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Dietary supplement

Glutamine Amino Acid 500 mg Ingredients & Drug Interactions

by Higher Nature

Glutamine Amino Acid 500 mg label
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Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine Amino Acid 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine Amino Acid 500 mg is a dietary supplement by Higher Nature with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine Amino Acid 500 mg by Higher Nature

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine Amino Acid 500 mg by Higher Nature — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine Amino Acid 500 mg by Higher Nature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine at 500 mg per capsule. Glutamine is an amino acid — one of the building blocks your body uses to make protein.

The capsule itself is made from hydroxypropyl methylcellulose, an inactive ingredient that holds the glutamine together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glutamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glutamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Natural Medicines).

L-glutamine is effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma.

For other uses, the evidence in our data isn't established.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated by healthy adults when taken orally. The most common side effects are belching, bloating, constipation, diarrhea, flatulence, stomach pain, headache, nausea, and vomiting — usually seen at higher doses (10–30 grams daily or more).

A few cases of dizziness and, in people with bipolar disorder, mood changes (mania or hypomania) have been reported, but these are rare. If you have kidney or liver disease, use this supplement only under medical supervision.

There is not enough safety data in pregnancy or while breastfeeding; talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (seizure drugs), double-check with your doctor or pharmacist before starting this supplement — glutamine might theoretically reduce how well they work, though this hasn't been seen in patients yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and possibly with muscle loss in HIV/AIDS, post-surgical recovery, or critical illness. If you take anticonvulsants, check with your doctor or pharmacist before starting it.

Generally well tolerated, but people with kidney or liver disease and those who are pregnant or breastfeeding should confirm it's safe for them first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine Amino Acid 500 mg, straight from the product label.

Brand Higher Nature
Barcode (UPC) 5031013101236
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41263
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine Amino Acid 500 mg by Higher Nature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
10 Capsule(s)
UPC/BARCODE
5031013101236
IngredientAmount% DV
L-Glutamine1000 mg--

Other ingredients: Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Glucose is used in the manufacture of the L-Glutamine.

This product is not tested on animals.

Charitable organisations policy: supplements regularly donated

~ The amino acid, glutamine, becomes conditionally ‘essential’ when the body is being challenged physically or mentally.

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

This bottle has a UV filter.

Formulation

DOES NOT CONTAIN: sugar, salt, starch, soya, wheat, gluten, maize, corn, yeast, lactose, dairy products, artificial preservatives, colours or flavourings.

Suitable for vegetarians and vegans.

VEGETARIAN

Seals/Symbols

Jar {Recycle} 1 PET Lid {Recycle} 5 PP

FDA Statement of Identity

FOOD SUPPLEMENT

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 2-10 capsules (children over 8 years, 1-2 capsules; over 10 years, as adults), 1-3 times a day half an hour before meals, or as your health professional advises.

Take with a cool drink.

Precautions

Do not exceed recommended daily intake.

Keep out of reach of children.

Storage

Do not refrigerate.

Ensure lid is tight and store in a cool, dry, steam-free environment as damp conditions can affect the product quality.

General

GLC030 107 GLC-038-03

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine Amino Acid 500 mg by Higher Nature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine Amino Acid 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine Amino Acid 500 mg by Higher Nature

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
1000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glutamine Amino Acid 500 mg by Higher Nature Drug Interactions

Want to check YOUR meds against Glutamine Amino Acid 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine Amino Acid 500 mg interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine Amino Acid 500 mg interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine Amino Acid 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine Amino Acid 500 mg, from the product label.

Higher Nature

See all Higher Nature products
Name
Higher Nature
City
Burwash Common
State
East Sussex
ZipCode
TN19 7LX
Web Address
www.highernature.com
Pharmacist Counseling Corner

Glutamine Amino Acid 500 mg by Higher Nature: Common Questions

Does Glutamine Amino Acid 500 mg by Higher Nature interact with any medications?
Yes. Based on its ingredients, Glutamine Amino Acid 500 mg has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine Amino Acid 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine and what does it do?
L-glutamine is an amino acid — a building block your body uses to make protein. It plays roles in immune function, gut health, and muscle metabolism. This product is used mainly for sickle cell disease and possibly for muscle loss related to HIV/AIDS, surgery, or critical illness.
What side effects might I get?
At normal doses, glutamine is generally well tolerated. You might experience belching, bloating, constipation, diarrhea, stomach pain, nausea, or headache — mostly at higher doses (10–30 grams daily or more). Dizziness has been reported rarely. If you have bipolar disorder, mention this supplement to your doctor, since a couple of cases of mood elevation have been reported.
Is it safe if I'm pregnant or breastfeeding?
The data says L-glutamine is likely safe in pregnancy, but there isn't enough reliable safety information for breastfeeding. Talk with your doctor or pharmacist about whether to take it while breastfeeding — they can weigh the specific risks and benefits for you.
Can I take it if I have kidney or liver disease?
If you have kidney or liver disease, use this supplement only under medical supervision. Your doctor or pharmacist can tell you whether it's safe and what dose is right for you.
Is this the right supplement for me if I'm getting over surgery?
L-glutamine is possibly effective for recovery after surgery, but the evidence isn't as strong as for sickle cell disease. Talk with your doctor or pharmacist about whether it makes sense for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glutamine Amino Acid 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine Amino Acid 500 mg label
Go deeper

The Full Monographs Behind Glutamine Amino Acid 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine Amino Acid 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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