Interactions on record — worth a quick check against your medications. Based on 3 of 9 ingredients. Check your meds →
Dietary supplement

Ezgest RX Ingredients & Drug Interactions

by AmazeRx

Ezgest RX label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ezgest RX against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ezgest RX is a dietary supplement by AmazeRx with 9 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine HCl, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ezgest RX by AmazeRx

Ask about any prescription or over-the-counter medication and we check it for interactions with Ezgest RX by AmazeRx — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ezgest RX by AmazeRx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 8 of its 9 active ingredients.
  • “Gastric Phase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Enteric Phase” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Ezgest RX is a 9-ingredient digestive enzyme blend. It contains papain (an enzyme from papaya), pepsin (a stomach enzyme that breaks down protein), pancrelipase (a mix of enzymes from the pancreas), betaine HCl (an acidifier), and ox bile extract — all meant to help your body break down and absorb food.

It also includes stomach and duodenal substances (tissues from these organs) and cellulase (an enzyme for plant fiber). The capsule itself is gelatin, with cellulose, stearic acid, and magnesium stearate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Phased release formula to aid digestion.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating, Protein maldigestion.
  • The closest evidence on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).

The evidence on papain for its claimed uses — cancer, dental cavities, radiation skin damage, muscle soreness, shingles, and intestinal parasites — is insufficient to rate. The same holds for betaine HCl and conditions like poor digestion, low thyroid, diarrhea, rheumatoid arthritis, food allergies, and hay fever.

We hold no effectiveness ratings for the other ingredients. In short, the data we have doesn't establish whether Ezgest RX works for its intended purposes.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but can irritate your digestive tract and cause allergic reactions in sensitive people — itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. High doses may cause serious harm, including severe stomach inflammation or even a tear in your esophagus.

Betaine HCl can irritate the stomach and is unsafe if you have ulcers, gastritis, or true acid reflux. Pepsin is usually well tolerated but may cause digestive upset or allergic reactions.

Occupational exposure to airborne papain or pepsin dust has caused respiratory allergies and asthma in some people. For pregnancy, concentrated papain and unripe papaya products should be avoided — safety data advises against them.

Betaine HCl safety in pregnancy hasn't been established, so it's best avoided. Pepsin safety in pregnancy also hasn't been confirmed, so it's best avoided unless a doctor prescribes it.

Data on papain, betaine HCl, and pepsin during breastfeeding is too limited — avoid these ingredients unless your doctor or pharmacist advises otherwise. We hold no safety data for cellulase, ox bile extract, stomach substance, pancrelipase, or duodenal substance.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases) Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Ezgest RX if you're on warfarin (Coumadin) or any blood thinner — papain may increase its effects and raise your bleeding risk. Also double-check if you take any stomach acid medication: H2-blockers like famotidine, antacids, or proton pump inhibitors (PPIs) like omeprazole — betaine HCl can reduce how well they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Ezgest RX is a digestive enzyme supplement with multiple active ingredients, but the evidence that it works for any of its claimed uses isn't established in our data. If you take warfarin or any stomach acid medication, talk with your doctor or pharmacist before starting — papain and betaine HCl can interact with these drugs and reduce their effectiveness or raise your bleeding risk.

If you have ulcers, gastritis, or acid reflux, avoid it. And if you're pregnant or breastfeeding, check with your doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ezgest RX, straight from the product label.

Brand AmazeRx
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2012
DSLD ID 5589
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ezgest RX by AmazeRx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
IngredientAmount% DV
Papain100 mg--
Cellulase2 mg--
Betaine HCl115 mg--
Pepsin30 mg--
Ox Bile extract50 mg--
Stomach Substance5 mg--
Pancrelipase100 mg--
Duodenal Substance5 mg--
Gastric Phase0 NP--
Enteric Phase0 NP--
Enzyme Activity Per Capsule:0 NP--

Other ingredients: Cellulose, Stearic Acid, Powdered, Magnesium Stearate, Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

DIETARY SUPPLEMENT

General Statements

Phased Release Formula to Aid Digestion*

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ezgest RX by AmazeRx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ezgest RX label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ezgest RX by AmazeRx

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gastric Phase

0 NP per serving

Enteric Phase

0 NP per serving
  • › Papain
  • › Cellulase
  • › Ox Bile extract
  • › Pancrelipase
  • › Duodenal Substance

Enzyme Activity Per Capsule:

0 NP per serving

Other (inactive) ingredients: Cellulose, Stearic Acid, Powdered, Magnesium Stearate, Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ezgest RX by AmazeRx Drug Interactions

Want to check YOUR meds against Ezgest RX?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betaine HCl 36
Papain 2

Individual Drug Interactions

The ingredients in Ezgest RX interact with 38 drugs. Click any drug to see the details.

2 of the 9 ingredients in Ezgest RX interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Ezgest RX with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ezgest RX, from the product label.

AmazeRx

See all AmazeRx products
Name
Amaze RX
City
Dallas
State
TX
ZipCode
75201
Phone Number
800-721-5734
Pharmacist Counseling Corner

Ezgest RX by AmazeRx: Common Questions

Does Ezgest RX by AmazeRx interact with any medications?
Yes. Based on its ingredients, Ezgest RX has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ezgest RX contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Ezgest RX if I'm pregnant?
Not safely without talking to your doctor or pharmacist first. Papain — especially in concentrated form — is possibly unsafe in pregnancy. Betaine HCl and pepsin safety data in pregnancy hasn't been established, so they're best avoided unless a doctor prescribes them. Your healthcare provider can weigh the risks and benefits for your situation.
What if I'm breastfeeding?
There isn't enough safety data on papain, betaine HCl, or pepsin during breastfeeding. Talk with your doctor or pharmacist before taking this product while nursing.
Does papain in this product really digest food?
We don't have reliable evidence that papain works for digestive purposes or any of the conditions it's claimed to treat. The data shows insufficient evidence to rate its effectiveness.
Are there any common side effects?
Papain and pepsin can cause allergic reactions in sensitive people — symptoms include itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. Betaine HCl may cause heartburn or digestive upset. At high doses, papain can cause serious stomach damage. Short-term use at normal doses is generally well tolerated.
Can I take this with my stomach acid medication?
Not without checking first. Betaine HCl increases stomach acid and can reduce the effects of H2-blockers, antacids, and PPIs. If you take any of these, talk with your doctor or pharmacist before starting Ezgest RX.
Is this safe if I have an ulcer or acid reflux?
No. Betaine HCl can irritate your stomach and is unsafe if you have ulcers, gastritis, or true acid reflux. Don't take it if you have any of these conditions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ezgest RX label
Go deeper

The Full Monographs Behind Ezgest RX’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Ezgest RX's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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