Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Extra-Strength 5.0 Full-Spectrum Hemp Extract Ingredients & Drug Interactions

by Hemp Fusion

Extra-Strength 5.0 Full-Spectrum Hemp Extract label
See full label image
Capsule Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Extra-Strength 5.0 Full-Spectrum Hemp Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Extra-Strength 5.0 Full-Spectrum Hemp Extract is a dietary supplement by Hemp Fusion with 5 active ingredients. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 1,163 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Pepper extract, Clove Oil extract, Hemp Oil extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion

Ask about any prescription or over-the-counter medication and we check it for interactions with Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Proprietary Whole Food Hemp Complex” is a proprietary blend — the label gives one combined amount (340 mg) without saying how much of each component you get.

This product contains 5 active ingredients: a proprietary whole food hemp complex that's broken down into its individual components, plus hemp oil extract, black pepper extract, clove oil extract, and sunflower oil. These are combined in a capsule shell with rosemary extract as an inactive ingredient.

The hemp, black pepper, and clove work together as a full-spectrum extract blend, while the oils serve as carriers and have their own roles in the formulation.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Possibly Effective" (Sunflower Oil) (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Sunflower Oil) (Natural Medicines).
  • On file: Ventilator-associated pneumonia (VAP) — rated "Possibly Effective" (Clove) (Natural Medicines).

The evidence we hold for these ingredients is mixed and mostly limited. Sunflower oil is possibly effective for high cholesterol and heart disease risk, based on available research.

Clove shows possibly effective evidence for ventilator-associated pneumonia (a serious lung infection in hospitalized patients), but the other uses listed—cough, acute pain, and indigestion—don't have reliable evidence. For hemp oil, black pepper, and all the other conditions on file (constipation, eczema, familial high cholesterol), the evidence is insufficient to rate.

This doesn't mean they don't work; it means the research isn't solid enough yet to make a claim.

The evidence, ingredient by ingredient Hemp Black Pepper Clove Sunflower Oil

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods are generally well tolerated, but this is a concentrated extract and supplement, which are less studied. A small number of rare but serious cases have been reported with hemp products, including anaphylaxis (severe allergic reaction), heart rhythm problems, and liver inflammation, mostly in children given high doses or those with allergies.

Black Pepper is generally safe in food amounts; concentrated supplements carry less safety data. Clove is well tolerated as a spice but can be toxic in large doses (especially in children—even 5–10 mL of pure clove oil is dangerous).

Sunflower oil is considered safe in normal dietary amounts. Allergic reactions to hemp seed, black pepper, and clove have been reported in sensitive individuals, though they're uncommon.

Side effects, ingredient by ingredient Hemp Black Pepper Clove Sunflower Oil

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Sunflower Oil, Clove, Black Pepper, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,164 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use: propranolol or other beta-blockers, nevirapine (HIV), rifampin (TB), phenytoin (seizures), cyclosporine (transplant), pentobarbital or other sedatives, atorvastatin or other statins, theophylline (breathing), insulin or diabetes pills, drugs broken down by your liver (CYP1A2, CYP3A4, CYP2D6, CYP2C9 substrates), estrogen or hormone therapy, or blood thinners and antiplatelet drugs. The interactions range from Minor to Moderate severity across these medication types.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines five ingredients with documented drug interactions—most notably Black Pepper's effect on propranolol and other medications. The evidence for its effectiveness is limited or insufficient for most conditions.

Before you start, run your exact medications through the checker below or talk with your own doctor or pharmacist, especially if you take heart, blood pressure, diabetes, blood-thinning, or anti-seizure medications. If you have a history of allergies to plant families like ragweed or sunflower, mention it too.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Extra-Strength 5.0 Full-Spectrum Hemp Extract, straight from the product label.

Brand Hemp Fusion
Barcode (UPC) 816179020158
Net contents 30 Vegetarian Liquid Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 185239
Product type Botanical With Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Liquid Capsule(s)
Maximum serving Sizes:
1 Liquid Capsule(s)
Servings per container
30
UPC/BARCODE
816179020158
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Proprietary Whole Food Hemp Complex340 mg--
Hemp Oil extract0 NP--
Black Pepper extract0 NP--
Clove Oil extract0 NP--
organic MCT Oil100 mg--
Sunflower seed Oil100 mg--

Other ingredients: Capsule Shell, organic Rosemary extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Consult your physician before use if you are pregnant, lactating, have a medical condition or are taking any medication.

Keep out of reach of children.

As a reminder, always discuss the supplements and medications you take with your health care provider.

Contains Coconut

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions for Use: Take one liquid capsule daily with food or as directed by a health care professional. As a reminder, always discuss the supplements and medications you take with your health care provider.

Formulation

Contains No: Soy, Gluten, Wheat, Milk, Dairy, Eggs, Shellfish, Magnesium Stearate, Artificial Colors, Artificial Flavors, Chemical Processing Aids.

Non-GMO

Brand IP Statement(s)

Full spectrum Verdant Oasis Certified VO Genuine Whole food European Hemp

Phospholivery

Formula

Whole food hemp complex

Contains Coconut

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Extra-Strength 5.0 Full-Spectrum Hemp Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Liquid Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Whole Food Hemp Complex

340 mg per serving

Organic MCT Oil

100 mg per serving Form: organic Coconut Oil

Sunflower seed Oil

Interacts with
86 drugs
100 mg per serving

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a f...

Sunflower seed Oil monograph & interactions

Other (inactive) ingredients: Capsule Shell, Organic Rosemary extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion Drug Interactions

Want to check YOUR meds against Extra-Strength 5.0 Full-Spectrum Hemp Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,163Drugs
1,047 Moderate 116 Minor

Ingredients driving the most interactions

Black Pepper extract 1,019
Clove Oil extract 977
Hemp Oil extract 938
Sunflower seed Oil 86

Individual Drug Interactions

The ingredients in Extra-Strength 5.0 Full-Spectrum Hemp Extract interact with 1,163 drugs. Click any drug to see the details.

4 of the 5 ingredients in Extra-Strength 5.0 Full-Spectrum Hemp Extract interact with drugs. Each result below shows which ingredient is responsible. Black Pepper extract Clove Oil extract Hemp Oil extract Sunflower seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Extra-Strength 5.0 Full-Spectrum Hemp Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Pepper extract17 drug types · 1,019 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, black pepper might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit platelet aggregation. This has not been reported in humans.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that piperine, a constituent of black pepper, can reduce blood glucose levels. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Atorvastatin (Lipitor)

Theoretically, black pepper might increase blood levels of atorvastatin.
Animal research shows that taking piperine, a constituent of black pepper, 35 mg/kg can increase the maximum serum concentration of atorvastatin three-fold. This has not been reported in humans.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, black pepper might increase the effects and side effects of cyclosporine.
In vitro research shows that piperine, a constituent of black pepper, increases the bioavailability of cyclosporine. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP2D6.
In vitro research suggests that some constituents of black pepper inhibit CYP2D6. This has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, black pepper might increase levels of drugs metabolized by CYP3A4.
In vitro research and pharmacokinetic simulation data suggest that piperine, a constituent of black pepper, as well as the pepper fruit seem to inhibit CYP3A4. This has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, black pepper might increase blood levels of lithium due to its diuretic effects. The dose of lithium might need to be reduced.
Black pepper is thought to have diuretic properties.

Likelihood Probable Evidence D
Nevirapine (Viramune)

Black pepper might increase blood levels of nevirapine.
Clinical research shows that piperine, a constituent of black pepper, increases the plasma concentration of nevirapine. However, no adverse effects were observed in this study.

Likelihood Probable Evidence D
P-Glycoprotein Substrates

Theoretically, black pepper might increase levels of P-glycoprotein substrates.
In vitro research shows that piperine, a constituent of black pepper, seems to inhibit P-glycoprotein.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, black pepper might increase the sedative effects of pentobarbital.
Animal research shows that piperine, a constituent of black pepper, increases pentobarbital-induced sleeping time.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

Black pepper might increase blood levels of phenytoin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption, slow elimination, and increase levels of phenytoin. Taking a single dose of black pepper 1 gram along with phenytoin seems to double the serum concentration of phenytoin. Consuming a soup with black pepper providing piperine 44 mg/200 mL of soup along with phenytoin also seems to increase phenytoin levels when compared with consuming the same soup without black pepper.

Likelihood Possible Evidence B
Propranolol (Inderal)

Black pepper might increase blood levels of propranolol.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of propranolol.

Likelihood Possible Evidence B
Rifampin (Rifadin)

Black pepper might increase blood levels of rifampin.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and serum levels of rifampin.

Likelihood Possible Evidence B
Theophylline

Black pepper might increase blood levels of theophylline.
Clinical research shows that piperine, a constituent of black pepper, seems to increase absorption and slow elimination of theophylline.

Likelihood Possible Evidence D
Amoxicillin (Amoxil, Trimox)

Theoretically, black pepper might increase the effects and side effects of amoxicillin.
Animal research shows that taking piperine, a constituent of black pepper, with amoxicillin increases plasma levels of amoxicillin. This has not been reported in humans.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, black pepper might increase blood levels of carbamazepine, potentially increasing the effects and side effects of carbamazepine.
One clinical study in patients taking carbamazepine 300 mg or 500 mg twice daily shows that taking a single 20 mg dose of purified piperine, a constituent of black pepper, increases carbamazepine levels. Piperine may increase carbamazepine absorption by increasing blood flow to the GI tract, increasing the surface area of the small intestine, or inhibiting cytochrome P450 3A4 (CYP3A4) in the gut wall. Absorption was significantly increased by 7-10 mcg/mL/hour. The time to eliminate carbamazepine was also increased by 4-8 hours. Although carbamazepine levels were increased, this did not appear to increase side effects. In vitro research also shows that piperine can increase carbamazepine levels by 11% in a time-dependent manner.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, black pepper might decrease levels and clinical effects of drugs metabolized by CYP1A2.
In vitro research suggests that black pepper induces CYP1A2. This has not been reported in humans.

Likelihood Possible Evidence D
Black Pepper extract full monograph & interactions

Clove Oil extract7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove Oil extract full monograph & interactions

Hemp Oil extract6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Oil extract full monograph & interactions

Sunflower seed Oil1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
A diet using sunflower oil as a fat source can cause increased fasting blood glucose levels in patients with type 2 diabetes. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Sunflower seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Extra-Strength 5.0 Full-Spectrum Hemp Extract, from the product label.

Hemp Fusion

See all Hemp Fusion products
Name
MetaCan, Inc.
Street Address
11660 Alpharetta Hwy, Suite 120
City
Roswell
State
GA
ZipCode
30076
Phone Number
877-669-4367
Web Address
hempfusion.com
Pharmacist Counseling Corner

Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion: Common Questions

Does Extra-Strength 5.0 Full-Spectrum Hemp Extract by Hemp Fusion interact with any medications?
Yes. Based on its ingredients, Extra-Strength 5.0 Full-Spectrum Hemp Extract has a known interaction with 1,163 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Extra-Strength 5.0 Full-Spectrum Hemp Extract contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Black pepper is likely safe during both pregnancy and breastfeeding. Clove is also likely safe in both periods. However, there isn't enough safety data on file for hemp extract in pregnancy or lactation to know either way. Talk with your doctor or pharmacist before taking this product if you're pregnant, planning to become pregnant, or breastfeeding.
What does black pepper extract do in this formula?
Black pepper (specifically its active compound piperine) is included to increase the absorption and effectiveness of the hemp and clove compounds. It acts as a bioavailability enhancer, helping your body absorb the other ingredients more efficiently.
Are there any common side effects I should expect?
Most users tolerate this product without issue when it's from food-level amounts. Black pepper may cause a burning aftertaste, upset stomach, or reduced taste perception. Clove as a spice is well tolerated, but concentrated doses can cause oral irritation. Serious adverse effects are rare but have included allergic reactions in sensitive individuals.
What is MCT oil, and is it safe?
MCT stands for medium-chain triglyceride—a type of fat that's easily absorbed and used for energy. We don't have interaction data on file for organic MCT oil, so we can't verify it for drug interactions, but it's widely used in supplements and foods without major safety concerns.
Will this help with my cholesterol or heart health?
Sunflower oil in this product is possibly effective for high cholesterol and heart disease risk based on available research. Hemp oil, black pepper, and clove don't have sufficient evidence in our data to claim they help with these conditions, so results would be individual.
Should I avoid this if I have a ragweed or sunflower allergy?
If you're allergic to the ragweed family (which includes sunflower, daisies, and similar plants), you should talk with your doctor or pharmacist before taking this product—the sunflower oil may trigger a reaction. Allergic reactions to hemp and clove have also been reported rarely, so mention any plant allergies.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Extra-Strength 5.0 Full-Spectrum Hemp Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Extra-Strength 5.0 Full-Spectrum Hemp Extract label
Go deeper

The Full Monographs Behind Extra-Strength 5.0 Full-Spectrum Hemp Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph → Herb & supplement monograph

Black Pepper

Interacts with 1,019 drugs

Black pepper is a common kitchen spice that is generally safe in the amounts used in food. Its extract, piperine, is mostly added to supplements to help the body absorb other ingredients (li...

Read the full Black Pepper monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Sunflower Oil

Interacts with 86 drugs

Sunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, an...

Read the full Sunflower Oil monograph →
Sources

Sources & How We Checked

Extra-Strength 5.0 Full-Spectrum Hemp Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 69 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
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Black Pepper 29 references
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See these in context on the Black Pepper monograph →

Clove 26 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
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  9. Sanchez-Perez, J. and Garcia-Diez, A. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Contact Dermatitis 1999;41(6):346-347. PubMed
  10. Andersen, K. E., Johansen, J. D., Bruze, M., Frosch, P. J., Goossens, A., Lepoittevin, J. P., Rastogi, S., White, I., and Menne, T. The time-dose-response relationship for elicitation of contact dermatitis in isoeugenol allergic individuals. Toxicol.Appl PubMed
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  14. Srivastava, K. C. and Malhotra, N. Acetyl eugenol, a component of oil of cloves (Syzygium aromaticum L.) inhibits aggregation and alters arachidonic acid metabolism in human blood platelets. Prostaglandins Leukot.Essent.Fatty Acids 1991;42(1):73-81. PubMed
  15. Dyrbye, B. A., Dubois, L., Vink, R., and Horn, J. A patient with clove oil intoxication. Anaesth.Intensive Care 2012;40(2):365-366.
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  18. Romaguera, C., Alomar, A., Camarasa, J. M., Garcia, Bravo B., Garcia, Perez A., Grimalt, F., Guerra, P., Lopez, Gorretcher B., Pascual, A. M., Miranda, A., and . Contact dermatitis in children. Contact Dermatitis 1985;12(5):283-284. PubMed
  19. Hackett, P. H., Rodriguez, G., and Roach, R. C. Clove cigarettes and high-altitude pulmonary edema. JAMA 6-28-1985;253(24):3551-3552. DOI
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  21. Saeed, S. A. and Gilani, A. H. Antithrombotic activity of clove oil. J Pak Med Assoc 1994;44(5):112-115.
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  23. Srivastava, K. C. Antiplatelet principles from a food spice clove (Syzygium aromaticum L) [corrected]. Prostaglandins Leukot.Essent.Fatty Acids 1993;48(5):363-372.
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See these in context on the Clove monograph →

Sunflower Oil 2 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. An J. Anaphylaxis to sunflower seed with tolerance to sunflower oil: A case report. Medicina (Kaunas) 2021;57(7):661. PubMed

See these in context on the Sunflower Oil monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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