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Dietary supplement

Reishi-Pure Ingredients & Drug Interactions

by Confidence USA

Reishi-Pure label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Reishi-Pure against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Reishi-Pure is a dietary supplement by Confidence USA with 1 active ingredient. Its ingredients are commonly taken for immune support, fatigue and general well-being, stress and sleep.Based on those ingredients, 375 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Reishi Mushroom (Ganoderma lucidum) fruit body extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Reishi-Pure by Confidence USA

Ask about any prescription or over-the-counter medication and we check it for interactions with Reishi-Pure by Confidence USA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Reishi-Pure by Confidence USA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Reishi-Pure contains one active ingredient: reishi mushroom fruit body extract (Ganoderma lucidum). The capsule itself is filled with inactive ingredients including microcrystalline cellulose and magnesium stearate, which are standard tablet and capsule fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Reishi Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support healthy immune function.
  • We looked for evidence on: Asthma, Bronchitis, Cancer, Cancer-related fatigue, Chronic fatigue syndrome (CFS), Coronavirus disease 2019 (COVID-19) — and 4 related terms.
  • The closest evidence on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Bronchitis (Natural Medicines).
  • Also on file: Reishi Mushroom is rated "Insufficient Reliable Evidence To Rate" for Asthma, Lung cancer, Chronic fatigue syndrome (CFS), Herpes labialis (cold sores), and more.

The evidence for reishi mushroom's effectiveness is mixed and limited. For lowering cholesterol (hyperlipidemia), it's rated possibly ineffective based on available data.

For altitude sickness, Alzheimer disease, and athletic performance, there simply isn't enough reliable evidence to rate whether it works. The data we hold doesn't support claims for other uses.

The evidence, ingredient by ingredient Reishi Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Reishi mushroom is generally well tolerated in the short term, but long-term safety hasn't been well studied. The most common side effects are dizziness, dry mouth, itching, nausea, rash, and stomach upset.

Some people experience respiratory allergy to reishi spores, with sore throat and runny nose. Rare side effects include insomnia and headache.

There isn't enough safety data to know whether reishi is safe in pregnancy or while breastfeeding; the safety data advises against use during both. If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist about whether this product is right for you.

Side effects, ingredient by ingredient Reishi Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Reishi Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 375 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start Reishi-Pure, double-check with your doctor or pharmacist if you take blood pressure medications (antihypertensive drugs), blood thinners or antiplatelet drugs, or diabetes medications. All three types have Moderate-severity interactions with reishi mushroom extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Reishi-Pure may appeal to you if you're interested in a supplement with some traditional use, but the evidence for its effectiveness is limited or unclear. The main caution is if you take blood pressure drugs, blood thinners, or diabetes medications — you'll need to check with your doctor or pharmacist first, since reishi can affect how those work.

It's generally well tolerated short-term, though long-term safety isn't established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Reishi-Pure, straight from the product label.

Brand Confidence USA
Barcode (UPC) 892483001724
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246756
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Reishi-Pure by Confidence USA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
892483001724
IngredientAmount% DV
Reishi Mushroom (Ganoderma lucidum) fruit body extract1000 mg--

Other ingredients: Capsule Shell, Microcrystalline Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Do not take if you are pregnant or nursing. Consult with a physician before taking this product if you have or had heart disease, other medical conditions, or are taking other medications.

Discontinue use of this product and consult with your doctor if any adverse reactions occur.

Keep out of reach of children.

If outer safety seal is broken or missing, do not consume.

Formula

Reishi-Pure is scientifically formulated with 100% natural pure Reishi Mushroom Fruit Body Extract containing polysaccharides to support healthy immune function. Reishi-Pure contains high quality Reishi Extract made from Reishi Mushrooms that were harvested at the optimal growth stage to ensure maximum efficacy.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Reishi-Pure is manufactured by Confidence USA, Inc., and FDA registered manufacturer following strict current Good Manufacturing Practices. (FDA Registration# 10362791850 - Product Code# FP0741)

Made in USA

100% Pure Potency guaranteed Supports healthy immune function

Seals/Symbols

GMP Good Manufacturing Practice

General Statements

For more info and reorders: www.ConfidenceUSA.com Better products for a better life

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Adult - Take 2 capsules daily as dietary supplement.

Storage

Store at room temperature, with lid tightly closed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Reishi-Pure by Confidence USA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Reishi-Pure label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Reishi-Pure by Confidence USA

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Reishi Mushroom (Ganoderma lucidum) fruit body extract

Interacts with
375 drugs
1000 mg per serving

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits...

Reishi Mushroom (Ganoderma lucidum) fruit body extract monograph & interactions

Other (inactive) ingredients: Capsule Shell, Microcrystalline Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Reishi-Pure by Confidence USA Drug Interactions

Want to check YOUR meds against Reishi-Pure?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
375Drugs
375 Moderate

Ingredients driving the most interactions

Reishi Mushroom (Ganoderma lucidum) fruit body extract 375

Individual Drug Interactions

The ingredients in Reishi-Pure interact with 375 drugs. Click any drug to see the details.

1 of the 1 ingredient in Reishi-Pure interact with drugs. Each result below shows which ingredient is responsible. Reishi Mushroom (Ganoderma lucidum) fruit body extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Reishi-Pure with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Reishi Mushroom (Ganoderma lucidum) fruit body extract3 drug types · 375 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, high doses of reishi mushroom might increase the risk of bleeding.
A dose of 1.5 grams daily of reishi mushroom does not seem to decrease platelet aggregation, but a higher dose of 3 grams daily does.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, reishi mushroom might have additive effects with antidiabetes drugs.
Animal research suggests that reishi mushroom decreases blood sugar. However, in patients with type 2 diabetes, taking reishi mushroom does not reduce fasting glucose levels, and its effects on glycated hemoglobin are inconsistent.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, concurrent use of reishi mushroom with antihypertensive drugs might increase the risk of hypotension.
Reishi mushroom has shown hypotensive activity in animal research. Clinical evidence suggests that reishi mushroom reduces blood pressure in some, but not all, patients with hypertension.

Likelihood Possible Evidence D
Reishi Mushroom (Ganoderma lucidum) fruit body extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Reishi-Pure, from the product label.

Confidence USA

See all Confidence USA products
Name
Confidence USA, INC.
City
Port Washington
State
NY
ZipCode
11050
Phone Number
1-800-887-7161
Web Address
ConfidenceUSA.com
Pharmacist Counseling Corner

Reishi-Pure by Confidence USA: Common Questions

Does Reishi-Pure by Confidence USA interact with any medications?
Yes. Based on its ingredients, Reishi-Pure has a known interaction with 375 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Reishi-Pure contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is reishi mushroom extract, and what's it supposed to do?
Reishi mushroom (Ganoderma lucidum) is a fungus used in traditional medicine. In this product, it's concentrated as a fruit body extract. The evidence we hold shows it's possibly ineffective for lowering cholesterol, and there isn't enough reliable evidence to say whether it works for altitude sickness, Alzheimer disease, or athletic performance.
Can I take this if I'm on blood pressure medication?
Not without checking first. Reishi can lower blood pressure on its own, so combining it with blood pressure drugs might cause your pressure to drop too low. Talk with your doctor or pharmacist before starting — they can help you decide if it's safe for you and whether you need monitoring.
What are the most common side effects?
The most common are dizziness, dry mouth, itching, nausea, rash, and stomach upset. Some people also report respiratory allergy symptoms like sore throat and runny nose. Rare side effects include insomnia and headache.
Is it safe to take while I'm breastfeeding?
There isn't enough safety data to know either way. The safety data we have advises against use while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you if you're nursing.
Does this product have any fillers?
Yes — the capsule contains microcrystalline cellulose and magnesium stearate, which are standard inactive ingredients used in capsules as binders and flow agents.
How long can I take this safely?
Reishi mushroom is generally well tolerated in the short term, but long-term safety hasn't been well studied. If you're thinking of taking it for more than a few weeks, check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Reishi-Pure label
Go deeper

The Full Monographs Behind Reishi-Pure’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Reishi Mushroom

Interacts with 375 drugs

Reishi is a traditional Asian mushroom widely used to support the immune system and overall wellness. Human evidence for most of its claimed benefits is limited or low-quality, so it should...

Read the full Reishi Mushroom monograph →
Sources

Sources & How We Checked

Reishi-Pure's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 17 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Reishi Mushroom 17 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Tao J, Feng KY. Experimental and clinical studies on inhibitory effect of ganoderma lucidum on platelet aggregation. J Tongji Med Univ 1990;10:240-3. PubMed
  3. Singh AB, Gupta SK, Pereira BM, Prakash D. Sensitization to Ganoderma lucidum in patients with respiratory allergy in India. Clin Exp Allergy 1995;25:440-7.
  4. Lee SY, Rhee HM. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 1990;38:1359-64. PubMed
  5. Kwok Y, Ng KFJ, Li, CCF, et al. A prospective, randomized, double-blind, placebo-controlled study of the platelet and global hemostatic effects of Ganoderma lucidum (Ling-Zhi) in healthy volunteers. Anesth Analg 2005;101:423-6. PubMed
  6. Wanmuang, H., Leopairut, J., Kositchaiwat, C., Wananukul, W., and Bunyaratvej, S. Fatal fulminant hepatitis associated with Ganoderma lucidum (Lingzhi) mushroom powder. J Med Assoc Thai. 2007;90(1):179-181.
  7. Seto, S. W., Lam, T. Y., Tam, H. L., Au, A. L., Chan, S. W., Wu, J. H., Yu, P. H., Leung, G. P., Ngai, S. M., Yeung, J. H., Leung, P. S., Lee, S. M., and Kwan, Y. W. Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db
  8. Chu, T. T., Benzie, I. F., Lam, C. W., Fok, B. S., Lee, K. K., and Tomlinson, B. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial. Br.J.Nutr. 2012;107(7):1017-1027.
  9. Jin, X., Ruiz, Beguerie J., Sze, D. M., and Chan, G. C. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane.Database.Syst.Rev. 2012;6:CD007731.
  10. Kabir, Y., Kimura, S., and Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol.(Tokyo) 1988;34(4):433-438. PubMed
  11. Kanmatsuse, K., Kajiwara, N., Hayashi, K., Shimogaichi, S., Fukinbara, I., Ishikawa, H., and Tamura, T. [Studies on Ganoderma lucidum. I. Efficacy against hypertension and side effects]. Yakugaku Zasshi 1985;105(10):942-947. PubMed
  12. Gao, Y., Lan, J., Dai, X., Ye, J., and Zhou, S. A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum(W.Curt: Fr.) Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms 2004;6. DOI
  13. Jin H, Zhang G, Cao X, and et al. Treatment of hypertension by linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and microcirculation. In: Niimi H, Xiu RJ, Sawada T, and et al. Microcirculatory Approach to Asi
  14. Klupp NL, Chang D, Hawke F, Kiat H, Cao H, Grant SJ, Bensoussan A. Ganoderma lucidum mushroom for the treatment of cardiovascular risk factors. Cochrane Database Syst Rev. 2015 Feb 17;2:CD007259. PubMed
  15. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614.
  16. Pazzi F, Adsuar JC, Domínguez-Muñoz FJ, García-Gordillo MA, Gusi N, Collado-Mateo D. Ganoderma lucidum effects on mood and health-related quality of life in women with fibromyalgia. Healthcare (Basel) 2020;8(4):520. PubMed
  17. Kogure T, Koiwai A, Fukushi D, et al. Hypereosinophilia with hepatic nodule formation caused by Ganoderma lucidum. Intern Med 2021;60(24):3897-3903.

See these in context on the Reishi Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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