Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Flora Melts Fruit Punch Flavor Ingredients & Drug Interactions

by DNA Miracles

Flora Melts Fruit Punch Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flora Melts Fruit Punch Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Flora Melts Fruit Punch Flavor is a dietary supplement by DNA Miracles with 5 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,118 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Apple Fiber, Bacillus coagulans. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Flora Melts Fruit Punch Flavor by DNA Miracles

Ask about any prescription or over-the-counter medication and we check it for interactions with Flora Melts Fruit Punch Flavor by DNA Miracles — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Flora Melts Fruit Punch Flavor by DNA Miracles

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Proprietary Prebiotic Blend” is a proprietary blend — the label gives one combined amount (1,200 mg) without saying how much of each component you get.

Flora Melts Fruit Punch Flavor contains 4 active ingredients: apple fiber, chicory root fiber, Jerusalem artichoke, and a proprietary prebiotic blend that includes Bacillus coagulans, a live probiotic organism. The product also includes inactive ingredients (natural fruit punch and mixed berry flavors, malic acid, and monk fruit extract) as excipients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Gut and immune balance with prebiotic and probiotic blend.
  • We looked for evidence on: Constipation, Diarrhea, Irritable bowel syndrome (IBS), Flatulence, Dyspepsia, Antibiotic-associated diarrhea — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).
  • Also on file: Chicory is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia.

The evidence for this product's active ingredients is limited. Apple fiber has insufficient evidence to rate for conditions including Alzheimer disease, cancer, dental plaque, diabetes, and diarrhea.

Chicory root fiber similarly has insufficient evidence for neonatal jaundice, fatty liver disease, osteoarthritis, indigestion, high cholesterol, and fatty liver disease. Bacillus coagulans shows possibly effective evidence for constipation and irritable bowel syndrome, though evidence and product quality vary across probiotic preparations.

We hold no effectiveness data for Jerusalem artichoke.

The evidence, ingredient by ingredient Black Psyllium Apple Chicory Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple fiber is well tolerated when eaten as food in normal amounts and is considered safe in pregnancy and while breastfeeding, though concentrated extracts haven't been well studied. The most common side effects are bloating and flatulence.

Rarely, allergic reactions including anaphylaxis can occur, especially in people allergic to other fruits in the Rosaceae family (apricot, almond, plum, peach, pear, strawberry). Chicory root fiber is generally well tolerated in food amounts but may cause gas and trigger allergies in sensitive people; medicinal amounts are possibly unsafe in pregnancy and lack enough safety data for breastfeeding.

Bacillus coagulans is generally well tolerated in healthy adults, though there's theoretical concern it could cause infection in severely immunocompromised or hospitalized patients with central catheters. There isn't enough safety data for pregnancy and breastfeeding — talk with your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Black Psyllium Apple Chicory Bacillus Coagulans

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Chicory, Black Psyllium, Apple, Bacillus Coagulans.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,119 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of the following: OATP substrate drugs (fexofenadine, atenolol, aliskiren, and others affected through apple fiber), blood pressure medications, diabetes drugs, lithium, or antibiotics. Apple fiber can significantly lower blood levels of several of these; chicory root fiber may increase the risk of low blood sugar with diabetes medications; and the probiotic may reduce antibiotic effectiveness if taken together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is a fiber and probiotic blend with limited established effectiveness — apple fiber and chicory root fiber have insufficient evidence for most claimed uses, while the probiotic may help with constipation or irritable bowel syndrome. The key concern is that apple fiber and chicory root can interfere with blood pressure control, diabetes medications, and other drugs; if you take any prescription medication, run it through the checker on this page before starting.

Talk with your doctor or pharmacist before taking this product if you're pregnant, breastfeeding, or have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flora Melts Fruit Punch Flavor, straight from the product label.

Brand DNA Miracles
Net contents 2.24 Oz(s); 63.42 Gram(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 218024
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flora Melts Fruit Punch Flavor by DNA Miracles, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2.114 Gram(s)
Maximum serving Sizes:
2.114 Gram(s)
Servings per container
30
IngredientAmount% DV
Total Carbohydrates2 Gram(s)1%
Dietary Fiber1 Gram(s)4%
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Apple Fiber0 NP--
Chicory root Fiber0 NP--
Jerusalem Artichoke0 NP--
Proprietary Prebiotic Blend1200 mg--
Bacillus coagulans0 NP--

Other ingredients: natural Fruit Punch flavor, Natural Mixed Berry Flavor, Malic Acid, Monk Fruit extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free

Gut Immune Balance

No added sugar

Vegan

General Statements

DNA miracles

30- 0.0746 oz (2.114 g) packets

Healthy bellies make happy little miracles!

Formula

pre + probiotic blend with fiber

Fruit punch flavor with other natural flavors

DNA Miracles Flora Melts are a delicious melt delivering the probiotic LactoSpore paired with one gram of fiber from a prebiotic blend for a microflora balance and strong immune support.

Natural flavors

Directions for use, for ages 4+

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

LactoSpore is a registered trademark of Sabinsa Corporation.

Suggested/Recommended/Usage/Directions

Directions for use, for ages 4+ Mix it! Sprinkle the contents of one packet (2.114 g) into food or 120 ml (4 oz.) of water or preferred beverage. Stir until dissolved. Consume within 8-12 hours. Melt it! With adult supervision, slowly sprinkle the contents of the packet onto tongue. Close mouth and allow to dissolve.

Precautions

Warning: If you have an ongoing medical condition or are taking any other prescription medication, consult your healthcare provider before taking this product.

If you are allergic to any of the ingredients listed, do not use this product.

Keep out of the reach of children.

Powder is a choking hazard.

Storage

Store at 15-30 degrees C (59-86 degrees F). Protect from heat, light, and moisture.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flora Melts Fruit Punch Flavor by DNA Miracles label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flora Melts Fruit Punch Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flora Melts Fruit Punch Flavor by DNA Miracles

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2.114 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dietary Fiber

Interacts with
2,025 drugs
1 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Proprietary Prebiotic Blend

1200 mg per serving

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Other (inactive) ingredients: Natural Fruit Punch flavor, Natural Mixed Berry Flavor, Malic Acid, Monk Fruit extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flora Melts Fruit Punch Flavor by DNA Miracles Drug Interactions

Want to check YOUR meds against Flora Melts Fruit Punch Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,118Drugs
47 Major 419 Moderate 1,652 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Apple Fiber 300
Bacillus coagulans 182
Chicory root Fiber 86

Individual Drug Interactions

The ingredients in Flora Melts Fruit Punch Flavor interact with 2,118 drugs. Click any drug to see the details.

4 of the 5 ingredients in Flora Melts Fruit Punch Flavor interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Apple Fiber Bacillus coagulans Chicory root Fiber

Each ingredient & the kinds of drugs it affects

For each ingredient in Flora Melts Fruit Punch Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Apple Fiber7 drug types · 300 drugs

Organic Anion-Transporting Polypeptide Substrates (Oatp)

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of OATP substrates.
Research shows that consuming apple juice inhibits OATP, which reduces bioavailability of oral drugs that are substrates of OATP. Fexofenadine, atenolol, and aliskiren are substrates of OATP. Clinical research shows that coadministration of apple juice decreases bioavailability of fexofenadine by up to 78%, aliskiren by 63%, and atenolol by up to 82%. These effects appear to increase with larger quantities of apple juice. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.

Likelihood Likely Evidence B
Aliskiren (Tekturna, Rasilez)

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of aliskiren.
Pharmacokinetic research shows that coadministration of apple juice 200 mL along with aliskiren 150 mg decreases the bioavailability of aliskiren by 63%. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.

Likelihood Probable Evidence B
Antidiabetes Drugs

Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.
Clinical research suggests that consuming apples or drinking apple juice can raise blood glucose levels, with the effects of drinking apple juice being more significant than consuming apples.

Likelihood Possible Evidence D
Antihypertensive Drugs

Consuming apple juice with antihypertensive drugs might interfere with blood pressure control.
Some clinical evidence suggests that consuming apple and cherry juice can increase blood pressure in elderly patients.

Likelihood Probable Evidence B
Atenolol (Tenormin)

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of atenolol.
Pharmacokinetic research shows that coadministration of apple juice 600-1200 mL decreases levels of atenolol by 58% to 82% in a dose-dependent manner. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.

Likelihood Probable Evidence B
Fexofenadine (Allegra)

Concomitant consumption of apple juice can significantly decrease oral absorption and blood levels of fexofenadine.
Pharmacokinetic research shows that coadministration of apple juice 400-1200 mL along with fexofenadine 60-120 mg decreases bioavailability of fexofenadine by up to 78%. Coadministration with smaller quantities of apple juice (150 mL or less) does not appear to affect the bioavailability of fexofenadine. Apple juice seems to inhibit organic anion transporting polypeptide (OATP), which is involved in drug uptake in the gut, liver, and kidney. It is thought that apple juice might affect OATP for only a short time. Therefore, separating drug administration and consumption of apple juice by at least 4 hours might avoid this interaction.

Likelihood Likely Evidence B
Lithium

There is some concern that concomitant consumption of apple juice might decrease oral absorption and blood levels of lithium.
In one case report, a patient had an undetectable serum lithium level when lithium citrate was administered with apple juice. When lithium was administered with an alternative beverage, the lithium level became detectable and the patient demonstrated clinical improvement.

Likelihood Possible Evidence D
Apple Fiber full monograph & interactions

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions

Chicory root Fiber1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research shows that chicory extracts have antidiabetic effects.

Likelihood Possible Evidence D
Chicory root Fiber full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flora Melts Fruit Punch Flavor, from the product label.

DNA Miracles

See all DNA Miracles products
Name
Market America, Inc.
Street Address
1302 Pleasant Ridge Rd.
City
Greensboro
State
NC
ZipCode
27409
Pharmacist Counseling Corner

Flora Melts Fruit Punch Flavor by DNA Miracles: Common Questions

Does Flora Melts Fruit Punch Flavor by DNA Miracles interact with any medications?
Yes. Based on its ingredients, Flora Melts Fruit Punch Flavor has a known interaction with 2,118 medications, including 47 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flora Melts Fruit Punch Flavor contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure or diabetes medication?
Both apple fiber and chicory root fiber in this product can interfere with blood pressure control and diabetes medications. Check with your doctor or pharmacist before starting to see if it's safe for you and whether you need to adjust timing or dosing.
What's Bacillus coagulans and what does it do?
Bacillus coagulans is a live probiotic organism. The evidence shows it's possibly effective for constipation and irritable bowel syndrome, though the quality and strength of different probiotic products vary. If you take antibiotics, separate them from this product — antibiotics can kill the probiotic organisms.
Is this safe to take while I'm pregnant?
Apples eaten as food are considered safe in pregnancy, but concentrated apple extracts haven't been well studied. Chicory in medicinal amounts is possibly unsafe during pregnancy. There isn't enough safety data for the probiotic. Talk with your doctor or pharmacist before starting this product if you're pregnant.
What side effects might I notice?
Bloating and flatulence are the most common side effects from the fiber ingredients. Allergic reactions are rare but possible, especially if you're allergic to fruits like peaches, plums, or strawberries. If you experience severe allergic symptoms, stop and seek medical help.
I take allergy medication — is this okay?
If you take fexofenadine (Allegra) or another OATP substrate medication, the apple fiber in this product can significantly lower its blood levels, making it less effective. Check with your pharmacist before starting.
Does this actually work for what it claims?
The apple fiber and chicory root don't have reliable evidence for most uses. Bacillus coagulans shows some evidence for constipation and irritable bowel syndrome, but results vary. We have no data on Jerusalem artichoke's effectiveness.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flora Melts Fruit Punch Flavor label
Go deeper

The Full Monographs Behind Flora Melts Fruit Punch Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Apple

Interacts with 300 drugs

Apples are a nutritious whole food that provides fiber, vitamins, and antioxidant plant compounds, and eating them regularly fits well into a healthy diet. While research suggests apples may...

Read the full Apple monograph → Herb & supplement monograph

Chicory

Interacts with 86 drugs

Chicory is best known as a caffeine-free coffee substitute and as a source of inulin, a soluble prebiotic fiber that may support digestion and regularity. Strong human evidence for most othe...

Read the full Chicory monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Flora Melts Fruit Punch Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Apple 16 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Bailey DG, Dresser GK, Munoz C, et al. Reduction of fexofenadine bioavailability by fruit juices. Clin Pharmacol Ther 2001;69:P21.
  3. Rodriguez J, Crespo JF, Lopez-Rubio A, et al. Clinical cross-reactivity among foods of the Rosaceae family. J Allergy Clin Immunol 2000;106:183-189. PubMed
  4. Greenblatt DJ. Analysis of drug interactions involving fruit beverages and organic anion-transporting polypeptides. J Clin Pharmacol 2009;49:1403-7. PubMed
  5. Bailey DG. Fruit juice inhibition of uptake transport: a new type of food-drug interaction. Br J Clin Pharmacol 2010;70:645-55. PubMed
  6. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in rats. J Pharm Sci 2005;94:233-9. PubMed
  7. Tapaninen T, Neuvonen PJ, Niemi M. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren. Br J Clin Pharmacol 2011;71:718-26. PubMed
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See these in context on the Apple monograph →

Chicory 13 references
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Bacillus Coagulans 20 references
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See these in context on the Bacillus Coagulans monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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