Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Royal Chanca Piedra Ingredients & Drug Interactions

by Whole World Botanicals

Royal Chanca Piedra label
See full label image
Other (e.g. Tea Bag) Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Royal Chanca Piedra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Royal Chanca Piedra is a dietary supplement by Whole World Botanicals with 1 active ingredient. Its ingredients are commonly taken for kidney stones, gallstones, liver support.Based on those ingredients, 1,020 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Chanca Piedra. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Royal Chanca Piedra by Whole World Botanicals

Ask about any prescription or over-the-counter medication and we check it for interactions with Royal Chanca Piedra by Whole World Botanicals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Royal Chanca Piedra by Whole World Botanicals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Royal Chanca Piedra contains one active ingredient: chanca piedra, a plant used in herbal medicine. The product is sold as a tea bag for brewing.

The inactive ingredients list shows chanca piedra itself, which means this is the plant material you're steeping — there are no added fillers or binders listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: kidney, liver and gallbladder health support.
  • We looked for evidence on: Gallbladder disease, Kidney stones (nephrolithiasis), Nonalcoholic fatty liver disease (NAFLD), Urinary tract infections (UTIs), Biliary colic, Hepatic function — and 2 related terms.
  • The strongest evidence on file: Chanca Piedra is rated "Possibly Effective" for Kidney stones (nephrolithiasis) (Natural Medicines).
  • Also on file: Chanca Piedra is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Gallbladder disease, Urinary tract infections (UTIs), Colic.

Chanca piedra is possibly effective for kidney stones. Most of the other uses studied — hepatitis B, anemia of chronic disease, and benign prostatic hyperplasia (enlarged prostate) — don't have enough reliable evidence in our data for us to rate them.

For hepatitis B specifically, the evidence we have suggests it's likely ineffective.

The evidence, ingredient by ingredient Chanca Piedra

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chanca piedra is generally well tolerated in the short term, but high-quality safety data are limited. The most common side effects reported are abdominal pain, nausea, and vomiting when taken by mouth.

One clinical trial also noted fatigue in some participants. Because we don't have enough safety information, the data advises against use during pregnancy and while breastfeeding — talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Chanca Piedra

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Chanca Piedra.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,021 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Royal Chanca Piedra, double-check it with your doctor or pharmacist if you take blood thinners or antiplatelet drugs, diuretics (water pills), lithium, blood pressure medications, diabetes medications, or any drug your liver breaks down — especially ones metabolized through the CYP3A4 or CYP1A2 pathways. Also mention it if you take norepinephrine.

Use the medication checker on this page to verify your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Chanca piedra may help with kidney stones based on available evidence, but it interacts with blood thinners, several blood pressure and diabetes medications, and drugs your liver processes — so check with your doctor or pharmacist before starting it. Safety data are limited, and it's not recommended in pregnancy or while breastfeeding.

If none of those apply and you're interested, a short-term trial is generally well tolerated, though some people do experience stomach upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Royal Chanca Piedra, straight from the product label.

Brand Whole World Botanicals
Barcode (UPC) 691195003909
Net contents 125 Gram(s); 4.4 Ounce(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 276153
Product type Botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Royal Chanca Piedra by Whole World Botanicals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Cup(s)
Maximum serving Sizes:
1 Cup(s)
Servings per container
125
UPC/BARCODE
691195003909
IngredientAmount% DV
Chanca Piedra1 Gram(s)--

Other ingredients: Chanca Piedra, Chanca Piedra

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Phyllanthus Spp.

Sustainably wildcrafted Chanca Piedra loose tea

Formulation

Supports kidney, liver & gall bladder health

Traditional scientific uses: To support the health of the kidneys, liver, gall bladder, bladder and pancreas. Also promotes healthy fat digestion.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

For urgent and immediate use: Take one cup of tea 3-4 times daily for liver-gall bladder support & 6-8 times daily for kidney-bladder support on an empty stomach for up to one month or as directed by your health care practitioner. For maintenance: Take one cup of tea once or twice daily on an empty stomach 5 or 6 days a week. To Prepare: Add 4 level teaspoons to 5 cups of boiling water. Reduce heat and let simmer 15-20 minutes. When cool, strain tea and discard leaves. Make 4 cups of pleasant tasting and healthful tea. Serve hot or cold.

Storage

Store in refrigerator in a glass container with a lid for up to a week.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to treat, prevent, or cure any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Royal Chanca Piedra by Whole World Botanicals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Royal Chanca Piedra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Royal Chanca Piedra by Whole World Botanicals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Cup(s) Dosage formOther (e.g. Tea Bag) Servings per container125 Amounts shown are per serving.

Chanca Piedra

Interacts with
1,020 drugs
1 Gram(s) per serving

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence f...

Chanca Piedra monograph & interactions

Other (inactive) ingredients: Chanca Piedra, Chanca Piedra. These complete the product’s ingredient list but are not active constituents.

Interaction report

Royal Chanca Piedra by Whole World Botanicals Drug Interactions

Want to check YOUR meds against Royal Chanca Piedra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,020Drugs
871 Moderate 149 Minor

Ingredients driving the most interactions

Chanca Piedra 1,020

Individual Drug Interactions

The ingredients in Royal Chanca Piedra interact with 1,020 drugs. Click any drug to see the details.

1 of the 1 ingredient in Royal Chanca Piedra interact with drugs. Each result below shows which ingredient is responsible. Chanca Piedra

Each ingredient & the kinds of drugs it affects

For each ingredient in Royal Chanca Piedra with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Chanca Piedra8 drug types · 1,020 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, chanca piedra might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In vitro research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can inhibit platelet aggregation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, chanca piedra might reduce the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that chanca piedra extract increases CYP1A2 activity. Theoretically, chanca piedra might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, use of chanca piedra might increase the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that chanca piedra extract inhibits CYP3A4. Theoretically, chanca piedra might increase the levels of CYP3A4 substrates. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of chanca piedra with diuretics might increase diuresis.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking diuretic drugs.

Likelihood Possible Evidence D
Lithium

Theoretically, chanca piedra might reduce excretion and increase levels of lithium.
Some preliminary clinical research in adults with hypertension shows that chanca piedra has diuretic properties. However, higher quality research in adults with kidney stones shows that taking chanca piedra does not increase urine volume when compared with placebo. Until more is known, use cautiously in patients taking lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Norepinephrine (Levophed)

Theoretically, chanca piedra may reduce the effects of norepinephrine.
Animal research suggests that methyl brevifolincarboxylate, a constituent isolated from chanca piedra, can reverse blood vessel contraction caused by norepinephrine.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, concomitant use with antidiabetes drugs might affect glucose control and increase the risk of hypoglycemia.
Animal research suggests that chanca piedra can have hypoglycemic effects. However, a small clinical study in adults with diabetes shows that chanca piedra extract 25 grams orally daily for 1 week does not lower fasting or postprandial blood glucose levels.

Likelihood Unlikely Evidence D
Antihypertensive Drugs

Theoretically, concomitant use of chanca piedra with antihypertensive drugs might have additive blood pressure lowering effects.
Animal research suggests that chanca piedra can decrease blood pressure. However, this effect was not observed in most hypertensive patients treated with chanca piedra for 10 days.

Likelihood Unlikely Evidence D
Chanca Piedra full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Royal Chanca Piedra, from the product label.

Whole World Botanicals

See all Whole World Botanicals products
Name
Whole World Botanicals, Inc.
City
NY
State
NY
ZipCode
10032
Phone Number
(646) 290-8651
Web Address
www.wholeworldbotanicals.com
Pharmacist Counseling Corner

Royal Chanca Piedra by Whole World Botanicals: Common Questions

Does Royal Chanca Piedra by Whole World Botanicals interact with any medications?
Yes. Based on its ingredients, Royal Chanca Piedra has a known interaction with 1,020 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Royal Chanca Piedra contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is chanca piedra, and what's it supposed to do?
Chanca piedra is a plant used traditionally to help with kidney stones. Our data shows it's possibly effective for that use. It's also been studied for hepatitis B, anemia, and enlarged prostate, but the evidence for those isn't strong enough to recommend it.
Can I take this if I'm pregnant or breastfeeding?
No — the safety data advise against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe. Talk with your doctor or pharmacist about whether it's right for you in those situations.
What side effects might I get?
The most common ones reported are abdominal pain, nausea, and vomiting. One study also noted fatigue. Overall, it's generally well tolerated in the short term, but we don't have thorough safety data for long-term use.
Does chanca piedra interact with a lot of medications?
Yes — it interacts with blood thinners, blood pressure drugs, diabetes medications, diuretics, lithium, and drugs your liver processes. Many of these are theoretical risks from lab or animal research, not yet seen in people, but they're important to check before you start. Use the medication checker on this page or ask your pharmacist.
Is it safe to take long-term?
The data we have focus on short-term use and show it's generally well tolerated then, but high-quality long-term safety information isn't available. If you're thinking about taking it for more than a few weeks, check with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Royal Chanca Piedra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Royal Chanca Piedra label
Go deeper

The Full Monographs Behind Royal Chanca Piedra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Chanca Piedra

Interacts with 1,020 drugs

Chanca piedra is a tropical herb traditionally used as a 'stone breaker' for kidney and gallstones, and for liver and urinary health. Human evidence for these uses is limited and mostly smal...

Read the full Chanca Piedra monograph →
Sources

Sources & How We Checked

Royal Chanca Piedra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Chanca Piedra 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Srividya N, Periwal S. Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus. Indian J Exp Biol 1995; 33:861-4.
  3. Rao, M. V. and Alice, K. M. Contraceptive effects of Phyllanthus amarus in female mice. Phytother.Res 2001;15(3):265-267.
  4. Moshi, M. J., Lutale, J. J., Rimoy, G. H., Abbas, Z. G., Josiah, R. M., and Swai, A. B. The effect of Phyllanthus amarus aqueous extract on blood glucose in non-insulin dependent diabetic patients. Phytother.Res 2001;15(7):577-580.
  5. Nishiura, J. L., Campos, A. H., Boim, M. A., Heilberg, I. P., and Schor, N. Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients. Urol.Res 2004;32(5):362-366. PubMed
  6. Iizuka, T., Moriyama, H., and Nagai, M. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biol.Pharm.Bull. 2006;29(1):177-179. PubMed
  7. Adeneye, A. A., Amole, O. O., and Adeneye, A. K. Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice. Fitoterapia 2006;77(7-8):511-514. PubMed
  8. Iizuka, T., Nagai, M., Taniguchi, A., Moriyama, H., and Hoshi, K. Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation. Biol.Pharm.Bull. 2007;30(2):382-384. PubMed
  9. Amaechina, F. C. and Omogbai, E. K. Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae). Acta Pol.Pharm. 2007;64(6):547-552.
  10. Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., and Salawu, O. A. Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharm.Biol. 2011;49(3):248-255.
  11. Moshi MJ, Uiso FC Mahunnah RL et al. A study of the effect of Phyllanthus amarus extracts on blood glucose in rabbits. International Journal of Pharmacognosy 1997;35(3):167-173. DOI
  12. Kumar NG, Nair AN Raghunandanan VR et al. Hypoglycaemic effect of Phyllanthus niruri leaves in rabbits. Kerala Journal of Veterinary Science 1989;20(1):77-80.
  13. Navarro M, Coussio J Hnatyszyn O et al. Hypoglycemic Effect of an Aqueous Extract of Phyllanthus sellowianus ("sarandi blanco") in C57BL/Ks mice. Acta Farmaceutica Bonaerense 2004;23:520-523.
  14. Etta HE, Udoh PB Asuquo BO et al. Effect of Phyllanthus amarus on breeding efficiency of female albino rats. Global Journal of Agricultural Sciences 2007;215-217. DOI
  15. Etta H. Effects of Phyllanthus amarus on litter traits in albino rats. Scientific Research and Essays 2008;370-372.
  16. Pucci ND, Marchini GS, Mazzucchi E, et al. Effect of phyllanthus niruri on metabolic parameters of patients with kidney stone: a perspective for disease prevention. Int Braz J Urol 2018;44(4):758-64. PubMed
  17. Sowjanya K, Girish C, Bammigatti C, Prasanna Lakshmi NC. Efficacy of Phyllanthus niruri on improving liver functions in patients with alcoholic hepatitis: A double-blind randomized controlled trial. Indian J Pharmacol 2021;53(6):448-456. PubMed
  18. Husain I, Abdulrahman B, Dale OR, et al. Interaction of Phyllanthus amarus extract and its lignans with human xenobiotic receptors, drug metabolizing enzymes and drug transporters. J Ethnopharmacol 2025;339:119142. PubMed

See these in context on the Chanca Piedra monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team