Soy Genistein Isoflavone Powder Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Soy Genistein Isoflavone Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Soy Genistein Isoflavone Powder is a dietary supplement by Planetary Herbals with 5 active ingredients. Its ingredients are commonly taken for menopause symptoms (hot flashes), high cholesterol, bone health/osteoporosis.Based on those ingredients, 867 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Genistein. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Soy Genistein Isoflavone Powder by Planetary Herbals
Ask about any prescription or over-the-counter medication and we check it for interactions with Soy Genistein Isoflavone Powder by Planetary Herbals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Soy Genistein Isoflavone Powder by Planetary Herbals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This powder contains 4 ingredients total. The active ones are genistein, daidzein, and glycitein—three isoflavones (phytoestrogens, or estrogen-like compounds) that come from soy and other plant sources.
The product also includes SoyLife non-GMO Isoflavone Complex as a standardized source. There are no inactive fillers or binders listed.
Does it work?
Insufficient evidence
The evidence for what genistein and daidzein actually do isn't established in our data. For the uses this product might target—androgenic alopecia (male-pattern hair loss), menopausal symptoms, osteoarthritis, and osteoporosis—our data shows insufficient reliable evidence to rate whether these ingredients work.
You'd want to talk with your pharmacist or doctor about what the current research says for your specific situation.
How safe is it?
Well-documented data
Short-term, these isoflavones are generally well tolerated in healthy adults, but their estrogen-like effects mean certain people need to be cautious. The most common side effects reported are muscle pain (myalgia), nausea, and vaginal spotting.
There's been some concern that long-term use of red clover and soy isoflavones might modestly increase breast density in women who haven't gone through menopause yet, though postmenopausal women didn't show this effect in the trials reviewed. One red clover isoflavone product has been linked to headache at rates similar to placebo.
Avoid this product during pregnancy because of its estrogen-like effects and lack of safety data. There isn't enough safety information for breastfeeding either—your best move is to skip it while nursing.
Meds to double-check
Moderate interaction found
Before taking this, double-check with your pharmacist if you use hormone replacement therapy (estrogen), methotrexate, or tamoxifen—those carry Moderate severity risks. You should also verify any drugs metabolized by CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes, or blood thinners (anticoagulants) and antiplatelet medications, which carry Minor risks.
Two ingredients—Total Isoflavones and Glycitein—could not be checked against our data.
The bottom line
Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is for people interested in isoflavone supplementation who aren't on hormone therapy, methotrexate, tamoxifen, or drugs metabolized by major liver enzymes. If you take any prescription medications, check them against the interaction tool on this page first.
Pregnant or breastfeeding? Talk to your pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Soy Genistein Isoflavone Powder, straight from the product label.
| Brand | Planetary Herbals |
|---|---|
| Barcode (UPC) | 021078104674 |
| Net contents | 4 Oz(s); 113 Gram(s) |
| Market status | On market |
| Date entered into DSLD | Aug 22, 2017 |
| DSLD ID | 77595 |
| Product type | Other Combinations |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Soy Genistein Isoflavone Powder by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 1 Gram(s) | 1% |
| Protein | 1 Gram(s) | 2% |
| Genistein | 2.5 mg | -- |
| Total Isoflavones | 50 mg | -- |
| Daidzein | 19.5 mg | -- |
| SoyLife non-GMO Isoflavone Complex | 2.5 Gram(s) | -- |
| Glycitein | 8.25 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Non GMO validated
Seals/Symbols
Non GMO validated
FDA Statement of Identity
Herbal Supplement
General Statements
Approved by Michael Tierra L.Ac, O.M.D
Isoflavones are unique polyphenol compounds which are found in the soybean plant. Research suggests that soy protein and soy isoflavones may reduce the frequency and severity of hot flashes during menopause.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 teaspoon mixed with water or juice, twice daily with a meal.
Convenient to mix with water or juice.
Storage
Store in a cool, dry place.
Formula
Planetary Herbals Soy Genistein Isoflavone Powder contains 50 mg of SoyLIfe isoflavones per serving which are naturally occurring and come from non-GMO soy.
One teaspoon provides slightly more isoflavones than two 1,000 mg tablets.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
PF0467 REV E171
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Soy Genistein Isoflavone Powder by Planetary Herbals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Soy Genistein Isoflavone Powder by Planetary Herbals
These are the 5 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 tsp Dosage formPowder Servings per container45 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Soy Genistein Isoflavone Powder by Planetary Herbals Drug Interactions
HelloPharmacist Interaction Report
Soy Genistein Isoflavone Powder by Planetary Herbals contains two checked active ingredients—genistein and daidzein—that carry documented interactions.
Both share the same interaction profile, with the most serious concern involving hormone replacement therapy (estrogen). These phytoestrogens (plant compounds with estrogen-like activity) may compete for estrogen receptors and theoretically interfere with how your body uses prescription estrogens, a Moderate severity risk.
Read the full breakdown — every affected drug type, severity by severity
The other Moderate severity interaction is with methotrexate (Trexall), a medication used for psoriasis and other conditions. A case report documented severe toxicity symptoms—intense vomiting and stomach pain—when someone taking methotrexate started red clover at high doses; toxicity reversed once they stopped.
There's also a Moderate concern with tamoxifen (Nolvadex), a breast cancer drug, because laboratory and animal research hints that genistein might work against tamoxifen's tumor-fighting effects, though one animal study suggested it may not.
Minor interactions are documented with several drug-metabolizing enzyme systems: CYP1A2, CYP2C19, CYP2C9, and CYP3A4 substrates. Theoretically these could raise drug levels, but a small clinical trial found no actual effect in healthy people taking red clover isoflavones.
There's also a Minor concern with blood thinners (anticoagulants) and antiplatelet drugs, though lab research hasn't translated to clinical problems so far.
We could not check two ingredients in this product: Total Isoflavones and Glycitein. Altogether, these interactions span 857 individual medications.
Run your exact prescriptions through the checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Soy Genistein Isoflavone Powder?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Soy Genistein Isoflavone Powder interact with 867 drugs. Click any drug to see the details.
1 of the 5 ingredients in Soy Genistein Isoflavone Powder interact with drugs. Each result below shows which ingredient is responsible. Genistein
Bazedoxifene Acetate, Conjugated EstrogensDuavee
How Bazedoxifene Acetate, Conjugated Estrogens interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Bazedoxifene Acetate, Conjugated Estrogens interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Conjugated Estrogens interactionConjugated Estrogens, Medroxyprogesterone AcetatePremplus, Prempro
How Conjugated Estrogens, Medroxyprogesterone Acetate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Conjugated Estrogens, Medroxyprogesterone Acetate interactionConjugated Estrogens, MeprobamatePMB 200, PMB 400
How Conjugated Estrogens, Meprobamate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Conjugated Estrogens, Meprobamate interactionConjugated Estrogens, MethyltestosteronePremarin with Methyltestosterone
How Conjugated Estrogens, Methyltestosterone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Conjugated Estrogens, Methyltestosterone interactionCyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Cyproterone Acetate, Ethinyl Estradiol interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Desogestrel, Ethinyl Estradiol interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Drospirenone, Ethinyl Estradiol interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Estrone interactionEstropipateOgen, Ortho EST
How Estropipate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Estropipate interactionEthiny Estradiol, LevonorgestrelLogynon, Microgynon 30 ED
How Ethiny Estradiol, Levonorgestrel interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Ethiny Estradiol, Levonorgestrel interactionEthinyl EstradiolEstinyl
How Ethinyl Estradiol interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol interactionEthinyl Estradiol, DesogestrelApri, Cesia, Cyclessa, Gedarel, Kariva, Linessa +4 more
How Ethinyl Estradiol, Desogestrel interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 2c9 (cyp2c9) Substrates, Estrogens +2 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol, Desogestrel interactionEthinyl Estradiol, DrospirenoneYaz
How Ethinyl Estradiol, Drospirenone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol, Drospirenone interactionEthinyl Estradiol, Ethynodiol DiacetateDemulen 1/35, Demulen 1/50, Demulen Compack, Kelnor 1/35, Zovia, Zovia 1/35 +1 more
How Ethinyl Estradiol, Ethynodiol Diacetate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Ethinyl Estradiol, Ethynodiol Diacetate interactionEthinyl Estradiol, LevonorgestrelAlesse, Alesse 21, Alesse 28, Aviane, Enpresse, Jolessa +18 more
How Ethinyl Estradiol, Levonorgestrel interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol, Levonorgestrel interactionEthinyl Estradiol, NorethindroneAranelle, Brevicon, Brevicon .5/35 21 day, Brevicon .5/35 28 day, Brevicon 1/35 21 day, Brevicon 1/35 28 day +50 more
How Ethinyl Estradiol, Norethindrone interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Ethinyl Estradiol, Norethindrone interactionEthinyl Estradiol, Norethindrone, Ferrous FumarateEstrostep Fe, Femcon FE, Junel Fe 1.5/30, Loestrin Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20 +3 more
How Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 1a2 (cyp1a2) Substrates, Estrogens +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interactionEthinyl Estradiol, NorgestimateCilest, Mononessa, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Ortho Tri-Cylcen, Ortho-Cyclen +5 more
How Ethinyl Estradiol, Norgestimate interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Ethinyl Estradiol, Norgestimate interactionEthinyl Estradiol, NorgestrelCryselle, Lo/Ovral, Low-Ogestrel, Ogestrel 0.5/50, Ovral
How Ethinyl Estradiol, Norgestrel interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
Read the full Daidzein + Ethinyl Estradiol, Norgestrel interactionEthinyl Estradiol, LevonogestrelLybrel
How Ethinyl Estradiol, Levonogestrel interacts with Soy Genistein Isoflavone Powder — through 1 ingredient. Tap an ingredient for the detail:
DaidzeinEstrogens, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Read the full Daidzein + Ethinyl Estradiol, Levonogestrel interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Soy Genistein Isoflavone Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Genistein
Estrogens
Theoretically, concomitant use of large amounts of red clover might interfere with estrogen therapy.
Red clover contains phytoestrogens which might have estrogenic activity in some people. Theoretically, red clover might compete for estrogen receptors and interfere with estrogen-containing drug therapy.
Methotrexate (Trexall, Others)
Theoretically, red clover might increase the risk of methotrexate toxicity.
In a case report, a 52-year-old female receiving weekly methotrexate injections for psoriasis developed symptoms of methotrexate toxicity, including severe vomiting and epigastric pain, after three days of taking red clover 430 mg daily. Toxicity resolved after red clover was discontinued. However, no liver function tests or methotrexate levels were reported.
Tamoxifen (Nolvadex)
Theoretically, the phytoestrogens in red clover might interfere with tamoxifen.
In vitro and animal research suggests that genistein, a constituent of red clover, might antagonize the antitumor effects of tamoxifen. However, there is some evidence from an animal study that red clover does not reduce the efficacy of tamoxifen. Until more is known, tell patients taking tamoxifen to avoid red clover.
Anticoagulant/Antiplatelet Drugs
Although some laboratory research suggests that red clover may have anticoagulant and antiplatelet activity, clinical research has not shown this effect.
In vitro research suggests that genistein in red clover has antiplatelet effects, and historically, red clover was thought to have anticoagulant effects due to its coumarin content. However, some experts state that this is unlikely as most natural coumarins have not been shown to have anticoagulant effects, and their content in red clover is low. Additionally, some clinical research in postmenopausal patients found no effect on coagulation or prothrombin time with the use of red clover flowering tops 378 mg daily for 12 months or red clover isoflavone (Rimostil) 50 mg daily for 2 years.
Caffeine
Theoretically, soy might reduce the clearance of caffeine; however, a small clinical study found no effect.
Red clover contains genistein. Taking genistein 1 gram daily for 14 days seems to inhibit caffeine clearance and metabolism in healthy females. However, this effect does not seem to occur with the lower amounts of genistein found in red clover. A clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP1A2; however, a small clinical study found no effect.
In vitro evidence shows that red clover inhibits CYP1A2. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of caffeine, a CYP1A2 probe substrate.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, red clover might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that red clover weakly inhibits CYP2C19. This interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP2C9; however, a small clinical study found no effect.
In vitro evidence suggests that red clover might inhibit CYP2C9. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of tolbutamide, a CYP2C9 probe substrate.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, red clover might increase levels of drugs metabolized by CYP3A4; however, a small clinical study found no effect.
In vitro evidence shows that red clover might inhibit CYP3A4 isoenzymes. However, a clinical study in healthy postmenopausal individuals shows that taking red clover capsules standardized to contain 60 mg isoflavones twice daily for 14 days does not affect the pharmacokinetics of alprazolam, a CYP3A4 probe substrate.
Brand information
Manufacturer and brand details for Soy Genistein Isoflavone Powder, from the product label.
Planetary Herbals
See all Planetary Herbals products- Name
- Planetary Herbals, LLC
- Street Address
- P.O. Box 1760
- City
- Soquel
- State
- CA
- ZipCode
- 95073
- Web Address
- www.planetaryherbals.com
Soy Genistein Isoflavone Powder by Planetary Herbals: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Soy Genistein Isoflavone Powder’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Soy Genistein Isoflavone Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 24 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Red Clover 24 references
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
- This P, De La Rochefordiere A, Clough K, et al. Phytoestrogens after breast cancer. Endocr Relat Cancer 2001;8:129-34. PubMed
- Tice J, Cummings SR, Ettinger B, et al. Few adverse effects of two red clover extracts rich in phytoestrogens: a multicenter, placebo-controlled trial. Alt Ther 2001;7:S33.
- Ingram DM, Hickling C, West L, et al. A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 2002;11:170-4. PubMed
- Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. PubMed
- Geller SE, Shulman LP, van Breemen RB, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor symptoms: a randomized controlled trial. Menopause 2009;16:1156-66. PubMed
- Hidalgo LA, Chedraui PA, Morocho N, et al. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol 2005;21(5):257-264. PubMed
- Campbell MJ, Woodside JV, Honour JW, et al. Effect of red clover-derived isoflavone supplementation on insulin-like growth factor, lipid and antioxidant status in healthy female volunteers: a pilot study. Eur J Clin Nutr 2004;58(1):173-179. PubMed
- Guerrero JA, Lozano ML, Castillo J, et al. Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost 2005;3(2):369-376. PubMed
- Kondo K, Suzuki Y, Ikeda Y, Umemura K. Genistein, an isoflavone included in soy, inhibits thrombotic vessel occlusion in the mouse femoral artery and in vitro platelet aggregation. Eur J Pharmacol 2002;455(1):53-57. PubMed
- Polini N, Rauschemberger MB, Mendiberri J, et al. Effect of genistein and raloxifene on vascular dependent platelet aggregation. Mol Cell Endocrinol 2007;267(1-2):55-62. PubMed
- Wuttke W, Jarry H, Seidlova-Wuttke D. Plant-derived alternative treatments for the aging male: facts and myths. Aging Male 2010;13(2):75-81. PubMed
- Villaseca P. Non-estrogen conventional and phytochemical treatments for vasomotor symptoms: what needs to be known for practice. Climacteric 2012;15(2):115-124. PubMed
- Chen, Y., Xiao, C. Q., He, Y. J., Chen, B. L., Wang, G., Zhou, G., Zhang, W., Tan, Z. R., Cao, S., Wang, L. P., and Zhou, H. H. Genistein alters caffeine exposure in healthy female volunteers. Eur.J Clin.Pharmacol. 2011;67(4):347-353. PubMed
- Friedman, J. A., Taylor, S. A., McDermott, W., and Alikhani, P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. Neurocrit.Care 2007;7(1):76-80. PubMed
- Hooper, L., Madhavan, G., Tice, J. A., Leinster, S. J., and Cassidy, A. Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials. Hum.Reprod.Update. 2010;16(6):745-7 PubMed
- Orr A and Parker R. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. Menopause Int. 2013;19(3):133-134. PubMed
- Clifton-Bligh PB, et al. Red cover isoflavones enriched with formononetin lower serum LDL cholesterol- a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2015;69(1):134-142.
- Risk assessment for peri- and post-menopausal women taking food supplements containing isolated isoflavones. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS). 2015. DOI
- Ferraris C, Ballestra B, Listorti C, et al. Red clover and lifestyle changes to contrast menopausal symptoms in premenopausal patients with hormone-sensitive breast cancer receiving tamoxifen. Breast Cancer Res Treat 2020;180(1):157-65. doi: 10.1007/s1054 PubMed
- Chen L, Choi J, Leonard SW, et al. No Clinically Relevant Pharmacokinetic Interactions of a Red Clover Dietary Supplement with Cytochrome P450 Enzymes in Women. J Agric Food Chem. 2020;68(47):13929-13939. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC