L-Citrulline 1000 mg Ingredients & Drug Interactions
by Nutricost
What is this page for?
First and foremost: checking L-Citrulline 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
L-Citrulline 1000 mg is a dietary supplement by Nutricost with 1 active ingredient. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against L-Citrulline 1000 mg by Nutricost
Ask about any prescription or over-the-counter medication and we check it for interactions with L-Citrulline 1000 mg by Nutricost — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of L-Citrulline 1000 mg by Nutricost
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Nutricost L-Citrulline 1000 mg is a single-ingredient supplement — each capsule delivers 1 gram of L-Citrulline, an amino acid your body converts to L-arginine. L-Arginine plays a role in blood vessel function and circulation.
The capsule itself contains gelatin, rice flour, magnesium stearate, and stearic acid as inactive ingredients (binders and fillers).
Does it work?
Moderate evidence
L-Citrulline is possibly effective for athletic performance — some evidence supports its use to help with endurance and exercise capacity. For muscle loss related to aging (sarcopenia), the evidence points toward it being possibly ineffective.
The data we hold is insufficient to rate its role in cardiovascular disease, heart failure, diabetes, or Reye syndrome.
How safe is it?
Well-documented data
L-Citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been thoroughly studied. The most common side effects are gastrointestinal — some people report stomach discomfort, heartburn, or general GI upset.
A small number of people taking it for lung-related conditions reported cough. There isn't enough safety data to recommend L-Citrulline during pregnancy or while breastfeeding.
Talk with your doctor or pharmacist about whether this product is appropriate for you if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Before you start, check whether you take any blood pressure medications (antihypertensives) or erectile dysfunction drugs (phosphodiesterase-5 inhibitors like sildenafil). Both carry a Moderate interaction risk with L-Citrulline.
Your doctor or pharmacist can review your exact medications and advise whether it's safe to combine them.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
L-Citrulline may be worth considering if you're looking to support athletic performance and you don't take blood pressure medications or ED drugs. If you do take either of those medication types, check with your doctor or pharmacist first — the interaction is real and could lower your blood pressure too much.
Long-term safety data is limited, so this isn't one to take indefinitely without a reason.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about L-Citrulline 1000 mg, straight from the product label.
| Brand | Nutricost |
|---|---|
| Barcode (UPC) | 857077008497 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 223380 |
| Product type | Amino Acid/protein |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for L-Citrulline 1000 mg by Nutricost, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Citrulline | 1000 mg | -- |
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended Use: As a dietary supplement, take 1-2 capsules 1-2 times daily, preferably between meals. As a preworkout amplfier, take 2-4 capsules 15-30 minutes before workout.
Precautions
Warning: This product is only intended to be consumed by healthy individuals 18 years of age or older.
Consult your physician prior to use if you are pregnant or nursing.
Do not exceed recommended use. Improper use will not improve results and is not advised.
Keep out of reach of children.
Do not use if safety seal is broken.
Storage
Store in a cool dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
L-Citrulline 1,000 mg per serving
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Nutricost Quality guaranteed Third party tested
Formulation
Non GMO Gluten free product
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
L-Citrulline 1000 mg by Nutricost label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in L-Citrulline 1000 mg by Nutricost
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
L-Citrulline
Interacts with178 drugs
L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...
L-Citrulline monograph & interactionsOther (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
L-Citrulline 1000 mg by Nutricost Drug Interactions
HelloPharmacist Interaction Report
Nutricost L-Citrulline 1000 mg interacts with two major medication categories: blood pressure drugs (antihypertensives) and erectile dysfunction medications (phosphodiesterase-5 inhibitors).
Both interactions are Moderate in severity. L-Citrulline is converted in your body to L-arginine, which widens your blood vessels.
When combined with blood pressure medications, this could add up and drop your blood pressure more than intended. Similarly, ED medications like sildenafil work the same way — widening vessels — so taking them together with L-Citrulline might cause extra-strong blood vessel relaxation and a sharper blood pressure dip.
Read the full breakdown — every affected drug type, severity by severity
Although research on this interaction is limited (a small number of clinical studies suggest the effect may be modest at typical doses), the theoretical risk is real enough to warrant caution. Altogether, these interactions span 178 individual medications.
If you take any blood pressure medication or ED medication, check your exact drugs with the search tool below before starting L-Citrulline. Your doctor or pharmacist can tell you whether this product is right for you and whether any dose adjustment is needed.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against L-Citrulline 1000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in L-Citrulline 1000 mg interact with 178 drugs. Click any drug to see the details.
1 of the 1 ingredient in L-Citrulline 1000 mg interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline
Hydrochlorothiazide, ReserpineHydropres, Serpasil-Esidrix, Serpasil-Esidrix #1, Serpasil-Esidrix #2
How Hydrochlorothiazide, Reserpine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Reserpine interactionHydrochlorothiazide, SpironolactoneAldactazide, Aldactide 25, Aldactide 50, Spirozine
How Hydrochlorothiazide, Spironolactone interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Spironolactone interactionHydrochlorothiazide, TimololTimolide
How Hydrochlorothiazide, Timolol interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Timolol interactionHydrochlorothiazide, TriamtereneDyazide, Maxzide, Maxzide-25, Triamzide, Triazide
How Hydrochlorothiazide, Triamterene interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Triamterene interactionHydrochlorothiazide, ValsartanDiovan HCT
How Hydrochlorothiazide, Valsartan interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydrochlorothiazide, Valsartan interactionHydroflumethiazideSaluron
How Hydroflumethiazide interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydroflumethiazide interactionHydroflumethiazide, ReserpineSalutensin, Salutensin-Demi
How Hydroflumethiazide, Reserpine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Hydroflumethiazide, Reserpine interactionIloprostAurlumyn, Ventavis
How Iloprost interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Iloprost interactionIndapamideLozide, Lozol
How Indapamide interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Indapamide interactionIrbesartanAprovel, Avapro
How Irbesartan interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Irbesartan interactionIrbesartan, HydrochlorothiazideCoAprovel
How Irbesartan, Hydrochlorothiazide interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Irbesartan, Hydrochlorothiazide interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Isosorbide Dinitrate, Hydralazine interactionIsradipineDynacirc CR
How Isradipine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Isradipine interactionLabetalolNormodyne, Trandate
How Labetalol interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Labetalol interactionLercanidipine HydrochlorideZanidip
How Lercanidipine Hydrochloride interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Lercanidipine Hydrochloride interactionLevamlodipineConjupri
How Levamlodipine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Levamlodipine interactionLisinoprilPrinivil, Qbrelis, Zestril
How Lisinopril interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Lisinopril interactionLosartan PotassiumCozaar
How Losartan Potassium interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Losartan Potassium interactionMacitentanOpsumit
How Macitentan interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Macitentan interactionMacitentan, TadalafilOpsynvi
How Macitentan, Tadalafil interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs, Phosphodiesterase-5 Inhibitors Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Macitentan, Tadalafil interactionMannitolBronchitol, Osmitrol
How Mannitol interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Mannitol interactionMecamylamineInversine
How Mecamylamine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Mecamylamine interactionMethazolamideNeptazane
How Methazolamide interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Methazolamide interactionMethyclothiazideAquatensen, Enduron
How Methyclothiazide interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Methyclothiazide interactionMethyclothiazide, PargylineEutron
How Methyclothiazide, Pargyline interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Methyclothiazide, Pargyline interactionMethyclothiazide, ReserpineDiutensen-R
How Methyclothiazide, Reserpine interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Methyclothiazide, Reserpine interactionMethyldopaAldomet, Methyldopa
How Methyldopa interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Methyldopa interactionMetolazoneDiulo, Mykrox, Zaroxolyn
How Metolazone interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Metolazone interactionMetoprololLopressor, Toprol XL
How Metoprolol interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Metoprolol interactionMinoxidilLoniten, Minoxidil, Rogaine
How Minoxidil interacts with L-Citrulline 1000 mg — through 1 ingredient. Tap an ingredient for the detail:
L-citrullineAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
Read the full L-citrulline + Minoxidil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in L-Citrulline 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
L-Citrulline
Antihypertensive Drugs
Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.
Phosphodiesterase-5 Inhibitors
Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.
Brand information
Manufacturer and brand details for L-Citrulline 1000 mg, from the product label.
Nutricost
See all Nutricost products- Name
- Nutricost
- Street Address
- 7 S 1550 W #200
- City
- Lindon
- State
- UT
- ZipCode
- 84042
- Phone Number
- (866) 438-3694
- Web Address
- www.nutricost.com
L-Citrulline 1000 mg by Nutricost: Common Questions
Does L-Citrulline 1000 mg by Nutricost interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does L-Citrulline really help with workouts?
What's the most common side effect?
Can I take this while I'm pregnant or breastfeeding?
What actually is L-Citrulline and what does it do?
Is this the same as L-arginine?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if L-Citrulline 1000 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind L-Citrulline 1000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
L-Citrulline 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 8 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
L-citrulline 8 references
- Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
- Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
- Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
- Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
- Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
- Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
- Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC