No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Perimine Ingredients & Drug Interactions

by Metagenics

Perimine label
See full label image
Tablet Or Pill Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Perimine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Perimine is a dietary supplement by Metagenics with 1 active ingredient. Its ingredients are commonly taken for seasonal and food allergies, asthma and airway inflammation, atopic dermatitis (eczema).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Perimine by Metagenics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Perimine contains one active ingredient: perilla seed extract. Perilla is a plant used traditionally in Asian cuisines and herbal medicine.

The tablet also includes several inactive ingredients—microcrystalline cellulose, stearic acid, sodium starch glycolate, silica, and magnesium stearate—which are common binders and fillers that help hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Perilla's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: respiratory and immune function support.
  • We looked for evidence on: Asthma, Common cold, Cough, Allergic rhinitis (hay fever), airway inflammation, seasonal allergies.
  • The closest evidence on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Perilla is rated "Insufficient Reliable Evidence To Rate" for Asthma, Common cold, Cough.

The evidence for perilla seed extract is limited. Our data rates it as having insufficient reliable evidence to support its use for age-related cognitive decline, allergic rhinitis (hay fever), asthma, osteoporosis, cancer, and headache.

This doesn't mean it doesn't work; it means the research so far hasn't been robust enough to make a confident claim either way.

The evidence, ingredient by ingredient Perilla

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Perilla seed extract is generally well tolerated when eaten as a food, but supplement-strength products haven't been well studied for safety. The most commonly reported side effect from topical use is dermatitis (skin irritation).

Orally, a rare but serious risk is anaphylaxis (a severe allergic reaction)—multiple cases have been reported in both adults and children who consumed perilla seeds, likely due to a component called oleosin. Breathing in smoke from roasted perilla seeds can trigger occupational asthma in susceptible people.

Because of insufficient safety data, medicinal amounts should be avoided during pregnancy and breastfeeding; talk with your doctor or pharmacist for personalized advice if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Perilla

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for perilla seed extract with any medications. Even so, talk with your own doctor or pharmacist before taking Perimine alongside any prescription or over-the-counter drugs, since perilla in supplement form hasn't been thoroughly studied for interactions.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

Perimine may appeal to you if you're interested in perilla's traditional use, but the evidence for its benefits is not yet established. Because supplement-strength perilla products are not well studied and anaphylaxis has been reported, it's important to discuss this product with your doctor or pharmacist before starting—especially if you have a history of food allergies or reactions to seeds.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Perimine, straight from the product label.

Brand Metagenics
Barcode (UPC) 755571026392
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2023
DSLD ID 295852
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Perimine by Metagenics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
755571026392
IngredientAmount% DV
Perilla Seed Extract100 mg--

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Sodium Starch Glycolate, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Perimine features a extract of perilla seed (Perilla frutescens), a unique herb traditionally used to promote healthy respiratory and immune function. Perilla seed extract features a concentrated blend of biologically active flavonoids, including luteolin and rosmarinic acid.

Suggested/Recommended/Usage/Directions

Directions: Take one tablet twice daily with food or as directed by your healthcare practitioner.

Formulation

This product is non-GMO, gluten-free, and vegetarian.

This product is non-GMO, gluten-free, and vegetarian.

GFCO.org (Gluten-Free Certification Organization)

Traditional support for respiratory health

Precautions

Caution: If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.

Keep out of the reach of children.

Practitioner exclusive

Storage

Storage: Keep tightly closed in a cool, dry place.

Seals/Symbols

GFCO.org (Gluten-Free Certification Organization)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Perimine by Metagenics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Perimine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Perimine by Metagenics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Perilla Seed Extract

No known
interactions
100 mg per serving Form: Luteolin, Rosmarinic Acid

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human ev...

Perilla Seed Extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Stearic Acid, Sodium Starch Glycolate, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Perimine by Metagenics Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Perimine. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Perimine, from the product label.

Metagenics

See all Metagenics products
Name
Metagenics
City
Gig Harbor
State
WA
ZipCode
98332
Phone Number
800 692 9400
Web Address
metagenics.com
Pharmacist Counseling Corner

Perimine by Metagenics: Common Questions

Does Perimine by Metagenics interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Perimine. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Perimine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Perimine if I'm pregnant or breastfeeding?
The safety data isn't sufficient to know either way. Because of not enough information, medicinal amounts should be avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What are the side effects of perilla seed extract?
Orally, perilla is generally well tolerated, but a rare and serious side effect is anaphylaxis (a severe allergic reaction)—cases have been reported in both adults and children. Topically, dermatitis (skin irritation) is the most common effect. Breathing in smoke from roasted perilla seeds can also trigger asthma in sensitive people.
Does Perimine actually work for age-related cognitive decline or hay fever?
Our data rates perilla for these uses as having insufficient reliable evidence to rate. That means research so far hasn't been strong enough to say whether it works. Talk with your doctor about what the current science supports for your specific concern.
Is perilla seed extract the only active ingredient in this tablet?
Yes, perilla seed extract is the single active ingredient. The tablet also contains inactive fillers and binders like microcrystalline cellulose, stearic acid, and magnesium stearate, which are standard excipients in tablets.
I have a tree nut or seed allergy—is it safe for me to take Perimine?
Because anaphylaxis has been reported from perilla seeds and is thought to be linked to a compound called oleosin, and because you have a seed or nut allergy, you should talk with your doctor or pharmacist before taking this product. They can assess your specific risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Perimine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Perimine label
Go deeper

The Full Monographs Behind Perimine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Perilla

Perilla is an Asian mint-family plant used in cooking and traditional medicine, mainly for allergy, breathing, and digestive complaints. Most human evidence is limited or preliminary, so it...

Read the full Perilla monograph →
Sources

Sources & How We Checked

Perimine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Perilla 4 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Kanzaki, T. and Kimura, S. Occupational allergic contact dermatitis from Perilla frutescens (shiso). Contact Dermatitis 1992;26(1):55-56.
  3. Yu H, Qiu JF, Ma LJ, Hu YJ, Li P, Wan JB. Phytochemical and phytopharmacological review of Perilla frutescens L. (Labiatae), a traditional edible-medicinal herb in China. Food Chem Toxicol 2017;108(Pt B):375-91. PubMed
  4. Jeong K, Lee SY, Jeon SA, et al. Clinical and immunological characterization of perilla seed allergy in children. J Investig Allergol Clin Immunol 2021. PubMed

See these in context on the Perilla monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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