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Dietary supplement

Gluten-Gest Ingredients & Drug Interactions

by NutriCology

Gluten-Gest label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Gluten-Gest against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Gluten-Gest is a dietary supplement by NutriCology with 5 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Gluten-Gest by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with Gluten-Gest by NutriCology — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Gluten-Gest by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 10 active ingredients.
  • “Glutenase, Powder” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Gluten-Gest contains 10 active ingredients: a mix of beneficial bacteria (Lactobacillus rhamnosus, B. lactis, L. casei, L. lactis, L. helveticus, and B. brevis), digestive enzymes (Amylase, Glucoamylase, Peptidase, and Protease), and Glutenase. Together they're meant to help break down carbohydrates, proteins, and gluten during digestion.

The capsule also contains inactive ingredients — Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, and Maltodextrin — which serve as fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Gluten digestion support with probiotics.
  • We looked for evidence on: Diarrhea, Lactose intolerance, Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS), Inflammatory bowel disease (IBD), Wheat intolerance — and 3 related terms.
  • The closest evidence on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Helveticus is rated "Insufficient Reliable Evidence To Rate" for Rotaviral diarrhea, Irritable bowel syndrome (IBS).

The evidence for L. helveticus (one of the probiotics in this blend) is not established: our data rates it as having insufficient reliable evidence for allergic rhinitis, antibiotic-associated diarrhea, cognitive function, depression, diarrhea, and exercise-induced respiratory infections. We hold no effectiveness ratings for the other ingredients.

If you're taking this to address a specific digestive or health concern, talk it over with your doctor or pharmacist about what the current evidence shows for your situation.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Acidophilus Lactobacillus Helveticus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. helveticus is generally well tolerated in healthy people, but if you're seriously ill or immunocompromised, you should be cautious — and use it only with your doctor's guidance. There's limited safety information overall.

Protease may cause digestive upset or allergic reactions in some people; rarely, occupational exposure to similar enzymes has triggered allergic rhinoconjunctivitis or asthma. Since L. helveticus contains live organisms, there is a theoretical concern it could cause infection in some patients, though this is uncommon.

Pregnancy and breastfeeding safety data isn't fully established for these ingredients — talk with your doctor before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Lactobacillus Acidophilus Lactobacillus Helveticus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Helveticus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, separate them from Gluten-Gest by a few hours — antibiotics can kill off the live organisms in the supplement and reduce its potential benefit. We could not check the interaction data for seven of the ten ingredients in this product, so if you take any medications at all, use the search tool on this page to look up your exact drugs before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gluten-Gest is a multi-ingredient digestive enzyme and probiotic blend; the evidence for how well it works isn't established in our data. The main medication concern is timing it away from antibiotics, which could interfere with the live bacteria.

If you're seriously ill, immunocompromised, pregnant, or nursing, check with your doctor before starting. Run your medications through the tool on this page to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Gluten-Gest, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947563605
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 199566
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Gluten-Gest by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
713947563605
IngredientAmount% DV
L. rhamnosus0 NP--
Amylase0 NP--
Glucoamylase0 NP--
B. lactis0 NP--
L. casei0 NP--
Peptidase0 NP--
L. lactis0 NP--
L. helveticus0 NP--
B. brevis0 NP--
Glutenase, Powder400 mg--
strong acid Protease0 NP--
Probiotic Blend0 NP--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains glutenase powder, which provides specific enzymes that target the more difficult-to-digest peptides found in wheat and other gluten-containing grains. Gluten-Gest also provides other enzyme activity and a blend of probiotic bacteria.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, adults take 2 capsules daily with food, or as directed by a health care professional.

Storage

Keep in a cool, dry place, tightly capped.

General

Rev. 006

General Statements

Innovative Nutrition

Formulation

Gluten and Dairy Free

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Gluten-Gest by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Gluten-Gest label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Gluten-Gest by NutriCology

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Glutenase, Powder

400 mg per serving

Probiotic Blend

Interacts with
182 drugs
0 NP per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions
  • › L. rhamnosus
  • › B. lactis
  • › L. casei
  • › L. lactis
  • › L. helveticus
  • › B. brevis

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Magnesium Stearate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Gluten-Gest by NutriCology Drug Interactions

Want to check YOUR meds against Gluten-Gest?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Probiotic Blend 182

Individual Drug Interactions

The ingredients in Gluten-Gest interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Gluten-Gest interact with drugs. Each result below shows which ingredient is responsible. Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Gluten-Gest with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Gluten-Gest, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
Alameda
State
CA
ZipCode
94502
Phone Number
510.263.2000
Web Address
www.nutricology.com
Pharmacist Counseling Corner

Gluten-Gest by NutriCology: Common Questions

Does Gluten-Gest by NutriCology interact with any medications?
Yes. Based on its ingredients, Gluten-Gest has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Gluten-Gest contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with antibiotics?
Not at the same time. Antibiotics can kill the live bacteria in Gluten-Gest, which would make the supplement less effective. Space them out by a few hours — your doctor or pharmacist can suggest the best timing for your specific antibiotic.
Is it safe if I'm immunocompromised?
The safety data advises caution for people who are seriously ill or have a weakened immune system. Use it only with your doctor's guidance if that's your situation.
Can I take it while pregnant or breastfeeding?
There isn't enough reliable safety data to know either way. Talk with your doctor or pharmacist before using it in pregnancy or while nursing — they can weigh your individual situation.
What does protease do in this product?
Protease is an enzyme that breaks down proteins during digestion. It's one of several digestive enzymes in Gluten-Gest meant to help your body process food.
Can this cause allergic reactions?
Yes — protease can trigger allergic reactions or digestive upset in some people. Very rarely, exposure to similar enzymes has caused allergic rhinoconjunctivitis or asthma, though this is usually from occupational exposure at much higher levels.
Does this really break down gluten?
The product contains Glutenase, an enzyme designed to target gluten, but our data doesn't hold an effectiveness rating for it. If you have celiac disease or severe gluten sensitivity, talk with your doctor before relying on any supplement as a substitute for a gluten-free diet.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Gluten-Gest is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Gluten-Gest label
Go deeper

The Full Monographs Behind Gluten-Gest’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Lactobacillus Helveticus

Interacts with 182 drugs

Lactobacillus helveticus is a lactic acid bacterium used as a probiotic, often combined with other strains in mood, gut, and general wellness products. Early research is interesting—especial...

Read the full Lactobacillus Helveticus monograph →
Sources

Sources & How We Checked

Gluten-Gest's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Helveticus 2 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed

See these in context on the Lactobacillus Helveticus monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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