Elderberry Syrup + Honey Ingredients & Drug Interactions
by New Chapter
What is this page for?
First and foremost: checking Elderberry Syrup + Honey against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Elderberry Syrup + Honey is a dietary supplement by New Chapter with 3 active ingredients. Its ingredients are commonly taken for cough and sore throat, wound and burn care, soothing minor skin irritation.Based on those ingredients, 736 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Honey. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Elderberry Syrup + Honey by New Chapter
Ask about any prescription or over-the-counter medication and we check it for interactions with Elderberry Syrup + Honey by New Chapter — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Elderberry Syrup + Honey by New Chapter
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This liquid contains 3 active ingredients. Honey is included for its topical and oral uses — it's possibly effective for cough, cold sores, oral sores from cancer treatment, burns, and dry eye.
The product also contains European Elderberry Concentrate and ElderCraft European Black Elderberry extract, though we have no interaction or effectiveness data on file for those specific preparations. The only listed inactive ingredient is water.
Does it work?
Couldn't assess
Honey in this syrup is possibly effective for cough, cold sores, oral mucositis (sores in the mouth or throat), burns, and dry eye. The evidence supports its use for these purposes, though "possibly effective" means the studies exist but aren't conclusive.
We don't have effectiveness data on file for the two elderberry extracts in this product.
How safe is it?
Well-documented data
Honey is generally well tolerated when taken by mouth or applied to skin for adults and children over 1 year of age. The most common side effects are mild — nausea, stomach pain, vomiting when taken orally, and burning or stinging when applied to skin.
Rarely, allergic reactions including anaphylaxis can occur. Important: some honey from Turkey's Black Sea coast contains toxins from rhododendrons that can cause serious heart problems; avoid honey from that region.
Because this product contains honey used medicinally (not just as food), check with your doctor first. If you're breastfeeding, eating honey yourself is fine, but talk to your provider before using it as a medicine.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take phenytoin (Dilantin) for seizures — honey may raise its levels. Also double-check if you take blood thinners like warfarin or antiplatelet drugs like aspirin, or if you take any drug your liver metabolizes, since honey's effect on those is unclear and may vary.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This syrup may help with cough, cold sores, and sore throats, and it's usually well tolerated. But if you take seizure medications, blood thinners, or drugs your liver breaks down (ask your pharmacist if you're not sure), you need to check with your doctor or pharmacist first — honey can interfere.
Same goes if you have a history of allergies or if you're using this medicinally while breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Elderberry Syrup + Honey, straight from the product label.
| Brand | New Chapter |
|---|---|
| Net contents | 4 fl. Oz.; 118 mL |
| Market status | On market |
| Date entered into DSLD | Sep 22, 2022 |
| DSLD ID | 274054 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Gluten Free, Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Elderberry Syrup + Honey by New Chapter, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 15 Calorie(s) | -- |
| Total Carbohydrate | 5 Gram(s) | 2%, 3% |
| Total Sugars | 4 Gram(s) | -- |
| added Sugars | 4 Gram(s) | 16%, 8% |
| Honey | 4450 mg | -- |
| European Elderberry Concentrate | 1625 mg | -- |
| ElderCraft European Black Elderberry extract | 50 mg | -- |
Other ingredients: Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Boost immunity Activate your immune defenses with the proven force of pure black elderberry. Superfood antioxidant Powerful antioxidant action from super-dark elderberry flavonoids for immune support. Potency unlocked Made with potent elderberry extract, concentrated 64x for optimal benefit. Naturally sweetened with throat-soothing honey. Pure and potent Power up your immune system with clinically studied black elderberry (Sambucus nigra). Our potent, superior-quality fruit is sustainably grown in Austria, then highly concentrated in a solvent-free process. With sustainably sourced bee-friendly honey.
64x concentrated extract The magic inside: Great-tasting elderberry with sustainably sourced, throat-soothing, bee-friendly honey
Suggested/Recommended/Usage/Directions
Suggested use: Ages 2-12: Take 1/2 teaspoon daily. Age 12+: Take 1 teaspoon daily. Swirl bottle gently under warm water to mix, if needed.
Storage
Refrigerate after opening.
Formulation
Advanced immune defense Nutrition crafted for: Immune support
Gluten free; 100% vegetarian; no artificial flavors or colors.
Gluten free; 100% vegetarian; no artificial flavors or colors.
Seals/Symbols
Non GMO Project Verified nongmoproject.org Certified B corporation
FDA Statement of Identity
Dietary Supplement
Precautions
Caution: This product contains honey and as such it should not be used by children under 12 months of age.
As with any dietary supplement, you should advise your healthcare professional of the use of this product if you have a medical condition or are taking medication. If you are nursing, pregnant, or considering pregnancy, consult your healthcare professional prior to using this product.
Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction.
Do not exceed suggested use.
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
For questions or comments call 888-874-4461
Brand IP Statement(s)
Copyright 2020 New Chapter, Inc.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Elderberry Syrup + Honey by New Chapter label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Elderberry Syrup + Honey by New Chapter
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size2.5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Honey
Interacts with736 drugs
Honey is a natural food with some real, modest evidence for easing coughs and helping certain wounds, especially when special medical-grade or Manuka...
Honey monograph & interactionsEuropean Elderberry Concentrate
ElderCraft European Black Elderberry extract
Other (inactive) ingredients: Water. These complete the product’s ingredient list but are not active constituents.
Elderberry Syrup + Honey by New Chapter Drug Interactions
HelloPharmacist Interaction Report
New Chapter's Elderberry Syrup + Honey does interact with medications, but only through its honey content.
Three drug types are affected: seizure medications like phenytoin (Dilantin), drugs metabolized by your liver's CYP3A4 enzyme system, and blood thinners or antiplatelet drugs. The most serious interaction is with phenytoin — honey may raise its levels in your bloodstream, which could increase side effects.
This effect was shown in animals but hasn't been reported in humans.
Read the full breakdown — every affected drug type, severity by severity
Honey may also interact with blood thinners (anticoagulants) and antiplatelet drugs like aspirin by raising your bleeding risk, though the evidence comes mostly from lab and animal work, not human studies. Additionally, honey's effect on CYP3A4 drugs is unclear — some research suggests it may lower their levels, but other studies show no effect, and different honey types may behave differently.
We could not check the two elderberry ingredients (European Elderberry Concentrate and ElderCraft European Black Elderberry extract) for interactions — we hold no data on file for them. Altogether, these interactions span 737 individual medications.
Before starting this product, check your exact medications with the tool on this page or talk to your pharmacist or doctor.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Elderberry Syrup + Honey?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Elderberry Syrup + Honey interact with 736 drugs. Click any drug to see the details.
1 of the 3 ingredients in Elderberry Syrup + Honey interact with drugs. Each result below shows which ingredient is responsible. Honey
FosphenytoinCerebyx
How Fosphenytoin interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, honey might increase levels of phenytoin.
Read the full Honey + Fosphenytoin interactionFosphenytoin SodiumSesquient
How Fosphenytoin Sodium interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, honey might increase levels of phenytoin.
Read the full Honey + Fosphenytoin Sodium interactionMephenytoinMesantoin
How Mephenytoin interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, honey might increase levels of phenytoin.
Read the full Honey + Mephenytoin interactionPhenobarbital, PhenytoinDilantin with PB
How Phenobarbital, Phenytoin interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, honey might increase levels of phenytoin.
Read the full Honey + Phenobarbital, Phenytoin interactionPhenytoinDi-Phen, Dilantin, Dilantin Infatabs, Dilantin injection, Dilantin Kapseals, Phenytek
How Phenytoin interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyPhenytoin (dilantin) Moderate
Interaction Summary
Theoretically, honey might increase levels of phenytoin.
Read the full Honey + Phenytoin interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Read the full Honey + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Elderberry Syrup + Honey — through 1 ingredient. Tap an ingredient for the detail:
HoneyCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Read the full Honey + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Elderberry Syrup + Honey with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Honey
Phenytoin (Dilantin)
Theoretically, honey might increase levels of phenytoin.
In an animal model, the rate and extent of absorption of phenytoin was increased by honey. This effect has not been reported in humans.
Anticoagulant/Antiplatelet Drugs
Theoretically, honey may increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro, honey inhibits platelet aggregation and increases the time to clotting. Furthermore, animal research suggests that feeding mice large doses of honey for 12 days increases bleeding time when compared with no intervention. However, these effects have not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, honey might decrease levels of drugs metabolized by CYP3A4, but research is conflicting.
Some clinical research shows that honey induces CYP3A4. However, other clinical studies found no effect on CYP3A4 activity. Different honey preparations may have different effects on CYP3A4.
Brand information
Manufacturer and brand details for Elderberry Syrup + Honey, from the product label.
New Chapter
See all New Chapter products- Name
- New Chapter, Inc.
- Street Address
- 90 Technology Dr.
- City
- Brattleboro
- State
- VT
- ZipCode
- 05301
- Phone Number
- 888-874-4461
Elderberry Syrup + Honey by New Chapter: Common Questions
Does Elderberry Syrup + Honey by New Chapter interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does honey actually help with cough?
Is it safe for my toddler?
What if I'm taking Dilantin for seizures?
Can I use this if I'm on a blood thinner?
What are the side effects?
Can I use this while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Elderberry Syrup + Honey is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Elderberry Syrup + Honey’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Elderberry Syrup + Honey's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Honey 40 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Bose B. Honey or sugar in treatment of infected wounds? Lancet 1982;1:963. PubMed
- Ozhan H, Akdemir R, Yazici M, et al. Cardiac emergencies caused by honey ingestion: a single centre experience. Emerg Med J 2004;21:742-4. PubMed
- Centers for Disease Control. Botulism in the Unites Sates, 1899-1996. Handbook for epidemiologists, clinicians, and laboratory workers, 1998. Available online: http://www.cdc.gov/ncidod/dbmd/diseaseinfo/botulism.PDF.
- Simon A, Traynor K, Santos K, et al. Medical honey for wound care - still the 'latest resort'? Evid Based Complement Alternat Med 2009;6:165-73. PubMed
- Gethin G, Cowman S. Case series of use of Manuka honey in leg ulceration. Int Wound J 2005;2:10-15. PubMed
- Ingle R, Levin J, Polinder K. Wound healing with honey - a randomised controlled trial. S Afr Med J 2006;96:831-5.
- Johnson DW, van Eps C, Mudge DW, et al. Randomized, controlled trial of topical exit-site application of honey (Medihoney) versus mupirocin for the prevention of catheter-associated infections in hemodialysis patients. J Am Soc Nephrol 2005;16:1456-62. PubMed
- Sukriti and Garg, S. K. Influence of honey on the pharmacokinetics of phenytoin in rabbits. Ind J Pharmacol 2002;34(147).
- Jung, A. and Ottosson, J. [Infantile botulism caused by honey]. Ugeskr Laeger 2001;163(2):169.
- Gunduz, A., Turedi, S., Uzun, H., and Topbas, M. Mad honey poisoning. Am J Emerg.Med 2006;24(5):595-598.
- van der Vorst, M. M., Jamal, W., Rotimi, V. O., and Moosa, A. Infant botulism due to consumption of contaminated commercially prepared honey. First report from the Arabian Gulf States. Med Princ.Pract. 2006;15(6):456-458. PubMed
- Tushar, T., Vinod, T., Rajan, S., Shashindran, C., and Adithan, C. Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers. Basic Clin Pharmacol Toxicol 2007;100(4):269-272. PubMed
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