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Dietary supplement

L. Bulgaricus Ingredients & Drug Interactions

by Custom Probiotics

L. Bulgaricus label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L. Bulgaricus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L. Bulgaricus is a dietary supplement by Custom Probiotics with 1 active ingredient. Its ingredients are commonly taken for digestive health, lactose digestion support, diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L. bulgaricus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L. Bulgaricus by Custom Probiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with L. Bulgaricus by Custom Probiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of L. Bulgaricus by Custom Probiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This powder contains one active ingredient: Lactobacillus delbrueckii (often called L. bulgaricus), a live probiotic bacterium. There are no other active ingredients and no inactive fillers listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lactobacillus Delbrueckii's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Probiotic dairy-free powder for digestive health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Radiation-induced diarrhea — and 2 related terms.
  • The closest evidence on file: Lactobacillus Delbrueckii is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Delbrueckii is rated "Insufficient Reliable Evidence To Rate" for Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Clostridioides difficile infection, and more.

The evidence we hold doesn't establish that L. bulgaricus works for acne, hay fever, antibiotic-associated diarrhea, asthma, fatty liver disease, or the common cold. The rating across all of these is insufficient reliable evidence — which means the research either hasn't been done or isn't strong enough to make a claim.

If you're considering this product for one of those purposes, talk it over with your doctor to see whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Lactobacillus Delbrueckii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L. bulgaricus is generally well tolerated in healthy people. However, if you're very ill or have a weakened immune system, use it cautiously and under guidance from your healthcare provider.

Because this is a live microbial preparation, there's a theoretical risk of infection in some patients — though documented cases are rare and usually occur in people with serious underlying illness or those who've had bacterial translocation from other parts of the body. For pregnancy and breastfeeding, probiotics in food are thought to be fine, but supplement safety during pregnancy hasn't been well studied.

The data on breastfeeding is limited. Talk with your doctor before taking this product if you're pregnant or nursing, so you can make the decision that fits your individual situation.

Side effects, ingredient by ingredient Lactobacillus Delbrueckii

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take L. Bulgaricus, double-check with your pharmacist if you're on antibiotic drugs — these can reduce how well the probiotic survives and works.

If you take any antibiotics, your pharmacist can help you space out the timing so they don't interfere with each other.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

L. Bulgaricus is a single-strain live probiotic that's generally well tolerated in healthy people.

The main thing to watch is timing — if you're on antibiotics, you'll want to space them out from this supplement so the antibiotic doesn't kill off the live organisms. If you're very ill, immunocompromised, or pregnant or breastfeeding, check with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L. Bulgaricus, straight from the product label.

Brand Custom Probiotics
Net contents 0 Not Present
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 181322
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L. Bulgaricus by Custom Probiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.1 Gram(s)
Maximum serving Sizes:
1.6 Gram(s)
IngredientAmount% DV
L. bulgaricus0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions of use: Dissolve 1-2 scoops (enclosed) of the dairy-free probiotic powder in one glass of purified water and drink it. Do this first thing in the morning and/or at bedtime.

Please read enclosed dosage suggestion or visit www.customprobiotics.com

Storage

Bottles should be kept tightly closed and stored in the refrigerator to retain maximum potency.

Formulation

Does not contain: Artificial colors, flavors, preservatives, sugar, gluten, soy, wheat or FOS.

Dairy free probiotic powder

General Statements

Ultra potency

50 billion cfu's per gram

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L. Bulgaricus by Custom Probiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L. Bulgaricus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L. Bulgaricus by Custom Probiotics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.1 Gram(s) Dosage formPowder Amounts shown are per serving.

L. bulgaricus

Interacts with
182 drugs
0 NP per serving

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is g...

L. bulgaricus monograph & interactions
Interaction report

L. Bulgaricus by Custom Probiotics Drug Interactions

Want to check YOUR meds against L. Bulgaricus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

L. bulgaricus 182

Individual Drug Interactions

The ingredients in L. Bulgaricus interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in L. Bulgaricus interact with drugs. Each result below shows which ingredient is responsible. L. bulgaricus

Each ingredient & the kinds of drugs it affects

For each ingredient in L. Bulgaricus with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L. bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
L. bulgaricus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L. Bulgaricus, from the product label.

Custom Probiotics

See all Custom Probiotics products
Name
Custom Probiotics, Inc.
City
Glendale
State
California
ZipCode
91214
Phone Number
(800) 219-8405
Web Address
www.customprobiotics.com
Pharmacist Counseling Corner

L. Bulgaricus by Custom Probiotics: Common Questions

Does L. Bulgaricus by Custom Probiotics interact with any medications?
Yes. Based on its ingredients, L. Bulgaricus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L. Bulgaricus contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this probiotic while I'm on antibiotics?
Not at the same time. Antibiotics can kill the live organisms in this product, which would reduce how well it works. Talk to your pharmacist about spacing them out — usually taking them a few hours apart helps protect the probiotic.
Is L. bulgaricus safe if I have a weakened immune system?
You should be cautious. While serious infections from probiotics are rare, they can happen in people who are very ill or immunocompromised. Work with your healthcare provider to decide whether it's right for you.
Can I take this while pregnant?
There isn't enough data to know whether supplement probiotics are safe in pregnancy. Probiotics in food are thought to be fine, but we don't have solid information on supplements. Talk with your doctor before starting this product so you can make the choice that's best for you.
What is L. bulgaricus supposed to do?
We hold no evidence that this ingredient reliably works for acne, hay fever, antibiotic-associated diarrhea, asthma, fatty liver disease, or colds. If you're considering it for one of those reasons, ask your doctor whether the current evidence supports it.
Does this product contain any fillers or additives?
No — this is a single-ingredient powder with only L. delbrueckii and no inactive fillers listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L. Bulgaricus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L. Bulgaricus label
Go deeper

The Full Monographs Behind L. Bulgaricus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph →
Sources

Sources & How We Checked

L. Bulgaricus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Delbrueckii 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. Neonakis IK, Skamagkas I, Stafylaki D, Maraki S. Lactobacillus delbrueckii urinary tract infection in a male patient: a case report. Germs 2022;12(2):304-307. PubMed
  8. Maillet F, Passeron A, Podglajen I, Ranque B, Pouchot J. Lactobacillus delbrueckii urinary tract infection in a male patient. Med Mal Infect 2019;49(3):226-228. PubMed
  9. Darbro BW, Petroelje BK, Doern GV. Lactobacillus delbrueckii as the cause of urinary tract infection. J Clin Microbiol 2009;47(1):275-7.

See these in context on the Lactobacillus Delbrueckii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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