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Dietary supplement

Purity Protein Natural Ingredients & Drug Interactions

by HealthForce SuperFoods

Powder Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Purity Protein Natural is a dietary supplement by HealthForce SuperFoods with 3 active ingredients. Its ingredients are commonly taken for blood sugar control, high cholesterol, hangover symptoms.Based on those ingredients, 1,018 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Protein, Nopal Cactus, sprouted Brown Rice protein. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Purity Protein Natural by HealthForce SuperFoods

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Organic Proteins” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Purity Protein Natural contains 3 active ingredients: nopal cactus (also called prickly pear cactus), sprouted brown rice protein, and hemp protein. These are blended together to provide plant-based protein and whole-food nutrients.

The product has no inactive fillers or other ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: complete plant-based protein for digestion and health.
  • We looked for evidence on: Exercise-induced muscle soreness, Muscle strength, Dyspepsia, Food allergies, Constipation, Protein synthesis — and 2 related terms.
  • The strongest evidence on file: Rice Protein is rated "Possibly Effective" for Food allergies (Natural Medicines).
  • Also on file: Prickly Pear Cactus is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Rice Protein is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness, Muscle strength.

The evidence for this product's ingredients is mixed. Nopal cactus is possibly effective for type 2 diabetes, but we don't have enough reliable data to rate it for age-related cognitive decline, prostate health, indigestion, or cholesterol.

Sprouted brown rice protein is possibly effective for food allergies, but evidence is insufficient for muscle soreness or strength. Hemp protein's evidence is also insufficient for the conditions we hold data on — constipation, eczema, and cholesterol.

If you're looking to use this product for a specific health goal, check with your pharmacist or doctor about what the current evidence actually shows for your situation.

The evidence, ingredient by ingredient Prickly Pear Cactus Rice Protein Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nopal cactus is generally well tolerated when used as food, but supplement safety is less studied. The most common side effects are abdominal fullness, indigestion, mild diarrhea, and nausea; a small number of people in trials experienced headache, insomnia, or dizziness.

Rice protein is generally well tolerated as food; rare allergies and cases of intestinal inflammation have been reported, especially in young children. Hemp protein is generally well tolerated in food amounts, though rare cases of allergic reactions (hives, facial swelling, anaphylaxis) and very rare cases of liver enzyme elevation have been reported.

For pregnancy: there isn't enough safety data for nopal cactus or hemp in supplement amounts — talk with your doctor or pharmacist. Rice protein used as a whole food is fine, but concentrated supplements aren't well studied in pregnancy, so check with your provider first.

While breastfeeding, the same caution applies: whole food amounts of rice are likely okay, but supplement forms of any of these ingredients are not well studied.

Side effects, ingredient by ingredient Prickly Pear Cactus Rice Protein Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Prickly Pear Cactus, Rice Protein, Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,019 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes drugs (metformin, glyburide, glipizide, chlorpropamide, or others), ACE inhibitors for blood pressure, estrogen or hormone therapy, blood pressure medications, blood thinners (anticoagulants or antiplatelets), or medications broken down by your liver (CYP1A2 or CYP3A4 substrates), run this product through the interaction checker on this page before you start. The diabetes and blood pressure interactions are the most serious documented.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may work well for someone looking for plant-based protein without dairy or soy, but it's not appropriate if you take diabetes medications, blood pressure drugs, hormone therapy, blood thinners, or certain other medications — check with us first. If you're pregnant, breastfeeding, or have a history of food allergies (especially to rice or hemp), talk to your pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Purity Protein Natural, straight from the product label.

Brand HealthForce SuperFoods
Barcode (UPC) 650786001205
Net contents 20 Gram(s); 0.71 Oz(s)
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 75633
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Purity Protein Natural by HealthForce SuperFoods, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
20 Gram(s)
Maximum serving Sizes:
20 Gram(s)
Servings per container
1
UPC/BARCODE
650786001205
IngredientAmount% DV
Nopal Cactus0 NP--
sprouted Brown Rice protein0 NP--
Organic Proteins0 NP--
Hemp Protein0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Hype is nothing. Substance is everything! Many protein powders are acid forming, difficult to digest/assimilate, create bloating, gas, and allergic reactions, are hard on the kidneys, contain pesticides, GMOs, and hexane solvent residues. Isolated proteins (animal or vegetable) are lacking critical accessory nutrients.

New!

Raw

Only the best possible. Only purity.

Formulation

In contrast, Purity Protein is a 100% TruGanic, plant-based, non-toxic, raw, easy-to-digest, highly bioavailable, hypoallergenic, and complete protein.

Non GMO

Vegan

Gluten free

Seals/Symbols

Non GMO project verified nongmoproject.org

General

Version 1.5 PPNT|16092801

Suggested/Recommended/Usage/Directions

Suggested Use: Add 2 heaping tablespoons to a smoothie, juice, nut/seed milk, breakfast porridge, or any other foods. Plain water is okay, too!

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Purity Protein Natural by HealthForce SuperFoods label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Purity Protein Natural by HealthForce SuperFoods

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size20 Gram(s) Dosage formPowder Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Organic Proteins

0 NP per serving
Interaction report

Purity Protein Natural by HealthForce SuperFoods Drug Interactions

Want to check YOUR meds against Purity Protein Natural?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,018Drugs
150 Moderate 868 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Purity Protein Natural with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Protein6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D

Nopal Cactus1 drug type · 86 drugs

Antidiabetes Drugs

Combining prickly pear cactus with antidiabetes drugs might increase the risk of hypoglycemia.
Case reports show that combining prickly pear cactus with antidiabetes drugs such as chlorpropamide, glyburide, glipizide, and metformin can increase the risk of hypoglycemia in patients with type 2 diabetes. Advise patients to monitor glucose levels closely. Dose adjustments may be necessary.

Likelihood Probable Evidence D

sprouted Brown Rice protein1 drug type · 23 drugs

Ace Inhibitors (Aceis)

In laboratory research, hydrolyzed rice protein inhibits angiotensin-converting enzyme (ACE). In animal research, the inhibition of ACE is correlated with a reduction in systolic blood pressure. So far, this effect has not been shown in humans. Theoretically, concomitant use of rice protein and ACE inhibitors may increase the risk of blood pressure becoming too low. Use with caution. ACE inhibitors include benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik).

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Purity Protein Natural, from the product label.

HealthForce SuperFoods

See all HealthForce SuperFoods products
City
Las Vegas
State
NV
ZipCode
89126
Phone Number
(800)357-2717
Web Address
HealthForce.com
Pharmacist Counseling Corner

Purity Protein Natural by HealthForce SuperFoods: Common Questions

Does Purity Protein Natural by HealthForce SuperFoods interact with any medications?
Yes. Based on its ingredients, Purity Protein Natural has a known interaction with 1,018 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Purity Protein Natural contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me build muscle?
The ingredients provide protein, which is essential for muscle, but we don't have enough reliable evidence to say whether this product specifically improves muscle strength or reduces soreness from exercise. It could be a good protein source if you're already doing strength training — just talk with your doctor or trainer about whether it fits your routine.
Can I take this if I have type 2 diabetes?
Nopal cactus in this product is possibly effective for type 2 diabetes, but it can also increase the risk of low blood sugar when combined with diabetes medications like metformin or glyburide. If you take diabetes drugs, you'd need to monitor your glucose levels closely and check with your pharmacist or doctor first — it's not a simple yes or no.
What are the most common side effects?
The nopal cactus component most commonly causes abdominal fullness, indigestion, mild diarrhea, and nausea. Rice and hemp proteins are generally well tolerated, though allergies to rice or hemp are rare. Start with a small amount to see how your body responds.
Is this safe during pregnancy?
We don't have enough safety data for nopal cactus or hemp in supplement amounts during pregnancy, so you'd need to talk with your doctor or pharmacist. Rice used as a whole food is fine, but concentrated rice protein supplements also aren't well studied in pregnancy.
What is nopal cactus supposed to do?
Nopal cactus is possibly effective for blood sugar control in type 2 diabetes. We don't have enough evidence to say whether it helps with cognitive decline, prostate health, indigestion, or cholesterol on its own.
Can someone with a rice allergy take this?
No. Sprouted brown rice protein is one of the three active ingredients, and although rice protein is considered hypoallergenic, allergies to rice have been reported. If you have a rice allergy, this product isn't safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Purity Protein Natural is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Purity Protein Natural label
Sources

Sources & How We Checked

Purity Protein Natural's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Prickly Pear Cactus 9 references
  1. Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.
  2. Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.
  3. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  4. Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. PubMed
  5. Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607.
  6. Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. PubMed
  7. Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118.
  8. Onakpoya IJ, O'Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. PubMed
  9. Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):11

See these in context on the Prickly Pear Cactus monograph →

Rice Protein 6 references
  1. Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J 2013;12:86. PubMed
  2. Li GH, Qu MR, Wan JZ, You JM. Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac J Clin Nutr. 2007;16 Suppl 1:275-80.
  3. Reche M, Pascual C, Fiandor A, et al. The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy. Pediatr Allergy Immunol. 2010;21(4 Pt 1):577-85. PubMed
  4. Amended final report on the safety assessment of Oryza sativa (rice) bran oil, Oryza sativa (rice) germ oil, rice bran acid, Oryza sativa (rice) bran wax, hydrogenated rice bran wax, Oryza sativa (rice) bran extract, Oryza sativa (rice) extract, Oryza sat
  5. Yasutomi M, Kosaka T, Kawakita A, et al. Rice protein-induced enterocolitis syndrome with transient specific IgE to boiled rice but not to retort-processed rice. Pediatr Int. 2014;56(1):110-2.
  6. Hojsak I, Kljaic-Turkalj M, Misak Z, Kolacek S. Rice protein-induced enterocolitis syndrome. Clin Nutr. 2006;25(3):533-6. PubMed

See these in context on the Rice Protein monograph →

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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