Major interaction on record — check this product against your medications before combining. Based on 5 of 7 ingredients. Check your meds →
Dietary supplement

Super Advanced Isolate Protein Vanilla Creme Ingredients & Drug Interactions

by Body Fortress

Super Advanced Isolate Protein Vanilla Creme label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Super Advanced Isolate Protein Vanilla Creme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Super Advanced Isolate Protein Vanilla Creme is a dietary supplement by Body Fortress with 7 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 319 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Calcium, Iron. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Super Advanced Isolate Protein Vanilla Creme by Body Fortress

Ask about any prescription or over-the-counter medication and we check it for interactions with Super Advanced Isolate Protein Vanilla Creme by Body Fortress — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Super Advanced Isolate Protein Vanilla Creme by Body Fortress

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 6 active ingredients.

This powder contains six active ingredients. Calcium supports bone health and is effective for kidney failure and heartburn relief.

Iron helps prevent and treat anemia. Sodium and potassium are electrolytes your body needs for nerve and muscle function.

BetaPower (betaine anhydrous) is an amino acid compound studied for homocysteine metabolism. The product also contains Tri-Phase Isolate Matrix, which we could not evaluate.

The remaining ingredients are inactive—natural and artificial flavors, lecithin, sweeteners, and thickeners.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: muscle and strength development.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Muscle growth, Protein synthesis, Recovery.
  • The closest evidence on file: Iron is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Iron is rated "Insufficient Reliable Evidence To Rate" for Postoperative recovery.

Calcium in this product is effective for supporting kidney function, relieving heartburn (dyspepsia), and treating low blood calcium, and is likely effective for osteoporosis. Iron is effective for iron-deficiency anemia and possibly effective for heart failure.

BetaPower is effective for homocystinuria (a rare metabolic disorder) and possibly effective for elevated homocysteine levels; evidence for NASH, depression, and GERD is currently insufficient. We hold no effectiveness data for Tri-Phase Isolate Matrix.

The evidence, ingredient by ingredient Calcium Iron Sodium Potassium Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended amounts; high doses can cause constipation, diarrhea, or stomach upset, and rare cases of kidney stones have been reported. Iron is generally well tolerated and commonly causes mild GI upset like nausea or constipation; the product should be used when there's a real need rather than routinely.

Sodium is essential but excess intake is linked to high blood pressure and heart strain. Potassium from food is safe, but supplements can raise blood levels dangerously, especially in people with kidney problems.

BetaPower is generally well tolerated but may cause body odor, nausea, or diarrhea. For pregnancy and breastfeeding: calcium and iron are considered likely safe when used at recommended doses under medical guidance; sodium is likely safe at normal dietary levels; potassium from food is likely safe; BetaPower has insufficient safety data—talk with your doctor or pharmacist about use in pregnancy or while nursing.

Side effects, ingredient by ingredient Calcium Iron Sodium Potassium Betaine Anhydrous

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Calcium, Potassium, Iron, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 319 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check whether you use dolutegravir or elvitegravir (HIV medications), intravenous ceftriaxone (antibiotic), levothyroxine (thyroid), blood-pressure medications including ACE inhibitors or ARBs, potassium-sparing diuretics, beta-blockers like sotalol, lithium, levodopa (Parkinson's), bisphosphonates (osteoporosis), tetracycline or quinolone antibiotics, or diltiazem (heart medication). These interactions range from Major to Moderate severity.

Use the medication search tool on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is a multi-ingredient supplement with significant medication interactions, particularly with HIV medications, blood-pressure drugs, levothyroxine, and antibiotics. If you take any prescription medication, especially for heart rhythm, blood pressure, thyroid, or infection, check your exact drugs with the tool below before use.

Talk with your pharmacist or doctor about whether this product fits your individual health situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Super Advanced Isolate Protein Vanilla Creme, straight from the product label.

Brand Body Fortress
Barcode (UPC) 074312004681
Net contents 1.5 Pound(s); 24 Ounce(s); 680 Gram(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 271156
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Super Advanced Isolate Protein Vanilla Creme by Body Fortress, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
38 Gram(s), 76 Gram(s)
Maximum serving Sizes:
38 Gram(s), 76 Gram(s)
Servings per container
9
UPC/BARCODE
074312004681
IngredientAmount% DV
Protein60 Gram(s), 30 Gram(s)120%, 60%
Trans Fat0 Gram(s), 0 Gram(s)--
Cholesterol30 mg, 15 mg10%, 5%
Total Fat2.5 Gram(s), 1 Gram(s)3%, 1%
Added Sugars0 Gram(s), 0 Gram(s)--
Saturated Fat1 Gram(s), 0 Gram(s)5%
Calories290 Calorie(s), 140 Calorie(s)--
Total Carbohydrate4 Gram(s), 2 Gram(s)2%, 1%
Total Sugars2 Gram(s), 1 Gram(s)--
Calcium509 mg, 254 mg39%, 20%
Iron2 mg, 1 mg11%, 6%
Sodium340 mg, 170 mg15%, 7%
Potassium210 mg, 100 mg4%, 2%
BetaPower2.5 Gram(s), 1.25 Gram(s)--
Tri-Phase Isolate Matrix0 NP--

Other ingredients: Natural and Artificial flavors, Sunflower Lecithin, Soy Lecithin, Sucralose, Acesulfame Potassium, Carrageenan, Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

60g protein Featuring 100% isolate per 2 scoops Vanilla creme naturally & artificially flavored

Super Advanced Isolate Protein per 2 scoop serving Protein and amino acid profile 60g protein 12g BCAAs from protein 2.5g BetaPower betaine anhydrous Macro-nutrient and calorie content Reduced amounts of unwanted fat, carbohydrates and cholesterol 290 calories 2g sugar 2.5g fat 30mg cholesterol Super Advanced Isolate Protein contains faster, medium and slow acting proteins that work together to deliver a sustained-release of amino acids, plus a full dose of betaine to support lean mass.

100% ultra-pure isolate Reduced fat & carbohydrates

General Statements

America's #1 muscle and strength development powder brand Source: IRI, MULO, 52 Week Ending 5/24/20, excluding online sales. Training isn't about shortcuts. You get out what you put in. Body Fortress knowns that it isn't about flashy gimmicks - it's what's on the inside that really counts. No hype - just hard work.

Super Advanced Isolate Protein is always on the clock because you deserve a protein powder that works just as hard as you do.

For more information on other Body Fortress products or for complete training and nutrition programs, visit www.bodyfortress.com. For workout motivation and exclusive content, follow Instagram @OfficialBodyFortress

Contents are sold by weight. Some settling may occur. Typical amino acid profile (milligrams per 38g scoop) Essential amino acids Histidine 780 mg Isoleucine 1,580 mg Leucine 2,890 mg Lysine 2,430 mg Methionine 640 mg Phenylalanine 1,200 mg Threonine 1,620 mg Tryptophan 460 mg Valine 1,690 mg Nonessential amino acids Alanine 1,290 mg Arginine 1,280 mg Aspartic Acid 2,960 mg Cysteine 460 mg Glutamic Acid 5,520 mg Glycine 720 mg Proline 1,930 mg Serine 1,540 mg Tyrosine 1,080 mg L-Tryptophan is naturally occurring, not added. Approximate values

Please recycle

Servings Per Container about 18 about 9

Formulation

That's why our Super Advanced Isolate Protein undergoes state-of-the-art manufacturing processes. To ensure we're delivering a protein you can count on to be highly purified and contain reduced amounts of unwanted fat, carbohydrates, and cholesterol. Compared to protein concentrates

This makes our multi-functional formula a great choice for any time of day including; post-workout, between meals, or before bed.

Triple-phase sustained release isolate matrix 01 fast = Whey isolate provides immediate amino acid delivery. 02 medium = Soy isolate creates a bridge between milk and whey to keep steady flow of amino acids to muscles. 03 slow = Milk isolate delivers and helps feed muscles for longer periods of time.

Build lean muscle & strength Boost post-workout recovery

Zero aspartame Gluten free

Free of: Yeast, wheat, artificial color.

Seals/Symbols

Contents Certified NSF

cGMP Manufactured Manufactured according to cGMP standards, as is required for all dietary supplements. Made in the USA from select ingredients from around the world.

Suggested/Recommended/Usage/Directions

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Precautions

Contains milk and soy ingredients. Made in a facility that also processes peanuts, tree nuts, egg, wheat, sesame, fish, and shellfish.

Contains bioengineered food ingredients.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of the reach of children.

For your protection, do not use if seal under cap is broken or missing.

Storage

Directions: For adults, add one (1) scoop to 6-8 ounces or two (2) scoops to 14-16 ounces of your favorite beverage. Super Advanced Isolate Protein can be taken before or after exercise, between meals or before bed. Stir Stir for 20-30 seconds or until completely blended Shake Cover and shake for 25-30 seconds. Blend Cover and blend for 20-30 seconds Use in conjunction with an intense daily exercise program and a balanced diet including an adequate caloric intake.

Store at room temperature, tightly closed and avoid excessive heat.

Brand IP Statement(s)

BetaPower is a registered trademark of Dupont Nutrition Biosciences. Supro is a registered trademark of Solae, LLC.

Body Fortress Your body - Your fortress

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Super Advanced Isolate Protein Vanilla Creme by Body Fortress label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Super Advanced Isolate Protein Vanilla Creme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Super Advanced Isolate Protein Vanilla Creme by Body Fortress

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size38 Gram(s) Dosage formPowder Servings per container9 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

60 Gram(s) per serving

Calcium

Interacts with
168 drugs
509 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Iron

Interacts with
80 drugs
2 mg per serving

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Sodium

Interacts with
205 drugs
340 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
210 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

BetaPower

No known
interactions
2.5 Gram(s) per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

BetaPower monograph & interactions

Tri-Phase Isolate Matrix

0 NP per serving Form: Milk Protein isolate, Supro 661 Soy Protein isolate, Whey Protein isolate

Other (inactive) ingredients: Natural and Artificial flavors, Sunflower Lecithin, Soy Lecithin, Sucralose, Acesulfame Potassium, Carrageenan, Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Super Advanced Isolate Protein Vanilla Creme by Body Fortress Drug Interactions

Want to check YOUR meds against Super Advanced Isolate Protein Vanilla Creme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
319Drugs
7 Major 309 Moderate 3 Minor

Ingredients driving the most interactions

Sodium 205
Calcium 168
Iron 80
Potassium 62

Individual Drug Interactions

The ingredients in Super Advanced Isolate Protein Vanilla Creme interact with 319 drugs. Click any drug to see the details.

4 of the 7 ingredients in Super Advanced Isolate Protein Vanilla Creme interact with drugs. Each result below shows which ingredient is responsible. Sodium Calcium Iron Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Super Advanced Isolate Protein Vanilla Creme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Super Advanced Isolate Protein Vanilla Creme, from the product label.

Body Fortress

See all Body Fortress products
Name
United States Nutrition, Inc.
City
Bohemia
State
NY
ZipCode
11716
Phone Number
1-800-215-5980
Web Address
www.bodyfortress.com
Pharmacist Counseling Corner

Super Advanced Isolate Protein Vanilla Creme by Body Fortress: Common Questions

Does Super Advanced Isolate Protein Vanilla Creme by Body Fortress interact with any medications?
Yes. Based on its ingredients, Super Advanced Isolate Protein Vanilla Creme has a known interaction with 319 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Super Advanced Isolate Protein Vanilla Creme contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this protein powder have fillers?
It contains inactive ingredients including lecithin, sweeteners (sucralose and acesulfame potassium), carrageenan, and dextrin. These are binders and thickeners, not fillers that bulk up the product without purpose—they're standard in powdered supplements.
Is the iron in here enough to treat anemia?
The product contains iron, which is effective for iron-deficiency anemia, but we don't have the exact dose listed in our data. Check the label for the amount per serving, or talk with your doctor about whether it's right for your situation.
Is it safe to take while pregnant?
Calcium and iron are considered likely safe at recommended doses during pregnancy and are often advised. However, BetaPower has insufficient safety data in pregnancy. Talk with your prenatal care provider before use, since they can review the full ingredient list and your individual needs.
Can I take this if I'm on blood-pressure medication?
This product contains sodium and potassium, both of which can interact with blood-pressure drugs. High sodium can reduce their effectiveness, and potassium supplements can dangerously raise blood levels, especially with ACE inhibitors or ARBs. Check with your doctor or pharmacist before starting.
What is BetaPower?
BetaPower is betaine anhydrous, an amino acid compound. It's effective for a rare metabolic condition called homocystinuria and possibly helpful for elevated homocysteine levels. It may cause body odor or mild GI upset in some people.
Will this interact with my thyroid medication?
Yes—both calcium and iron in this product can reduce how well levothyroxine (Synthroid) is absorbed. Take your thyroid medication at least 2–4 hours apart from this product. Talk with your pharmacist about the best timing for your dose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Super Advanced Isolate Protein Vanilla Creme label
Go deeper

The Full Monographs Behind Super Advanced Isolate Protein Vanilla Creme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Super Advanced Isolate Protein Vanilla Creme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 195 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
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  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
  31. Bolland MJ, Barber PA, Doughty RN, et al. Vascular events in healthy older women receiving calcium supplementation: randomised control trial. BMJ 2008;336:262-6.
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  39. Dickinson, H. O., Nicolson, D. J., Cook, J. V., Campbell, F., Beyer, F. R., Ford, G. A., and Mason, J. Calcium supplementation for the management of primary hypertension in adults. Cochrane.Database.Syst.Rev. 2006;(2):CD004639. PubMed
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  42. Castelo-Branco, C., Ciria-Recasens, M., Cancelo-Hidalgo, M. J., Palacios, S., Haya-Palazuelos, J., Carbonell-Abello, J., Blanch-Rubio, J., Martinez-Zapata, M. J., Manasanch, J., and Perez-Edo, L. Efficacy of ossein-hydroxyapatite complex compared with ca
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See these in context on the Calcium monograph →

Iron 72 references
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  35. Liabeuf S, Gras V, Moragny J, et al. Ulceration of the oral mucosa following direct contact with ferrous sulfate in elderly patients: a case report and a review of the French National Pharmacovigilance Database. Clin Interv Aging. 2014 Apr 25;9:737-40. PubMed
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  41. Zlotkin S, Newton S, Aimone AM, et al. Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial. JAMA 2013;310(9):938-47. PubMed
  42. Khambalia AZ, Aimone A, Nagubandi P, et al. High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabet Med. 2016;33(9):1211-21. PubMed
  43. Kinnunen TI, Luoto R, Helin A, Hemminki E. Supplemental iron intake and the risk of glucose intolerance in pregnancy: re-analysis of a randomised controlled trial in Finland. Matern Child Nutr. 2016;12(1):74-84.
  44. Low MS, Speedy J, Styles CE, De-Regil LM, Pasricha SR. Daily iron supplementation for improving anaemia, iron status and health in menstruating women. Cochrane Database Syst Rev. 2016;4:CD009747. PubMed
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Sodium 38 references
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Potassium 12 references
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Betaine Anhydrous 11 references
  1. Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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