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Dietary supplement

Solomon's Seal Ingredients & Drug Interactions

by Herbalist & Alchemist

Solomon's Seal label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Solomon's Seal against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Solomon's Seal is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for joint and muscle discomfort, tendon and ligament injuries, inflammation.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are fresh Solomon's Seal rhizome extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Solomon's Seal by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Solomon's Seal by Herbalist & Alchemist — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Solomon's Seal by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Solomon's Seal by Herbalist & Alchemist is a liquid extract made from fresh Solomon's Seal rhizome. This single active ingredient is suspended in ethyl alcohol and distilled water.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promotes respiratory health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness data on this product in our current information.

The evidence, ingredient by ingredient Solomon's Seal

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Limited safety data exists for Solomon's Seal in people, so use it carefully and choose reputable products. Long-term use has been reported to cause stomach irritation, and large doses may bring on nausea, diarrhea, and other digestive complaints.

Safety has not been established in pregnancy, so it's best to avoid it if you're pregnant. There isn't enough information to consider it safe while breastfeeding — talk to your doctor or pharmacist for personalized advice if you're nursing.

Side effects, ingredient by ingredient Solomon's Seal

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Solomon's Seal.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes medications — insulin, chlorpropamide, or other antidiabetes drugs — double-check them before taking Solomon's Seal. All carry a moderate risk of additive blood-sugar-lowering effects that may require dose adjustment or closer glucose monitoring.

No interactions are documented for the other drug types we could assess.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Solomon's Seal may lower blood sugar and could enhance the effect of diabetes medications. If you take insulin, chlorpropamide, or another antidiabetes drug, check with your doctor or pharmacist before starting this product — your medication dose may need adjusting.

Given limited safety data, use a reputable brand and watch for stomach upset, especially with long-term or high-dose use.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Solomon's Seal, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056126032
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Jun 25, 2018
DSLD ID 174804
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Solomon's Seal by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056126032
IngredientAmount% DV
fresh Solomon's Seal rhizome extract2 mL--

Other ingredients: Ethyl Alcohol, distilled Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Polygonatum biflorum

OK

General Statements

Promotes respiratory health

Botanical preparation ratio 1:2

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 20-40 drops (1-2 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO. SOL-2 1739TH

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Solomon's Seal by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Solomon's Seal label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Solomon's Seal by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Fresh Solomon's Seal rhizome extract

Interacts with
86 drugs
2 mL per serving

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largel...

Fresh Solomon's Seal rhizome extract monograph & interactions

Other (inactive) ingredients: Ethyl Alcohol, Distilled Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Solomon's Seal by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Solomon's Seal?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

fresh Solomon's Seal rhizome extract 86

Individual Drug Interactions

The ingredients in Solomon's Seal interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Solomon's Seal interact with drugs. Each result below shows which ingredient is responsible. fresh Solomon's Seal rhizome extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Solomon's Seal with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

fresh Solomon's Seal rhizome extract3 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, concomitant use may enhance hypoglycemic drug effects and alter blood glucose control. Monitor blood glucose.

Likelihood Possible Evidence D
Chlorpropamide (Diabinese)

Concomitant use may cause additive hypoglycemic effects.

Likelihood Possible Evidence D
Insulin

Insulin dosage adjustments may be necessary, due to the possible hypoglycemic effects of Solomon's seal.

Likelihood Possible Evidence D
fresh Solomon's Seal rhizome extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Solomon's Seal, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Solomon's Seal by Herbalist & Alchemist: Common Questions

Does Solomon's Seal by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Solomon's Seal has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Solomon's Seal contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Safety has not been established in pregnancy, so you should avoid it if you're pregnant. There isn't enough information to say it's safe while breastfeeding. Talk to your doctor or pharmacist for personalized advice based on your situation.
What side effects might I notice?
Long-term use has been reported to cause stomach irritation. Large doses may cause nausea, diarrhea, and other digestive complaints. A full safety evaluation hasn't been done, so other effects may exist that we don't yet know about.
Why should I be careful if I take diabetes medicine?
Solomon's Seal may lower blood sugar on its own, and it can add to the effect of insulin, chlorpropamide, and other diabetes drugs. This could drop your blood sugar too low, so your doctor may need to adjust your medication dose and monitor your glucose more carefully.
Does this product have any fillers or added ingredients?
The active ingredient is fresh Solomon's Seal rhizome extract. It's dissolved in ethyl alcohol and distilled water — those are the other ingredients in the liquid form.
How do I know if I'm using a reputable product?
The product facts don't specify what to look for, but because safety data is limited, it's worth asking your pharmacist to recommend a trusted brand and to verify the product's quality before you start using it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Solomon's Seal is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Solomon's Seal label
Go deeper

The Full Monographs Behind Solomon's Seal’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Solomon's Seal

Interacts with 86 drugs

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable...

Read the full Solomon's Seal monograph →
Sources

Sources & How We Checked

Solomon's Seal's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Solomon's Seal 2 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

See these in context on the Solomon's Seal monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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