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Dietary supplement

Somaplex 18 Copper - Gold - Silver Ingredients & Drug Interactions

by Nestmann

Somaplex 18 Copper - Gold - Silver label
See full label image
Liquid Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Somaplex 18 Copper - Gold - Silver against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Somaplex 18 Copper - Gold - Silver is a dietary supplement by Nestmann with 3 active ingredients. Its ingredients are commonly taken for preventing or treating copper deficiency, supporting red blood cell formation, bone and connective tissue health.Based on those ingredients, 31 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cupric Gluconate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Somaplex 18 Copper - Gold - Silver by Nestmann

Ask about any prescription or over-the-counter medication and we check it for interactions with Somaplex 18 Copper - Gold - Silver by Nestmann — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Somaplex 18 Copper - Gold - Silver by Nestmann

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This liquid product contains three active ingredients: cupric gluconate (a form of copper), sodium tetrachloaurate (a gold salt), and silver nitrate. It also includes water and ethyl alcohol as inactive ingredients.

Copper is an essential mineral your body needs for nerve function, immune strength, and iron metabolism. The other two ingredients — the gold salt and silver nitrate — are not standard supplement components and carry significant safety concerns outlined below.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Ionized trace elements supplement.
  • We looked for evidence on: Copper deficiency.
  • The strongest evidence on file: Copper is rated "Likely Effective" for Copper deficiency (Natural Medicines).

Copper is likely effective for treating copper deficiency. For other uses listed in our data — Alzheimer's disease, acne, chemotherapy-related anemia, and brain tumors — the evidence is either insufficient to rate or points toward ineffectiveness (in the case of Alzheimer's).

We hold no effectiveness data for sodium tetrachloroaurate or silver nitrate.

The evidence, ingredient by ingredient Copper Sodium Tetrachloroaurate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Copper is safe in food amounts and standard supplements, but excess copper is toxic. You need copper in pregnancy, but stick to recommended amounts and avoid high-dose supplements without medical guidance.

Skin reactions from copper contact have been reported rarely. Sodium tetrachloroaurate is an industrial gold salt, not a supplement, and the facts advise against consuming it entirely.

Gold salts taken by mouth may cause nausea, vomiting, diarrhea, and abdominal cramps, and in rare cases ulcerative inflammation of the intestines. Orally or by injection, gold salts can trigger serious blood and bone marrow problems — including low platelets, low white blood cells, and aplastic anemia — and skin reactions ranging from itching and rash to an irreversible blue-gray discoloration (chrysiasis) that worsens in sunlight.

Safety data for silver nitrate are not on file.

Side effects, ingredient by ingredient Copper Sodium Tetrachloroaurate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Copper.
  • The most serious interaction on file is rated Moderate.
  • For scale: 31 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take penicillamine, copper may reduce how well it works — check with us before combining them. Oral contraceptives may raise your copper levels and increase the risk of copper's toxic effects.

Before starting this product, run your exact medications through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines copper — a mineral with genuine use in deficiency — with two ingredients the safety data advises against. Sodium tetrachloroaurate is flagged as an industrial chemical not safe for human use, and silver nitrate carries no established safety profile.

If you're considering it for copper alone, talk to a pharmacist first; if you take penicillamine or birth control, you'll need to check interactions carefully.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Somaplex 18 Copper - Gold - Silver, straight from the product label.

Brand Nestmann
Net contents 1 fl. Oz.; 29.5 mL
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 25513
Product type Other Combinations
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Somaplex 18 Copper - Gold - Silver by Nestmann, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.3 mL
Maximum serving Sizes:
0.6 mL
Servings per container
49
IngredientAmount% DV
Cupric Gluconate0.195 mcg--
Sodium Tetrachloroaurate0.195 mcg--
Silver Nitrate0.195 mcg--

Other ingredients: Water, ethyl alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

1392

IONIZED TRACE ELEMENTS

18

>>NESTMANN<<

Made in Germany Nestmann Pharma Zapfendorf/Bamberg

FDA Statement of Identity

SUPPLEMENT

Suggested/Recommended/Usage/Directions

Suggested Use: Adults take 20 drops on the tongue or in 1 oz. water two times daily. Children receive 1/2 or less of the adult amount.

Precautions

Tamper Evident: Use this product only if tamper evident ring has not been broken away from base of cap.

Seals/Symbols

MPI

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Somaplex 18 Copper - Gold - Silver by Nestmann label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Somaplex 18 Copper - Gold - Silver label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Somaplex 18 Copper - Gold - Silver by Nestmann

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.3 mL Dosage formLiquid Servings per container49 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Cupric Gluconate

Interacts with
31 drugs
0.195 mcg per serving

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...

Cupric Gluconate monograph & interactions

Sodium Tetrachloroaurate

No known
interactions
0.195 mcg per serving

Sodium tetrachloroaurate is a gold(III) chemical compound used in laboratories and industry, not a dietary supplement or herb. It is not approved or r...

Sodium Tetrachloroaurate monograph & interactions

Silver Nitrate

0.195 mcg per serving

Other (inactive) ingredients: Water, Ethyl alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Somaplex 18 Copper - Gold - Silver by Nestmann Drug Interactions

Want to check YOUR meds against Somaplex 18 Copper - Gold - Silver?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
31Drugs
1 Moderate 30 Minor

Ingredients driving the most interactions

Cupric Gluconate 31

Individual Drug Interactions

The ingredients in Somaplex 18 Copper - Gold - Silver interact with 31 drugs. Click any drug to see the details.

1 of the 3 ingredients in Somaplex 18 Copper - Gold - Silver interact with drugs. Each result below shows which ingredient is responsible. Cupric Gluconate

Each ingredient & the kinds of drugs it affects

For each ingredient in Somaplex 18 Copper - Gold - Silver with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cupric Gluconate2 drug types · 31 drugs

Penicillamine (Cuprimine, Depen)

Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.

Likelihood Probable Evidence D
Contraceptive Drugs

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.

Likelihood Possible Evidence D
Cupric Gluconate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Somaplex 18 Copper - Gold - Silver, from the product label.

Nestmann

See all Nestmann products
Name
Marco Pharma Int'l
City
Roseburg
State
OR
ZipCode
97470
Pharmacist Counseling Corner

Somaplex 18 Copper - Gold - Silver by Nestmann: Common Questions

Does Somaplex 18 Copper - Gold - Silver by Nestmann interact with any medications?
Yes. Based on its ingredients, Somaplex 18 Copper - Gold - Silver has a known interaction with 31 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Somaplex 18 Copper - Gold - Silver contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant?
The copper ingredient is rated likely safe in pregnancy at recommended amounts, but you should avoid high-dose copper supplements without medical guidance. Sodium tetrachloroaurate is flagged as possibly unsafe in pregnancy and should be avoided entirely. Talk to your doctor or pharmacist before taking this product during pregnancy.
What is sodium tetrachloroaurate and why is it in here?
It's an industrial gold(III) salt, not a supplement ingredient. The facts advise against consuming it — it may cause serious stomach problems, blood disorders, and skin damage similar to other gold salts used in older medicine. This is a red flag for the product.
Does copper actually work for anything?
Yes — copper is likely effective for treating copper deficiency. For Alzheimer's disease, acne, chemotherapy-related anemia, and brain tumors, the evidence we hold is either too weak to rate or suggests it doesn't help.
Can I take this with my birth control pill?
Oral contraceptives can raise copper levels in your blood, and this product could push them higher. That's a minor interaction, but it's worth a quick conversation with your pharmacist, especially if you're on it long-term.
Is there anything else I should know about copper itself?
Copper is safe in normal amounts, but too much is toxic. In rare cases, direct contact with copper has caused skin reactions. Stick to recommended doses and avoid high-dose supplements without a doctor's OK.
What about the silver nitrate — is that safe?
We don't have safety data on file for silver nitrate. Combined with the sodium tetrachloroaurate being flagged as unsafe for human consumption, this product carries serious safety uncertainties — talk to a pharmacist before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Somaplex 18 Copper - Gold - Silver is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Somaplex 18 Copper - Gold - Silver label
Go deeper

The Full Monographs Behind Somaplex 18 Copper - Gold - Silver’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Copper

Interacts with 31 drugs

Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...

Read the full Copper monograph → Herb & supplement monograph

Sodium Tetrachloroaurate

Sodium tetrachloroaurate is a gold(III) chemical compound used in laboratories and industry, not a dietary supplement or herb. It is not approved or recommended for human use, and ingesting...

Read the full Sodium Tetrachloroaurate monograph →
Sources

Sources & How We Checked

Somaplex 18 Copper - Gold - Silver's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Copper 11 references
  1. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  2. Campbell IA, Elmes PC. Ethambutol and the eye: zinc and copper (letter). Lancet 1975;2:711. DOI
  3. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  4. Kozak SF, Inderlied CB, Hsu HY, et al. The role of copper on ethambutol's antimicrobial action and implications for ethambutol-induced optic neuropathy. Diag Microbiol Infect Dis 1998;30:83-7. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  6. Cantilena LR, Klaassen CD. The effect of chelating agents on the excretion of endogenous metals. Toxicol Appl Pharmacol 1982;63:344-50.
  7. Babic Z, Tariba B, Kovacic J, Pizent A, Varnai VM, Macan J. Relevance of serum copper elevation induced by oral contraceptives: a meta-analysis. Contraception. 2013 Jun;87(6):790-800. PubMed
  8. Qui Q, Zhang F, Zhu W, Wu J, Liang M. Copper in diabetes mellitus: a meta-analysis and systematic review of plasma and serum studies. Biol Trace Elem Res 2017;177(1):53-63.
  9. Walker-Smith PK, Keith DJ, Kennedy CT, Sansom JE. Allergic contact dermatitis caused by copper. Contact Dermatitis 2016;75(3):186-7. PubMed
  10. Gallentine A. Third-degree burn on the neuropathic lower extremity in a patient with diabetes while wearing a copper-containing compression sock: a case report. Wound Manag Prev 2021;67(12):26-29. DOI
  11. Chung KJ, Chin YM, Wong MS, Sanmugam A, Singaravel S, Nah SA. Effectiveness of table salt versus copper sulphate in treating umbilical granuloma: A pilot randomized controlled trial. J Pediatr Surg 2022;57(2):261-265. PubMed

See these in context on the Copper monograph →

Sodium Tetrachloroaurate 3 references
  1. Ridaura (auranofin) [package insert]. San Diego, CA: Prometheus Laboratories, Inc; 2011.
  2. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Gold Preparations. [Updated 2017 Aug 2].
  3. Eisler R. Chrysotherapy: a synoptic review. Inflamm Res. 2003;52(12):487-501. PubMed

See these in context on the Sodium Tetrachloroaurate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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