Major interaction on record — check this product against your medications before combining. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free Ingredients & Drug Interactions

by XYMOGEN

Powder Category: Other Combinations
Most serious interaction: Major
The interaction bottom line Most serious interaction: Major

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free is a dietary supplement by XYMOGEN with 3 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 103 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Colostral Whey Peptides, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Colostral Whey Peptides” is listed as a grouped ingredient — the label gives one combined amount (2.50 Gram(s)) without saying how much of each component you get.

GI Protect contains 2 active ingredients: L-glutamine and immunoglobulin G. L-glutamine is an amino acid your body makes and uses for gut lining support and immune function.

Immunoglobulin G is an antibody naturally present in colostrum (early breast milk), and colostral whey peptides are protein fragments from the same source. The powder also contains inactive ingredients like cherry flavor, beet powder, citric acid, malic acid, monk fruit extract, silica, and sunflower lecithin for taste and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: gastrointestinal system support.
  • We looked for evidence on: Antiretroviral-associated diarrhea, Chemotherapy-induced diarrhea, Crohn disease, Cystic fibrosis, Irritable bowel syndrome (IBS), Oral mucositis — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Pancreatitis (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease, Radiation-induced diarrhea.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Cystic fibrosis, Antiretroviral-associated diarrhea, Irritable bowel syndrome (IBS).

L-glutamine is rated effective for sickle cell disease. It's rated possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

We don't have effectiveness ratings on file for immunoglobulin G or colostral whey peptides in this product.

The evidence, ingredient by ingredient Glutamine Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is rated likely safe during pregnancy and lactation. In healthy adults, it's generally well tolerated, but people with kidney or liver disease should use it only under medical supervision.

The most common side effects from oral glutamine are belching, bloating, constipation, diarrhea, flatulence, gastrointestinal pain, headache, nausea, and vomiting — especially at higher doses (10–30 grams daily). A small number of people have reported dizziness, and in rare cases, people with bipolar disorder taking glutamine have experienced mania or hypomania.

If you have liver or kidney disease, neurological conditions, or bipolar disorder, talk with your pharmacist or doctor before starting.

Side effects, ingredient by ingredient Glutamine Whey Protein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your anticonvulsant medications (seizure drugs) before taking this product — glutamine theoretically could reduce their effectiveness, though this hasn't been reported in patients. We have no documented interactions for immunoglobulin G or colostral whey peptides.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

GI Protect may help with gut support and recovery, particularly if you have sickle cell disease or are recovering from surgery or critical illness. If you take anticonvulsant medications, check them against the interaction tool on this page first.

Anyone with kidney, liver, or bipolar disorder should talk with their pharmacist before using it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about GI Protect Natural Cherry Flavor Sugar- and Stevia-Free, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149003555
Net contents 6.67 Ounce(s); 189 Gram(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 335460
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6.3 Gram(s)
Maximum serving Sizes:
6.3 Gram(s)
Servings per container
30
UPC/BARCODE
871149003555
IngredientAmount% DV
Calories25 Calorie(s)--
L-Glutamine2.5 Gram(s)--
Immunoglobulin G1 Gram(s)--
Protein2 Gram(s)--
Colostral Whey Peptides2.5 Gram(s)--

Other ingredients: Cherry Flavor, Natural, Red Beet, Powder, Citric Acid, Malic Acid, Monk Fruit Extract, Silica, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Dissolve 1 level scoop (6.3 g) into at least 6 oz of water or other beverage and consume once daily, or use as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

STORAGE: Keep closed in a cool, dry place out of reach of children.

Contains: Milk.

Formula

GI Protect combines immunoglobulin concentrate with L-glutamine for proactive gastrointestinal system support. The colostral whey peptide-derived immunoglobulin concentrate is standardized to 40% IgG and delivers bioactive proteins and growth factors. This formula is designed for individuals with active lifestyles, weekend warriors, and dedicated athletes, providing targeted support for the gut mucosal barrier and promoting cytokine balance, immune health, gut health, and tissue repair.

Featuring IgG 2000 CWP and L-Glutamine

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formulation

FORMULATED TO EXCLUDE: Wheat, gluten, yeast, soy protein, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, and artificial sweeteners.

Brand IP Statement(s)

Xymogen Professional formulas

Copyright 2025 XYMOGEN

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

GMP compliant third-party verified

General Statements

Scan to learn

See for yourself

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size6.3 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2.5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Protein

2 Gram(s) per serving Form: Colostral Whey Peptides

Colostral Whey Peptides

Interacts with
53 drugs
2.5 Gram(s) per serving Form: Immunoglobulin Concentrate

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

Colostral Whey Peptides monograph & interactions
  • › Immunoglobulin G

Other (inactive) ingredients: Cherry Flavor, Natural, Red Beet, Powder, Citric Acid, Malic Acid, Monk Fruit Extract, Silica, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN Drug Interactions

Want to check YOUR meds against GI Protect Natural Cherry Flavor Sugar- and Stevia-Free?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
103Drugs
5 Major 98 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in GI Protect Natural Cherry Flavor Sugar- and Stevia-Free with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Colostral Whey Peptides4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for GI Protect Natural Cherry Flavor Sugar- and Stevia-Free, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
xymogen.com
Pharmacist Counseling Corner

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN: Common Questions

Does GI Protect Natural Cherry Flavor Sugar- and Stevia-Free by XYMOGEN interact with any medications?
Yes. Based on its ingredients, GI Protect Natural Cherry Flavor Sugar- and Stevia-Free has a known interaction with 103 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
GI Protect Natural Cherry Flavor Sugar- and Stevia-Free contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-glutamine safe while I'm breastfeeding?
L-glutamine is rated likely safe during breastfeeding. However, there isn't much reliable safety data on supplement doses, so talk with your doctor or pharmacist before starting — they can advise based on your individual situation.
What are the most common side effects?
The most common side effects are belching, bloating, constipation, diarrhea, flatulence, gastrointestinal pain, and nausea — especially at higher doses. These are usually mild and dose-dependent. If you experience them, mention it to your pharmacist; lowering your dose often helps.
Can I take this if I have kidney disease?
If you have kidney or liver disease, use L-glutamine only under medical supervision. Talk with your doctor or pharmacist about whether this product is right for you.
Does this really work for gut health?
L-glutamine is rated effective for sickle cell disease and possibly effective for recovery after surgery, trauma, or with HIV/AIDS-related wasting. We don't have effectiveness data on file for general gut health claims.
What is colostral whey?
Colostral whey peptides are protein fragments from colostrum — the first milk produced by mammals. This product sources them from bovine (cow) colostrum. They're included for immune and gut support, though we don't have effectiveness ratings for them in our data.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if GI Protect Natural Cherry Flavor Sugar- and Stevia-Free is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free label
Sources

Sources & How We Checked

GI Protect Natural Cherry Flavor Sugar- and Stevia-Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Whey Protein 25 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  3. Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food 2000;3:1-13. PubMed
  4. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  5. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  6. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  7. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  8. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook. 4th ed. Hudson, OH: Lexicomp, 1998.
  9. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  10. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  11. Micke, P., Beeh, K. M., and Buhl, R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur.J Nutr 2002;41(1):12-18. PubMed
  12. Chitapanarux, T., Tienboon, P., Pojchamarnwiputh, S., and Leelarungrayub, D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol.Hepatol. 2009;24(6):1045-1050. PubMed
  13. Sataloff, R. T., Bittermann, T., Marks, L., Lurie, D., and Hawkshaw, M. The effects of glutathione enhancement on sensorineural hearing loss. Ear Nose Throat J 2010;89(9):422-433.
  14. Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V., Binns, C. W., and Prince, R. L. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal
  15. Bjorkman, M. P., Pilvi, T. K., Kekkonen, R. A., Korpela, R., and Tilvis, R. S. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health A
  16. Brun, A. C., Stordal, K., Johannesdottir, G. B., Bentsen, B. S., and Medhus, A. W. The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy. Clin.Nutr 2012;31(1):108-112. PubMed
  17. Gouni-Berthold, I., Schulte, D. M., Krone, W., Lapointe, J. F., Lemieux, P., Predel, H. G., and Berthold, H. K. The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised plac
  18. Errichiello, L., Pezzella, M., Santulli, L., Striano, S., Zara, F., Minetti, C., Mainardi, P., and Striano, P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011;26(14):2573-2575. PubMed
  19. Carcillo, J. A., Dean, J. M., Holubkov, R., Berger, J., Meert, K. L., Anand, K. J., Zimmerman, J., Newth, C. J., Harrison, R., Burr, J., Willson, D. F., and Nicholson, C. The randomized comparative pediatric critical illness stress-induced immune suppres
  20. Chungchunlam, S. M., Moughan, P. J., Henare, S. J., and Ganesh, S. Effect of time of consumption of preloads on measures of satiety in healthy normal weight women. Appetite 2012;59(2):281-288. PubMed
  21. Rencuzogullari I, Börekçi A, Karakoyun S, et al. Coronary thrombosis in three coronary arteries due to whey protein. Am J Emerg Med. 2017;35(4):664.e3-664.e4. PubMed
  22. Silverberg NB. Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes. Case Reports Cutis. 2012;90(2):70-2.
  23. Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8. PubMed
  24. Pontes TC, Costa Fernandes Filho GM, Pereira Trindade AS, Sobral Filho JF. Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa-PB. An Bras Dermatol. 2013;88(6):907-12.
  25. Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May;58(5):787-93. PubMed

See these in context on the Whey Protein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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