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Dietary supplement

Graviola 650 mg Ingredients & Drug Interactions

by Herbal Secrets

Graviola 650 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Graviola 650 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Graviola 650 mg is a dietary supplement by Herbal Secrets with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Graviola 650 mg by Herbal Secrets

Ask about any prescription or over-the-counter medication and we check it for interactions with Graviola 650 mg by Herbal Secrets — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Graviola 650 mg by Herbal Secrets

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: graviola, a tropical fruit extract used in herbal medicine. Each capsule holds 650 mg of graviola.

The capsule itself is made from gelatin, microcrystalline cellulose (a plant-based binder), magnesium stearate, and silicon dioxide — all standard inactive ingredients that help form and preserve the capsule.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: stress and anxiety support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold doesn't establish that graviola works for any condition. The data shows insufficient reliable evidence for HPV infection, headache, insect repellency, and male infertility.

If you're considering graviola for one of these uses, talk with your doctor about what the science actually supports and what other options exist.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular graviola use comes with real cautions. The most common side effects are stomach pain (epigastrium pain) and nausea — some people reported these after taking graviola leaf extract daily.

More serious but rare side effects include movement disorders and nerve damage (myeloneuropathy) that resemble Parkinson disease symptoms. One large study even found that even small amounts of graviola fruit or tea were linked to worsened movement and thinking problems in people who already had Parkinson disease.

During pregnancy, there isn't enough safety data, so the evidence advises against it. While breastfeeding, no reliable safety information exists either, so it's best avoided.

Because human safety data are limited overall, caution is warranted with long-term use.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures, graviola may lower its blood levels and weaken its effect — check with your doctor or pharmacist before combining them. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Graviola hasn't been proven effective for the conditions it's marketed for, and it carries real safety concerns — especially the rare risk of nerve damage and movement problems with regular use. If you take carbamazepine or have Parkinson disease, this product isn't a fit.

Before starting graviola, talk with your doctor or pharmacist about whether the potential risks make sense for you and whether safer alternatives exist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Graviola 650 mg, straight from the product label.

Brand Herbal Secrets
Barcode (UPC) 810180021609
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 282830
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Graviola 650 mg by Herbal Secrets, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
120
UPC/BARCODE
810180021609
IngredientAmount% DV
Graviola650 mg--

Other ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Graviola (also known as soursop), is a fruit native to Cuba, Central America, and the northern part of South America. Graviola is rich in vitamin B1, vitamin B2, and vitamin C. B vitamins may help to reduce stress and anxiety, supporting heart and brain functions. Vitamin C may help to neutralize free radicals and strengthen your immune system. In addition, Graviola may help to detoxify the body, promoting relaxation and positive mood for overall health and well-being.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults take two (2) capsules daily or as directed by a health care professional.

Precautions

Caution: Not intended for use by pregnant or nursing women. If you are taking any medication(s), planning any medical procedure or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Visit us online @ amazingnutrition.com

Formulation

100% natural

Nutrient-dense Supports immune function Promotes relaxation & positive mood Supports healthy heart & brain functions

Contains no: artificial preservatives, flavors or sweeteners, sugar, milk, soy, wheat, yeast, fish or sodium.

Seals/Symbols

Made in the USA

GMP Good manufacturing practice Quality product

FDA Statement of Identity

Natural Dietary Supplement

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Graviola 650 mg by Herbal Secrets label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Graviola 650 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Graviola 650 mg by Herbal Secrets

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Graviola

Interacts with
1 drug
650 mg per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola monograph & interactions

Other (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Graviola 650 mg by Herbal Secrets Drug Interactions

Want to check YOUR meds against Graviola 650 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola 1

Individual Drug Interactions

The ingredients in Graviola 650 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Graviola 650 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola

Each ingredient & the kinds of drugs it affects

For each ingredient in Graviola 650 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Graviola 650 mg, from the product label.

Herbal Secrets

See all Herbal Secrets products
Name
Herbal Secrets
Street Address
629 Grove Street
City
Jersey City
State
NJ
ZipCode
07310
Web Address
amazingnutrition.com
Pharmacist Counseling Corner

Graviola 650 mg by Herbal Secrets: Common Questions

Does Graviola 650 mg by Herbal Secrets interact with any medications?
Yes. Based on its ingredients, Graviola 650 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Graviola 650 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is graviola?
Graviola is an extract from a tropical fruit used in herbal medicine. It's been studied for several potential uses, though the evidence isn't strong enough yet to confirm it works for any of them.
Can I take this while pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so the evidence advises against it, and while breastfeeding, no reliable safety information exists either — so it's best avoided. Talk with your doctor or pharmacist for personalized advice.
What side effects should I watch for?
The most common are stomach pain and nausea. Rare but serious side effects include movement disorders and nerve damage that can look like Parkinson disease. This risk is higher with regular, long-term use.
Does graviola work for HPV, headaches, or insect repellent?
We don't have reliable evidence that it works for any of these. The data shows insufficient evidence to rate it for HPV, headache, insect repellency, or male infertility.
Are there any fillers or other junk in this capsule?
The capsule contains gelatin and a few standard binders and flow agents — gelatin, microcrystalline cellulose, magnesium stearate, and silicon dioxide. These are typical inactive ingredients that hold the capsule together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Graviola 650 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Graviola 650 mg label
Go deeper

The Full Monographs Behind Graviola 650 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Graviola 650 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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