Interactions on record — worth a quick check against your medications. Based on 1 of 5 ingredients. Check your meds →
Dietary supplement

Immune-Biotic Orange Ingredients & Drug Interactions

by Natrol

Immune-Biotic Orange label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Immune-Biotic Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Immune-Biotic Orange is a dietary supplement by Natrol with 5 active ingredients. Its ingredients are commonly taken for digestive health and bloating, diarrhea support, immune support.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DE111 (Bacillus subtillis). Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Immune-Biotic Orange by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Immune-Biotic Orange by Natrol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Immune-Biotic Orange by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “PreforPro” is listed as a grouped ingredient — the label gives one combined amount (15 mg) without saying how much of each component you get.

This product contains 5 active ingredients: DE111 (Bacillus subtilis), a live probiotic strain; PreforPro, a prebiotic blend; and three bacteriophage strains (LH01 Myoviridae, LL5 Siphoviridae, T4D Myoviridae, and LL12 Myoviridae) — viruses that target specific bacteria in the gut. The inactive ingredients are xylitol, sorbitol, tapioca dextrin, natural flavoring, malic acid, and citric acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: immune and digestive health support.
  • We looked for evidence on: Diarrhea, Flatulence, Dyspepsia, Irritable bowel syndrome (IBS), Constipation, Antibiotic-associated diarrhea — and 3 related terms.
  • The strongest evidence on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bacillus Subtilis is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Dyspepsia, Flatulence, and more.

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea — loose stools that can happen when antibiotics wipe out your normal gut bacteria. For other uses listed — athletic performance, cirrhosis, constipation, eczema, and diabetes — the evidence we have is insufficient to know whether it works.

The effectiveness data for the other active ingredients (PreforPro and the bacteriophage strains) isn't established in our records.

The evidence, ingredient by ingredient Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DE111 (Bacillus subtilis) is generally well tolerated in healthy adults, but quality and safety can vary between products and strains. Safety data is limited overall, so you should check with your doctor before use.

In clinical trials, a small number of reports noted headache and, rarely, diarrhea. Very rarely, consuming Bacillus subtilis var. natto (a fermented soybean preparation) has been linked to serious bloodstream or brain infections, mainly in people with weakened immune systems or multiple health conditions; the risk appears tied to specific circumstances and vulnerable populations.

We hold no safety data on file for the pregnancy and lactation status of this ingredient, so talk with your doctor or pharmacist if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check with your doctor or pharmacist if you take any antibiotic drugs — the live organisms could lose effectiveness if dosed at the same time. We couldn't confirm interaction data for three of the bacteriophage strains in the formula, so having a conversation with your pharmacist about your full medication list is important.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with antibiotic-associated diarrhea, but timing it right with antibiotics matters because the antibiotics can kill the live organisms. If you're on any antibiotics or have a weakened immune system, run this by your doctor or pharmacist first.

Otherwise, it's generally well tolerated — just know that safety data is still limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Immune-Biotic Orange, straight from the product label.

Brand Natrol
Net contents 30 Packet(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 274818
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Immune-Biotic Orange by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Packet(s)
Maximum serving Sizes:
1 Packet(s)
Servings per container
30
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
DE111 (Bacillus subtillis)0 NP--
PreforPro15 mg--
LH01 Myoviridae0 NP--
LL5 Siphoviridae0 NP--
T4D Myoviridae0 NP--
LL12 Myoviridae0 NP--

Other ingredients: Xylitol, Sorbitol, Tapioca Dextrin, Natural flavoring, Malic Acid, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

New! Immune support never tasted so good

Formulation

Natrol Immune-Biotic is a convenient and delicious new way to support your immune and digestive health.

Non-GMO Gluten free No artificial flavors or sweeteners

Vegetarian

Immune health Supports the body's natural immunity

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, synthetic dyes or flavors.

Natrol Immune-Biotic is a convenient new way to support your immune system and digestive health at home or on-the-go.

Suggested/Recommended/Usage/Directions

Pour the contents of quick dissolve packet directly on your tongue and enjoy.

No water needed

Directions: Dissolve one packet directly on the tongue once daily. No water needed.

Formula

1 Billion CFU

Orange with other natural flavors

The great-tasting orange flavored quick dissolve packets contain a combination of prebiotics and probiotics with clinically supported Bacillus subtilis DE111.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Precautions

Keep out of reach of children.

Warning: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, are pregnant or lactating.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

PreforPro and dE111 are registered trademarks of Deerland Probiotics & Enzymes, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Immune-Biotic Orange by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Immune-Biotic Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Immune-Biotic Orange by Natrol

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Packet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

DE111 (Bacillus subtillis)

Interacts with
182 drugs
0 NP per serving

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and diges...

DE111 (Bacillus subtillis) monograph & interactions

PreforPro

15 mg per serving
  • › LH01 Myoviridae
  • › LL5 Siphoviridae
  • › T4D Myoviridae
  • › LL12 Myoviridae

Other (inactive) ingredients: Xylitol, Sorbitol, Tapioca Dextrin, Natural flavoring, Malic Acid, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Immune-Biotic Orange by Natrol Drug Interactions

Want to check YOUR meds against Immune-Biotic Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

DE111 (Bacillus subtillis) 182

Individual Drug Interactions

The ingredients in Immune-Biotic Orange interact with 182 drugs. Click any drug to see the details.

1 of the 5 ingredients in Immune-Biotic Orange interact with drugs. Each result below shows which ingredient is responsible. DE111 (Bacillus subtillis)

Each ingredient & the kinds of drugs it affects

For each ingredient in Immune-Biotic Orange with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

DE111 (Bacillus subtillis)1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
DE111 (Bacillus subtillis) full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Immune-Biotic Orange, from the product label.

Natrol

See all Natrol products
Name
Natrol LLC
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
1-800-262-8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Immune-Biotic Orange by Natrol: Common Questions

Does Immune-Biotic Orange by Natrol interact with any medications?
Yes. Based on its ingredients, Immune-Biotic Orange has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Immune-Biotic Orange contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm taking antibiotics for an infection?
DE111 is possibly effective for antibiotic-associated diarrhea — the loose stools some people get when antibiotics kill off their good gut bacteria. But here's the catch: if you take the antibiotic and this probiotic at the same time, the antibiotic can kill the live organisms in the product. Your doctor or pharmacist can tell you how to space the doses so the probiotic can work.
Are there any side effects I should know about?
Most people tolerate it well. In clinical trials, a small number reported headache, and very rarely, diarrhea. There have been rare reports of serious bloodstream or brain infections with Bacillus subtilis var. natto, but those were mainly in people with weakened immune systems or multiple chronic conditions — still worth knowing if that applies to you.
Can I take this if I'm pregnant or breastfeeding?
We don't have safety data on file for pregnancy and lactation with this ingredient. Talk with your doctor or pharmacist about whether it's right for you in those circumstances — they can give you personalized advice based on your health.
What is DE111, and why is it in here?
DE111 is Bacillus subtilis, a live probiotic — a beneficial bacterium that supports your gut health. It's possibly effective for diarrhea caused by antibiotics, and research suggests it may help in other areas, though we don't have reliable evidence for those uses yet.
What are the bacteriophages (LH01, LL5, T4D, LL12) in this formula?
They're viruses that target specific bacteria in your gut. The idea is they work alongside the probiotic to help rebalance your bacterial community. We don't have safety or effectiveness data on file for these strains individually, so your pharmacist is a good resource if you have detailed questions.
Will this work for constipation or diabetes?
Bacillus subtilis shows insufficient reliable evidence for both of those uses in our data. That doesn't mean it won't help you, just that we don't have enough solid research backing it for those specific conditions yet — something to discuss with your doctor if you're considering it for either.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Immune-Biotic Orange is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Immune-Biotic Orange label
Go deeper

The Full Monographs Behind Immune-Biotic Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Immune-Biotic Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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