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Dietary supplement

Glutamine Ingredients & Drug Interactions

by Universal

Glutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Glutamine is a dietary supplement by Universal with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Glutamine by Universal

Ask about any prescription or over-the-counter medication and we check it for interactions with Glutamine by Universal — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Glutamine by Universal

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: glutamine, an amino acid. It comes as a powder you mix into drinks or food.

The only other component listed is the glutamine powder itself — no added fillers or binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Glutamine's overall clinical evidence instead.

Strong

Strong clinical evidence supports Glutamine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Sickle cell disease — rated "Effective" (Natural Medicines).
  • On file: HIV/AIDS-related wasting — rated "Possibly Effective" (Natural Medicines).
  • On file: Critical illness (trauma) — rated "Possibly Effective" (Natural Medicines).
  • On file: Postoperative recovery — rated "Possibly Effective" (Natural Medicines).
  • On file: Pancreatitis — rated "Possibly Effective" (Natural Medicines).

Glutamine is rated effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

The data on file doesn't cover other uses you might be considering.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is generally well tolerated by healthy adults. The most common side effects are gastrointestinal — belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and stomach pain — along with occasional headache and musculoskeletal pain.

At high doses (10–30 grams daily used in sickle cell trials), GI upset is more likely. Rare cases of dizziness, mood changes (mania or hypomania in bipolar disorder), and abdominal pain have been reported.

If you have kidney or liver disease, use glutamine only under medical supervision. There isn't enough safety data to recommend it during pregnancy beyond normal dietary amounts — talk with your doctor about whether supplemental doses are right for you.

Safety data during breastfeeding is limited; avoid supplement doses unless a clinician advises it. People with neurological conditions should be aware glutamine is metabolized to glutamate, which has neurological effects.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use any anticonvulsant medications (drugs to prevent seizures) — glutamine may theoretically reduce their effectiveness, though this hasn't been confirmed in people. If you take any other prescription medications, you can search them below to confirm there are no other documented interactions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Universal Glutamine is a straightforward single-ingredient supplement with the strongest evidence for sickle cell disease and some support in HIV/AIDS wasting and recovery from surgery or critical illness. If you take anticonvulsant medications, check with your doctor or pharmacist before starting.

Those with kidney, liver, or neurological conditions should discuss it with their provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Glutamine, straight from the product label.

Brand Universal
Barcode (UPC) 039442046628
Net contents 600 Gram(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37749
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Glutamine by Universal, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
10 Gram(s)
Servings per container
120
UPC/BARCODE
039442046628
IngredientAmount% DV
Glutamine5 Gram(s)--

Other ingredients: Glutamine, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

G1713-G-32569

General Statements

732-545-3130

Before beginning any program, consult your health care practitioner.

Plant #3001104580

MADE PROUDLY IN THE U.S.A.

WHO WE ARE Universal Nutrition has been providing cutting edge and staple nutritional supplements to bodybuilders and hard training athletes the world over since 1977. As time passes, certain ideals never go out of style. Honesty. Integrity. Respect. These are the values we uphold and are the bedrock upon which we built our business.

Glutamine is a "conditionally" essential pro-anabolic amino acid and is the most abundant amino acid in muscle. Glutamine may be the most important variable in promoting optimum protein synthesis, while helping block cortisol to prevent protein breakdown in muscle. * HOW WE BACK IT UP What is on the label is in the bottle and what is in the bottle will help you reach your goals. We believe it and proudly stand behind every product we manufacture. Our word is our bond.

Finest Pharmaceutical Grade Amino Acid

100% Pure Optimum Cellular Recovery

Suggested/Recommended/Usage/Directions

DOSAGE: Mix 1-2 rounded teaspoonfuls in 8-12 oz. of your beverage of choice. For optimal results, try using it in your favorite protein shake or meal replacement powder.

Precautions

WARNINGS: Keep out of reach of children.

Made in a GMP facility on equipment that processes milk, soy, egg, peanuts, tree nuts, fish, shellfish, and wheat.

FDA Disclaimer Statement

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

(C) 2014 UniversalNutrition

WHAT IT IS Glutamine Powder(TM) from Universal Nutrition provides the purest L-glutamine powder available.

FDA Statement of Identity

Recovery Supplement

Formula

Pure L-Glutamine

Full 5000mg of Glutamine Per Serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Glutamine by Universal label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Glutamine by Universal

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container120 Amounts shown are per serving.

Glutamine

Interacts with
50 drugs
5 Gram(s) per serving Form: L-Glutamine

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine monograph & interactions

Other (inactive) ingredients: Glutamine, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Glutamine by Universal Drug Interactions

Want to check YOUR meds against Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Glutamine 50

Individual Drug Interactions

The ingredients in Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Glutamine interact with drugs. Each result below shows which ingredient is responsible. Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Glutamine, from the product label.

Universal

See all Universal products
Name
Universal Nutrition
City
New Brunswick
State
New Jersey
ZipCode
08901
Phone Number
800-872-0101
Web Address
www.UniversalUSA.com
Pharmacist Counseling Corner

Glutamine by Universal: Common Questions

Does Glutamine by Universal interact with any medications?
Yes. Based on its ingredients, Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does glutamine do in the body?
Glutamine is an amino acid your body uses for muscle recovery, immune function, and gut health. Your body makes some glutamine, but after intense exercise, illness, or surgery, supplementing it may support recovery. It's metabolized to glutamate and ammonia, both of which have effects in the nervous system.
What side effects should I expect?
Most people tolerate glutamine well, but GI upset is common — bloating, constipation, diarrhea, nausea, and stomach pain, especially at higher doses. Headache and muscle aches can occur. Rare cases of dizziness and mood changes have been reported, particularly in people with bipolar disorder.
Is it safe during pregnancy?
Glutamine is rated likely safe during pregnancy, meaning the data available so far supports its use at normal dietary levels. If you're considering supplemental doses beyond what's in food, talk with your doctor to make sure it's right for your situation.
Can I take glutamine if I have kidney or liver disease?
Only under medical supervision. If you have either condition, check with your doctor before starting; they'll need to monitor you or adjust your dose.
Does glutamine actually work for muscle recovery?
The data on file doesn't cover general muscle recovery — it's strongest for sickle cell disease and possibly helpful for HIV/AIDS wasting and recovery from surgery or critical illness. Talk with your doctor about whether it fits your specific goal.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Glutamine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Glutamine label
Go deeper

The Full Monographs Behind Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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