Pycnogenol-50 50 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pycnogenol-50 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pycnogenol-50 50 mg is a dietary supplement by DaVinci Laboratories with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pycnogenol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pycnogenol-50 50 mg by DaVinci Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol-50 50 mg by DaVinci Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pycnogenol-50 50 mg by DaVinci Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: 50 mg of Pycnogenol, a standardized extract of maritime pine bark. The capsule also holds inactive ingredients—cellulose, microcrystalline cellulose, leucine, and silica—which are typical fillers and binders.
Does it work?
Moderate evidence
Pycnogenol is possibly effective for osteoarthritis and chronic venous insufficiency (CVI)—a condition where blood pools in the legs. The evidence for asthma is also possibly effective.
For high cholesterol (hyperlipidemia), the data rates it as possibly ineffective. Keep in mind that 'possibly effective' means some clinical evidence supports it, but more research would help confirm the benefit.
How safe is it?
Well-documented data
Maritime pine bark extract is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects reported are stomach upset, dizziness, and vertigo.
Headache and one case of chest pain have been reported in trials, though it's unclear whether the chest pain was directly caused by the supplement—that patient had a history of heart attack. Another patient experienced worsening heart failure, but had pre-existing coronary artery disease.
During pregnancy, there isn't enough safety data, so it's best avoided. The same goes for breastfeeding—insufficient data means talk with your doctor or pharmacist about whether it's right for you in either situation.
Meds to double-check
Moderate interaction found
Before taking Pycnogenol-50, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—Moderate risk of increased bleeding. Also flag any immunosuppressants or diabetes medications you're on, as this supplement may interfere with their effectiveness or cause low blood sugar.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pycnogenol may help with osteoarthritis and leg swelling from poor circulation, but you need to be careful if you're on blood thinners, immunosuppressants, or diabetes medications—all can interact. If you have a history of heart problems, discuss this with your doctor or pharmacist first.
Check your exact medications on this page before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pycnogenol-50 50 mg, straight from the product label.
| Brand | DaVinci Laboratories |
|---|---|
| Barcode (UPC) | 026664277930 |
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2024 |
| DSLD ID | 313232 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pycnogenol-50 50 mg by DaVinci Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pycnogenol | 100 mg | -- |
Other ingredients: Cellulose, Microcrystalline Cellulose, Leucine, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Truth We pledge total truth in labeling. Our family of products contains only the purest and most potent ingredients. Guaranteed.
Formulation
Color of this product may vary due to color variations of the natural ingredients.
A dietary supplement to support vascular function and skin health
Vegetarian / gluten free
Vegetarian / gluten free
Precautions
Warning: If pregnant or nursing, consult your healthcare practitioner before taking this product.
Keep out reach of children.
To obtain product information or report a serious adverse event, call 1-800-325-1776. Not labeled for sale in California.
Storage
Store in a cool, dry place.
Brand IP Statement(s)
Pycnogenol is a registered trademark of Horphag Research Ltd. Use of this product may be protected by one or more U.S patents and other international patents.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
A Dietary Supplement to support vascular function and skin health
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 2 capsules with breakfast and 2 capsules with lunch for two weeks. Then take 2 capsules daily with breakfast, or directed by your healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pycnogenol-50 50 mg by DaVinci Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pycnogenol-50 50 mg by DaVinci Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container15 Amounts shown are per serving.
Pycnogenol
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
Pycnogenol monograph & interactionsOther (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Leucine, Silica. These complete the product’s ingredient list but are not active constituents.
Pycnogenol-50 50 mg by DaVinci Laboratories Drug Interactions
HelloPharmacist Interaction Report
Pycnogenol-50 by DaVinci Laboratories contains maritime pine bark extract, which has documented interactions with blood thinners and antiplatelet drugs (Moderate severity), immunosuppressants (Moderate), and diabetes medications (Moderate).
The most serious concern is bleeding risk: maritime pine bark extract appears to slow platelet clumping, which could increase bleeding if you're on blood thinners like warfarin or antiplatelet drugs like aspirin or clopidogrel.
Read the full breakdown — every affected drug type, severity by severity
It may also interfere with how well immunosuppressant drugs work—animal studies suggest it can boost immune activity, though this hasn't been seen in people yet. And if you take diabetes medications, maritime pine bark extract has lowered blood sugar in at least one clinical trial, so there's a theoretical risk of low blood sugar (hypoglycemia); close monitoring and dose adjustment might be needed.
Altogether, these interactions span 327 individual medications. Use the search tool on this page to check your exact prescriptions before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pycnogenol-50 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pycnogenol-50 50 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pycnogenol-50 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pycnogenol
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pycnogenol + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pycnogenol + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Pycnogenol-50 50 mg — through 1 ingredient. Tap an ingredient for the detail:
PycnogenolAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pycnogenol + Anisindione interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pycnogenol-50 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pycnogenol
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Pycnogenol-50 50 mg, from the product label.
DaVinci Laboratories
See all DaVinci Laboratories products- Name
- DaVinci Laboratories a division of FoodScience LLC
- Street Address
- 929 Harvest Lane
- City
- Williston
- State
- VT
- ZipCode
- 05495
- Phone Number
- 1-800-325-1776
- Web Address
- www.davincilabs.com
Pycnogenol-50 50 mg by DaVinci Laboratories: Common Questions
Does Pycnogenol-50 50 mg by DaVinci Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What does maritime pine bark extract do?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Is this effective for high cholesterol?
Does this contain any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pycnogenol-50 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pycnogenol-50 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pycnogenol-50 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC