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Dietary supplement

L-Glutamine Pure Powder Ingredients & Drug Interactions

by Protocol For Life Balance

Powder Category: Amino Acid/protein
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

L-Glutamine Pure Powder is a dietary supplement by Protocol For Life Balance with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of L-Glutamine Pure Powder by Protocol For Life Balance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine, an amino acid your body produces naturally and uses for muscle, gut, and immune function. It's supplied as a pure powder, with no fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports immune system and gastrointestinal health.
  • We looked for evidence on: Oral mucositis, Chemotherapy-induced diarrhea, Radiation-induced diarrhea, Radiation-induced esophagitis, Short bowel syndrome, Crohn disease — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Crohn disease, Radiation-induced diarrhea.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Irritable bowel syndrome (IBS), Oral mucositis, Postoperative infection.

L-glutamine is effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

The evidence for those other uses is not as solid, but the data we hold supports that it may help in those situations.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. Most side effects are mild and gastrointestinal — belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and abdominal pain have been reported, especially at higher doses (10–30 grams daily).

Dizziness and headache can occur; one person had dizziness at a very high dose that resolved when the dose was cut in half. Two people with bipolar disorder reported mania or hypomania on high doses (up to 4 grams daily), so people with bipolar disorder should be cautious.

If you have kidney or liver disease, use it only under medical supervision. The safety data for pregnancy is adequate — it's rated likely safe.

For breastfeeding, not enough reliable safety information exists; talk with your doctor or pharmacist about whether to use it while nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsants (seizure medications), check your exact drug names on this page's medication checker or discuss them with your doctor or pharmacist before taking L-glutamine. Glutamine might theoretically reduce how well these drugs work, though no cases have been reported in humans yet.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may help with sickle cell disease and possibly with recovery after surgery or critical illness. If you take seizure medication, check with your doctor or pharmacist first.

People with kidney or liver disease, bipolar disorder, or those who are breastfeeding should discuss it with their healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about L-Glutamine Pure Powder, straight from the product label.

Brand Protocol For Life Balance
Barcode (UPC) 707359102217
Net contents 1 lb; 454 Gram(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258682
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for L-Glutamine Pure Powder by Protocol For Life Balance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Rounded Teaspoon(s)
Maximum serving Sizes:
1 Rounded Teaspoon(s)
Servings per container
91
UPC/BARCODE
707359102217
IngredientAmount% DV
L-Glutamine5 Gram(s)--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: Mix 1 rounded teaspoon in water or juice, preferably between meals, 1 to 2 times daily as needed, or as directed by your healthcare practitioner.

Formula

How it works: Glutamine, the most abundant amino acid in the body, is an important constituent of proteins and participates in many key metabolic processes. Glutamine helps to regulate acid/base balance, maintains nitrogen balance, and acts as a nitrogen reservoir for the production of other amino acids. It also serves as an important energy source for certain cell types, such as gut, immune, and kidney cells. Glutamine is known to support gastrointestinal integrity, normal immune system function, and the preservation of muscle tissue.

Precautions

Cautions/Interactions: Glutamine may interact with lactulose, anti-convulsant medications, and chemotherapy agents. If you are taking any of these medications or if you are pregnant/lactating, if you have MSG hypersensitivity, a kidney condition, a seizure disorder, bipolar disorder, or impaired liver function, consult your healthcare practitioner before using this product.

Produced in a GMP facility that processes other ingredients containing these allergens.

Do not eat freshness packet enclosed.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Pure powder - Supports a healthy immune system - Promotes gastrointestinal health

Non-GMO

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Protocol For Life Balance L-Glutamine Powder is a pure, free-form, non-essential amino acid.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

General Statements

This product is sold by weight not volume.

See for yourself

L-Glutamine Pure Powder by Protocol For Life Balance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in L-Glutamine Pure Powder by Protocol For Life Balance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Rounded Teaspoon(s) Dosage formPowder Servings per container91 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

L-Glutamine Pure Powder by Protocol For Life Balance Drug Interactions

Want to check YOUR meds against L-Glutamine Pure Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in L-Glutamine Pure Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for L-Glutamine Pure Powder, from the product label.

Protocol For Life Balance

See all Protocol For Life Balance products
Name
Protocol For Life Balance
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.protocolforlife.com
Pharmacist Counseling Corner

L-Glutamine Pure Powder by Protocol For Life Balance: Common Questions

Does L-Glutamine Pure Powder by Protocol For Life Balance interact with any medications?
Yes. Based on its ingredients, L-Glutamine Pure Powder has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
L-Glutamine Pure Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is L-glutamine safe during pregnancy?
Yes, L-glutamine is rated likely safe in pregnancy. If you're pregnant and considering it, it's still a good idea to mention it to your obstetrician or midwife to confirm it fits your individual situation.
What are the most common side effects?
Digestive upset is most common — belching, bloating, constipation, diarrhea, flatulence, nausea, and stomach pain. Headache and dizziness have also been reported. These tend to happen more at higher doses.
Can I take this if I have kidney or liver disease?
Not without medical supervision. Talk with your doctor or pharmacist first if you have either condition — they can advise whether it's appropriate for you and at what dose.
Does L-glutamine actually work for muscle recovery after surgery?
The evidence suggests it possibly helps with postoperative recovery, but it's not as well proven as it is for sickle cell disease. Your surgeon or doctor can help you decide if it makes sense for your situation.
Can I take this while breastfeeding?
There isn't enough reliable safety data on supplemental doses during breastfeeding. Talk with your doctor, midwife, or pharmacist to figure out whether it's okay for you and your baby.
Is there anything in this powder besides L-glutamine?
No — it's L-glutamine only, with no fillers or other inactive ingredients listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if L-Glutamine Pure Powder is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

L-Glutamine Pure Powder label
Go deeper

The Full Monographs Behind L-Glutamine Pure Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

L-Glutamine Pure Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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