Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Hormonal Balance Ingredients & Drug Interactions

by femMED

Hormonal Balance label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hormonal Balance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Hormonal Balance is a dietary supplement by femMED with 6 active ingredients. Its ingredients are commonly taken for liver health and protection, hepatitis, cirrhosis.Based on those ingredients, 1,125 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Milk Thistle, Powder, Scullcap herb powder, Saw Palmetto, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hormonal Balance by femMED

Ask about any prescription or over-the-counter medication and we check it for interactions with Hormonal Balance by femMED — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hormonal Balance by femMED

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

femMED Hormonal Balance is a capsule containing six ingredients. Five are herbal powders: milk thistle (supports liver function), red raspberry leaf extract (traditionally used for women's health), saw palmetto (historically used for urinary symptoms), wild yam powder (contains compounds similar to hormones), and skullcap herb powder (traditionally calming).

One ingredient, chaste tree, we cannot verify further. The capsule also contains inactive ingredients—cellulose, microcrystalline cellulose, magnesium stearate, and water—that serve as fillers and binders.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: relieve PMS and peri-menopausal symptoms.
  • We looked for evidence on: Premenstrual syndrome (PMS), Premenstrual dysphoric disorder (PMDD), Menopausal symptoms, Postmenopausal conditions, Dysmenorrhea, Menorrhagia — and 4 related terms.
  • The closest evidence on file: Wild Yam is rated "Possibly Ineffective" for Menopausal symptoms (Natural Medicines).
  • Also on file: Milk Thistle is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms.
  • Also on file: Red Raspberry is rated "Insufficient Reliable Evidence To Rate" for Dysmenorrhea, Menorrhagia.

The evidence for most ingredients in this product is limited. Milk thistle is rated possibly effective for type 2 diabetes; the other conditions it's studied for (liver disease, hay fever, acne, gambling disorder, mushroom poisoning) lack sufficient reliable evidence to rate.

Red raspberry leaf, wild yam, saw palmetto, and skullcap all show insufficient reliable evidence for the conditions they're traditionally used for—meaning we don't yet have solid proof they work for hormonal balance, menopausal symptoms, prostate issues, or stress. We hold no effectiveness data for chaste tree.

The evidence, ingredient by ingredient Milk Thistle Red Raspberry Saw Palmetto Wild Yam Skullcap

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Milk thistle, red raspberry leaf, and saw palmetto are generally well tolerated, though side effects like mild digestive upset (bloating, diarrhea, nausea) and headache can occur—though often no more frequently than placebo. Rare allergic reactions, including anaphylaxis, have been reported with milk thistle and wild yam.

Skullcap at higher doses may cause sedation and cognitive impairment. The product should be avoided in pregnancy: milk thistle and skullcap lack safety data, wild yam and saw palmetto are rated unsafe, and red raspberry leaf's safety in pregnancy is not well established.

During breastfeeding, milk thistle and skullcap safety is unknown, saw palmetto and wild yam are unsafe, and red raspberry leaf safety is not confirmed—talk with your pharmacist or doctor before using this product if you're pregnant or nursing.

Side effects, ingredient by ingredient Milk Thistle Red Raspberry Saw Palmetto Wild Yam Skullcap

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Milk Thistle, Red Raspberry, Wild Yam, Saw Palmetto, Skullcap.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,126 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking femMED Hormonal Balance, check whether you use blood thinners or antiplatelet drugs (warfarin, aspirin, etc.)—saw palmetto and red raspberry leaf may increase bleeding risk. Also double-check if you take antidiabetes medications, hormonal contraceptives or estrogen therapy, hepatitis C drugs (ledipasvir, sofosbuvir), morphine, sedatives or other CNS depressants, or drugs that depend on the CYP2B6 enzyme or glucuronidation for clearance.

Run your exact medication list through the tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines five herbal ingredients with limited evidence and multiple medication interactions. If you take blood thinners, diabetes drugs, hormonal contraceptives, estrogen therapy, or central nervous system depressants, you need to check your specific medications before starting.

Pregnant or breastfeeding? Skip this product and talk with your pharmacist.

If you're considering it for general wellness, chat with us first about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hormonal Balance, straight from the product label.

Brand femMED
Barcode (UPC) 629204000014
Net contents 120 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 323190
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Women (not pregnant or lactating), Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hormonal Balance by femMED, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
629204000014
IngredientAmount% DV
Milk Thistle, Powder50 mg--
Red Raspberry Leaf Extract50 mg--
Saw Palmetto, Powder200 mg--
Wild Yam powder50 mg--
Scullcap herb powder50 mg--
Chaste Tree, Powder100 mg--

Other ingredients: Cellulose, Water, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

This product does not contain dairy, egg, gluten, GMO, yeast, soy, wheat, colours, flavours, sweeteners, preservatives or chemical additives.

This product is vegetarian and not tested on animals.

Made in Canada

Helps to relieve PMS and peri-menopausal symptoms Hormonal balance is specially formulated to stabilize menstrual cycle irregularities and relieve the symptoms of PMS and perimenopause(including bloating, cramping, and mood swings).

Please allow 4 weeks of consecutive use for optimal results.

General Statements

Phone 905-813-7444 Fax 905-286-1444

NPN 80027750

Brand IP Statement(s)

femMed is a registered trademark of / femMed Canada, Inc.

Suggested/Recommended/Usage/Directions

Suggested Usage: Adults - take 2 capsules twice daily on an empty stomach or as directed by your health care practitioner.

Precautions

Caution: Do not take this product if you are pregnant, breastfeeding or have a sensitivity/allergy to Milk Thistle. Consult a health care practitioner prior to use if you have a pre-existing medical condition, are taking prescription medications, or hormone-containing medications such as progesterone, oral contraceptives or hormone replacement therapy.

Caution: Do not take this product if you are pregnant, breastfeeding or have a sensitivity/allergy to Milk Thistle.

Consult a health care practitioner if symptoms persist or worse. Some people may experience drowsiness; use discretion with alcohol and sedatives.

Do not use this product if the safety seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hormonal Balance by femMED label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hormonal Balance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hormonal Balance by femMED

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Milk Thistle, Powder

Interacts with
954 drugs
50 mg per serving

Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called silymarin....

Milk Thistle, Powder monograph & interactions

Red Raspberry Leaf Extract

Interacts with
135 drugs
50 mg per serving

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific eviden...

Red Raspberry Leaf Extract monograph & interactions

Saw Palmetto, Powder

Interacts with
174 drugs
200 mg per serving

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto, Powder monograph & interactions

Wild Yam powder

Interacts with
41 drugs
50 mg per serving

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for t...

Wild Yam powder monograph & interactions

Scullcap herb powder

Interacts with
248 drugs
50 mg per serving

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally cons...

Scullcap herb powder monograph & interactions

Chaste Tree, Powder

100 mg per serving Form: Vitex agnus-castus, Powder, Vitex agnus-castus, Powder

Other (inactive) ingredients: Cellulose, Water, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Hormonal Balance by femMED Drug Interactions

Want to check YOUR meds against Hormonal Balance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,125Drugs
577 Moderate 548 Minor

Ingredients driving the most interactions

Milk Thistle, Powder 954
Scullcap herb powder 248
Saw Palmetto, Powder 174
Red Raspberry Leaf Extract 135
Wild Yam powder 41

Individual Drug Interactions

The ingredients in Hormonal Balance interact with 1,125 drugs. Click any drug to see the details.

5 of the 6 ingredients in Hormonal Balance interact with drugs. Each result below shows which ingredient is responsible. Milk Thistle, Powder Scullcap herb powder Saw Palmetto, Powder Red Raspberry Leaf Extract Wild Yam powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Hormonal Balance with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Milk Thistle, Powder17 drug types · 954 drugs

Antidiabetes Drugs

Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.
Clinical research shows that milk thistle extract, alone or along with tree turmeric extract, can lower blood glucose levels and glycated hemoglobin (HbA1c) in patients with type 2 diabetes, including those already taking antidiabetes drugs. Additionally, animal research shows that milk thistle extract increases the metformin maximum plasma concentration and area under the curve and decreases the renal clearance of metformin, due to inhibition of the multi-drug and toxin extrusion protein 1 (MATE1) renal tubular transport protein.

Likelihood Possible Evidence B
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, milk thistle might inhibit CYP2B6.
An in vitro study shows that silybin, a constituent of milk thistle, binds to and noncompetitively inhibits CYP2B6. Additionally, silybin might downregulate the expression of CYP2B6 by decreasing mRNA and protein levels.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, milk thistle might affect the clearance of drugs that undergo glucuronidation.
Laboratory research shows that milk thistle constituents inhibit uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation. Theoretically, this could decrease the clearance and increase levels of glucuronidated drugs. Other laboratory research suggests that a milk thistle extract of silymarin might inhibit beta-glucuronidase, although the significance of this effect is unclear.

Likelihood Possible Evidence D
Ledipasvir

Theoretically, milk thistle might increase the levels and clinical effects of ledipasvir.
Animal research in rats shows that milk thistle increases the area under the curve (AUC) for ledipasvir and slows its elimination.

Likelihood Possible Evidence D
Morphine

Theoretically, concomitant use of milk thistle with morphine might affect serum levels of morphine and either increase or decrease its effects.
Animal research shows that milk thistle reduces serum levels of morphine by up to 66%. In contrast, laboratory research shows that milk thistle constituents inhibit uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation. Theoretically, this could decrease the clearance and increase morphine levels. The effect of taking milk thistle on morphine metabolism in humans is not known.

Likelihood Possible Evidence D
Raloxifene (Evista)

Theoretically, milk thistle might decrease the clearance and increase levels of raloxifene.
Laboratory research suggests that the milk thistle constituents silibinin and silymarin inhibit the glucuronidation of raloxifene in the intestines.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Milk thistle might decrease the clearance of sirolimus.
Pharmacokinetic research shows that a milk thistle extract of silymarin decreases the apparent clearance of sirolimus in hepatically impaired renal transplant patients. It is unclear if this interaction occurs in patients without hepatic impairment.

Likelihood Possible Evidence B
Sofosbuvir (Solvaldi)

Theoretically, milk thistle might decrease the levels and clinical effects of sofosbuvir.
Animal research in rats shows that milk thistle reduces the metabolism of sofosbuvir, as well as the hepatic uptake of its active metabolite.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the milk thistle constituent silibinin might increase tamoxifen levels and interfere with its conversion to an active metabolite.
Animal research suggests that the milk thistle constituent silibinin might increase plasma levels of tamoxifen and alter its conversion to an active metabolite. The mechanism appears to involve inhibition of pre-systemic metabolism of tamoxifen by cytochrome P450 (CYP) 2C9 and CYP3A4, and inhibition of P-glycoprotein-mediated efflux of tamoxifen into the intestine for excretion. Whether this interaction occurs in humans is not known.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, milk thistle might increase the effects of warfarin.
In one case report, a man stabilized on warfarin experienced an increase in INR from 2.64 to 4.12 after taking a combination product containing milk thistle 200 mg daily, as well as dandelion, wild yam, niacinamide, and vitamin B12. Levels returned to normal after stopping the supplement. Although a direct correlation between milk thistle and the change in INR cannot be confirmed, some in vitro research suggests that milk thistle might inhibit cytochrome P450 2C9 (CYP2C9), an enzyme involved in the metabolism of various drugs, including warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

It is unclear if milk thistle inhibits CYP2C9; research is conflicting.
In vitro research suggests that milk thistle might inhibit CYP2C9. Additionally, 3 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are CYP2C9 substrates, including imatinib and capecitabine. However, contradictory clinical research shows that milk thistle extract does not inhibit CYP2C9 or significantly affect levels of the CYP2C9 substrate tolbutamide. Differences in results could be due to differences in dosages or formulations utilized.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

It is unclear if milk thistle inhibits CYP3A4; research is conflicting.
While laboratory research shows conflicting results, pharmacokinetic research shows that taking milk thistle extract 420-1350 mg daily does not significantly affect the metabolism of the CYP3A4 substrates irinotecan, midazolam, or indinavir. However, 8 case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are CYP3A4 substrates, including gefitinib, sorafenib, doxorubicin, and vincristine.

Likelihood Unlikely Evidence D
Estrogens

Theoretically, milk thistle might interfere with estrogen therapy through competition for estrogen receptors.
Animal research suggests that a milk thistle extract of silymarin binds to estrogen receptor beta.

Likelihood Possible Evidence D
Hmg-Coa Reductase Inhibitors ("Statins")

Theoretically, milk thistle might interfere with statin therapy by decreasing the activity of organic anion transporting polypeptide 1B1 (OATB1B1) and inhibiting breast cancer resistance protein (BCRP).
Preliminary evidence suggests that a milk thistle extract of silymarin can decrease the activity of the OATP1B1, which transports HMG-CoA reductase inhibitors into the liver to their site of action, and animal research shows this increases the maximum plasma concentration of pitavastatin and pravastatin. The silibinin component also inhibits BCRP, which transports statins from the liver into the bile for excretion. However, in a preliminary study in healthy males, silymarin 140 mg three times daily had no effect on the pharmacokinetics of a single 10 mg dose of rosuvastatin.

Likelihood Unlikely Evidence D
Indinavir (Crixivan)

Theoretically, milk thistle may induce cytochrome P450 3A4 (CYP3A4) enzymes and increase the metabolism of indinavir; however, results are conflicting.
One pharmacokinetic study shows that taking milk thistle (Standardized Milk Thistle, General Nutrition Corp.) 175 mg three times daily in combination with multiple doses of indinavir 800 mg every 8 hours decreases the mean trough levels of indinavir by 25%. However, results from the same pharmacokinetic study show that milk thistle does not affect the overall exposure to indinavir. Furthermore, two other pharmacokinetic studies show that taking specific milk thistle extract (Legalon, Rottapharm Madaus; Thisilyn, Nature's Way) 160-450 mg every 8 hours in combination with multiple doses of indinavir 800 mg every 8 hours does not reduce levels of indinavir.

Likelihood Unlikely Evidence B
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Milk thistle may inhibit one form of OATP, OATP-B1, which could reduce the bioavailability and clinical effects of OATP-B1 substrates.
In vitro research shows that milk thistle inhibits OATP-B1. Two case reports from the World Health Organization (WHO) adverse drug reaction database describe increased toxicity in patients taking milk thistle and cancer medications that are OATP substrates, including sorafenib and methotrexate. OATPs are expressed in the small intestine and liver and are responsible for the uptake of drugs and other compounds into the body. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, milk thistle might increase the absorption of P-glycoprotein substrates. However, this effect does not seem to be clinically significant.
In vitro research shows that milk thistle can inhibit P-glycoprotein activity and 1 case report from the World Health Organization (WHO) adverse drug reaction database describes increased abdominal pain in a patient taking milk thistle and the cancer medication vincristine, a P-glycoprotein substrate, though this patient was also taking methotrexate. However, a small pharmacokinetic study in healthy volunteers shows that taking milk thistle (Enzymatic Therapy Inc.) 900 mg, standardized to 80% silymarin, in 3 divided doses daily for 14 days does not affect absorption of digoxin, a P-glycoprotein substrate.

Likelihood Unlikely Evidence B
Milk Thistle, Powder full monograph & interactions

Scullcap herb powder1 drug type · 248 drugs

Cns Depressants

Theoretically, skullcap can have additive effects when used with other CNS depressants.
Animal and clinical research suggests that skullcap can cause sedation and cognitive impairment.

Likelihood Possible Evidence D
Scullcap herb powder full monograph & interactions

Saw Palmetto, Powder3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto, Powder full monograph & interactions

Red Raspberry Leaf Extract2 drug types · 135 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking red raspberry leaf with anticoagulant/antiplatelet drugs might increase the risk of bleeding.
In vitro research suggests that red raspberry leaf extract has antiplatelet activity and enhances the in vitro effects of the antiplatelet medication cangrelor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Insulin

Red raspberry leaf might reduce glucose levels in patients being treated with insulin.
In one case report, a 38-year-old patient with gestational diabetes, whose blood glucose was being controlled with medical nutrition therapy and insulin, developed hypoglycemia after consuming two servings of raspberry leaf tea daily for 3 days beginning at 32 weeks' gestation. The patient required an insulin dose reduction. The hypoglycemia was considered to be probably related to use of red raspberry leaf tea.

Likelihood Possible Evidence D
Red Raspberry Leaf Extract full monograph & interactions

Wild Yam powder1 drug type · 41 drugs

Estrogens

Theoretically, wild yam might increase or decrease the effects of estrogen.
Wild yam root shows estrogenic and anti-estrogenic effects in vitro. Theoretically, wild yam might interfere with hormone therapy.

Likelihood Possible Evidence D
Wild Yam powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hormonal Balance, from the product label.

femMED

See all femMED products
Name
femMed Cananda, Inc.
Street Address
2850 Argentia Road, Unit #4
City
Mississauga
State
Ontario
ZipCode
L5N 8G4
Phone Number
1-866-799-8035
Web Address
femmed.ca
Pharmacist Counseling Corner

Hormonal Balance by femMED: Common Questions

Does Hormonal Balance by femMED interact with any medications?
Yes. Based on its ingredients, Hormonal Balance has a known interaction with 1,125 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hormonal Balance contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or trying to conceive?
No. Milk thistle, wild yam, saw palmetto, and skullcap lack sufficient safety data or are rated unsafe during pregnancy. Red raspberry leaf's safety in pregnancy is not well established. Talk with your pharmacist or doctor before using this product if you're pregnant, planning pregnancy, or breastfeeding.
What are the most common side effects?
Mild digestive upset—nausea, bloating, diarrhea—is the most common. Headache, dizziness, and mild stomach pain have also been reported. These usually don't happen more often than with placebo, and most people tolerate the ingredients well.
Is milk thistle really in here, and does it work?
Yes, it's the first ingredient. Milk thistle is possibly effective for type 2 diabetes; for the other conditions it's used for (liver disease, hay fever, acne), the evidence isn't solid enough to say it works.
Will this interfere with my birth control?
Saw palmetto in this product may reduce the effectiveness of hormonal contraceptives. If you rely on birth control, talk with your pharmacist or doctor before taking this supplement.
Can I take this with my blood thinner?
Probably not safely. Milk thistle may increase warfarin's effects, and both saw palmetto and red raspberry leaf may increase bleeding risk. Check your specific medications with the tool on this page and ask us before starting.
Does skullcap make you drowsy?
At typical doses, a single 100 mg dose doesn't seem to cause drowsiness. But higher doses (200 mg or more) can cause sedation and impair thinking. If you take sedatives or other downers, skullcap can add to that effect.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hormonal Balance label
Go deeper

The Full Monographs Behind Hormonal Balance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Milk Thistle

Interacts with 954 drugs

Milk thistle is a popular herbal supplement most often used for liver health, and its main active component is a group of compounds called silymarin. While it is generally well tolerated, th...

Read the full Milk Thistle monograph → Herb & supplement monograph

Red Raspberry

Interacts with 135 drugs

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is gene...

Read the full Red Raspberry monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Wild Yam

Interacts with 41 drugs

Wild yam is a root traditionally used for menopausal symptoms, cramps, and as a so-called 'natural' hormone supplement, but solid human evidence for these uses is lacking. Despite popular cl...

Read the full Wild Yam monograph → Herb & supplement monograph

Skullcap

Interacts with 248 drugs

American skullcap is an herb traditionally used to calm anxiety and promote relaxation, but solid human evidence is very limited. It is generally considered relatively safe for short-term us...

Read the full Skullcap monograph →
Sources

Sources & How We Checked

Hormonal Balance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Milk Thistle 69 references
  1. Ferenci P, Dragosics B, Dittrich H, et al. Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver. J Hepatol 1989;9:105-13. PubMed
  2. Anon. Milk thistle: Effects on liver disease and cirrhosis and clinical adverse effects. Summary, Evidence Report/Technology Assessment: Number 21, September 2000. Agency for Healthcare Research and Quality, Rockville, MD. Available at: http://www.ahrq.g
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Red Raspberry 8 references
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Saw Palmetto 22 references
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Wild Yam 7 references
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Skullcap 3 references
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  2. Awad, R., Arnason, J. T., Trudeau, V., Bergeron, C., Budzinski, J. W., Foster, B. C., and Merali, Z. Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Phytomedicine. 2003;10(8):6 PubMed
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