Sheer DHEA Extra Strength Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sheer DHEA Extra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sheer DHEA Extra Strength is a dietary supplement by Sheer Strength Labs with 1 active ingredient. Its ingredients are commonly taken for anti-aging and low dhea levels, mood and depression, vaginal dryness and sexual health.Based on those ingredients, 776 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dehydroepiandrosterone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sheer DHEA Extra Strength by Sheer Strength Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Sheer DHEA Extra Strength by Sheer Strength Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sheer DHEA Extra Strength by Sheer Strength Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dehydroepiandrosterone (DHEA), a hormone your body naturally makes. The capsule also includes inactive ingredients—cellulose, hypromellose, magnesium stearate, and silica—which are binders and fillers that hold the supplement together.
Does it work?
Strong evidence
The evidence for DHEA varies by use. It's rated likely effective for vaginal atrophy (drying and thinning of vaginal tissue).
It's rated possibly effective for infertility and for aging skin. It's also rated possibly effective for depression, though the research is still developing.
For other uses, we don't have established effectiveness ratings in our data.
How safe is it?
Well-documented data
DHEA is generally well tolerated in typical doses over the short term, but because it's a hormone, it needs medical oversight. Long-term use raises some concern about increased cancer risk.
The most common side effects are acne (usually mild and dose-dependent), headache, insomnia, mood changes, and nausea. Women may experience masculinization—voice deepening, increased facial hair, irregular periods, oily skin, and breast size changes.
Men may report aggression and breast tenderness. DHEA can also trigger mood problems including anxiety, irritability, and in rare cases, mania.
During pregnancy, the safety data advises against using DHEA. While breastfeeding, there isn't enough safety information, so avoid it then too.
Because DHEA is a hormone, talk with your doctor or pharmacist before taking it if you're pregnant, breastfeeding, or planning either.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you're on antidepressants (risk of mood changes including mania), blood thinners or antiplatelet drugs (increased bleeding risk), medications your liver metabolizes using the CYP3A4 pathway (levels may rise), triazolam or other sleep aids, or any estrogen-blocking cancer treatment (aromatase inhibitors, tamoxifen, or fulvestrant). If you've had a tuberculosis vaccine, DHEA may reduce its effectiveness.
No interactions are documented for the inactive ingredients.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
DHEA is possibly helpful for infertility, aging skin, and depression, and likely helpful for vaginal atrophy—but it's a hormone, so it belongs under medical supervision. If you take antidepressants, blood thinners, sleep aids, or hormone-related cancer medications, you'll need to clear this with your doctor or pharmacist first.
Talk it over with your own healthcare provider before starting, especially if you're on any regular medications or have concerns about long-term use.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sheer DHEA Extra Strength, straight from the product label.
| Brand | Sheer Strength Labs |
|---|---|
| Barcode (UPC) | 850009007162 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 22, 2020 |
| DSLD ID | 219362 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sheer DHEA Extra Strength by Sheer Strength Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Dehydroepiandrosterone | 100 mg | -- |
Other ingredients: Cellulose, Hypromellose, Magnesium Stearate, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1 vegetarian capsule per day, with a meal. For adult use only.
Precautions
Warning: Not for use by individuals under the age of 18 years.
Do not use if pregnant or nursing. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of breast cancer, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.
Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.
Keep out of reach of children.
Do not use if the safety seal is damaged or missing.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Supports & promotes Hormonal balance Natural energy levels Muscle building
Non GMO Gluten free
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Made in the USA from Global Ingredients GMP Good Manufacturing Practice Quality Product
Third Party Tested Purity & Potency
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sheer DHEA Extra Strength by Sheer Strength Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sheer DHEA Extra Strength by Sheer Strength Labs
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Dehydroepiandrosterone
Interacts with776 drugs
DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...
Dehydroepiandrosterone monograph & interactionsOther (inactive) ingredients: Cellulose, Hypromellose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.
Sheer DHEA Extra Strength by Sheer Strength Labs Drug Interactions
HelloPharmacist Interaction Report
Sheer DHEA Extra Strength contains dehydroepiandrosterone (DHEA), a hormone that interacts with multiple medication types.
The most serious concern is with antidepressants (a Moderate interaction): DHEA may increase the risk of psychiatric side effects, and there's a case report of an SSRI combined with DHEA triggering a manic episode.
Read the full breakdown — every affected drug type, severity by severity
DHEA also has Moderate interactions with blood thinners and antiplatelet drugs (increasing bleeding risk), drugs metabolized by the liver enzyme CYP3A4 (which may accumulate to higher levels), and specific medications including triazolam (a sleep aid that DHEA can raise in the bloodstream). Additionally, because DHEA acts as an estrogen agonist, it may interfere with aromatase inhibitors, tamoxifen, and fulvestrant—all hormone-related cancer treatments.
The tuberculosis vaccine (BCG) may be less effective if you're taking DHEA.
Altogether, these interactions span 777 individual medications. Because DHEA is a hormone that affects your whole system, you'll want to run any prescription or over-the-counter medications you take through the interaction checker below before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sheer DHEA Extra Strength?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sheer DHEA Extra Strength interact with 776 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sheer DHEA Extra Strength interact with drugs. Each result below shows which ingredient is responsible. Dehydroepiandrosterone
AmlodipineNorliqva
How Amlodipine interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amlodipine, Celecoxib interactionAmoxapineAsendin
How Amoxapine interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAntidepressant Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
Read the full Dehydroepiandrosterone + Amoxapine interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmprenavirAgenerase
How Amprenavir interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Amprenavir interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Anagrelide interactionAnastrozoleArimidex
How Anastrozole interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAromatase Inhibitors Moderate
Interaction Summary
Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
Read the full Dehydroepiandrosterone + Anastrozole interactionAnisindioneMiradon
How Anisindione interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Anisindione interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Antithrombin Iii interactionApalutamideErleada
How Apalutamide interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Apalutamide interactionApixabanEliquis
How Apixaban interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Apixaban interactionApremilastOtezla
How Apremilast interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Apremilast interactionAprepitantCinvanti, Emend
How Aprepitant interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aprepitant interactionArgatrobanArgatroban
How Argatroban interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Argatroban interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aripiprazole Lauroxil interactionArmodafinilNuvigil
How Armodafinil interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Armodafinil interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
How Aspirin interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
How Aspirin, Butalbital interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
How Aspirin, Butalbital, Caffeine interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Butalbital, Caffeine interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
How Aspirin, Butalbital, Caffeine, Phenacetin interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
How Aspirin, Caffeine interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneCytochrome P450 3a4 (cyp3a4) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Sheer DHEA Extra Strength — through 1 ingredient. Tap an ingredient for the detail:
DehydroepiandrosteroneAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone + Aspirin, Caffeine, Codeine Phosphate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sheer DHEA Extra Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Dehydroepiandrosterone
Anticoagulant/Antiplatelet Drugs
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.
Antidepressant Drugs
Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.
Aromatase Inhibitors
Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.
Fulvestrant (Faslodex)
Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.
Tamoxifen (Nolvadex)
Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.
Triazolam (Halcion)
DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.
Tuberculosis Vaccine
DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.
Estrogens
Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.
Testosterone
Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.
Brand information
Manufacturer and brand details for Sheer DHEA Extra Strength, from the product label.
Sheer Strength Labs
See all Sheer Strength Labs products- Name
- Sheer Strength Labs
- Street Address
- 15950 Dallas Parkway Suite 400
- City
- Dallas
- State
- TX
- ZipCode
- 75248
Sheer DHEA Extra Strength by Sheer Strength Labs: Common Questions
Does Sheer DHEA Extra Strength by Sheer Strength Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does DHEA actually work for what it's supposed to do?
What are the most common side effects I should watch for?
Is it safe to take DHEA long-term?
Can I take this if I'm pregnant or breastfeeding?
Why does DHEA interact with so many medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sheer DHEA Extra Strength is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sheer DHEA Extra Strength’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sheer DHEA Extra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 98 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Dhea 98 references
- Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
- Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. PubMed
- Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9.
- Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. DOI
- Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-81. PubMed
- Yen SS, Morales AJ, Khorram O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 1995;774:128-42. PubMed
- Labrie F, Diamond P, Cusan L, et al. Effect of 12 month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women. J Clin Endocrinol Metab 1997;82:3498-505. PubMed
- Casson PR, Faquin LC, Stentz FB. Replacement of dehydroepiandrosterone enhances T-lymphocyte insulin binding in postmenopausal women. (abstract) Fertil Steril 1995;63:1027-31. DOI
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