pharmacist—they know your full health picture and can give you personalized advice.
What exactly is in this capsule besides elderberry?
The active ingredient is 450 mg of elderberry extract. The rest is inactive ingredients: the vegetable cellulose capsule itself, an organic rice bran extract blend, and silica. These help form and stabilize the capsule but don't add therapeutic effect.
Does elderberry actually work for colds or flu?
The evidence we have on elderberry for respiratory infections doesn't establish that it works—the rating is insufficient reliable evidence. That means the research so far isn't strong enough to say yes or no. You'd want to talk with your doctor if you're considering it for that reason.
Could this cause nausea or stomach upset?
When prepared from ripe fruit and properly cooked—as this product should be—it's generally well tolerated and nausea is not common. Raw or unripe elderberries can cause nausea and diarrhea, but this supplement shouldn't carry that risk. If you do get nausea, check with your pharmacist or doctor.
I have an autoimmune disease. Is this safe for me?
There's one case report of a patient with underlying autoimmune disease who developed autoimmune hepatitis after taking elderberry for years. Because of its immune-stimulating activity, talk with your doctor or pharmacist before taking this if you have an autoimmune condition—they can weigh your individual situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Elderberry 450 mg label
Go deeper

The Full Monographs Behind Elderberry 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Elderberry 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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