Extra Strength Bitter Melon 25:1 Extract Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Extra Strength Bitter Melon 25:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Extra Strength Bitter Melon 25:1 Extract is a dietary supplement by Zazzee Naturals with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, diabetes, digestive complaints.Based on those ingredients, 283 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bitter Melon Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: bitter melon fruit extract in a concentrated 25:1 form, meaning 25 pounds of bitter melon fruit are reduced to make 1 pound of extract. Each capsule delivers a potent dose of the plant's compounds.
The capsule itself is made from cellulose with rice powder, magnesium stearate, and silica as inactive ingredients to hold it together and aid absorption.
Does it work?
Not established
The evidence for bitter melon in the conditions it's used for — including diabetes, constipation, liver disease, dyspepsia (indigestion), amenorrhea (absent periods), and athletic performance — is insufficient reliable evidence to rate in our data. That means we don't have strong clinical proof that it works for these uses.
If you're considering it for any of these reasons, talk with your doctor about whether there's a stronger case outside our current database or whether other options might be better supported.
How safe is it?
Well-documented data
Bitter melon is generally well tolerated when taken by mouth, but the gastrointestinal side effects are real and fairly common — heartburn, nausea, vomiting, diarrhea, constipation, flatulence, and abdominal discomfort occur in roughly 3 to 16 percent of people in studies. Dizziness, fatigue, and headache have also been reported.
Because the supplement can lower blood sugar, it may cause dizziness or more serious low blood sugar (hypoglycemia) in some people. One case report described acute kidney inflammation after someone took high doses of bitter melon extract over several months for diabetes, though kidney function improved after stopping it.
In pregnancy, the safety data advises against it because seeds and high doses traditionally have been avoided due to concerns about effects on the uterus and other organs. There isn't enough reliable safety information to know whether it's safe while breastfeeding, so it's best avoided then — talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before you take this product, double-check it with your pharmacist or doctor if you're on pazopanib (Votrient) for cancer, any antidiabetes drug (insulin, metformin, glipizide, and others), or any P-glycoprotein substrate medication. The moderate interactions with the first two are the most important ones to confirm are safe for you.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Bitter melon extract may be worth considering if you're looking for a concentrated plant supplement, but the evidence for how well it actually works for common uses isn't established in our data. More importantly, if you take antidiabetes drugs, pazopanib for cancer, or P-glycoprotein substrate medications, you'll want to check with your pharmacist or doctor before starting it — the interactions are real and the risk of low blood sugar is a genuine concern.
It's generally well tolerated, but gastrointestinal upset and dizziness are fairly common, and you should avoid it in pregnancy and breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Extra Strength Bitter Melon 25:1 Extract, straight from the product label.
| Brand | Zazzee Naturals |
|---|---|
| Barcode (UPC) | X00327A5OT |
| Net contents | 150 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Sep 25, 2024 |
| DSLD ID | 318707 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Bitter Melon Fruit Extract | 360 mg | -- |
Other ingredients: Cellulose, Rice, Powder, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule once daily, preferably with food, or as directed by a healthcare practitioner.
Formula
Zazzee Naturals Extra Strength Bitter Melon 25:1 Extract is an all-natural herbal supplement commonly used to support healthy cardiovascular function and healthy blood sugar levels already within the normal range. For maximum potency, our Bitter Melon is standardized to a minimum of 10% Bitter Principles and is made from a concentrated 25:1 extract.
Extra Strength Bitter Melon 25:1 Extract 9000mg Strength Standardized to min. 10% bitter principles
Precautions
Warnings: For adults only. Keep out of reach of children.
Do not use if you are pregnant or nursing. Consult physician if taking medication (including insulin and oral diabetic medications) or have a medical condition.
Do not eat freshness packet.
Allergen Information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Formulation
Natural color variation may occur in this product.
Supports healthy blood sugar levels Supports healthy cardiovascular function
Allergen Information: Not manufactured with wheat, corn, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.
Made with non GMO ingredients
Storage
Store in a cool, dry place after opening. Do not eat freshness packet. Keep in bottle.
General Statements
Please recycle.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Good Manufacturing Practice GMP Consistent Quality Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.
Bitter Melon Fruit Extract
Interacts with283 drugs
Bitter melon is a tropical fruit eaten as food and used in traditional medicine, most often for blood sugar control. While some small studies hint it...
Bitter Melon Fruit Extract monograph & interactionsOther (inactive) ingredients: Cellulose, Rice, Powder, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals Drug Interactions
HelloPharmacist Interaction Report
Zazzee Naturals Extra Strength Bitter Melon 25:1 Extract interacts with medications through its bitter melon fruit extract.
The most serious concern is with pazopanib (Votrient), a cancer drug — bitter melon may raise levels of the drug in your body, raising the risk of side effects. One case reported acute pancreatitis in a patient taking pazopanib who drank bitter melon juice daily.
Read the full breakdown — every affected drug type, severity by severity
Bitter melon also interacts with antidiabetes drugs (insulin, metformin, sulfonylureas, and similar medications). Because bitter melon itself can lower blood sugar, combining it with these drugs raises the risk of low blood sugar (hypoglycemia).
You'll want to monitor your blood glucose closely if you take both.
Additionally, bitter melon may increase levels of P-glycoprotein substrate drugs — a class that includes certain cancer and heart medications processed through an intestinal pump. The effect is theoretical based on lab studies, but it's worth checking.
Altogether, these interactions span 282 individual medications. Before you start this supplement, run it through the interaction checker on this page with your exact prescriptions, or ask your pharmacist to review them.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Extra Strength Bitter Melon 25:1 Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Extra Strength Bitter Melon 25:1 Extract interact with 283 drugs. Click any drug to see the details.
1 of the 1 ingredient in Extra Strength Bitter Melon 25:1 Extract interact with drugs. Each result below shows which ingredient is responsible. Bitter Melon Fruit Extract
AcalabrutinibCalquence
How Acalabrutinib interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Acetohexamide interactionAfatinib DimaleateGilotrif
How Afatinib Dimaleate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Afatinib Dimaleate interactionAlbiglutideTanzeum
How Albiglutide interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Bitter Melon Fruit Extract + Alogliptin, Pioglitazone interactionAlvimopanEntereg
How Alvimopan interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Alvimopan interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Ambrisentan interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Amphotericin, Tetracycline interactionAmprenavirAgenerase
How Amprenavir interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Amprenavir interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionApixabanEliquis
How Apixaban interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apixaban interactionApomorphineAPO-go, APO-go Pen, APO-go PFS, Apokyn, Uprima
How Apomorphine interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apomorphine interactionApomorphine HydrochlorideKynmobi
How Apomorphine Hydrochloride interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apomorphine Hydrochloride interactionApremilastOtezla
How Apremilast interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Apremilast interactionArmodafinilNuvigil
How Armodafinil interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Armodafinil interactionAtogepantQulipta
How Atogepant interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Atogepant interactionAtropine, Morphine SulfateAtropine, Morphine Sulfate
How Atropine, Morphine Sulfate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Atropine, Morphine Sulfate interactionAvatrombopag MaleateDoptelet
How Avatrombopag Maleate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Avatrombopag Maleate interactionBazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Bazedoxifene Acetate, Conjugated Estrogens interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Beclomethasone Dipropionate interactionBelinostatBeleodaq
How Belinostat interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Belinostat interactionBerotralstat HydrochlorideOrladeyo
How Berotralstat Hydrochloride interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Berotralstat Hydrochloride interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Extra Strength Bitter Melon 25:1 Extract — through 1 ingredient. Tap an ingredient for the detail:
Bitter Melon Fruit ExtractP-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Read the full Bitter Melon Fruit Extract + Betamethasone Dipropionate, Calcipotriene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Extra Strength Bitter Melon 25:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Bitter Melon Fruit Extract
Antidiabetes Drugs
Taking bitter melon with antidiabetes drugs might increase the risk of hypoglycemia.
Bitter melon can lower blood glucose levels and might have additive effects when used with antidiabetes drugs. This might increase the risk of hypoglycemia in some patients. Monitor blood glucose levels closely.
P-Glycoprotein Substrates
Theoretically, bitter melon might increase levels of P-glycoprotein substrates.
Bitter melon might inhibit the p-glycoprotein (P-gp) intestinal pump and increase intracellular levels of P-gp substrates. In vitro research in intestinal cells shows that 1-monopalmitin, a constituent of bitter melon, increases levels of daunomycin, a P-gp substrate. Additionally, drinking bitter melon juice has been associated with a case of acute pancreatitis in a patient who had been taking pazopanib, a P-gp substrate, for 8 years. Researchers theorize that inhibition of P-gp led to increased levels of pazopanib, resulting in pazopanib-induced pancreatitis.
Pazopanib (Votrient)
Theoretically, bitter melon might increase levels of pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 8 years for renal cell carcinoma experienced signs and symptoms consistent with acute pancreatitis 4 days after drinking bitter melon juice at a dose of 100-150 mL daily. The patient's symptoms, amylase levels, and lipase levels improved upon discontinuation of bitter melon and pazopanib. Pazopanib treatment was re-initiated with no further evidence of pancreatitis. Researchers theorize that inhibition of P-glycoprotein by bitter melon led to increased levels of pazopanib, a P-glycoprotein substrate, resulting in pazopanib-induced pancreatitis.
Brand information
Manufacturer and brand details for Extra Strength Bitter Melon 25:1 Extract, from the product label.
Zazzee Naturals
See all Zazzee Naturals products- Name
- Zazzee Naturals
- Street Address
- 400 Rella Blvd Ste 123 Box 182
- City
- Montebello
- State
- NY
- Web Address
- ZazzeeNaturals.com
Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals: Common Questions
Does Extra Strength Bitter Melon 25:1 Extract by Zazzee Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on diabetes medication?
What are the most common side effects?
Is this safe to take while pregnant?
Is this safe while breastfeeding?
Does bitter melon actually work for diabetes?
Why is this a 25:1 extract instead of plain bitter melon powder?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Extra Strength Bitter Melon 25:1 Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Extra Strength Bitter Melon 25:1 Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Extra Strength Bitter Melon 25:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bitter Melon 18 references
- Leatherdale B, Panesar RK, Singh G, et al. Improvement in glucose tolerance due to Momordica charantia. Br Med J (Clin Res Ed) 1981;282:1823-4.
- Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 1986;17:277-82. PubMed
- Srivastava Y, Venkatakrishna-Bhatt H, Verma Y, et al. Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation. Phytother Res 1993;7:285-9.
- Baldwa VS, Bhandari CM, Pangaria A, Goyal RK. Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant sources. Ups J Med Sci 1977;82:39-41. PubMed
- Aslam M, Stockley IH. Interaction between curry ingredient (karela) and drug (chlorpropamide). Lancet 1979:1:607. PubMed
- Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients (abstract). Bangladesh Med Res Counc Bull 1999;25:11-3.
- Basch E, Gabardi S, Ulbricht C. Bitter melon (Momordica charantia): a review of efficacy and safety. Am J Health Syst Pharm 2003;60:356-9. PubMed
- Yin RV, Lee NC, Hirpara H, Phung OJ. T. The effect of bitter melon (Mormordica charantia) in patients with diabetes mellitus: s systematic review and meta-analysis. Nutr Diabetes. 2014;4:e145.
- Rahman IU, Khan RU, Rahman KU, Bashir M. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13. PubMed
- Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. PubMed
- Konishi T, Satsu H, Hatsugai Y, et al. Inhibitory effect of a bitter melon extract on the P-glycoprotein activity in intestinal Caco-2 cells. Br J Pharmacol. 2004;143(3):379-87. PubMed
- Peter EL, Kasali FM, Deyno S, et al. Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analysis. J Ethnopharmacol. 2019;231:311-24. doi: 10.1016/j.jep.2018.10.033. PubMed
- Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, González-Ortiz M, Méndez-Del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J Med Food. 2018;21(7):672-7. doi: 10.108
- Kim SK, Jung J, Jung JH, et al. Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus. Complement Ther Med. 2020 Aug;52:102524. doi: 10.1016/j.ctim.2020.102524. PubMed
- Unsal O, Sütcüoglu O, Yazici O. Dangerous interaction of bitter melon (Momordica charantia) with pazopanib: a case of acute pancreatitis. J Oncol Pharm Pract 2022;28(2):486-8.
- Bae W, Kim S, Choi J, et al. Acute interstitial nephritis associated with ingesting a Momordica charantia extract: a case report. Medicine (Baltimore) 2021;100(27):e26606. PubMed
- Chattopadhyay K, Wang H, Kaur J, et al. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Front Pharmacol. 2022;13:821810. Published 2022 Jun 8. PubMed
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