Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Omega Q Plus Ingredients & Drug Interactions

by Dr. Sinatra

Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Omega Q Plus is a dietary supplement by Dr. Sinatra with 8 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 426 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Coenzyme Q10, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Omega Q Plus by Dr. Sinatra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 8 of its 8 active ingredients.
  • “CalaMarine Oil concentrate” is listed as a grouped ingredient — the label gives one combined amount (1,250 mg) without saying how much of each component you get.

Omega Q Plus contains 8 active ingredients. The main components are omega-3 fatty acids (EPA and DHA from CalaMarine Oil concentrate), coenzyme Q10 (a compound your cells use for energy), L-carnitine (an amino acid your body makes naturally), three B vitamins (B12, B6, and folate), and chromium (a trace mineral).

These work together to support heart health and energy production. The softgel capsule also contains inactive ingredients like gelatin, glycerin, and medium-chain triglycerides that help deliver and stabilize the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support for heart health, brain health, and cellular energy.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Cognitive impairment, Cardiovascular disease (CVD), Coronary heart disease (CHD), Congestive heart failure (CHF) — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF) (Natural Medicines).
  • Also on file: L-carnitine is rated "Possibly Effective" for Angina, Congestive heart failure (CHF).
  • Also on file: Vitamin B12 is rated "Possibly Ineffective" for Age-related cognitive decline, Cognitive impairment.

Vitamin B12 is effective for B12 deficiency and likely effective for cyanide poisoning; it's possibly effective for canker sores and nerve pain after shingles. L-carnitine is effective for carnitine deficiency and possibly effective for high cholesterol, heart failure, and angina.

Vitamin B6 is effective for sideroblastic anemia and vitamin B6 deficiency, likely effective for high homocysteine, and possibly effective for pregnancy-related nausea. Coenzyme Q10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraines, heart failure, and diabetic nerve pain.

Chromium is likely effective for chromium deficiency and possibly effective for diabetes, but the evidence doesn't support it for prediabetes, schizophrenia, or high blood pressure. We don't have effectiveness data for EPA, DHA, or folate on file.

The evidence, ingredient by ingredient Vitamin B12 L-carnitine Vitamin B6 Coenzyme Q10 Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B12 is generally very safe and is considered safe in pregnancy and breastfeeding at recommended amounts; your excess B12 is simply removed in the urine. L-carnitine is generally well tolerated at typical doses but can cause stomach upset and a fishy body odor at higher doses; safety in pregnancy isn't established, and safety while breastfeeding hasn't been well studied.

Vitamin B6 is safe at normal dietary amounts, but high doses over time can damage nerves; in pregnancy, stick to recommended amounts under your doctor's guidance. Coenzyme Q10 is generally well tolerated; gastrointestinal side effects like nausea or diarrhea occur in less than 1% of users.

Chromium is usually well tolerated at supplement doses, though high or long-term doses may carry risks; avoid extra chromium in pregnancy unless your doctor advises it.

Side effects, ingredient by ingredient Vitamin B12 L-carnitine Vitamin B6 Coenzyme Q10 Chromium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Vitamin B12, Chromium, Vitamin B6, Coenzyme Q10, L-carnitine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; Parkinson's medications.
  • For scale: 426 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Omega Q Plus, check with your doctor or pharmacist if you take blood thinners (warfarin, acenocoumarol), seizure medications (phenobarbital, phenytoin), blood pressure drugs, heart rhythm medications (amiodarone), levothyroxine (thyroid hormone), diabetes medications or insulin, levodopa (Parkinson's), or chemotherapy drugs. Minor interactions are also possible with NSAIDs and aspirin.

No interactions are documented for the EPA, DHA, and folate in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Omega Q Plus is a multi-ingredient heart and energy support formula, but it's not right for everyone — especially if you take blood thinners, seizure medications, thyroid hormone, diabetes drugs, or certain heart medications. Check your specific medications using the tool on this page before starting.

Talk with your doctor or pharmacist about whether this product fits your situation and whether any dose adjustments are needed for your other drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Omega Q Plus, straight from the product label.

Brand Dr. Sinatra
Barcode (UPC) 678829203102
Net contents 180 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 267435
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Omega Q Plus by Dr. Sinatra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
90
UPC/BARCODE
678829203102
IngredientAmount% DV
Calories20 Calorie(s)--
Vitamin B12500 mcg20833%
Cholesterol5 mg2%
Total Fat1.5 Gram(s)2%
EPA200 mg--
DHA350 mg--
Folate680 mcg DFE170%
L-Carnitine Fumarate174 mg--
Vitamin B630 mg1765%
CalaMarine Oil concentrate1250 mg--
Coenzyme Q1050 mg--
Chromium400 mcg1143%

Other ingredients: Gelatin, Glycerin, Gamma-Cyclodextrin, Medium Chain Triglycerides, yellow Beeswax, Dicalcium Phosphate, purified Water, Sunflower Lecithin, Mixed Tocopherols, Annatto (color) suspension, Silica, Lemon Oil, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Almost out? Call 1-800-304-1708 or visit healthydirections.com Choose refill & save, Get free shipping forever

Formulation

Omega Q Plus is a patent-pending blend of premium ingredients that provide support for everyday heart health, brain health, and cellular energy.

Unconditionally guaranteed for purity and labeled potency.

SF Soy free GF Gluten free

Brand IP Statement(s)

Patent Pending

Crominex 3+, Capros and PrimaVie are registered trademarks of Natron, Inc. CalaMarine is a registered trademark of Pharma Marine AS. Hydro Q-Sorb is a registered trademark of Tishcon Corp.

Storage

To preserve quality and freshness, store bottle with cap tightly closed in a cool, dry place.

Precautions

Precautions: Consult a health care practitioner if you are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Seals/Symbols

Friend of the sea

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Doctor's Suggested Use: Take 2 softgels once daily with a meal.

See for yourself

Omega Q Plus by Dr. Sinatra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Omega Q Plus by Dr. Sinatra

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
500 mcg per serving Form: Cyanocobalamin

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Folate

680 mcg DFE per serving

L-Carnitine Fumarate

Interacts with
19 drugs
174 mg per serving

L-carnitine is a compound your body makes naturally and also gets from foods like meat. It helps cells turn fat into energy, and supplements are most...

L-Carnitine Fumarate monograph & interactions

Vitamin B6

Interacts with
210 drugs
30 mg per serving Form: Pyridoxal 5-Phosphate, Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

CalaMarine Oil concentrate

1250 mg per serving Form: Squid
  • › EPA
  • › DHA

Coenzyme Q10

Interacts with
198 drugs
50 mg per serving Form: Ubiquinone

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Coenzyme Q10 monograph & interactions

Chromium

Interacts with
178 drugs
400 mcg per serving Form: Crominex 3+ Chromium

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Gamma-Cyclodextrin, Medium Chain Triglycerides, Yellow Beeswax, Dicalcium Phosphate, Purified Water, Sunflower Lecithin, Mixed Tocopherols, Annatto (color) suspension, Silica, Lemon Oil, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Omega Q Plus by Dr. Sinatra Drug Interactions

Want to check YOUR meds against Omega Q Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
426Drugs
334 Moderate 92 Minor

Ingredients driving the most interactions

Chromium 178

Each ingredient & the kinds of drugs it affects

For each ingredient in Omega Q Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D

Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A

L-Carnitine Fumarate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Omega Q Plus, from the product label.

Dr. Sinatra

See all Dr. Sinatra products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Phone Number
1-800-304-1708
Web Address
healthydirections.com
Pharmacist Counseling Corner

Omega Q Plus by Dr. Sinatra: Common Questions

Does Omega Q Plus by Dr. Sinatra interact with any medications?
Yes. Based on its ingredients, Omega Q Plus has a known interaction with 426 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Omega Q Plus contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Vitamin B12 is considered safe in pregnancy and breastfeeding at recommended amounts. Vitamin B6 is likely safe in pregnancy at recommended levels but should only be used under your doctor's guidance. L-carnitine, coenzyme Q10, and chromium don't have enough reliable safety data in pregnancy — talk with your doctor or pharmacist before taking this product while pregnant or nursing.
Will this help my cholesterol or triglycerides?
L-carnitine is possibly effective for high cholesterol, and the omega-3s (EPA and DHA) in this product are included for heart support, though we don't have effectiveness data on file for those specific ingredients in this product. Talk with your doctor about your cholesterol goals and whether this supplement fits your plan.
What are the most common side effects?
Most ingredients are well tolerated. L-carnitine and chromium can cause stomach upset or headache at typical doses. A fishy body odor has been reported with L-carnitine, and vitamin B6 can cause nausea or headache. Coenzyme Q10 occasionally causes mild digestive symptoms in less than 1% of users.
Is this safe to take with my diabetes medication?
Chromium in this product may lower blood sugar and increase the risk of hypoglycemia when combined with diabetes drugs or insulin. Check with your doctor or pharmacist before taking it alongside your diabetes medication — you may need monitoring or a dose adjustment.
Can I take this if I'm on warfarin or another blood thinner?
L-carnitine and coenzyme Q10 in this product can affect blood thinners — they may increase warfarin's effects or reduce its effectiveness depending on the drug. Do not take this product with blood thinners without checking with your doctor or pharmacist first, as your medication may need adjustment.
What is L-carnitine and why is it in here?
L-carnitine is an amino acid your body naturally produces. It helps cells burn fat for energy and is used to support heart function and energy levels. In this product, it's part of a heart-health formula, and it's effective for treating carnitine deficiency.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Omega Q Plus label
Go deeper

The Full Monographs Behind Omega Q Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Omega Q Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 196 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

L-carnitine 41 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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