Drug & supplement interaction

Hemp + Diltiazem, Enalapril

Diltiazem, Enalapril brand name: Teczem.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Diltiazem, Enalapril falls into 3 drug categories that Hemp can interact with; the most serious is rated minor. Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.

Read the full interaction report
SeverityMinor
LikelihoodUnlikely
Interactions3
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Hemp and Diltiazem, Enalapril

These two interact in 3 distinct ways. Each one is explained separately below.

Why Are There 3 Interactions?

Hemp interacts with whole categories of medication. Diltiazem, Enalapril falls into 3 of those categories, so it can interact with Hemp in 3 different ways. We’ve listed each one below — your overall risk is driven by the most serious of them (Minor).

Minor

ANTIHYPERTENSIVE DRUGS

1 of 3

Why this applies to Diltiazem, Enalapril

Diltiazem, Enalapril falls under ANTIHYPERTENSIVE DRUGS — the group Hemp interacts with.

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Teczem combines two blood pressure medicines: diltiazem (a calcium channel blocker) and enalapril (an ACE inhibitor). The concern with hemp is purely additive, meaning hemp might nudge your blood pressure down a little further on top of what your medicine already does. Interestingly, lab work suggests hemp seed protein can block renin and ACE, similar to how enalapril works, so in theory the effects could stack.

Honestly though, this is very weak. The blood pressure drop only showed up in animals with high blood pressure, and hemp seed oil did not lower blood pressure in people. Food amounts of hemp seeds are unlikely to matter. If you ever feel dizzy, lightheaded, or unusually tired, check in with your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  2. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
Minor

ACE INHIBITORS (ACEIs)

2 of 3

Diltiazem, Enalapril also falls under ACE INHIBITORS (ACEIs).

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.
Severity Minor Likelihood Unlikely Evidence D

Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Teczem is a combo pill containing diltiazem (a calcium channel blocker) and enalapril (an ACE inhibitor), both of which lower blood pressure. The concern here is pretty mild: certain hemp seed proteins have shown a faint, ACE-inhibitor-like blood pressure lowering effect, but only in lab and animal studies. In theory, stacked on top of your Teczem, that could nudge your pressure a little lower than expected.

In practice, this is unlikely to cause trouble. Real human studies with hemp oil haven't shown a meaningful blood pressure drop, and food amounts of hemp seeds are very different from a concentrated protein isolate. If you start a hemp supplement, just keep an eye out for dizziness, lightheadedness, or feeling faint, and check in with your pharmacist or doctor, who may also watch your potassium.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  2. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
Minor

CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES

3 of 3

Diltiazem, Enalapril also falls under CYTOCHROME P450 3A4 (CYP3A4) SUBSTRATES.

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

This combo pill pairs diltiazem (a calcium channel blocker) with enalapril (an ACE inhibitor), and together they lower blood pressure. The diltiazem part is processed by a liver enzyme called CYP3A4. The concern on file is that hemp might gently speed up that enzyme, which could clear diltiazem a bit faster and make it slightly less effective. In real life that could mean your blood pressure creeps up a little.

Here is the reassuring part: this is theoretical and only comes from lab studies, not from people. Everyday hemp foods like hemp seeds or oil are very unlikely to matter. If you use concentrated hemp products, just mention it to your pharmacist or doctor and keep an eye on your blood pressure.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Hemp Also Interacts With Other Medications

Hemp has 41 moderate, 896 minor known drug interactions in our database — the Diltiazem, Enalapril one above is among them. If you take anything else, check it against the full list below.

Moderate 41 Minor 896 No known interaction 1,893 (incl. Diltiazem, Enalapril)
Taking anything else?

Check Another of Your Medications Against Hemp

Covers the 2,830 medications we’ve checked against Hemp. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Diltiazem, Enalapril

This page covers Hemp only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Diltiazem, Enalapril page lists 271 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), American Mistletoe (major), Asarabacca (major) and Coleus (major).

By severity: 9 major · 220 moderate · 42 minor.

From our pharmacist’s overview on the Diltiazem, Enalapril page

“Anyone taking Teczem (diltiazem with enalapril) for blood pressure should know that most of the 271 supplements with an interaction on file hit the same targets as the drug itself. The bulk either add to its blood-pressure-lowering effect or change how the body handles diltiazem, which is processed by an enzyme called CYP3A4.”

Reviewed by 2 · Jul 18, 2026

Open the Diltiazem, Enalapril interaction page

One more smart check

Taking Hemp as Part of a Dietary Supplement Product? Check It for Interactions

We hold 720 real supplement products containing Hemp, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Hemp. Your product may carry other ingredients that interact with Diltiazem, Enalapril too, on top of Hemp — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Hemp and Diltiazem, Enalapril Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Hemp
Top 25%

#177 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Diltiazem, Enalapril
Steady interest

#1,885 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Hemp

What is Hemp?

Hemp
  • Plant-based protein source
  • Heart health support
  • Skin and hair health
  • Reducing inflammation
  • General nutrition (omega fatty acids)

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While the nutrition is real, strong human evidence that hemp supplements treat specific medical conditions is limited. Talk with your pharmacist or doctor before using hemp products for a health concern, especially if you are pregnant or breastfeeding.

Read the full Hemp monograph & all interactions
Keep checking

Other Drugs & Hemp

Browse every other medication we’ve checked against Hemp — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
41Moderate
896Minor
1,892No known interaction
41 Moderate 896 Minor 1,892 No interaction
Moderate

41 interactions

Minor

896 interactions

Showing 60 of 896 minor interactions — see all 896 on the Hemp page.

No interaction 1,892 drugs checked — show the list

We also checked Hemp against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,892 medications checked with no known interaction — see the full Hemp list.

See the full Hemp interactions page
See every supplement checked against Diltiazem, Enalapril, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Hemp monograph › Uses, safety, and every drug interaction in one place Diltiazem, Enalapril supplement interactions › Every supplement checked against Diltiazem, Enalapril, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Hemp and Diltiazem, Enalapril Together: Common Questions

Can you take Hemp with Diltiazem, Enalapril?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
Why are there 3 interactions listed for Hemp and Diltiazem, Enalapril?
Diltiazem, Enalapril belongs to more than one drug category, and Hemp interacts with each of those categories a little differently. We list every one so nothing is missed — your overall risk is driven by the most serious of them.
How serious is the Hemp and Diltiazem, Enalapril interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.