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Dietary supplement

L-Glutamine Powder 5000 Unflavored Ingredients & Drug Interactions

by GNC Pro Performance

Powder Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine Powder 5000 Unflavored is a dietary supplement by GNC Pro Performance with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine Powder 5000 Unflavored by GNC Pro Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, an amino acid your body naturally makes and uses for gut health, immune function, and muscle recovery. You're getting 5,000 mg (5 grams) per serving in unflavored powder form, which you can mix into water or another beverage.

There are no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support muscle function and recovery.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Wound healing, Critical illness (trauma), HIV/AIDS-related wasting — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for HIV/AIDS-related wasting (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma), Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Muscular dystrophy.

L-glutamine is rated effective for sickle cell disease. For HIV/AIDS-related wasting, postoperative recovery, and recovery from critical illness or trauma, the evidence is marked possibly effective — meaning early studies look promising, but we need more research to be sure.

Whether it'll help you depends on which condition you're considering it for, so it's worth talking through with your doctor.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects from oral doses are digestive: belching, bloating, constipation, diarrhea, flatulence, gas pain, nausea, and vomiting.

Headache and musculoskeletal pain have also been reported. A small number of patients with bipolar disorder have experienced mania or hypomania when taking glutamine; if you have bipolar disorder or a history of mood episodes, discuss this supplement with your doctor first.

One important caution: if you have kidney or liver disease, use this only under medical supervision. Safety data in pregnancy is limited to an overall rating of likely safe, but because there isn't enough detailed information, talk with your doctor before taking it while pregnant.

There isn't enough safety data for breastfeeding, so avoid supplemental doses while nursing unless your clinician advises otherwise.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant medications (seizure drugs), double-check with your doctor or pharmacist before using this product. Glutamine might theoretically reduce how well these drugs work, though this hasn't been reported in patients yet.

For any other prescription medications you're on, you can use the interaction checker on this page to look them up.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and possibly with recovery after surgery, trauma, or in HIV/AIDS wasting, but the evidence for those last three is still building. If you take seizure medication, check with your doctor or pharmacist first — glutamine might theoretically work against how your anticonvulsant works.

People with kidney or liver disease need medical supervision before using it. Talk it over with your own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine Powder 5000 Unflavored, straight from the product label.

Brand GNC Pro Performance
Barcode (UPC) 048107042844
Net contents 16 Oz(s); 1 lb; 454 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74468
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine Powder 5000 Unflavored by GNC Pro Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
90
UPC/BARCODE
048107042844
IngredientAmount% DV
L-Glutamine5000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Glutamine is one of the most abundant amino acids found in muscles. It is involved in protein synthesis and plays an important role in hydrating muscle cells.

5000mg dose to help fuel muscle Anti-Catabolic & supports muscle recovery

90 servings

Notice: Significant product settling may occur.

This product has been tested for banned substances by the HFL Sport Science, a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2013 World Anti-Doping Agency (WADA) Prohibited List via HFL skip lot testing protocol #ICP0307. See gnc.com for more information.

Informed-Choice.org Trusted by sport

Formula

With this amino acid’s great benefits in the body, it will support muscle function. Each serving supplies 5,000mg of L-Glutamine and blends easily with any beverage or sports drink.

Brand IP Statement(s)

Stack with Pro Performance: RapidDrive Arginine 5000 Amplified Creatine XXX 100% Whey Protein

Nitro-Factor 6g

FDA Statement of Identity

Dietary Supplement

Formulation

Banned Substance free

No sugar, no starch, no artificial colors, no artificial flavors, no preservatives, sodium free no corn, no soy, no dairy.

Seals/Symbols

Banned Substance free

Suggested/Recommended/Usage/Directions

Daily

Post-Workout

Directions: As a dietary supplement, take one heaping teaspoon (5 g) post exercise in 8 fl. oz. of water or fruit juice and another 5 g serving two hours later.

General

Code 350528 FOG

Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

L-Glutamine Powder 5000 Unflavored by GNC Pro Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine Powder 5000 Unflavored by GNC Pro Performance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container90 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5000 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine Powder 5000 Unflavored by GNC Pro Performance Drug Interactions

Want to check YOUR meds against L-Glutamine Powder 5000 Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine Powder 5000 Unflavored with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine Powder 5000 Unflavored, from the product label.

GNC Pro Performance

See all GNC Pro Performance products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

L-Glutamine Powder 5000 Unflavored by GNC Pro Performance: Common Questions

Does L-Glutamine Powder 5000 Unflavored by GNC Pro Performance interact with any medications?
Yes. Based on its ingredients, L-Glutamine Powder 5000 Unflavored has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine Powder 5000 Unflavored contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will L-glutamine help my gut or immune system?
The facts we have show L-glutamine is effective for sickle cell disease and possibly effective for recovery after surgery, trauma, or in HIV/AIDS wasting. Evidence for general gut or immune support isn't documented in our data. Your doctor can let you know if it's right for your specific situation.
What side effects should I watch for?
Most common are digestive: bloating, gas, constipation, diarrhea, nausea, and vomiting. Headache and muscle pain have also been reported. If you have bipolar disorder, let your doctor know — a small number of patients have experienced mood changes like mania. Dizziness is rare but possible.
Is L-glutamine safe if I'm pregnant or breastfeeding?
Pregnancy is rated likely safe, but there isn't enough detailed information, so talk with your doctor before starting it. For breastfeeding, we don't have enough safety data, so avoid supplement doses unless your clinician advises you to take it.
Can I take this if I have kidney or liver disease?
Not without medical supervision. If you have either condition, check with your doctor before using L-glutamine.
What's in this powder besides the glutamine?
Just L-glutamine — there are no other inactive ingredients like fillers or binders in this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine Powder 5000 Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine Powder 5000 Unflavored label
Go deeper

The Full Monographs Behind L-Glutamine Powder 5000 Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine Powder 5000 Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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