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Dietary supplement

Organic Mucuna 20:1 Extract Ingredients & Drug Interactions

by Micro Ingredients

Organic Mucuna 20:1 Extract label
See full label image
Powder Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Mucuna 20:1 Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Organic Mucuna 20:1 Extract is a dietary supplement by Micro Ingredients with 1 active ingredient. Its ingredients are commonly taken for parkinson's disease symptoms, male fertility and libido, mood and stress support.Based on those ingredients, 193 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are organic Mucuna pruriens extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Mucuna 20:1 Extract by Micro Ingredients

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Mucuna 20:1 Extract by Micro Ingredients — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Mucuna 20:1 Extract by Micro Ingredients

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Mucuna pruriens extract in a 20:1 concentration. Mucuna pruriens is a tropical plant whose extract is rich in levodopa (L-dopa), a compound your body can convert to dopamine.

The product contains no other active ingredients; it's just the extract as a powder with no added fillers.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promote energy and anti-inflammatory support.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold on this product is incomplete. For all the conditions listed — anxiety, erythema (red skin), high prolactin levels, muscle pain, Parkinson disease, and rheumatoid arthritis — the data shows insufficient reliable evidence to rate how well it works.

That means studies either haven't been done, are too small, or the results aren't conclusive enough yet. If you're considering this for a specific condition, talk with your doctor or pharmacist about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Cowhage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Adverse effects reported with oral use are generally rare, but a complete safety evaluation hasn't been done. The most common side effects are diarrhea, flatulence (gas), and mucosal irritation.

At higher doses (22.5 to 67.5 grams per day split across multiple doses), some people experienced nausea, stomach bloating, vomiting, headaches, and insomnia — about 3% of trial participants reported insomnia at those levels. During pregnancy, there isn't enough safety data, and because this product has dopamine effects, it's best avoided.

While breastfeeding, avoid it too — levodopa can lower prolactin levels and reduce milk supply. Because this product contains an active drug-like compound, use it carefully and under professional guidance.

Side effects, ingredient by ingredient Cowhage

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cowhage.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; Parkinson's medications.
  • For scale: 193 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, double-check if you're on any monoamine oxidase inhibitors (MAOIs) — this is the highest-risk group. Also flag any blood pressure medications (especially methyldopa or guanethidine), diabetes drugs, antipsychotics, tricyclic antidepressants, or if you're facing surgery that requires certain anesthetics.

Run your exact medications through the search tool on this page and confirm with your doctor or pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is for people interested in mucuna extract who don't take blood pressure medications, diabetes drugs, antipsychotics, antidepressants, or MAOIs. If you take any of those, this isn't a match without checking with your doctor first.

Even if you don't, talk with your pharmacist or doctor before starting — the levodopa content means it needs to be treated seriously, especially if you're pregnant, breastfeeding, or have any chronic health condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Mucuna 20:1 Extract, straight from the product label.

Brand Micro Ingredients
Barcode (UPC) X001P1H81X
Net contents 1 lb(s); 454 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2020
DSLD ID 231827
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Mucuna 20:1 Extract by Micro Ingredients, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Gram(s)
Maximum serving Sizes:
0.5 Gram(s)
Servings per container
908
UPC/BARCODE
X001P1H81X
IngredientAmount% DV
organic Mucuna pruriens extract500 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promote energy Anti-inflammatory

Vegan

Non-GMO Gluten-free

Free of: soy, dairy, yeast, gluten & additives.

Certified organic by Organic Certifiers

Seals/Symbols

USDA Organic

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 scoop three times daily. For best results, please consult your physician.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

If pregnant/lactating or taking any medications, please consult your physician prior to use.

Keep out of the reach of children.

Storage

Keep in a cool, dry place.

General Statements

B

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Mucuna 20:1 Extract by Micro Ingredients label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Mucuna 20:1 Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Mucuna 20:1 Extract by Micro Ingredients

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 Gram(s) Dosage formPowder Servings per container908 Amounts shown are per serving.

Organic Mucuna pruriens extract

Interacts with
193 drugs
500 mg per serving

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied...

Organic Mucuna pruriens extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Mucuna 20:1 Extract by Micro Ingredients Drug Interactions

Want to check YOUR meds against Organic Mucuna 20:1 Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
193Drugs
17 Major 176 Moderate

Ingredients driving the most interactions

organic Mucuna pruriens extract 193

Individual Drug Interactions

The ingredients in Organic Mucuna 20:1 Extract interact with 193 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Mucuna 20:1 Extract interact with drugs. Each result below shows which ingredient is responsible. organic Mucuna pruriens extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Mucuna 20:1 Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Mucuna pruriens extract8 drug types · 193 drugs

Levodopa

Concomitant use can increase the risk of levodopa-related adverse effects.
Cowhage contains levodopa. Some cowhage products have been standardized to contain 75-400 mg of levodopa per dose.

Likelihood Likely Evidence D
Methyldopa (Aldomet)

Theoretically, concomitant use of cowhage and methyldopa might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with methyldopa might cause additive hypotension. In addition, methyldopa may inhibit peripheral decarboxylation of levodopa and increase levodopa levels in the central nervous system; avoid using.

Likelihood Probable Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of cowhage and non-selective MAOIs might increase the risk of hypertensive crisis.
Cowhage contains levodopa. Use of levodopa with non-selective MAOIs might cause hypertensive crisis. However, this interaction has not been reported with MAO-B selective inhibitors such as selegiline.

Likelihood Probable Evidence D
Anesthesia

Theoretically, concomitant use of cowhage and anesthesia might increase the risk of arrhythmias.
Cowhage contains levodopa. Use of levodopa with cyclopropane or halogenated hydrocarbon anesthesia has led to arrhythmias. Other anesthetics have not been implicated. Use other anesthetics in patients taking cowhage or tell patients to stop taking cowhage at least 2 weeks before surgery.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use of cowhage and antidiabetes drugs might increase the risk of hypoglycemia.
Animal research shows that cowhage might have hypoglycemic effects.

Likelihood Possible Evidence D
Antipsychotic Drugs

Theoretically, use of cowhage might decrease the clinical effects of antipsychotic drugs.
Cowhage contains levodopa. Use of levodopa might counteract the antidopaminergic effects of antipsychotic medications.

Likelihood Possible Evidence D
Guanethidine (Ismelin)

Theoretically, concomitant use of cowhage and guanethidine might increase the risk of hypotension.
Cowhage contains levodopa. Use of levodopa with guanethidine might cause additive hypotension; avoid using.

Likelihood Probable Evidence D
Tricyclic Antidepressants (Tcas)

Theoretically, use of TCAs might reduce the levels and clinical effects of cowhage.
Cowhage contains levodopa. Use of TCAs might reduce the absorption of levodopa. Some case reports describe patients that developed hypertension and dyskinesia when taking both levodopa and TCAs.

Likelihood Possible Evidence D
organic Mucuna pruriens extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Mucuna 20:1 Extract, from the product label.

Micro Ingredients

See all Micro Ingredients products
Name
Micro Ingredients
Street Address
21660 Copley Dr.
City
Diamond Bar
State
CA
ZipCode
91765
Phone Number
1-844-836-8200
Web Address
www.microingredients.com
Pharmacist Counseling Corner

Organic Mucuna 20:1 Extract by Micro Ingredients: Common Questions

Does Organic Mucuna 20:1 Extract by Micro Ingredients interact with any medications?
Yes. Based on its ingredients, Organic Mucuna 20:1 Extract has a known interaction with 193 medications, including 17 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Mucuna 20:1 Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is levodopa, and why does this product contain it?
Levodopa (L-dopa) is a compound in the mucuna plant that your body converts into dopamine, a brain chemical. This product is standardized to deliver a high concentration of it, which is why it needs careful handling — it acts like a medication in your body.
Can I take this if I'm on an antidepressant?
If it's a tricyclic antidepressant (an older type like amitriptyline or nortriptyline), there's a Moderate-severity interaction — it may reduce how well this product works and can raise blood pressure. Check with your doctor or pharmacist before combining them; don't start on your own.
What are the most common side effects?
At typical doses, diarrhea, gas, and mouth irritation are the most reported. At higher doses (above 22.5 grams per day), some people experienced nausea, stomach bloating, vomiting, headaches, and insomnia — though insomnia was uncommon, reported in about 3% of those in studies.
Is it safe to take while breastfeeding?
No — the levodopa in this product can lower prolactin levels and reduce milk supply. Avoid it while breastfeeding and talk with your doctor or pharmacist about alternatives if you're looking for support during that time.
Does this product actually work for Parkinson disease?
The evidence we hold isn't conclusive enough to say. For Parkinson disease and every other condition listed — anxiety, skin redness, high prolactin, muscle pain, and rheumatoid arthritis — the data shows insufficient reliable evidence to rate how well it works.
What if I'm having surgery soon?
Tell your anesthesiologist or surgeon that you take this product. Certain older anesthetics (cyclopropane and halogenated hydrocarbons) can cause heart rhythm problems when combined with levodopa. Your doctor may ask you to stop it before the procedure or choose a different anesthetic.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Mucuna 20:1 Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Mucuna 20:1 Extract label
Go deeper

The Full Monographs Behind Organic Mucuna 20:1 Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cowhage

Interacts with 193 drugs

Cowhage (Mucuna pruriens) is a tropical legume best known as a natural source of L-dopa, the compound the body turns into dopamine. It is most studied for Parkinson's disease symptoms and ma...

Read the full Cowhage monograph →
Sources

Sources & How We Checked

Organic Mucuna 20:1 Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cowhage 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Anon. Epidemiological notes and reports: Mucuna pruriens-associated pruritus--New Jersey. MMWR Morb Mortal Wkly Rep 1985;34:732-3.
  4. HP-200 in Parkinson's Disease study group. An alternative medicine treatment for Parkinson's disease: Results of a multicenter clinical trial. J Alt Comp Med 1995;1:249-55. DOI
  5. Infante ME, Perez AM, Simao MR, et al. Outbreak of acute toxic psychosis attributed to Mucuna pruriens. Lancet 1990;336:1129. PubMed
  6. Vaidya AB, Rajagopalan TG, Mankodi NA, et al. Treatment of Parkinson's disease with the cowhage plant-Mucuna pruriens Bak. Neurol India 1978;26:171-6.
  7. Vadivel V, Janardhanan K. Nutritional and anti-nutritional composition of velvet bean: an under-utilized food legume in south India. Int J Food Sci Nutr 2000;51:279-87. PubMed
  8. Akhtar MS, Qureshi AQ, Iqbal J. Antidiabetic evaluation of Mucuna pruriens, Linn seeds. J Pak Med Assoc 1990;40:147-50.
  9. Prakash, D., Niranjan, A., and Tewari, S. K. Some nutritional properties of the seeds of three Mucuna species. Int.J.Food Sci.Nutr. 2001;52(1):79-82.
  10. Vadivel, V. and Janardhanan, K. Nutritional and antinutritional characteristics of seven South Indian wild legumes. Plant Foods Hum.Nutr 2005;60(2):69-75. PubMed
  11. Creapure (Creatine Monohydrate). Toxicological Datasheet. Degussa BioActives. Available at: https://www.fda.gov/ohrms/DOCKETS/.../95s-0316-rpt0154-54-Ref-50-vol112.pdf.
  12. Pulikkalpura H, Kurup R, Mathew PJ, Baby S. Levodopa in Mucuna pruriens and its degradation. Sci Rep 2015;5:11078. PubMed

See these in context on the Cowhage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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