Major interaction on record — check this product against your medications before combining. Based on 2 of 8 ingredients. Check your meds →
Dietary supplement

Secret Sauce Orange Ingredients & Drug Interactions

by MuscleMeds

Secret Sauce Orange label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Secret Sauce Orange against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Secret Sauce Orange is a dietary supplement by MuscleMeds with 8 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 399 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Secret Sauce Orange by MuscleMeds

Ask about any prescription or over-the-counter medication and we check it for interactions with Secret Sauce Orange by MuscleMeds — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Secret Sauce Orange by MuscleMeds

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 19 active ingredients.
  • “10:1:1 BCAA Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “SECRET SAUCE Bioactive Muscle Growth and Recovery Activator” is listed as a grouped ingredient — the label gives one combined amount (700,000 mg) without saying how much of each component you get.
  • “iSPIKE Technology” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Secret Sauce Orange contains 19 ingredients, including active amino acids and performance-support compounds. The main actives are sodium, glycine, L-phenylalanine, and three forms of creatine (creatine monohydrate, creatine gluconate, and creatine magnapower), plus chromium and agaricus mushroom extract.

You'll also find a branched-chain amino acid (BCAA) complex and several enzyme blends listed as part of the product's muscle-growth and carbohydrate-absorption systems. The remaining ingredients are fillers and flavoring agents — citric acid, natural flavors, guar gum, beta-carotene, acesulfame potassium, and sucralose.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: post-workout muscle growth and recovery.
  • We looked for evidence on: Athletic performance, Muscle breakdown, Muscle cramps, Muscle strength, Physical performance, Postoperative recovery — and 4 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength, Sarcopenia.
  • Also on file: Creatine is rated "Insufficient Reliable Evidence To Rate" for Muscle breakdown, Muscle cramps, Physical performance, Postoperative recovery.

Creatine in this product is possibly effective for muscle strength and athletic performance, and may help with sarcopenia (age-related muscle loss). Chromium is possibly effective for diabetes support.

Glycine is possibly effective for schizophrenia, though the evidence is limited. Sodium has been rated likely effective for cystic fibrosis and possibly effective for amphotericin B nephrotoxicity (kidney damage from a specific antifungal), but those aren't typical reasons people take a sports supplement.

L-phenylalanine is possibly effective for vitiligo but possibly ineffective for ADHD. The effectiveness of agaricus mushroom for the conditions listed — allergies, bone health, cancer, heart disease, chemotherapy side effects, and Crohn disease — hasn't been established in the data we hold.

For a muscle-recovery powder, the creatine and amino acid content are the most relevant.

The evidence, ingredient by ingredient Sodium Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine is generally well tolerated in healthy adults but can cause dehydration, diarrhea, muscle cramps, and water retention; people with kidney problems should be cautious. Sodium is essential in small amounts, but too much is linked to high blood pressure and heart strain — avoid sodium supplements or very high intake without medical advice.

L-phenylalanine may cause anxiety, insomnia, constipation, heartburn, nausea, and sedation at supplement doses. Chromium is usually well tolerated but can cause GI irritation, headaches, insomnia, and mood changes; rare cases of kidney damage have been reported.

Glycine is generally well tolerated, though rare mild sedation, GI upset, and nausea have occurred. Agaricus mushroom is generally well tolerated as food but can cause abdominal discomfort, diarrhea, and nausea; rare cases of liver damage and allergic reactions have been reported.

Regarding pregnancy and breastfeeding: the data show creatine safety has not been established in pregnancy or while nursing, so those populations should avoid it. L-phenylalanine supplement doses should be avoided during pregnancy and breastfeeding.

Sodium and chromium have insufficient information on file — talk with your doctor before using this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Sodium Chromium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Phenylalanine, Chromium, Glycine, Agaricus Mushroom, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium; Parkinson's medications.
  • For scale: 399 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Secret Sauce Orange, double-check with your pharmacist if you take levodopa (Parkinson disease) — this is a Major interaction. Also flag if you're on blood pressure medications, thyroid drugs (levothyroxine), diabetes or insulin medications, antipsychotics (especially clozapine), NSAIDs, aspirin, lithium, corticosteroids, or any sodium-containing medication, as these have Moderate or Minor interactions with ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Secret Sauce Orange is a multi-ingredient sports supplement best suited for strength training and muscle recovery in healthy adults without kidney disease. If you take any blood pressure medication, thyroid drug, diabetes medication, antipsychotic (especially clozapine), Parkinson medication (levodopa), or pain relievers, check your specific drugs with the tool below before starting.

Pregnant and nursing mothers should not use it due to creatine and phenylalanine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 19 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Secret Sauce Orange, straight from the product label.

Brand MuscleMeds
Barcode (UPC) 891597003730
Net contents 3.11 lbs; 1410 Gram(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42291
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Secret Sauce Orange by MuscleMeds, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
70.5 Gram(s)
Maximum serving Sizes:
70.5 Gram(s)
Servings per container
20
UPC/BARCODE
891597003730
IngredientAmount% DV
Calories220 {Calories}--
Total Carbohydrates50 Gram(s)17%
Sugar0 Gram(s)--
Protein4 Gram(s)8%
Sodium104 mg4%
Glycine0 NP--
Maltodextrin0 NP--
L-Leucine0 NP--
Waxy Maize0 NP--
L-Isoleucine0 NP--
Creatine Monohydrate0 NP--
L-Phenylalanine0 NP--
L-Valine0 NP--
Amylase0 NP--
Glucoamylase0 NP--
4-Hydroxyisoleucine0 NP--
Creatine Gluconate0 NP--
D-Pinitol0 NP--
Creatine Magnapower0 NP--
Chromium200 mcg167%
Agaricus blazei0 NP--
10:1:1 BCAA Complex0 NP--
SECRET SAUCE Bioactive Muscle Growth and Recovery Activator700000 mg--
iSPIKE Technology0 NP--
Insulin-Release Amplifying Reactive Carbohydrate System0 NP--
Insulin-Signal Amplifying System0 NP--
patent-pending Chromium 454(R)0 NP--
Pharmaceutical Grade Bioactive BSA0 NP--
Highly Anabolic and Insulinotropic Amino Complex0 NP--
Power-AMP Cre3 Creatine Complex0 NP--

Other ingredients: Citric Acid, Natural flavors, Guar Gum, Beta-Carotene, Acesulfame Potassium, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

SECRET SAUCE is the world's first BIOACTIVE POST-WORKOUT formula enhanced with Pharmaceutical grade BSA (Bovine Serum Albumin) for potent anabolic action and fast recovery.

Some of the biological factors and functional properties of BSA include its bioactive peptides and growth factors, high concentrations of leucine and essential muscle building amino acids, high osmolality and its ability to enhance the uptake and transport of nutrients such as creatine, amino acids and glucose into blood plasma and speed delivery to muscle tissue.*

SECRET SAUCE doubles down with both naturally occurring leucine in BSA and an additional 5 gram leucine-loaded dose of BCAAs in an anabolic 10:1:1 ratio to trigger increased protein synthesis. To ensure peak ATP replenishment, SECRET SAUCE utilizes MuscleMeds Power-AMP Cre3 Creatine Complex consisting of creatine monohydrate, Creatine Magnapower(R) and creatine gluconate.

SECRET SAUCE has taken insulin spiking and glycogen replnishment to an advanced level with the inclusion of the insulinotropic amino acids glycine and phenylalanine in combination with MuscleMeds proprietary iSPIKE Insulin-Release-Amplifying Reactive Carbohydrate System.

The World's First BIOACTIVE POST-WORKOUT FORMULA With Pharmaceutical Grade BOVINE SERUM ALBUMIN

5g BSA BIOACTIVE PEPTIDES & GROWTH FACTORS 5G LEUCINE LOADED 10:1:1 BCAAs 50g iSPIKE REACTIVE CARB SYSTEM 5g POWER-AMP CRE3 CREATINE COMPLEX

General Statements

BIOACTIVE POST-WORKOUT MUSCLE GROWTH & RECOVERY ACTIVATOR*

BSA is a scientifically documented bioactive protein derived from bovine blood plasma. Researchers have identified BSA to have multiple biological factors that help influence muscle growth.

While BSA is the central core to SECRET SAUCE's anabolic action, this unique muscle building formulation contains many other powerful clinically researched ingredients that help make SECRET SAUCE the most advanced post-workout formula on the market.* Stimulating protein synthesis, modulating the anabolic effects of insulin and replenishing muscle glycogen and ATP are critical for optimal post-workout supplementation. Research has shown leucine to be perhaps the most anabolic and effective amino acid for activating mTOR and stimulating protein synthesis.

Post-workout creatine uptake and ATP replenishment is enhanced by BSA's plasma transport gradient, leading increased cell volumizing, muscle size and recovery.*

The next important step to complete post-workout supplementation is to optimize the anabolic activity of insulin and replenish glycogen.

These insulinotropic aminos work in tandem with the iSPIKE reactive carbohydrates and BSA plasma transport to activate a highly anabolic insulin surge and super fast muscle glycogen and ATP saturation. This dynamic trio also enhances the uptake of the other key nutrients, peptides and growth factors in BSA to trigger the post-workout growth and repair of muscle tissue.* If you train hard and want to get the most out of your workouts, SECRET SAUCE is your post-workout recipe for massive gains in muscle mass and super-fast recovery!*

QR Scan to watch "The Making of SECRET SAUCE Video" from the Generation Iron DVD!

HIGH VELOCITY BSA PLASMA TRANSPORT

NEW!

MUSCLE GROWTH & RECOVERY ACTIVATOR*

Naturally & Artificially Flavored

GSN

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

iSPIKE TECHNOLOGY

MuscleMeds(TM) PERFORMANCE TECHNOLOGY

Suggested/Recommended/Usage/Directions

DIRECTIONS: Mix two scoops of SECRET SAUCE with 12 fl. oz. of water in a shaker. Shake vigorously and drink immediately after your workout.

General

MM-003730-1213

Storage

- Store at 10(0)-30(0)C (50(0)-85(0)F). - Protect from heat, light and moisture.

Precautions

- Keep out of reach of children.

- Do not purchase if seal is broken.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Secret Sauce Orange by MuscleMeds label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Secret Sauce Orange label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Secret Sauce Orange by MuscleMeds

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size70.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 Gram(s) per serving

Protein

4 Gram(s) per serving

Sodium

Interacts with
205 drugs
104 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Chromium

Interacts with
178 drugs
200 mcg per serving Form: Chromium 454(R) Bio-Organic Yeast Matrix

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

SECRET SAUCE Bioactive Muscle Growth and Recovery Activator

700000 mg per serving
  • › ISPIKE Technology
  • › Pharmaceutical Grade Bioactive BSA
  • › Highly Anabolic and Insulinotropic Amino Complex
  • › Power-AMP Cre3 Creatine Complex

Other (inactive) ingredients: Citric Acid, Natural flavors, Guar Gum, Beta-Carotene, Acesulfame Potassium, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Secret Sauce Orange by MuscleMeds Drug Interactions

Want to check YOUR meds against Secret Sauce Orange?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
399Drugs
5 Major 306 Moderate 88 Minor

Ingredients driving the most interactions

Sodium 205
Chromium 178

Individual Drug Interactions

The ingredients in Secret Sauce Orange interact with 399 drugs. Click any drug to see the details.

2 of the 8 ingredients in Secret Sauce Orange interact with drugs. Each result below shows which ingredient is responsible. Sodium Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Secret Sauce Orange with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Secret Sauce Orange, from the product label.

MuscleMeds

See all MuscleMeds products
Name
MuscleMeds Performance Technologies
Street Address
165 Clinton Road
City
West Caldwell
State
NJ
ZipCode
07006
Phone Number
1.888.575.7067
Web Address
MuscleMedsRx.com
Pharmacist Counseling Corner

Secret Sauce Orange by MuscleMeds: Common Questions

Does Secret Sauce Orange by MuscleMeds interact with any medications?
Yes. Based on its ingredients, Secret Sauce Orange has a known interaction with 399 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Secret Sauce Orange contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product have creatine in it?
Yes — it contains three forms: creatine monohydrate, creatine gluconate, and creatine magnapower. Creatine is possibly effective for muscle strength and athletic performance and may help with age-related muscle loss.
Can I take this if I'm pregnant or breastfeeding?
No. Creatine and L-phenylalanine in this product have not been shown to be safe during pregnancy or while nursing. Talk with your doctor before using this product if you're pregnant, planning to become pregnant, or breastfeeding.
What are the amino acids in Secret Sauce Orange?
The product contains L-leucine, L-isoleucine, L-valine (branched-chain amino acids), L-phenylalanine, and glycine. These are amino acids that support muscle growth and recovery.
Will this cause water retention or bloating?
Creatine commonly causes water retention and can lead to muscle cramps or dehydration. A small number of trial participants taking creatine also reported edema (swelling). Staying well hydrated while using this product is important.
What if I have kidney problems?
You should be cautious. Creatine is generally well tolerated in healthy adults but those with kidney issues should check with their doctor or pharmacist before using this product, since creatine is processed by the kidneys.
Does this contain sugar?
The product uses sucralose (an artificial sweetener) rather than sugar for flavoring, so it's a sugar-free option.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Secret Sauce Orange is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Secret Sauce Orange label
Go deeper

The Full Monographs Behind Secret Sauce Orange’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph →
Sources

Sources & How We Checked

Secret Sauce Orange's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 210 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
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See these in context on the Chromium monograph →

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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