Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Promensil Menopause Double Strength Ingredients & Drug Interactions

by Real Health Laboratories

Promensil Menopause Double Strength label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Promensil Menopause Double Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Promensil Menopause Double Strength is a dietary supplement by Real Health Laboratories with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 1,184 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are standardized Red Clover extract, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Promensil Menopause Double Strength by Real Health Laboratories

Ask about any prescription or over-the-counter medication and we check it for interactions with Promensil Menopause Double Strength by Real Health Laboratories — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Promensil Menopause Double Strength by Real Health Laboratories

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “standardized Red Clover extract” is listed as a grouped ingredient — the label gives one combined amount (200 mg) without saying how much of each component you get.

Promensil Menopause Double Strength contains 2 active ingredients: calcium and a standardized red clover extract (which delivers isoflavones—compounds with estrogenic activity). The product also contains several inactive ingredients—calcium phosphate, microcrystalline cellulose, silica, croscarmellose sodium, magnesium stearate, mixed tocopherols, carnauba wax, and a coating solution—that help bind and protect the tablet.

Calcium is a mineral essential for bone strength, and isoflavones are plant compounds that some formulations use to help with menopause symptoms.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: safe natural relief from menopause symptoms.
  • We looked for evidence on: Menopausal symptoms, Breast cancer-related hot flashes, Postmenopausal conditions, vasomotor symptoms, perimenopausal hot flashes.
  • The closest evidence on file: Calcium is rated "Possibly Ineffective" for Breast cancer (Natural Medicines).
  • Also on file: Kudzu is rated "Insufficient Reliable Evidence To Rate" for Menopausal symptoms, Postmenopausal conditions.

Calcium in this product is backed by solid evidence. It's effective for preventing bone loss in osteoporosis (likely effective), as well as for correcting low calcium levels (hypocalcemia), high potassium (hyperkalemia), kidney failure, and indigestion (dyspepsia).

For the isoflavones from red clover, the evidence is less clear. They're possibly effective for alcohol use disorder, but the data we hold rates them as insufficient to establish benefit for hay fever, angina, and back pain.

If menopause symptom relief is your main reason for considering this product, we don't have an effectiveness rating on file for that use.

The evidence, ingredient by ingredient Calcium Red Clover Kudzu

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause problems. The most common side effects taken by mouth are belching, constipation, diarrhea, flatulence, and stomach upset.

Rarely, case reports have raised concerns about kidney stones and a serious condition called calciphylaxis. There's also some concern that very high doses over 1500–2000 mg per day might increase the risk of advanced prostate cancer and possibly increase cardiovascular risk, though research remains mixed.

Isoflavones (from kudzu, the monograph used here) are generally well tolerated in short-term studies, though long-term safety isn't well established. Reported side effects in trials include nausea, indigestion, bloating, dizziness, and rarely rash—but these didn't occur more often than placebo.

The safety data advise against use in pregnancy and breastfeeding due to the possible hormone-like effects and insufficient information.

Side effects, ingredient by ingredient Calcium Red Clover Kudzu

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Kudzu, Calcium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 710 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir, raltegravir), levothyroxine (thyroid medication), heart or blood pressure drugs (diltiazem, sotalol), blood thinners or antiplatelet drugs, methotrexate, tamoxifen, estrogen therapy, diabetes medications, or any drug you know is toxic to the liver. These represent the most serious potential interactions, and timing or discontinuation may be needed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

If you take HIV medications, thyroid medication, blood thinners, diabetes drugs, or estrogen therapy, check your exact prescriptions with your doctor or pharmacist before starting this product—the interactions are significant. Calcium itself is effective for bone health and calcium deficiency, but high daily amounts carry potential cardiovascular and prostate concerns.

The isoflavone component has limited proven benefit beyond possibly helping with alcohol use disorder. Talk with your doctor or pharmacist about whether this product fits your health goals and medication list.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Promensil Menopause Double Strength, straight from the product label.

Brand Real Health Laboratories
Barcode (UPC) 647125603039
Net contents 30 Tablet(s)
Market status On market
Date entered into DSLD Mar 24, 2020
DSLD ID 214069
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Post-Menopause, Seniors/Mature (>50 Years) - Women ONLY
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Promensil Menopause Double Strength by Real Health Laboratories, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
30
UPC/BARCODE
647125603039
IngredientAmount% DV
Calcium50 mg5%
standardized Red Clover extract200 mg--
Isoflavones80 mg--

Other ingredients: Calcium Phosphate, Microcrystalline Cellulose, Coating Solution, Silica, Croscarmellose Sodium, Magnesium Stearate, Mixed Tocopherols, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Clinically proven to reduce Menopause symptoms Reduce hot flashes up to: 73% Reduce night sweats up to: 72%

No added sugar, yeast, milk, wheat, corn, gluten or artificial flavors

Safe & natural relief from the symptoms of Menopause

Clinically tested formula shown to help relieve Hot Flashes, Night Sweats, throughout Menopause

Promensil has been clinically tested to help: Reduce frequency and severity of hot flashes Reduce severity of night sweats Maintain a healthy cardiovascular system

Promensil also works to help support: Breast Health Emotional Well Being Bone Health Heart Health Hormone Balance Improved Libido

Formula

80mg Opitimun level Red Clover Isoflavones

Suggested/Recommended/Usage/Directions

30 Tablets One per day

Directions: Take one tablet per day with food. While individual results will vary, most will notice a difference within 6-8 weeks.

General Statements

1 month supply

Promensil Customer Care Toll Free 800-565-6656 www.promensil.com

Product of Australia

Lipovac, et al (2010), Gynecological Endocrinology, 2011, 1-5

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Real Health Laboratories

Storage

Store in a cool place

Precautions

Keep out of reach of children

Please consult with your primary care provider prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

People with allergies to soy should consult their healthcare provider before taking this product

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Promensil Menopause Double Strength by Real Health Laboratories label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Promensil Menopause Double Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Promensil Menopause Double Strength by Real Health Laboratories

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
50 mg per serving Form: Calcium Phosphate

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Standardized Red Clover extract

Interacts with
869 drugs
200 mg per serving

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot f...

Standardized Red Clover extract monograph & interactions

Other (inactive) ingredients: Calcium Phosphate, Microcrystalline Cellulose, Coating Solution, Silica, Croscarmellose Sodium, Magnesium Stearate, Mixed Tocopherols, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Promensil Menopause Double Strength by Real Health Laboratories Drug Interactions

Want to check YOUR meds against Promensil Menopause Double Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,184Drugs
7 Major 613 Moderate 564 Minor

Ingredients driving the most interactions

standardized Red Clover extract 869
Calcium 168

Individual Drug Interactions

The ingredients in Promensil Menopause Double Strength interact with 1,184 drugs. Click any drug to see the details.

2 of the 2 ingredients in Promensil Menopause Double Strength interact with drugs. Each result below shows which ingredient is responsible. standardized Red Clover extract Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Promensil Menopause Double Strength with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

standardized Red Clover extract9 drug types · 869 drugs

Estrogens

Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.

Likelihood Probable Evidence D
Methotrexate (Trexall, Others)

Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.

Likelihood Unlikely Evidence B
Caffeine

Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.

Likelihood Unlikely Evidence B
standardized Red Clover extract full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Promensil Menopause Double Strength, from the product label.

Real Health Laboratories

See all Real Health Laboratories products
Name
PharmaCare US, Inc.
City
San Diego
State
CA
ZipCode
92108
Phone Number
800-565-6656
Web Address
www.promensil.com
Pharmacist Counseling Corner

Promensil Menopause Double Strength by Real Health Laboratories: Common Questions

Does Promensil Menopause Double Strength by Real Health Laboratories interact with any medications?
Yes. Based on its ingredients, Promensil Menopause Double Strength has a known interaction with 1,184 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Promensil Menopause Double Strength contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is calcium safe to take during pregnancy and breastfeeding?
Calcium is likely safe in pregnancy when you stick to recommended amounts—adequate calcium is actually important during this time. For breastfeeding, calcium needs can be met through recommended doses as well. Check with your provider about the right amount for you specifically.
What about the isoflavones—are they safe in pregnancy or while breastfeeding?
No. The safety data advise against using isoflavones during pregnancy due to possible hormone-like effects. There's too little safety information to recommend them while breastfeeding either. Talk with your doctor if you're pregnant or nursing and considering this product.
Will this give me an upset stomach?
Calcium commonly causes belching, constipation, diarrhea, flatulence, or mild stomach upset when taken by mouth. The isoflavone component may cause nausea, indigestion, or bloating, though in trials these occurred at similar rates to placebo.
Can I take this if I'm on thyroid medication?
Calcium reduces how your body absorbs levothyroxine and other thyroid medications, making them less effective. Your doctor or pharmacist can advise you on spacing doses—typically at least 4 hours apart—to avoid this problem.
Does this product actually help with menopause symptoms?
The facts we hold don't include an effectiveness rating for red clover or its isoflavones specifically for menopause relief. We know calcium is effective for bone health and correcting low calcium, but for menopause symptom control, ask your doctor or pharmacist what the current evidence suggests.
How much calcium does each tablet contain?
The product facts provided don't specify the dose of calcium or isoflavones per tablet. Check the label or ask your pharmacist for the exact amounts so you can stay within safe daily limits.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Promensil Menopause Double Strength label
Go deeper

The Full Monographs Behind Promensil Menopause Double Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Red Clover

Interacts with 869 drugs

Red clover is a plant rich in isoflavones (plant compounds with weak estrogen-like activity) that is most often used for menopause symptoms like hot flashes. The evidence is mixed and genera...

Read the full Red Clover monograph → Herb & supplement monograph

Kudzu

Interacts with 586 drugs

Kudzu is a fast-growing vine whose root has long been used in traditional Chinese medicine and is now studied mostly for reducing alcohol intake. Early research is promising for cutting back...

Read the full Kudzu monograph →
Sources

Sources & How We Checked

Promensil Menopause Double Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 107 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
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Red Clover 24 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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