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Dietary supplement

Lb Liver/Gall Bladder Ingredients & Drug Interactions

by Systemic Formulas Bio Function

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Lb Liver/Gall Bladder is a dietary supplement by Systemic Formulas Bio Function with 4 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 898 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Red Beet, Betaine Hydrochloride, Choline Bitartrate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Lb Liver/Gall Bladder by Systemic Formulas Bio Function

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1,800 mg) without saying how much of each component you get.

This four-ingredient formula combines betaine hydrochloride (which raises stomach acid), lipase (a digestive enzyme), choline bitartrate (a nutrient involved in liver function and cell signaling), and red beet extract. The first three are the active components; the capsule itself and small amounts of leucine and silica are inactive fillers.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: liver and gallbladder function support.
  • We looked for evidence on: Gallbladder disease, Liver disease, Nonalcoholic fatty liver disease (NAFLD), Hepatitis, biliary function, portal circulation — and 1 related terms.
  • The closest evidence on file: Beet is rated "Insufficient Reliable Evidence To Rate" for Liver disease (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Gallbladder disease.
  • Also on file: Choline is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Hepatitis.

The evidence base for most uses in this formula is thin. Betaine hydrochloride, lipase, and choline bitartrate all have insufficient reliable evidence for their typical uses—dyspepsia (indigestion), inflammatory bowel conditions, and cognitive support among them.

Red beet shows the strongest signal: it's possibly effective for athletic performance and exercise-induced muscle soreness, though concentrated supplements lack the safety track record of eating beets as food. For other claimed uses, the data we hold doesn't establish effectiveness.

The evidence, ingredient by ingredient Betaine Hydrochloride Lipase Choline Beet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Betaine hydrochloride carries a real caution: it irritates the stomach and is unsafe for people with ulcers, gastritis, or true acid reflux—it can worsen heartburn and delay ulcer healing. It's also not safe in pregnancy and should be avoided while breastfeeding.

Lipase is generally well tolerated but should only be used under medical guidance if you have serious digestive conditions; safety in pregnancy and breastfeeding hasn't been well studied. Choline bitartrate is likely safe in pregnancy at appropriate doses (follow your doctor's guidance), and it's important while breastfeeding, but high-dose supplements can cause fishy body odor, nausea, vomiting, and diarrhea—the upper safe limit is 3.5 grams daily.

Red beet is generally well tolerated as a food, though concentrated supplements lack robust safety data; common minor effects are red or black stools (harmless), and rare serious effects include kidney damage and low blood calcium at very high doses.

Side effects, ingredient by ingredient Betaine Hydrochloride Lipase Choline Beet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Beet, Betaine Hydrochloride, Choline.
  • The most serious interaction on file is rated Moderate.
  • For scale: 899 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor about any medications you take that are metabolized by CYP3A4 enzymes—this is a long list including many heart drugs, antihistamines, statins, and immunosuppressants (red beet may increase their levels). If you take H2-blockers, antacids, or proton pump inhibitors for reflux or ulcers, this supplement's betaine could reduce their effectiveness.

Anyone on atropine should verify safety first. Because the affected medication count is substantial, run your exact prescriptions through the interaction checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a four-ingredient liver support formula whose individual components lack strong evidence for effectiveness. The bigger issue is that betaine hydrochloride can interfere with common acid-reflux and digestive medications, and red beet can increase levels of hundreds of medications processed through your liver.

If you have ulcers, gastritis, or acid reflux, skip the betaine. If you take any prescription medications, especially heart drugs, antidepressants, statins, or immunosuppressants, talk it over with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lb Liver/Gall Bladder, straight from the product label.

Brand Systemic Formulas Bio Function
Barcode (UPC) 635585006118
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2013
DSLD ID 21940
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lb Liver/Gall Bladder by Systemic Formulas Bio Function, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
UPC/BARCODE
635585006118
IngredientAmount% DV
Proprietary Blend1800 mg--
Betaine Hydrochloride0 NP--
Lipase0 NP--
Choline Bitartrate0 NP--
Red Beet0 NP--

Other ingredients: Gelatin, Leucine, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage

Keep away from Heat, Sunlight and Children.

Precautions

Keep away from Heat, Sunlight and Children.

General Statements

Helps establish proper portal duct functions.

SOLD THROUGH PROFESSIONALS

MADE IN U.S.A.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any diseases.

Suggested/Recommended/Usage/Directions

DIRECTIONS FOR NUTRITIONAL USE: 1-3 capsules up to twice a day for 1-3 months, or as directed. Then, take as needed for maintenance. Increase the amount of liquids you drink each day while taking this product.

General

#61 F/12

FDA Statement of Identity

Dietary Supplement

See for yourself

Lb Liver/Gall Bladder by Systemic Formulas Bio Function label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Lb Liver/Gall Bladder by Systemic Formulas Bio Function

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1800 mg per serving

Other (inactive) ingredients: Gelatin, Leucine, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lb Liver/Gall Bladder by Systemic Formulas Bio Function Drug Interactions

Want to check YOUR meds against Lb Liver/Gall Bladder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
898Drugs
643 Moderate 255 Minor

Ingredients driving the most interactions

Red Beet 861

Each ingredient & the kinds of drugs it affects

For each ingredient in Lb Liver/Gall Bladder with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Red Beet3 drug types · 861 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, beet might increase the levels of CYP3A4 substrates.
In vitro research suggests that betanin, the major pigment in beet, competitively inhibits CYP3A4 in a dose-dependent manner similarly to strong CYP3A4 inhibitor ketoconazole.

Likelihood Possible Evidence D
Antihypertensive Drugs

Beet and beetroot contain nitrates, which can cause vasodilation, potentially leading to lower blood pressure. However, a study published in the European Journal of Clinical Nutrition using concentrated beetroot juice found no significant impact on blood pressure or heart rate in different age groups. Other small clinical studies suggest that while beet consumption might transiently lower blood pressure due to vessel dilation, there's no consistent evidence of a lasting effect. Overall, the theoretical risk of reduced blood pressure due to beet's nitrate content exists, but studies generally indicate a low and temporary impact rather than a sustained decrease.

Likelihood Possible Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, beet might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research suggests that beet induces CYP1A2 enzymes.

Likelihood Possible Evidence D

Betaine Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D

Choline Bitartrate1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Lb Liver/Gall Bladder, from the product label.

Systemic Formulas Bio Function

See all Systemic Formulas Bio Function products
Name
Systemic Formulas Inc.
Street Address
P.O.Box 1516
City
Ogden
State
UT
ZipCode
84402
Web Address
www.systemicformulas.com
Pharmacist Counseling Corner

Lb Liver/Gall Bladder by Systemic Formulas Bio Function: Common Questions

Does Lb Liver/Gall Bladder by Systemic Formulas Bio Function interact with any medications?
Yes. Based on its ingredients, Lb Liver/Gall Bladder has a known interaction with 898 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lb Liver/Gall Bladder contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have acid reflux or an ulcer?
No. Betaine hydrochloride, one of the main ingredients, increases stomach acid and is not safe for people with gastritis, ulcers, or true acid reflux—it can make heartburn worse and slow ulcer healing. Talk to your doctor about whether this formula is right for you.
What does the red beet in this do?
Red beet shows promise for athletic performance and exercise-related muscle soreness—those are the uses with solid evidence. For other claimed benefits in this formula, the evidence isn't established in the data we hold.
Is it safe to take this while pregnant or breastfeeding?
Betaine hydrochloride is not safe in pregnancy and should be avoided while breastfeeding. Choline bitartrate is likely safe in pregnancy at supplement doses your doctor recommends, and choline needs are actually higher while breastfeeding—but use it only under professional guidance. For lipase and red beet, there isn't enough safety data to know either way; talk with your doctor or pharmacist for personalized advice.
Does this have any side effects?
Betaine hydrochloride can irritate your stomach and cause heartburn. Choline at high doses (over 3.5 grams daily) may cause nausea, vomiting, diarrhea, and a fishy body odor. Red beet commonly causes red or black stools—harmless—but rare serious effects at very high doses include kidney damage. Lipase is generally well tolerated.
Will this interact with my acid reflux medication?
Yes. If you take an H2-blocker, antacid, or proton pump inhibitor (PPI), betaine hydrochloride in this product could decrease how well your medication works. Check with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lb Liver/Gall Bladder label
Sources

Sources & How We Checked

Lb Liver/Gall Bladder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 31 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Beet 14 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Clifford T, Berntzen B, Davison GW, et al. Effects of beetroot juice on recovery of muscle function and performance between bouts of repeated sprint exercise. Nutrients 2016;8. pii: E506. PubMed
  3. Siervo M, Lara J, Ogbonmwan I, Mathers JC. Inorganic nitrate and beetroot juice supplementation reduces blood pressure in adults: a systematic review and meta-analysis. J Nutr 2013;143:818-26. PubMed
  4. Clifford T, Howatson G, West DJ, Stevenson EJ. Beetroot juice is more beneficial than sodium nitrate for attenuating muscle pain after strenuous eccentric-bias exercise. Appl Physiol Nutr Metab. 2017;42(11):1185-1191. PubMed
  5. Clifford T, Bell O, West DJ, Howatson G, Stevenson EJ. The effects of beetroot juice supplementation on indices of muscle damage following eccentric exercise. Eur J Appl Physiol. 2016;116(2):353-62. PubMed
  6. Wylie LJ, Kelly J, Bailey SJ, et al. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol (1985). 2013;115(3):325-36. PubMed
  7. Garnacho-Castaño MV, Palau-Salvà G, Cuenca E, et al. Effects of a single dose of beetroot juice on cycling time trial performance at ventilatory thresholds intensity in male triathletes. J Int Soc Sports Nutr. 2018;15(1):49. PubMed
  8. Rasica L, Porcelli S, Marzorati M, et al. Ergogenic effects of beetroot juice supplementation during severe-intensity exercise in obese adolescents. Am J Physiol Regul Integr Comp Physiol. 2018;315(3):R453-R460. PubMed
  9. Henrohn D, Björkstrand K, Lundberg JO, et al. Effects of oral supplementation with nitrate-rich beetroot juice in patients with pulmonary arterial hypertension-results from BEET-PAH, an exploratory randomized, double-blind, placebo-controlled, crosso
  10. Serra-Payá N, Garnacho-Castaño MV, Sánchez-Nuño S, et al. The relationship between resistance exercise performance and ventilatory efficiency after beetroot juice intake in well-trained athletes. Nutrients 2021;13(4):1094. PubMed
  11. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  12. Hemmatinafar M, Zaremoayedi L, Koushkie Jahromi M, et al. Effect of Beetroot Juice Supplementation on Muscle Soreness and Performance Recovery after Exercise-Induced Muscle Damage in Female Volleyball Players. Nutrients 2023;15(17):3763. PubMed
  13. Lim SH, Bae S, Lee HS, Han HK, Choi CI. Effect of Betanin, the Major Pigment of Red Beetroot (Beta vulgaris L.), on the Activity of Recombinant Human Cytochrome P450 Enzymes. Pharmaceuticals (Basel) 2023;16(9):1224. PubMed
  14. Oscherwitz M, Tamayo RM, Heudebert A, Centor R. A Case of Pseudo-Hematochezia from Beet Supplement Ingestion. Am J Med 2023;136(9):e177-e178. PubMed

See these in context on the Beet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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