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Dietary supplement

Pure L-Glutamine Free Form Powder Ingredients & Drug Interactions

by Precision Engineered

Pure L-Glutamine Free Form Powder label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure L-Glutamine Free Form Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure L-Glutamine Free Form Powder is a dietary supplement by Precision Engineered with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure L-Glutamine Free Form Powder by Precision Engineered

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure L-Glutamine Free Form Powder by Precision Engineered — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure L-Glutamine Free Form Powder by Precision Engineered

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: L-glutamine free form. Glutamine is an amino acid your body makes naturally and uses for immune function, digestive health, and muscle recovery.

You're getting it in powder form with no other active or inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and exercise performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, muscle glycogen repletion, workout recovery.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence behind glutamine is mixed depending on what you're taking it for. It's rated effective for sickle cell disease.

For HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma, the evidence is considered possibly effective—meaning there's some support, but we need more research to be sure. If you're considering it for another reason, that data isn't on file with us.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Glutamine is generally well tolerated in healthy adults. The most common side effects when taken by mouth are digestive issues—belching, bloating, constipation, diarrhea, flatulence, gas pain, nausea, and vomiting—along with headache and muscle pain.

A few rare cases of dizziness, mania, or hypomania have been reported, though they're uncommon. The safety data advises against taking supplemental doses while pregnant or breastfeeding unless your doctor recommends it.

If you have kidney or liver disease, you should only use this under medical supervision. Don't use supplement doses of glutamine on your own if you fall into either of these groups—talk with your doctor or pharmacist first.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start L-glutamine, double-check with your doctor or pharmacist if you take anticonvulsant medications (seizure drugs). This is the one medication type we have documented interaction data for.

For any other prescription you're on, use the search tool on this page to confirm there's no issue.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

L-glutamine may be worth considering if you're recovering from surgery or dealing with critical illness, or if your doctor has recommended it for sickle cell disease or HIV-related wasting. If you take seizure medication, check with your doctor or pharmacist before adding this.

People with kidney or liver disease, or anyone pregnant or breastfeeding, should talk it over with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure L-Glutamine Free Form Powder, straight from the product label.

Brand Precision Engineered
Barcode (UPC) 766443678137
Net contents 14.1 oz.; 400 Gram(s)
Market status On market
Date entered into DSLD Jul 25, 2016
DSLD ID 63136
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure L-Glutamine Free Form Powder by Precision Engineered, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 tsp
Maximum serving Sizes:
1 tsp
Servings per container
89
UPC/BARCODE
766443678137
IngredientAmount% DV
Calories20 Calorie(s)--
L-Glutamine4500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pro-Amino Muscle Fuel* PROTEIN METABOLISM* SUPPORTS EXERCISE RECOVERY*

Pure L-Glutamine Powder ~ Glutamine is a crucial component of muscle cells. ~ Glutamine may promote replenishment of muscle glycogen stores after exercise when combined with carbohydrates.* ~ Intense exercise promotes Glutamine formation and release from muscle.* ~ Supports protein metabolism.*

Precision Engineered has pioneered the manufacture of premium sports nutrition supplements. Our commitment to quality is the highest in our industry. Every product undergoes rigorous analysis for purity, potency, safety and freshness. We guarantee it.

FDA Statement of Identity

VEGETARIAN DIETARY SUPPLEMENT

Formulation

VEGETARIAN DIETARY SUPPLEMENT

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Soy, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, mix one (1) teaspoon (4.5 g) into 4-8 ounces of water or your favorite beverage one to two times daily. Stir or mix in your Precision Engineered shaker and drink one hour before a workout.

Seals/Symbols

QA QUALITY ASSURED

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Not intended for use by persons under the age of 18. Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

2016 Precision Engineered Limited (USA)

General

PROD. # 67813 B67808 04A

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure L-Glutamine Free Form Powder by Precision Engineered label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure L-Glutamine Free Form Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure L-Glutamine Free Form Powder by Precision Engineered

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 tsp Dosage formPowder Servings per container89 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
4500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions
Interaction report

Pure L-Glutamine Free Form Powder by Precision Engineered Drug Interactions

Want to check YOUR meds against Pure L-Glutamine Free Form Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Pure L-Glutamine Free Form Powder interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure L-Glutamine Free Form Powder interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure L-Glutamine Free Form Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure L-Glutamine Free Form Powder, from the product label.

Precision Engineered

See all Precision Engineered products
Phone Number
1-800-228-4533
Web Address
www.vitaminworld.com
Pharmacist Counseling Corner

Pure L-Glutamine Free Form Powder by Precision Engineered: Common Questions

Does Pure L-Glutamine Free Form Powder by Precision Engineered interact with any medications?
Yes. Based on its ingredients, Pure L-Glutamine Free Form Powder has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure L-Glutamine Free Form Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine used for?
L-glutamine is an amino acid your body produces naturally. This supplement is backed by evidence for sickle cell disease, and there's some support for using it to help with postoperative recovery, HIV/AIDS-related wasting, and recovery from critical illness or trauma.
What side effects might I experience?
Most people tolerate glutamine well. The most common side effects are digestive—bloating, constipation, diarrhea, nausea, gas, and stomach pain. Headache and muscle pain have also been reported. Dizziness is rare. Stop and talk to your doctor if you notice any mood changes like unusual cheerfulness or elevated mood.
Is it safe to take while pregnant or breastfeeding?
The safety data advises against supplemental doses during pregnancy and breastfeeding unless your doctor specifically recommends it. There isn't enough reliable data to know it's safe on your own, so talk it over with your healthcare provider first.
Can I take this if I have kidney or liver disease?
No—you should only use glutamine under medical supervision if you have kidney or liver disease. Check with your doctor or pharmacist before starting.
Does glutamine really work?
The evidence is strongest for sickle cell disease, where it's rated effective. For postoperative recovery, HIV-related wasting, and critical illness, the evidence is considered possibly effective—there's some support, but more research is needed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure L-Glutamine Free Form Powder label
Go deeper

The Full Monographs Behind Pure L-Glutamine Free Form Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Pure L-Glutamine Free Form Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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