Elderberry 450 mg Ingredients & Drug Interactions
by Solaray
What is this page for?
First and foremost: checking Elderberry 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Elderberry 450 mg is a dietary supplement by Solaray with 2 active ingredients. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Elderberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Elderberry 450 mg by Solaray
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Elderberry 450 mg by Solaray
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 450 mg of elderberry per capsule. Elderberry is a concentrated extract from the ripe fruit of the elder plant.
The product also includes inactive ingredients—vegetable cellulose for the capsule, organic rice bran extract blend, and silica—which are fillers and binders that help hold the capsule together.
Does it work?
Couldn't assess
The evidence we hold on elderberry doesn't establish that it works for any of the conditions commonly marketed for it—hay fever, heart disease, chronic fatigue, COPD, thinking and memory, or respiratory infections all carry a rating of insufficient reliable evidence. That doesn't mean it doesn't help; it means the research so far hasn't been strong enough to confirm it one way or the other.
How safe is it?
Well-documented data
Elderberry extracts made from ripe, properly cooked fruit are generally well tolerated. The main caution: raw or unripe berries, seeds, leaves, and bark contain compounds that can cause nausea, vomiting, severe diarrhea, weakness, dizziness, and numbness—but cooking destroys these toxins, so this product shouldn't pose that risk.
There is one case report of autoimmune hepatitis in a patient with underlying autoimmune disease who took elderberry for years; symptoms resolved after stopping it and starting prednisone. Regarding pregnancy and breastfeeding, the safety data is not enough to know either way—talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Check before taking this product if you're on immunosuppressants (such as those used after organ transplant or for autoimmune disease) or pazopanib (Votrient) for cancer. Both have documented moderate interactions with elderberry.
Your doctor or pharmacist can tell you whether it's safe to combine them.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Elderberry is generally well tolerated as a cooked extract, but if you take immunosuppressants or pazopanib, this product isn't for you without checking first. Evidence for what it actually does remains unproven.
Talk to your doctor or pharmacist before starting it, especially if you're pregnant, breastfeeding, or have an autoimmune condition.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Elderberry 450 mg, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Elderberry 450 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Elderberry | 350 mg | -- |
| Elderberry | 100 mg | -- |
Other ingredients: Vegetable Cellulose Capsule, organic Rice Bran extract blend, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Formula
Sambucus nigra 450 mg per capsule Whole berry & flower
Discussion: Elderberry (Sambucus nigra) is a small shrub native to Europe. The fruit is a sweet, juicy, dark purple berry which has commonly been used in teas, wines and jellies.
Elderberry contains naturally-occurring antioxidants including flavonoids and phenolic compounds.
Formulation
Lab verified
Elderberry has a history of use both topically and internally and is intended to provide nutritive support for general well-being during the cold season.
Precautions
Warning: Do not use if safety seal is broken or missing.
Keep out of reach of children.
Keep your licensed health care practitioner informed when using this product.
California residents only Warning: Reproductive harm - www.P65Warnings.ca.gov
Suggested/Recommended/Usage/Directions
Directions: Use only as directed. Take one VegCap three times daily with a meal or glass of water.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Elderberry 450 mg by Solaray label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Elderberry 450 mg by Solaray
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 VegCap(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Elderberry
Interacts with121 drugs
Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...
Elderberry monograph & interactionsElderberry
Interacts with121 drugs
Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...
Elderberry monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose Capsule, Organic Rice Bran extract blend, Silica. These complete the product’s ingredient list but are not active constituents.
Elderberry 450 mg by Solaray Drug Interactions
HelloPharmacist Interaction Report
Solaray Elderberry 450 mg interacts with medications through its elderberry content, most seriously with immunosuppressants (drugs that weaken your immune system to prevent rejection after transplant or manage autoimmune conditions).
Elderberry stimulates immune activity, which could work against what these medications are trying to do.
Read the full breakdown — every affected drug type, severity by severity
Elderberry also has a documented moderate interaction with pazopanib (Votrient), a cancer drug. One patient taking pazopanib developed severe nausea, loose stools, and liver injury after the combination.
Altogether, these interactions span 121 individual medications.
If you take any immunosuppressant or pazopanib, check with your doctor or pharmacist before starting this supplement. They'll help you decide if the timing or dose needs to change, or if elderberry isn't right for you at all.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Elderberry 450 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Elderberry 450 mg interact with 121 drugs. Click any drug to see the details.
1 of the 2 ingredients in Elderberry 450 mg interact with drugs. Each result below shows which ingredient is responsible. Elderberry
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Abrocitinib interactionAdalimumabHumira
How Adalimumab interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Alemtuzumab interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Anifrolumab-fnia interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Antithymocyte Globulin interactionAtezolizumabTecentriq
How Atezolizumab interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Azathioprine interactionBasiliximabSimulect
How Basiliximab interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Basiliximab interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Beclomethasone Dipropionate interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Betamethasone Valerate interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Bimekizumab-bkzx interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Ciclesonide interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Cisplatin interactionCladribineLeustatin, Mavenclad
How Cladribine interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Cladribine interactionCopanlisibAliqopa
How Copanlisib interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Copanlisib interactionCortisone AcetateCortisone Tablets, Cortone
How Cortisone Acetate interacts with Elderberry 450 mg — through 1 ingredient. Tap an ingredient for the detail:
ElderberryImmunosuppressants Moderate
Interaction Summary
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Read the full Elderberry + Cortisone Acetate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Elderberry 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Elderberry
Immunosuppressants
Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.
Pazopanib (Votrient)
Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
Brand information
Manufacturer and brand details for Elderberry 450 mg, from the product label.
Elderberry 450 mg by Solaray: Common Questions
Does Elderberry 450 mg by Solaray interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe during pregnancy or while breastfeeding?
What exactly is in this capsule besides elderberry?
Does elderberry actually work for colds or flu?
Could this cause nausea or stomach upset?
I have an autoimmune disease. Is this safe for me?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Elderberry 450 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Elderberry 450 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Elderberry 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Elderberry 6 references
- Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
- Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
- European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
- Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
- Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
- Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC