Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Ligandrol LGD-4033 Ingredients & Drug Interactions

by Hardcore Formulations

Ligandrol LGD-4033 label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ligandrol LGD-4033 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ligandrol LGD-4033 is a dietary supplement by Hardcore Formulations with 1 active ingredient. Its ingredients are commonly taken for muscle building, athletic performance and strength, body recomposition.Based on those ingredients, 370 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Select Androgen Receptor Modulator LGD-4033. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Ligandrol LGD-4033 by Hardcore Formulations

Ask about any prescription or over-the-counter medication and we check it for interactions with Ligandrol LGD-4033 by Hardcore Formulations — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Ligandrol LGD-4033 by Hardcore Formulations

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Select Androgen Receptor Modulator LGD-4033, commonly called ligandrol. It's a selective androgen receptor modulator (SARM) — a type of investigational compound.

The capsule also contains gelatin, silica, and magnesium stearate as inactive ingredients (binders and flow agents).

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: muscle building and athletic strength.
  • We looked for evidence on: Athletic performance, Muscle strength, body composition, lean mass.
  • The closest evidence on file: Ligandrol is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Ligandrol is rated "Insufficient Reliable Evidence To Rate" for Muscle strength.

The evidence on ligandrol for athletic performance, muscle strength, cancer, cachexia (muscle wasting), and muscular dystrophy is insufficient to rate reliably. We hold no data showing it works for any of these uses in our files — and because ligandrol is an unapproved investigational drug, clinical evidence remains limited.

The evidence, ingredient by ingredient Ligandrol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ligandrol carries real safety concerns. It is not an approved dietary supplement and the FDA has warned that SARMs like this one have been associated with liver toxicity.

There are documented cases of liver injury linked to ligandrol use, including a report of a 32-year-old who developed elevated liver enzymes after just 2 weeks at 10 mg daily. Additionally, even at low doses (0.3–1.0 mg daily), ligandrol reduced good cholesterol (HDL) in trial participants over 3 weeks.

For pregnancy, the safety data advises against use — it is rated possibly unsafe and could harm a developing baby. For breastfeeding, safety is unknown and the drug may pass into breast milk; avoid it completely.

Side effects, ingredient by ingredient Ligandrol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ligandrol.
  • The most serious interaction on file is rated Moderate.
  • For scale: 371 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any hepatotoxic drugs — medications that can harm the liver. The interaction is Moderate, and combining ligandrol with these drugs may increase liver damage risk.

Your healthcare provider needs to review your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ligandrol is an unapproved investigational drug, not a legal dietary supplement, with documented risks of liver injury. If you're considering it for muscle or athletic performance, talk with your doctor first — the evidence doesn't reliably support those uses, and the safety profile raises real concerns.

Do not use if you are pregnant, breastfeeding, or take medications that stress the liver.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ligandrol LGD-4033, straight from the product label.

Brand Hardcore Formulations
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 211473
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ligandrol LGD-4033 by Hardcore Formulations, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Select Androgen Receptor Modulator LGD-403325 mg--

Other ingredients: Gelatin, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Sarm series

Clinical grade

Formulation

Extreme dry, dense mass & strength

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ligandrol LGD-4033 by Hardcore Formulations label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ligandrol LGD-4033 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ligandrol LGD-4033 by Hardcore Formulations

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Select Androgen Receptor Modulator LGD-4033

Interacts with
370 drugs
25 mg per serving

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approve...

Select Androgen Receptor Modulator LGD-4033 monograph & interactions

Other (inactive) ingredients: Gelatin, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ligandrol LGD-4033 by Hardcore Formulations Drug Interactions

Want to check YOUR meds against Ligandrol LGD-4033?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
370Drugs
370 Moderate

Ingredients driving the most interactions

Select Androgen Receptor Modulator LGD-4033 370

Individual Drug Interactions

The ingredients in Ligandrol LGD-4033 interact with 370 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ligandrol LGD-4033 interact with drugs. Each result below shows which ingredient is responsible. Select Androgen Receptor Modulator LGD-4033

Each ingredient & the kinds of drugs it affects

For each ingredient in Ligandrol LGD-4033 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Select Androgen Receptor Modulator LGD-40331 drug type · 370 drugs

Hepatotoxic Drugs

Theoretically, concomitant use might have additive hepatotoxic effects.
In case reports, patients were diagnosed with liver injury thought to be related to the use of products containing ligandrol.

Likelihood Possible Evidence D
Select Androgen Receptor Modulator LGD-4033 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ligandrol LGD-4033, from the product label.

Hardcore Formulations

See all Hardcore Formulations products
Name
Hardcore Formulations
Pharmacist Counseling Corner

Ligandrol LGD-4033 by Hardcore Formulations: Common Questions

Does Ligandrol LGD-4033 by Hardcore Formulations interact with any medications?
Yes. Based on its ingredients, Ligandrol LGD-4033 has a known interaction with 370 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ligandrol LGD-4033 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is ligandrol a legal supplement I can just buy?
No. Ligandrol is an unapproved investigational drug, not a legal dietary supplement. The FDA has issued warnings about SARMs like this one sold as supplements.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against it completely in pregnancy — it could harm a developing baby. In breastfeeding, safety is unknown and the drug may pass into breast milk, so you should avoid it.
What are the main safety concerns with ligandrol?
Liver injury is the most serious concern. There are documented cases of liver damage tied to ligandrol use, and the FDA has specifically warned that SARMs like this have been associated with liver toxicity. It also reduced good cholesterol in trial participants.
Does ligandrol actually work for building muscle or athletic performance?
The evidence we hold is insufficient to rate it reliably for muscle strength, athletic performance, or any of its claimed uses. Clinical data on ligandrol remains limited because it is investigational and unapproved.
What's in each capsule besides the active ingredient?
Each capsule contains gelatin, silica, and magnesium stearate — these are inactive ingredients that help hold the capsule together and help it flow during manufacturing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ligandrol LGD-4033 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ligandrol LGD-4033 label
Go deeper

The Full Monographs Behind Ligandrol LGD-4033’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ligandrol

Interacts with 370 drugs

Ligandrol (LGD-4033) is a synthetic selective androgen receptor modulator (SARM), not a natural herb or approved dietary supplement. It is not approved for human use, is banned in sports, an...

Read the full Ligandrol monograph →
Sources

Sources & How We Checked

Ligandrol LGD-4033's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ligandrol 9 references
  1. Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
  2. Warning Letter: Ironmag Labs 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582464.htm Accessed: November 1, 2017
  3. Warning Letter: Panther Sports Nutrition 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm581630.htm. Accessed: November 1, 2017
  4. Warning Letter: Infantry Labs LLC 10/23/17. FDA Inspections, Compliance, Enforcement, and Criminal Investigations, October 23, 2017. https://www.fda.gov/iceci/enforcementactions/warningletters/2017/ucm582685.htm. Accessed: November 1, 2017
  5. Barbara M, Dhingra S, Mindikoglu AL. Drug-induced liver injury associated with alpha bolic (RAD-140) and alpha elite (RAD-140 and LGD-4033). ACG Case Rep J 2020;7(6):e00409. PubMed
  6. Barbara M, Dhingra S, Mindikoglu AL. Ligandrol (LGD-4033)-Induced Liver Injury. ACG Case Rep J 2020;7(6):e00370. PubMed
  7. Koller T, Vrbova P, Meciarova I, et al. Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review. World J Clin Cases 2021;9(16):4062-4071. PubMed
  8. Flores JE, Chitturi S, Walker S. Drug-induced liver injury by selective androgenic receptor modulators. Hepatol Commun. 2020;4(3):450-452. PubMed
  9. Basaria S, Collins L, Dillon EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. J Gerontol A Biol Sci Med Sci 2013;68(1):87-95. PubMed

See these in context on the Ligandrol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team