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Dietary supplement

Unprocessed Rehmannia Ingredients & Drug Interactions

by Herbalist & Alchemist

Unprocessed Rehmannia label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Unprocessed Rehmannia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Unprocessed Rehmannia is a dietary supplement by Herbalist & Alchemist with 1 active ingredient. Its ingredients are commonly taken for kidney and adrenal support, anemia and blood building (traditional), inflammatory conditions.Based on those ingredients, 258 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are dried unprocessed Rehmannia root extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Unprocessed Rehmannia by Herbalist & Alchemist

Ask about any prescription or over-the-counter medication and we check it for interactions with Unprocessed Rehmannia by Herbalist & Alchemist — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Unprocessed Rehmannia by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 24, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: dried unprocessed Rehmannia root extract in liquid form. The base includes distilled water and ethyl alcohol as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Rehmannia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports healthy immune balance.
  • We looked for evidence on: Atopic disease, immune function, hypersensitivity, inflammatory response.
  • The closest evidence on file: Rehmannia is rated "Insufficient Reliable Evidence To Rate" for Atopic disease (Natural Medicines).

The evidence for rehmannia varies by condition. For chronic kidney disease (CKD), it's possibly effective—meaning there's some supporting research, but it's not definitive.

For other uses listed here—aplastic anemia, atopic disease (like eczema or allergies), osteoporosis, diabetes, and diabetic nephropathy—we don't yet have enough reliable evidence to say whether it works. That doesn't mean it doesn't; it means the research isn't there yet in the data we hold.

The evidence, ingredient by ingredient Rehmannia

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rehmannia is used in traditional medicine, but human safety data are limited and product quality varies considerably between brands. The safety information isn't strong enough to recommend this product during pregnancy or while breastfeeding—talk with your doctor or pharmacist about whether it's right for you in those situations.

No adverse effects from trials are reported in our data, though that doesn't mean none can occur.

Side effects, ingredient by ingredient Rehmannia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Rehmannia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 258 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before combining this product with blood pressure medications (antihypertensives) or diabetes medications, both Moderate-severity concerns. Altogether, these interactions span 258 individual medications—use the checker on this page to look up your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Unprocessed Rehmannia may help with chronic kidney disease, though evidence is limited. If you take blood pressure or diabetes medications, you'll want to discuss this product with your doctor or pharmacist first, since it could lower blood pressure or blood sugar further.

Given the gaps in human safety data, it's worth confirming with your healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 23, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Unprocessed Rehmannia, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056134945
Net contents 2 fl. Oz.; 60 mL
Market status On market
Date entered into DSLD Mar 23, 2018
DSLD ID 174569
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Unprocessed Rehmannia by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
2 mL
Servings per container
30
UPC/BARCODE
667056134945
IngredientAmount% DV
dried unprocessed Rehmannia root extract2 mL--

Other ingredients: distilled Water, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Rehmannia glutinosa

OK

General Statements

Supports healthy immune balance

Botanical preparation ratio 1:5

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 30-40 drops (1.5-2 mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

NO RHU-2 1734FR

Seals/Symbols

OK

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Unprocessed Rehmannia by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Unprocessed Rehmannia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Unprocessed Rehmannia by Herbalist & Alchemist

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Dried unprocessed Rehmannia root extract

Interacts with
258 drugs
2 mL per serving

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human eviden...

Dried unprocessed Rehmannia root extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Unprocessed Rehmannia by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against Unprocessed Rehmannia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
258Drugs
258 Moderate

Ingredients driving the most interactions

dried unprocessed Rehmannia root extract 258

Individual Drug Interactions

The ingredients in Unprocessed Rehmannia interact with 258 drugs. Click any drug to see the details.

1 of the 1 ingredient in Unprocessed Rehmannia interact with drugs. Each result below shows which ingredient is responsible. dried unprocessed Rehmannia root extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Unprocessed Rehmannia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

dried unprocessed Rehmannia root extract2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, rehmannia might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that rehmannia may have hypoglycemic effects.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, rehmannia might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research shows that rehmannia may have hypotensive effects. Laboratory research shows that formulations of dried and processed rehmannia root inhibit angiotensin-converting enzyme (ACE).

Likelihood Possible Evidence D
dried unprocessed Rehmannia root extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Unprocessed Rehmannia, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

Unprocessed Rehmannia by Herbalist & Alchemist: Common Questions

Does Unprocessed Rehmannia by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, Unprocessed Rehmannia has a known interaction with 258 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Unprocessed Rehmannia contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
There isn't enough safety information to recommend it. Talk with your doctor or pharmacist about whether it's appropriate for you.
What does rehmannia actually do in the body?
Animal and lab research suggests it may have effects on blood pressure and blood sugar, and it may interact with an enzyme (ACE) involved in blood pressure regulation. The exact mechanisms in humans aren't fully understood.
Is this product standardized or guaranteed pure?
Quality and potency vary between products. Since this is a traditional herbal extract, consistency isn't guaranteed the way pharmaceutical drugs are.
What's the difference between processed and unprocessed Rehmannia?
The interaction data we hold shows that processed rehmannia affects ACE. Unprocessed versions may have different properties, but the research on how they differ clinically is limited.
Can I take this if I'm on blood pressure medicine?
Not without checking with your doctor or pharmacist first. Rehmannia may lower blood pressure on its own, so combining it with a blood pressure medication could drop your pressure too far.
Does this help diabetes?
We don't have enough reliable evidence yet to say whether it works for diabetes. Animal research suggests rehmannia might affect blood sugar, but human trials are lacking. If you have diabetes and want to try it, check with your doctor or pharmacist first—especially since it may interact with diabetes medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Unprocessed Rehmannia is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Unprocessed Rehmannia label
Go deeper

The Full Monographs Behind Unprocessed Rehmannia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rehmannia

Interacts with 258 drugs

Rehmannia is a root used for centuries in Traditional Chinese Medicine, often to 'tonify' the kidneys and support energy or blood health. Human evidence for most modern uses is limited, so i...

Read the full Rehmannia monograph →
Sources

Sources & How We Checked

Unprocessed Rehmannia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 3 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rehmannia 3 references
  1. Zhang R, Zhou J, Jia Z, et al. Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. J Ethnopharmacol 2004;90:39-43. PubMed
  2. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol 2008;117(2):199-214. PubMed
  3. Chao CH, Hsu JL, Chen MF, et al. Anti-hypertensive effects of Radix Rehmanniae and its active ingredients. Nat Prod Res. 2020;34(11):1547-1552.

See these in context on the Rehmannia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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