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Dietary supplement

Probiotics Extra Care Digestive Gummy Ingredients & Drug Interactions

by Renew Life

Probiotics Extra Care Digestive Gummy label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotics Extra Care Digestive Gummy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotics Extra Care Digestive Gummy is a dietary supplement by Renew Life with 3 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,093 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Sodium, Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Probiotics Extra Care Digestive Gummy by Renew Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotics Extra Care Digestive Gummy by Renew Life — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Probiotics Extra Care Digestive Gummy by Renew Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (20 mg) without saying how much of each component you get.

This gummy contains three active ingredients. Sodium is a mineral essential for nerve and muscle function, though this product's sodium content warrants caution if you're already managing sodium intake for blood pressure or heart health.

The probiotic blend includes Bacillus subtilis DE111 and Bacillus coagulans SNZ-1969 — both are live bacterial strains intended to support digestive health. The remaining ingredients are inactive excipients: inulin, sugar, natural flavors, pectin, citric acid, sodium citrate, black carrot juice concentrate, sunflower oil, carnauba wax, and corn starch.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive and immune health support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The strongest evidence on file: Black Psyllium is rated "Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

Evidence for these probiotics is mixed. Bacillus coagulans shows possibly effective evidence for constipation and irritable bowel syndrome (IBS).

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. For other uses — athletic performance, cirrhosis, atopic dermatitis, diabetes, and nonalcoholic fatty liver disease — the evidence we hold is insufficient to rate effectiveness.

Sodium itself has limited evidence in this context; the safety data we hold focuses on its risks rather than benefits as a supplement.

The evidence, ingredient by ingredient Sodium Black Psyllium Lactobacillus Acidophilus Bacillus Subtilis Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both Bacillus subtilis and Bacillus coagulans are generally well tolerated in healthy adults, though product quality and strain differences can vary. One case of headache and rare cases of diarrhea have been reported in trials.

In rare cases, people with compromised immune systems, central lines, or severe illness have developed bloodstream infections with probiotic bacteria; the risk in healthy people with intact immune systems appears low. Sodium is essential in small amounts, but excess intake is linked to high blood pressure and heart strain.

Normal dietary sodium is fine, but avoid sodium supplements or very high intake without medical advice. The pregnancy and lactation data on file shows sodium is possibly unsafe; for the Bacillus strains, safety information during pregnancy and breastfeeding is incomplete, so talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Sodium Black Psyllium Lactobacillus Acidophilus Bacillus Subtilis Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Black Psyllium, Bacillus Coagulans, Sodium, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,094 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this gummy, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensives), corticosteroids, lithium, didanosine (Videx), sodium phosphate, tolvaptan (Samsca), or other sodium-containing drugs — sodium in this product may reduce their effectiveness or raise your blood sodium levels. Also confirm timing if you're on antibiotics; you may need to separate doses so the antibiotics don't kill the live probiotic organisms.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This gummy may help with constipation, IBS, or antibiotic-associated diarrhea if the specific Bacillus strain evidence applies to you. The sodium content and antibiotic interactions make it important to check with your doctor or pharmacist first, especially if you take blood pressure medications, lithium, HIV drugs, or antibiotics, or if you're managing sodium intake for heart or kidney health.

Pregnant or nursing people should discuss this with their healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotics Extra Care Digestive Gummy, straight from the product label.

Brand Renew Life
Barcode (UPC) 631257122179
Net contents 48 Gummy(ies)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 306949
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotics Extra Care Digestive Gummy by Renew Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
24
UPC/BARCODE
631257122179
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Sodium10 mg--
Added Sugars2 Gram(s)4%
Total Sugars2 Gram(s)--
Dietary Fiber1 Gram(s)4%
Probiotic Blend20 mg--
Bacillus subtilis DE1110 NP--
Bacillus coagulans SNZ-19690 NP--

Other ingredients: Inulin, Sugar, Natural Flavors, Pectin, Citric Acid, Sodium Citrate, Black Carrot Juice Concentrate, Sunflower Oil, Carnauba Wax, Corn Starch

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

The Renew Life difference means feel the difference or your money back. Our Promise to you Multiple diverse strains Clinically tested probiotic strains Potency through expiration

Digestive Health 2 in 1 Support

Non-GMO Project Verified NonGmoproject.org

Potency, quality and purity guaranteed through expiration.

Gluten Free Dairy Free Soy Free

Made in Canada of Global Ingredients

Formula

A Difference You Can Feel: Renew Life Extra Care Digestive Gummy CFU 2B Multi Strain Clinically Tested Probiotic Strains Potency Through Expiration

Prebiotics and Probiotics Clinically Studied probiotic strains to support: Digestive Health Immune Health 2 Billion Live cultures per serving 2 Probiotic Strains Raspberry Flavored with other natural flavors

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose. treat, cure, or prevent any disease.

FDA Statement of Identity

Probiotic Supplement

Seals/Symbols

Non-GMO Project Verified NonGmoproject.org

Suggested/Recommended/Usage/Directions

Directions: Adults, chew and swallow two (2) gummies per day.

Storage

Store at 77 degrees F (25 degrees C) or below.

Precautions

Keep out of reach of children. For adults only.

Consult your physician prior to using this product if you are pregnant, nursing, taking any medication or have a medical condition.

Tamper Evident: Do not use if safety seal is broken or missing.

Brand IP Statement(s)

Copyright 2021

General Statements

Our Guarantee We stand by our products. Visit renewlife.com/customer-service for our 60-day satisfaction guarantee.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotics Extra Care Digestive Gummy by Renew Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotics Extra Care Digestive Gummy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotics Extra Care Digestive Gummy by Renew Life

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container24 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
10 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
1 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Probiotic Blend

Interacts with
182 drugs
20 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Inulin, Sugar, Natural Flavors, Pectin, Citric Acid, Sodium Citrate, Black Carrot Juice Concentrate, Sunflower Oil, Carnauba Wax, Corn Starch. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotics Extra Care Digestive Gummy by Renew Life Drug Interactions

Want to check YOUR meds against Probiotics Extra Care Digestive Gummy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,093Drugs
409 Moderate 1,684 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Probiotic Blend 182

Individual Drug Interactions

The ingredients in Probiotics Extra Care Digestive Gummy interact with 2,093 drugs. Click any drug to see the details.

3 of the 3 ingredients in Probiotics Extra Care Digestive Gummy interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Probiotic Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotics Extra Care Digestive Gummy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Probiotic Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotics Extra Care Digestive Gummy, from the product label.

Renew Life

Name
Renew Life Formulas, LLC
City
Durham
State
NC
ZipCode
27701
Phone Number
1-800-830-1800
Web Address
www.RenewLife.com
Pharmacist Counseling Corner

Probiotics Extra Care Digestive Gummy by Renew Life: Common Questions

Does Probiotics Extra Care Digestive Gummy by Renew Life interact with any medications?
Yes. Based on its ingredients, Probiotics Extra Care Digestive Gummy has a known interaction with 2,093 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotics Extra Care Digestive Gummy contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
Theoretically, yes, but timing matters. Antibiotics can kill the live Bacillus bacteria in this gummy and reduce its effectiveness. Ask your doctor or pharmacist whether you should space out the doses — for example, taking the antibiotic in the morning and the probiotic at night — to let the probiotic survive.
Is this safe if I have high blood pressure or take blood pressure medication?
That depends on your sodium intake overall and your specific medication. This gummy contains sodium, which can reduce how well blood pressure drugs work. Talk with your doctor or pharmacist about whether the sodium in this product fits your diet and whether it could affect your blood pressure control.
What does Bacillus coagulans do?
It's a live bacterial strain that may help with constipation and irritable bowel syndrome (IBS) based on possibly effective evidence. For other digestive or health issues, the evidence we hold is not yet established.
Does this gummy have any side effects?
In healthy adults, these probiotics are generally well tolerated. One case of headache and rare cases of diarrhea have been reported in studies. People with severely compromised immune systems should be cautious, as there are rare reports of infection from probiotic bacteria in that population.
Is it safe to take during pregnancy or while breastfeeding?
Sodium in this product is possibly unsafe during pregnancy and lactation. For the Bacillus strains, we don't have enough safety data on file. Talk with your doctor or pharmacist before using this gummy if you're pregnant or nursing — they can give you personalized advice based on your health.
Will this help with my digestive issues?
It depends on what you're dealing with. Bacillus coagulans is possibly effective for constipation and IBS. Bacillus subtilis is possibly effective for diarrhea caused by antibiotics. For other digestive concerns, the evidence we hold is insufficient. Your doctor can help you figure out if this is right for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotics Extra Care Digestive Gummy label
Go deeper

The Full Monographs Behind Probiotics Extra Care Digestive Gummy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Probiotics Extra Care Digestive Gummy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 101 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
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Black Psyllium 18 references
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Lactobacillus Acidophilus 15 references
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See these in context on the Lactobacillus Acidophilus monograph →

Bacillus Subtilis 10 references
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  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
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  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
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See these in context on the Bacillus Subtilis monograph →

Bacillus Coagulans 20 references
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  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
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See these in context on the Bacillus Coagulans monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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