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Dietary supplement

L-Citrulline DL-Malate 2:1 Ingredients & Drug Interactions

by BulkSupplements.com

L-Citrulline DL-Malate 2:1 label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Citrulline DL-Malate 2:1 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Citrulline DL-Malate 2:1 is a dietary supplement by BulkSupplements.com with 2 active ingredients. Its ingredients are commonly taken for exercise performance, muscle soreness and fatigue, blood flow and circulation.Based on those ingredients, 178 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline, DL-Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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HelloPharmacist Scorecard of L-Citrulline DL-Malate 2:1 by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: L-citrulline and DL-malate (a form of malic acid). L-citrulline is an amino acid that your body converts to another amino acid called L-arginine, which plays a role in blood vessel function and circulation.

DL-malate is an organic acid that may support muscle and energy function. There are no inactive ingredients listed for this product.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Exercise performance and muscle support.
  • We looked for evidence on: Athletic performance, Muscle strength, Fatigue, Muscular dystrophy, Sarcopenia, Muscle endurance — and 3 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Ineffective" for Sarcopenia.
  • Also on file: L-citrulline is rated "Insufficient Reliable Evidence To Rate" for Muscle strength, Muscular dystrophy.

L-citrulline has possibly effective evidence for athletic performance—it may help with exercise capacity and recovery. For muscle loss (sarcopenia), the evidence suggests it's probably not effective.

For heart health, heart failure, diabetes, and Reye syndrome, we don't have enough reliable evidence to rate whether it works. DL-malate shows possibly effective evidence for dry mouth.

For acne, acid reflux (GERD), fatigue, fibromyalgia, and psoriasis, the evidence is too limited to say either way.

The evidence, ingredient by ingredient L-citrulline Malic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-citrulline is generally well tolerated in healthy adults, though long-term safety hasn't been fully studied. The most common side effects are gastrointestinal discomfort and heartburn.

A small number of people have reported cough while taking it. The safety data advises against using L-citrulline during pregnancy and breastfeeding due to insufficient information.

DL-malate is generally well tolerated in food amounts, but supplement-dose safety hasn't been well studied. When taken orally, diarrhea and nausea have been reported in one study, though it's unclear whether the effect was from the malate itself or a companion ingredient (magnesium) with known laxative effects.

Side effects, ingredient by ingredient L-citrulline Malic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — L-citrulline, Malic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 178 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check if you take any blood pressure drugs (antihypertensives)—the risk is Moderate, meaning both ingredients can add to their blood-pressure-lowering effect. Also check for erectile dysfunction medications (phosphodiesterase-5 inhibitors, or PDE-5 inhibitors)—L-citrulline poses a Moderate risk of additive blood-vessel relaxation and lower blood pressure with those drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is marketed for athletic performance support, where L-citrulline has some evidence behind it. It's generally well tolerated in healthy adults, but you must check your blood pressure medications and ED medications before starting.

Talk to your pharmacist or doctor if you take any of those drug types—this product could increase your risk of low blood pressure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Citrulline DL-Malate 2:1, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X000HNRMOX
Net contents 250 Gram(s); 8.8 Ounce(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 312128
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Citrulline DL-Malate 2:1 by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3000 mg
Maximum serving Sizes:
3000 mg
Servings per container
83
UPC/BARCODE
X000HNRMOX
IngredientAmount% DV
L-Citrulline2000 mg--
DL-Malate1000 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & pure bulk supplements

Formulation

Free of: Added sugar, soy, dairy, yeast, gluten, additives

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 3000 mg (about 1 1/4 tsp) once or twice daily, or as directed by a physician.

General Statements

Use an accurate milligram scale.

New

Storage

Contents are sold by weight, not volume. Settling may occur. Store in a dry, cool place

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Always consult a physician before taking any dietary supplement.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Citrulline DL-Malate 2:1 by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Citrulline DL-Malate 2:1 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Citrulline DL-Malate 2:1 by BulkSupplements.com

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3000 mg Dosage formPowder Servings per container83 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Citrulline

Interacts with
178 drugs
2000 mg per serving

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. I...

L-Citrulline monograph & interactions

DL-Malate

Interacts with
172 drugs
1000 mg per serving

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain....

DL-Malate monograph & interactions
Interaction report

L-Citrulline DL-Malate 2:1 by BulkSupplements.com Drug Interactions

Want to check YOUR meds against L-Citrulline DL-Malate 2:1?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
178Drugs
178 Moderate

Ingredients driving the most interactions

L-Citrulline 178
DL-Malate 172

Individual Drug Interactions

The ingredients in L-Citrulline DL-Malate 2:1 interact with 178 drugs. Click any drug to see the details.

2 of the 2 ingredients in L-Citrulline DL-Malate 2:1 interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline DL-Malate

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Citrulline DL-Malate 2:1 with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

DL-Malate1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, malic acid might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that malic acid isolated from tagetes roots can reduce mean arterial blood pressure.

Likelihood Possible Evidence D
DL-Malate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Citrulline DL-Malate 2:1, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

L-Citrulline DL-Malate 2:1 by BulkSupplements.com: Common Questions

Does L-Citrulline DL-Malate 2:1 by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, L-Citrulline DL-Malate 2:1 has a known interaction with 178 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Citrulline DL-Malate 2:1 contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data advises against using L-citrulline during pregnancy due to lack of safety information. It's also best to avoid it while breastfeeding. DL-malate is likely safe in food amounts, but supplement doses haven't been studied during pregnancy or lactation either. Talk to your doctor or pharmacist before taking any supplement while pregnant or breastfeeding.
What are the main side effects I should watch for?
The most common side effects from L-citrulline are gastrointestinal discomfort and heartburn. A small number of people have reported cough. DL-malate is generally well tolerated when taken orally, though diarrhea and nausea have been reported in one study with a combination product—it's unclear if the malate or the companion ingredient caused them.
Does L-citrulline really improve athletic performance?
L-citrulline has possibly effective evidence for athletic performance, meaning some research supports it may help with exercise capacity and recovery. It's one of the more promising uses for this ingredient based on the data we have.
Is this product safe long-term?
L-citrulline is generally well tolerated in healthy adults for short-term use, but long-term safety hasn't been fully studied. DL-malate is well tolerated in food amounts, but supplement-dose safety hasn't been well researched either. If you plan to take this regularly, it's worth discussing with your pharmacist.
Can this help with heart health or heart failure?
We don't have enough reliable evidence in our data to say whether L-citrulline works for heart health or heart failure. If you have a heart condition, talk to your doctor before taking any supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Citrulline DL-Malate 2:1 label
Go deeper

The Full Monographs Behind L-Citrulline DL-Malate 2:1’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph → Herb & supplement monograph

Malic Acid

Interacts with 172 drugs

Malic acid is a natural acid found in apples and other fruits, often combined with magnesium in supplements marketed for fibromyalgia and muscle pain. The evidence for its health benefits is...

Read the full Malic Acid monograph →
Sources

Sources & How We Checked

L-Citrulline DL-Malate 2:1's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Malic Acid 7 references
  1. Russell IJ, Michalek JE, Flechas JD, Abraham GE. Treatment of fibromyalgia syndrome with Super Malic: a randomized, double blind, placebo controlled, crossover pilot study. J Rheumatol 1995;22:953-8.
  2. Fiume, Z. Final report on the safety assessment of malic acid and sodium malate. Int J Toxicol 2001;20 Suppl 1:47-55. PubMed
  3. Electronic Code of Federal Regulations. Title 21. Part 184 - Direct Food Substances Affirmed as Generally Recognized as Safe. Available at: http://www.ecfr.gov/cgi-bin/text-idx?c=ecfr&sid=786bafc6f6343634fbf79fcdca7061e1&rgn=div5&view=text&node=21:3.0.1.1
  4. Saleem R, Ahmad M, Naz A, et al. Hypotensive and toxicological study of citric acid and other constituents from Tagetes patula roots. Arch Pharm Res 2004;27(10):1037-42.
  5. Chiriac A, Brzezinski P. Topical malic acid in combination with citric acid: an option to treat recalcitrant warts. Dermatol Ther. 2015;28(6):336-8. PubMed
  6. CFR - Code of Federal Regulations Title 21 SUBCHAPTER B. 184.1069 Malic Acid. Food and Drug Administration Department Of Health And Human Services. Updated April 1, 2017. https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1069.
  7. Amended Safety Assessment of Malic Acid and Sodium Malate as Used in Cosmetics. Cosmetic Ingredient Review Expert Panel. Updated May 19, 2017. http://www.cir-safety.org/sites/default/files/malic%20acid.pdf. Accessed January 24, 2018.

See these in context on the Malic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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