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Dietary supplement

Premier Glutamine Ingredients & Drug Interactions

by Premier Research Labs

Premier Glutamine label
See full label image
Capsule Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premier Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premier Glutamine is a dietary supplement by Premier Research Labs with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Premier Glutamine by Premier Research Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Premier Glutamine by Premier Research Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Premier Glutamine by Premier Research Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Premier Glutamine is a single-ingredient supplement: L-glutamine, an amino acid your body makes naturally. The capsule also contains cellulose, water, and rice protein as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and gastrointestinal tract support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Crohn disease, Irritable bowel syndrome (IBS), Short bowel syndrome — and 4 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance, Crohn disease, Radiation-induced diarrhea.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced diarrhea, Irritable bowel syndrome (IBS), Oral mucositis.

The evidence behind L-glutamine is strongest for sickle cell disease, where it's rated effective. For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is rated possibly effective — meaning there's promise but the data isn't yet conclusive.

If you're considering this supplement for one of these conditions, talk with your doctor about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects are gastrointestinal: belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting — especially at higher doses.

Headache and musculoskeletal pain have also been reported. Two people with bipolar disorder developed mania or hypomania at doses up to 4 grams daily, though this is rare.

People with kidney or liver disease should take this only under a doctor's supervision. There isn't enough safety data to recommend supplemental doses during pregnancy without talking to your doctor first, and breastfeeding safety data is limited — discuss it with your clinician if you're nursing.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take anticonvulsant (seizure) medications, check your exact drugs below before starting this product — there's a theoretical concern that glutamine might reduce how well they work, though it hasn't been proven in patients. Use the search tool to verify your medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Premier Glutamine is a straightforward single-ingredient product that's well tolerated by most people. If you have kidney or liver disease, or if you take anticonvulsant medications, check with your pharmacist or doctor first.

Otherwise, it's worth a conversation with your healthcare provider if you're considering it for sickle cell disease, trauma recovery, or HIV-related wasting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premier Glutamine, straight from the product label.

Brand Premier Research Labs
Barcode (UPC) 807735008406
Net contents 100 Plant-Source Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 269257
Product type Amino Acid/protein
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premier Glutamine by Premier Research Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
807735008406
IngredientAmount% DV
L-Glutamine500 mg--

Other ingredients: Cellulose, Water, Rice Protein

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule, 3 times daily or as directed by a health professional.

Formula

Glutamine is the most abundant amino acid in the body and one of the few which can cross the blood-brain barrier; it plays an important role in biological functions including protein synthesis.

The Preferred Form: L-Glutamine (free form), derived from beneficial bacteria (not synthetic)

OU (Kosher) we are proud to offer many OU Kosher certified products.

Formulation

Provides support for the gastrointestinal tract while promoting intestinal mucosa health During catabolic states or stress, such as in post-exercise, glutamine supports muscle recovery and glycogen reloading. Glutamine is necessary in the production of glutathione, a key liver nutrient.

A key amino acid Premier muscle and gastrointestinal support

PRL's quality guarantee Purity verified Potency verified Tested for added adulterants No chemical or radiation sterilization Pathogen microbiology performed Heavy metal tested Identity by infrared spectroscopy

Pure vegan

Non-GMO

PRL's quality program. Manufactured to avoid: added magnesium stearate (an undesirable excipient), artificial colors, artificial flavors or artificial preservatives.

Precautions

Keep out of reach of children.

Tamper Seal: Use only if seal is intact.

Consult your health care practitioner if you are pregnant/nursing, taking medication or have a medical condition, before taking this or any other product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool, dry place.

Seals/Symbols

OU (Kosher) we are proud to offer many OU Kosher certified products.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premier Glutamine by Premier Research Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premier Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premier Glutamine by Premier Research Labs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Other (inactive) ingredients: Cellulose, Water, Rice Protein. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premier Glutamine by Premier Research Labs Drug Interactions

Want to check YOUR meds against Premier Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Premier Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Premier Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Premier Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premier Glutamine, from the product label.

Premier Research Labs

See all Premier Research Labs products
Name
Premier Research Labs
Pharmacist Counseling Corner

Premier Glutamine by Premier Research Labs: Common Questions

Does Premier Glutamine by Premier Research Labs interact with any medications?
Yes. Based on its ingredients, Premier Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premier Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is glutamine safe to take while pregnant?
The safety data is rated likely safe for pregnancy — meaning it's been used without clear harm — but there isn't a lot of reliable information. Talk with your doctor or pharmacist about whether you should take it during pregnancy; that's a personal decision based on your health.
What's the most common side effect I might notice?
Gastrointestinal symptoms are most likely: bloating, gas, constipation, or diarrhea. Headache and nausea have also been reported. These tend to happen at higher doses, and lowering your dose usually helps.
Can I take this if I have kidney disease?
You should only take glutamine under your doctor's supervision if you have kidney or liver disease. Talk with your doctor first — don't start it on your own.
Does this supplement actually work?
For sickle cell disease, it's rated effective. For HIV/AIDS wasting, postoperative recovery, and recovery from critical illness like trauma, the evidence is possibly effective — promising but not yet conclusive. Your doctor can tell you if it makes sense for your situation.
What exactly is L-glutamine?
It's an amino acid — one of the building blocks your body uses to make protein. Your body produces it naturally, and it plays roles in immune function, gut health, and muscle recovery. This supplement gives you a concentrated dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premier Glutamine is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premier Glutamine label
Go deeper

The Full Monographs Behind Premier Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Premier Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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