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Dietary supplement

L-Glutamine Ingredients & Drug Interactions

by Healthy Origins

L-Glutamine label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking L-Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

L-Glutamine is a dietary supplement by Healthy Origins with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against L-Glutamine by Healthy Origins

Ask about any prescription or over-the-counter medication and we check it for interactions with L-Glutamine by Healthy Origins — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of L-Glutamine by Healthy Origins

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: L-Glutamine, an amino acid your body uses for gut health, immune function, and recovery from stress and illness. The powder form allows you to mix it into drinks or food at your own dosage.

There are no inactive ingredients listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle health and immune function.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Oral mucositis, Chemotherapy-induced diarrhea, Radiation-induced diarrhea, Postoperative recovery — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Effective" for Sickle cell disease (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Radiation-induced diarrhea.

L-Glutamine is effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma.

The evidence supporting it for these other uses is less established than for sickle cell, so talk with your doctor about whether it's a fit for your specific situation.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is generally well tolerated in healthy adults. The most common side effects are digestive: belching, bloating, constipation, diarrhea, flatulence, and nausea—especially at higher doses (10 to 30 grams daily).

Headache and musculoskeletal pain have also been reported. A small number of people with bipolar disorder have reported mood changes (mania or hypomania) when taking glutamine, so those with a history of bipolar disorder should discuss this with their doctor.

If you have kidney or liver disease, use this only under medical supervision. Pregnancy and lactation safety is rated likely safe, though there isn't enough data to be completely certain.

If you're pregnant or breastfeeding and considering glutamine, talk with your doctor or pharmacist to weigh the benefit against any uncertainty.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (drugs to prevent seizures), confirm with your doctor or pharmacist before starting L-Glutamine. The interaction is theoretical but documented in the medical literature.

No other medication interactions are documented in our data for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-Glutamine may help if you have sickle cell disease or are recovering from surgery or critical illness. If you take an anticonvulsant (seizure medication), check with your pharmacist or doctor first—the interaction is theoretical but worth confirming.

Digestive upset is the main side effect most people notice. Talk it over with your own healthcare provider to see if it fits your needs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine, straight from the product label.

Brand Healthy Origins
Barcode (UPC) 603573413255
Net contents 10.6 Ounce(s); 300 Gram(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 269369
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine by Healthy Origins, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
60
UPC/BARCODE
603573413255
IngredientAmount% DV
L-Glutamine5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement for adults, add one (1) scoop of powder into 8 oz of water or juice once or twice daily, preferably on an empty stomach, or as directed by a physician.

Formulation

Healthy Origins American-Made L-Glutamine is an amino acid produced by the body to serve as a building block for proteins. It also helps supply fuel to the immune cells inside your GI tract. L-Glutamine is the most abundant amino acid found in your blood and muscle tissue. However, during times of stress or rigorous exercise, your natural levels of L-Glutamine may be reduced. L-Glutamine may help to optimize athletic performance, support muscle health, and support healthy immune cell function.

American-made Supports muscle health and immune function

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, peanut, or tree nut derived ingredients. Non GMO

Manufactured in a cGMP facility. This product meets the USP and FCC monograph requirements.

Suitable for vegans

Formula

For this reason, many athletes choose to add supplemental L-Glutamine to their diet and exercise regimen.

General Statements

Healthy Origins American-Made L-Glutamine is manufactured by BioKyowa, Inc. in Cape Girardeau, MO and packaged in Pennsylvania. New look

Brand IP Statement(s)

Kyowa Quality and/or the KQ logo are registered trademarks of Kyowa Hakko Bio Co., Ltd.

Healthy Origins Since 1996

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

KQ Kyowa Quality

3rd Party Tested

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: Consult a physician before use if you are pregnant, nursing, taking medication or have a medical condition.

If you are sensitive to monosodium glutamate (MSG), you may be sensitive to glutamine since the body naturally converts glutamine to glutamate.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

L-Glutamine by Healthy Origins label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

L-Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in L-Glutamine by Healthy Origins

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine by Healthy Origins Drug Interactions

Want to check YOUR meds against L-Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in L-Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in L-Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for L-Glutamine, from the product label.

Healthy Origins

See all Healthy Origins products
Name
Healthy Origins
City
Pittsburgh
State
PA
ZipCode
15241
Phone Number
1-888-228-6650
Pharmacist Counseling Corner

L-Glutamine by Healthy Origins: Common Questions

Does L-Glutamine by Healthy Origins interact with any medications?
Yes. Based on its ingredients, L-Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does L-Glutamine actually do in your body?
L-Glutamine is an amino acid your body uses to support gut health, immune function, and recovery from physical stress, surgery, or critical illness. Your body makes it naturally, but supplements provide extra when you're under strain or recovering.
What are the most common side effects?
Digestive symptoms are most typical: bloating, constipation, diarrhea, nausea, and flatulence. Headache and muscle pain have also been reported. These side effects are usually mild and often dose-related—lowering the dose may help.
Is L-Glutamine safe if I'm pregnant or breastfeeding?
The data we have rates it likely safe during pregnancy and lactation, but there isn't enough information to be completely certain. Talk with your doctor or pharmacist about your individual situation before taking it.
Can I take L-Glutamine if I have kidney or liver problems?
You should use it only under medical supervision if you have kidney or liver disease. Check with your doctor first, since your body processes glutamine through these organs.
Does L-Glutamine work for all conditions, or just some?
It's effective for sickle cell disease. For surgery recovery, HIV/AIDS-related wasting, and critical illness, the evidence is promising but less established. Your doctor can advise whether it's likely to help your specific situation.
I have bipolar disorder—is L-Glutamine safe for me?
A small number of people with bipolar disorder have reported mood changes (mania or hypomania) when taking glutamine. If you have bipolar disorder, talk with your doctor before starting this supplement.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine label
Go deeper

The Full Monographs Behind L-Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

L-Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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