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Dietary supplement

Ionic Manganese 10,000 PPM Ingredients & Drug Interactions

by Good State

Ionic Manganese 10,000 PPM label
See full label image
Liquid Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ionic Manganese 10,000 PPM against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ionic Manganese 10,000 PPM is a dietary supplement by Good State with 1 active ingredient. Its ingredients are commonly taken for bone health support, antioxidant and enzyme support, filling dietary gaps.Based on those ingredients, 83 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ionic Manganese 10,000 PPM by Good State

Ask about any prescription or over-the-counter medication and we check it for interactions with Ionic Manganese 10,000 PPM by Good State — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Ionic Manganese 10,000 PPM by Good State

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Good State's Ionic Manganese 10,000 PPM contains one active ingredient: manganese in ionic form, which means it's dissolved as individual charged particles ready for absorption. This is a liquid supplement, and the only other listed ingredient is reverse osmosis water.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Manganese's overall clinical evidence instead.

Strong

Strong clinical evidence supports Manganese for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Manganese deficiency — rated "Effective" (Natural Medicines).

Manganese is proven effective for manganese deficiency — a genuine but rare nutritional gap. For hay fever, osteoporosis, COPD, obesity, and osteoarthritis, the evidence is not established in the data we hold.

Before taking a high-dose manganese supplement for any reason beyond proven deficiency, talk with your doctor or pharmacist about whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Manganese

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At normal dietary doses, manganese is generally well tolerated. However, high-dose supplements — like this one — carry real risks.

The safety notes flag that these amounts are inappropriate unless a clinician advises otherwise. Serious but rare side effects include neurotoxicity and Parkinson-like symptoms with prolonged high-dose use.

One documented case involved irreversible Parkinson disease after taking 100 mg daily for 2–4 years. Manganese can also accumulate in the liver and cause cirrhosis and fatty liver disease, especially if your liver function is impaired.

For lactation, the data is conflicting — it's listed as both likely safe and possibly unsafe, as well as likely unsafe. Talk with your doctor or pharmacist about whether it's appropriate for you if you're nursing.

Side effects, ingredient by ingredient Manganese

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Manganese.
  • The most serious interaction on file is rated Moderate.
  • For scale: 83 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antipsychotic drugs (like haloperidol), quinolone antibiotics (like ciprofloxacin), or tetracycline antibiotics (like doxycycline), check your specific medications with the tool on this page before starting this product. Antipsychotics pose the most serious documented concern, followed by both antibiotic classes, which may be less effective when combined with manganese.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This high-dose manganese supplement is appropriate only if you've been diagnosed with manganese deficiency by a healthcare provider. If you take antipsychotics or antibiotics, you'll need to check this product against your exact medications before starting.

The high concentration carries risks of neurotoxicity and liver damage if used long-term, especially in people with existing liver problems. Discuss this supplement with your own doctor or pharmacist before adding it to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ionic Manganese 10,000 PPM, straight from the product label.

Brand Good State
Barcode (UPC) 857515003664
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 310832
Product type Mineral
Supplement form Liquid
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ionic Manganese 10,000 PPM by Good State, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL
Maximum serving Sizes:
0.5 mL
Servings per container
118
UPC/BARCODE
857515003664
IngredientAmount% DV
Manganese5 mg220%

Other ingredients: reverse osmosis Water, Ionic Manganese

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Made in USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Good State Health Solutions Give your body what it needs!

Formulation

Good State is proud to follow Good Manufacturing Practices (GMP) Ultra concentrate

Natural. Liquid.

Professional grade

100% satisfaction guaranteed

Formula

Nano-ionic minerals.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adults: take 10 drops daily with 6-8 oz of water or juice. Children: Take 3 drops daily with 4-8 oz of water or juice. Do not take on an empty stomach. Must be diluted. Do not take without water.

Shake well before using.

Precautions

Caution: Keep out of reach of children.

Always speak with your physician before using any dietary supplement. Do not use if tamper evident seal is broken or missing.

Storage

For freshness after opening, store in a cool, dark place.

General Statements

FBA USA X000H1X3FH

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ionic Manganese 10,000 PPM by Good State label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ionic Manganese 10,000 PPM label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ionic Manganese 10,000 PPM by Good State

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container118 Amounts shown are per serving.

Manganese

Interacts with
83 drugs
5 mg per serving Form: Manganese Chloride

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Other (inactive) ingredients: Reverse osmosis Water, Ionic Manganese. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ionic Manganese 10,000 PPM by Good State Drug Interactions

Want to check YOUR meds against Ionic Manganese 10,000 PPM?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
83Drugs
83 Moderate

Ingredients driving the most interactions

Manganese 83

Individual Drug Interactions

The ingredients in Ionic Manganese 10,000 PPM interact with 83 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ionic Manganese 10,000 PPM interact with drugs. Each result below shows which ingredient is responsible. Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Ionic Manganese 10,000 PPM with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ionic Manganese 10,000 PPM, from the product label.

Good State

Name
GoodState, Inc.
Street Address
575 Virginia Drive, Suite C
City
Fort Washington
State
PA
ZipCode
19034
Phone Number
1-866-227-6097
Web Address
www.GoodState.com
Pharmacist Counseling Corner

Ionic Manganese 10,000 PPM by Good State: Common Questions

Does Ionic Manganese 10,000 PPM by Good State interact with any medications?
Yes. Based on its ingredients, Ionic Manganese 10,000 PPM has a known interaction with 83 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ionic Manganese 10,000 PPM contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe if I have liver problems?
No — manganese can accumulate in your liver and cause serious damage, including cirrhosis and fatty liver disease. If you have any liver condition or concern, do not take this product without explicit approval from your doctor. One documented case required chelation therapy and plasma exchange to reverse severe manganese-related liver and neurological damage.
Can I take this while breastfeeding?
The safety data for lactation is conflicting, with ratings ranging from likely safe to possibly unsafe to likely unsafe. Because of this uncertainty and the high dose in this supplement, talk with your doctor or pharmacist before using it if you're nursing.
What is manganese supposed to do?
Manganese is proven to correct manganese deficiency, which is rare in healthy people eating normal food. For other conditions like hay fever, osteoporosis, and arthritis, the evidence isn't strong enough to rate. A normal diet provides the manganese your body needs.
What are the side effects at high doses?
At high doses — and this supplement qualifies as high-dose — manganese can cause neurotoxicity, including Parkinson-like symptoms. One severe case involved irreversible Parkinson disease after 2–4 years of taking 100 mg daily. Manganese also risks liver damage, fatty liver disease, and cirrhosis with long-term high-dose use.
Why is there ionic manganese listed twice in the ingredients?
One listing is the active ingredient (manganese itself), and the other is an inactive ingredient that helps keep the manganese in liquid form. You're getting one active ingredient that's been dissolved in water for absorption.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ionic Manganese 10,000 PPM is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ionic Manganese 10,000 PPM label
Go deeper

The Full Monographs Behind Ionic Manganese 10,000 PPM’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph →
Sources

Sources & How We Checked

Ionic Manganese 10,000 PPM's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
  2. Barrington WW, Angle CR, Willcockson NK, et al. Autonomic function in manganese alloy workers. Environ Res 1998;78:50-8. PubMed
  3. Hauser RA, Zesiewicz TA, Martinez C, et al. Blood manganese correlates with brain magnetic resonance imaging changes in patients with liver disease. Can J Neurol Sci 1996;23:95-8. PubMed
  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  5. Lee JW. Manganese intoxication. Arch Neurol 2000;57:597-9.. PubMed
  6. Powers KM, Smith-Weller T, Franklin GM, et al. Parkinson's disease risks associated with dietary iron, manganese, and other nutrient intakes. Neurology 2003;60:1761-6.. PubMed
  7. McMillan, D. E. A brief history of the neurobehavioral toxicity of manganese: some unanswered questions. Neurotoxicology 1999;20(2-3):499-507.
  8. Gerber, G. B., Leonard, A., and Hantson, P. Carcinogenicity, mutagenicity and teratogenicity of manganese compounds. Crit Rev Oncol Hematol. 2002;42(1):25-34. PubMed
  9. Jiang, Y. and Zheng, W. Cardiovascular toxicities upon manganese exposure. Cardiovasc.Toxicol 2005;5(4):345-354. PubMed
  10. Mehta, R. and Reilly, J. J. Manganese levels in a jaundiced long-term total parenteral nutrition patient: potentiation of haloperidol toxicity? Case report and literature review. JPEN J Parenter.Enteral Nutr 1990;14(4):428-430. PubMed
  11. Nemery, B. Metal toxicity and the respiratory tract. Eur Respir.J 1990;3(2):202-219. DOI
  12. Vanek VW, Borum P, Buchman A, et al. A.S.P.E.N. position paper: recommendations for changes in commercially available parenteral multivitamin and multi-trace element products. Nutr Clin Pract. 2012;27:440-491.doi: 10.1177/0884533612446706 PubMed
  13. Schuh MJ. Possible Parkinson's disease induced by chronic manganese supplement ingestion. Consult Pharm. 2016;31(12):698-703. doi: 10.4140/TCP.n.2016.698. PubMed
  14. Baker B, Ali A, Isenring L. Recommendations for manganese supplementation to adult patients receiving long-term home parenteral nutrition: an analysis of the supporting evidence. Nutr Clin Pract 2016;31(2):180-5. doi: 10.1177/0884533615591600. PubMed
  15. Ho CSH, Ho RCM, Quek AML. Chronic manganese toxicity associated with voltage-gated potassium channel complex antibodies in a relapsing neuropsychiatric disorder. Int J Environ Res Public Health 2018;15(4). pii: E783. doi: 10.3390/ijerph15040783. PubMed
  16. Yamamoto M, Sakurai K, Eguchi A, et al.; Japan Environment and Children's Study Group: Association between blood manganese level during pregnancy and birth size: the Japan environment and children's study (JECS). Environ Res 2019;172:117-26. PubMed
  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
  21. Uyar E, Gurkas E, Aksu AU, et al. Can therapeutic plasma exchange be life-saving in life-threatening manganese intoxication?. Transfus Apher Sci 2022;61(4):103417. PubMed

See these in context on the Manganese monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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